Lawrence J. Appel
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View article: The Impact of Baseline Sleep as a Potential Moderator of Weight Loss Intervention in Breast Cancer Survivors: Results From the <scp>POWER</scp> ‐Remote Trial
The Impact of Baseline Sleep as a Potential Moderator of Weight Loss Intervention in Breast Cancer Survivors: Results From the <span>POWER</span> ‐Remote Trial Open
Objective We evaluated whether sleep disturbance moderates weight loss in breast cancer survivors. We hypothesized that poor sleep prior to behavioral weight loss (BWL) would be associated with less weight reduction than better sleep. Meth…
View article: Partially Replacing Dietary Carbohydrate With Unsaturated Fat or Protein Shifts Protein-Based HDL Subspecies Toward Lower Coronary Heart Disease Risk
Partially Replacing Dietary Carbohydrate With Unsaturated Fat or Protein Shifts Protein-Based HDL Subspecies Toward Lower Coronary Heart Disease Risk Open
BACKGROUND: Dietary unsaturated fat, protein, and carbohydrate have well-established effects on HDL (high-density lipoprotein) cholesterol levels, but whether these effects are connected causally to coronary heart disease (CHD) has been ca…
View article: Evidence-Based, Streamlined Approach to Measure Blood Pressure in Primary Care Settings
Evidence-Based, Streamlined Approach to Measure Blood Pressure in Primary Care Settings Open
The current guideline-recommended clinic blood pressure (BP) measurement procedure takes nearly 10 minutes to complete and may not be feasible to implement in busy clinical practice settings. Additionally, evidence supporting the steps in …
View article: Association between cigarette smoking status, intensity, and cessation duration with long-term incidence of nine cardiovascular and mortality outcomes: The Cross-Cohort Collaboration (CCC)
Association between cigarette smoking status, intensity, and cessation duration with long-term incidence of nine cardiovascular and mortality outcomes: The Cross-Cohort Collaboration (CCC) Open
Background Uncertainties persist regarding the precise shape of the smoking-outcome curves across various cardiovascular and mortality endpoints. This study aims to elucidate the relationships among smoking burden, intensity, and cessation…
View article: Achieving cardiovascular health equity in community mental health: study protocol for a cluster-randomized hybrid Type 3 effectiveness-implementation trial
Achieving cardiovascular health equity in community mental health: study protocol for a cluster-randomized hybrid Type 3 effectiveness-implementation trial Open
ClinicalTrials.gov identifier: NCT06674616 , registered on November 1, 2024.
View article: Association of History of Dizziness and Long-term Adverse Outcomes With Early vs Later Orthostatic Hypotension Assessment Times in Middle-aged Adults
Association of History of Dizziness and Long-term Adverse Outcomes With Early vs Later Orthostatic Hypotension Assessment Times in Middle-aged Adults Open
Importance: Guidelines recommend assessing orthostatic hypotension (OH) 3 minutes after rising from supine to standing positions. It is not known whether measurements performed immediately after standing predict adverse events as strongly …
View article: Simplified blood pressure measurement approaches and implications for hypertension screening: the Atherosclerosis Risk in Communities study.
Simplified blood pressure measurement approaches and implications for hypertension screening: the Atherosclerosis Risk in Communities study. Open
OBJECTIVES: Averaging multiple blood pressure (BP) measurements is recommended for hypertension (HTN) screening but can be impractical, especially in resource-constrained settings. We aimed to explore the implications of fewer BP measureme…
View article: #303 Unraveling the biology of adversity: proteomic and metabolomic insights into socioeconomic disparities in kidney disease
#303 Unraveling the biology of adversity: proteomic and metabolomic insights into socioeconomic disparities in kidney disease Open
Background and Aims Socioeconomic deprivation is a key contributor to chronic kidney disease (CKD), and both disproportionately affect people of color. The mechanisms linking socioeconomic deprivation to adverse health outcomes in CKD rema…
View article: Estimated health impact, cost, and cost-effectiveness of taxation on unhealthy packaged foods in the Philippines: a modelling study
Estimated health impact, cost, and cost-effectiveness of taxation on unhealthy packaged foods in the Philippines: a modelling study Open
Resolve to Save Lives funded by Bloomberg Philanthropies.
View article: Primary Prevention Aspirin, Lipoprotein(a), and Cardiorenal Outcomes in Chronic Kidney Disease
Primary Prevention Aspirin, Lipoprotein(a), and Cardiorenal Outcomes in Chronic Kidney Disease Open
Individuals with CKD and elevated Lp(a) without clinical CVD may derive net benefit from low-dose aspirin for the primary prevention of MI and ESRD.
