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View article: Heat up, silence on: IDO1 gene silencing in THP-1-derived dendritic cells triggered by magnetic hyperthermia
Heat up, silence on: IDO1 gene silencing in THP-1-derived dendritic cells triggered by magnetic hyperthermia Open
Dendritic cells (DCs) are well-known antigen-presenting cells which have an important role in cancer immunomodulation due to the effective regulation of immune responses in the tumor microenvironment (TME). Indoleamine 2,3-dioxygenase 1 ge…
View article: Correction: Membrane-localized magnetic hyperthermia promotes intracellular delivery of cell-impermeant probes
Correction: Membrane-localized magnetic hyperthermia promotes intracellular delivery of cell-impermeant probes Open
Correction for ‘Membrane-localized magnetic hyperthermia promotes intracellular delivery of cell-impermeant probes’ by Javier Idiago-López et al. , Nanoscale , 2024, 16 , 15176–15195, https://doi.org/10.1039/D4NR01955E.
View article: Key factors influencing magnetic nanoparticle-based photothermal therapy: physicochemical properties, irradiation power, and particle concentration <i>in vitro</i>
Key factors influencing magnetic nanoparticle-based photothermal therapy: physicochemical properties, irradiation power, and particle concentration <i>in vitro</i> Open
The photothermal properties of a collection of magnetic nanoparticles were analyzed. One of these sets of particles was further tested in vitro triggering cell death after 10 minutes of laser exposure.
View article: Membrane-localized magnetic hyperthermia promotes intracellular delivery of cell-impermeant probes
Membrane-localized magnetic hyperthermia promotes intracellular delivery of cell-impermeant probes Open
In this work, we report the disruptive use of membrane-localized magnetic hyperthermia to promote the internalization of cell-impermeant probes (fluorescent molecules and small interfering RNA), without affecting cell viability.
View article: Remote Activation of Enzyme Nanohybrids for Cancer Prodrug Therapy Controlled by Magnetic Heating
Remote Activation of Enzyme Nanohybrids for Cancer Prodrug Therapy Controlled by Magnetic Heating Open
Herein, we have developed nanohybrids (nHs) to remotely activate a therapeutic enzyme for its use in Directed Enzyme Prodrug Therapy (DEPT). The coencapsulation of magnetic nanoparticles (MNPs) with horseradish peroxidase (HRP) using biomi…
View article: Influence of Magnetic Nanoparticle Degradation in the Frame of Magnetic Hyperthermia and Photothermal Treatments
Influence of Magnetic Nanoparticle Degradation in the Frame of Magnetic Hyperthermia and Photothermal Treatments Open
This work aims at studying how the transformations that magnetic nanoparticles suffer in vivo affect their heating properties in the frame of hyperthermia treatments. Iron oxide magnetic nanoparticles (≈13 nm) with two different coatings […
View article: Iron Speciation in Animal Tissues Using AC Magnetic Susceptibility Measurements: Quantification of Magnetic Nanoparticles, Ferritin, and Other Iron-Containing Species
Iron Speciation in Animal Tissues Using AC Magnetic Susceptibility Measurements: Quantification of Magnetic Nanoparticles, Ferritin, and Other Iron-Containing Species Open
The simultaneous detection and quantification of several iron-containing species in biological matrices is a challenging issue. Especially in the frame of studies using magnetic nanoparticles for biomedical applications, no gold-standard t…
View article: Nano-Second Laser Interference Photoembossed Microstructures for Enhanced Cell Alignment
Nano-Second Laser Interference Photoembossed Microstructures for Enhanced Cell Alignment Open
Photoembossing is a powerful photolithographic technique to prepare surface relief structures relying on polymerization-induced diffusion in a solventless development step. Conveniently, surface patterns are formed by two or more interferi…
View article: Critical Parameters to Improve Pancreatic Cancer Treatment Using Magnetic Hyperthermia: Field Conditions, Immune Response, and Particle Biodistribution
Critical Parameters to Improve Pancreatic Cancer Treatment Using Magnetic Hyperthermia: Field Conditions, Immune Response, and Particle Biodistribution Open
Magnetic hyperthermia (MH) was used to treat a murine model of pancreatic cancer. This type of cancer is generally characterized by the presence of dense stroma that acts as a barrier for chemotherapeutic treatments. Several alternating ma…
View article: Unveiling the role of surface, size, shape and defects of iron oxide nanoparticles for theranostic applications
Unveiling the role of surface, size, shape and defects of iron oxide nanoparticles for theranostic applications Open
Theranosticity of nanoparticles provided by their shape, size, defects and dendron coating.
View article: Influence of the magnetic nanoparticles biodistribution on the cytotoxicity mechanisms triggered by magnetic hyperthermia
Influence of the magnetic nanoparticles biodistribution on the cytotoxicity mechanisms triggered by magnetic hyperthermia Open
Trabajo presentado a la V Reunión de Jóvenes Investigadores en Coloides e Interfases, celebrada en la Universidad de Zaragoza del 2 al 4 de marzo de 2020.
View article: Design of stable magnetic hybrid nanoparticles of Si-entrapped HRP
Design of stable magnetic hybrid nanoparticles of Si-entrapped HRP Open
Hybrid and composite nanoparticles represent an attractive material for enzyme integration due to possible synergic advantages of the structural builders in the properties of the nanobiocatalyst. In this study, we report the synthesis of a…
View article: Functionalization of gold nanoparticles with peptidomimetics as a targeted therapy for multiple sclerosis
Functionalization of gold nanoparticles with peptidomimetics as a targeted therapy for multiple sclerosis Open
Póster presentado a la 2nd Spanish Conference on Biomedical Applications of Nanomaterials (SBAN), celebrada en Madrid del 6 al 7 de junio de 2019.
View article: The fate of magnetic nanoparticles after intratumoral injection
The fate of magnetic nanoparticles after intratumoral injection Open
Resumen del trabajo presentado a la 2nd Spanish Conference on Biomedical Applications of Nanomaterials (SBAN), celebrada en Madrid del 6 al 7 de junio de 2019.
View article: Heating at the Nanoscale through Drug‐Delivery Devices: Fabrication and Synergic Effects in Cancer Treatment with Nanoparticles
Heating at the Nanoscale through Drug‐Delivery Devices: Fabrication and Synergic Effects in Cancer Treatment with Nanoparticles Open
Nanocarriers for cancer therapy have been extensively studied, but there is still some research that must be addressed in order to achieve their safe application. In this field, hyperthermia thermal treatments mediated by the use of respon…
View article: Beyond Traditional Hyperthermia: In Vivo Cancer Treatment with