View article: Contextual and Landscape Analysis of Team-Based Care Practices for Hypertension Management in Ghana: A Cross-Sectional Nationwide Study
Contextual and Landscape Analysis of Team-Based Care Practices for Hypertension Management in Ghana: A Cross-Sectional Nationwide Study Open
Introduction The World Health Organization recommends team-based care (TBC) for hypertension control, particularly in low-resourced settings. This study assessed current practices, task distribution, and perspectives on a team-based approa…
View article: Intradialytic Cognitive and Aerobic Exercise Training to Preserve Cognitive Function: IMPCT, A Multi-Dialysis Center 2x2 Factorial Block-Randomized Controlled Trial
Intradialytic Cognitive and Aerobic Exercise Training to Preserve Cognitive Function: IMPCT, A Multi-Dialysis Center 2x2 Factorial Block-Randomized Controlled Trial Open
Introduction: Patients with end-stage kidney disease (ESKD) develop cognitive impairment due to comorbidities and dialysis dependence. Among community-dwelling older adults, cognitive (CT) and exercise training (ET) are promising intervent…
View article: Effects of intensive blood pressure treatment on orthostatic hypertension: individual level meta-analysis
Effects of intensive blood pressure treatment on orthostatic hypertension: individual level meta-analysis Open
Objective To determine the effects of intensive blood pressure treatment on orthostatic hypertension. Design Systematic review and individual participant data meta-analysis. Data sources MEDLINE, Embase, and Cochrane CENTRAL databases thro…
View article: 105 Risk factors for hypokalemia in adults in Bangladesh
105 Risk factors for hypokalemia in adults in Bangladesh Open
Objectives/Goals: A sample of 1,073 hypertensive adults in Bangladesh showed unusually high rates of hypokalemia. We analyzed sociodemographic and clinical factors – including age, sex, weight, body mass index, blood pressure, creatinine c…
View article: Proteomic Correlates of Vitamin D Supplementation in the Atherosclerosis Risk in Communities (ARIC) Study
Proteomic Correlates of Vitamin D Supplementation in the Atherosclerosis Risk in Communities (ARIC) Study Open
Purpose Proteins are key effectors of biological functions and play roles in signaling, transport, growth, repair, and immunity. Vitamin D biomarkers may be reflected in the plasma proteome. The aim of this discovery study was to identify …
View article: Dyskalemia Prior to and After Initiation of a Fixed Dose Combination of Telmisartan and Amlodipine in Adults with Hypertension in Bangladesh
Dyskalemia Prior to and After Initiation of a Fixed Dose Combination of Telmisartan and Amlodipine in Adults with Hypertension in Bangladesh Open
Background: The World Health Organization recommends fixed-dose combination (FDC) pills for treating hypertension. Antihypertensive FDC pills often contain a renin-angiotensin inhibitor (RASI) or diuretic. Thus, screening and monitoring fo…
View article: Cigar, Pipe, and Smokeless Tobacco Use and Cardiovascular Outcomes From Cross Cohort Collaboration
Cigar, Pipe, and Smokeless Tobacco Use and Cardiovascular Outcomes From Cross Cohort Collaboration Open
Importance Cardiovascular health outcomes associated with noncigarette tobacco products (cigar, pipe, and smokeless tobacco) remain unclear, yet such data are required for evidence-based regulation. Objective To investigate the association…
View article: Urinary Sodium and Potassium Excretion in Bangladeshi Adults: Results from a Population-Based Survey with 24-Hour Urine Collections
Urinary Sodium and Potassium Excretion in Bangladeshi Adults: Results from a Population-Based Survey with 24-Hour Urine Collections Open
In Bangladesh, salt intake exceeded WHO's recommended <5g/day limit, while potassium intake was substantially lower than the recommended intake of ≥ 3.5g/day for adults. Promoting low-sodium and potassium-rich diets through nationwide camp…
View article: Effects of medication procurement reforms and extended prescription duration on medication coverage for hypertension in India’s public health system: a modelling study
Effects of medication procurement reforms and extended prescription duration on medication coverage for hypertension in India’s public health system: a modelling study Open
Objectives To estimate the effects of procurement reforms and extended prescription duration on medication coverage for hypertension in India’s public health system. Design Simulation study incorporating data from governmental medication p…
View article: Pulse Pressure and Cardiovascular and Kidney Outcomes by Age in the Chronic Renal Insufficiency Cohort (CRIC)
Pulse Pressure and Cardiovascular and Kidney Outcomes by Age in the Chronic Renal Insufficiency Cohort (CRIC) Open
BACKGROUND Wide pulse pressure (PP) is associated with cardiovascular events and the progression of chronic kidney disease (CKD) to kidney failure. PP naturally widens with age, but it is unclear whether the risks associated with greater P…
View article: Correction: Behavioral Weight Loss Programs for Cancer Survivors Throughout Maryland: Protocol for a Pragmatic Trial and Participant Characteristics
Correction: Behavioral Weight Loss Programs for Cancer Survivors Throughout Maryland: Protocol for a Pragmatic Trial and Participant Characteristics Open
[This corrects the article DOI: 10.2196/54126.].
View article: Associations of Hypertension and Orthostatic Hypotension With Subclinical Cardiovascular Disease
Associations of Hypertension and Orthostatic Hypotension With Subclinical Cardiovascular Disease Open
Background Orthostatic hypotension is associated with cardiovascular disease. It remains unclear if low standing blood pressure or high seated blood pressure is responsible for this association. We compared associations of orthostatic hypo…
View article: Task-sharing with community health workers to treat hypertension: a scoping review
Task-sharing with community health workers to treat hypertension: a scoping review Open
Many studies have implemented and evaluated task-sharing interventions with community health workers (CHWs) to manage hypertension. To identify gaps in research, we conducted a scoping review. We searched original articles published in Pub…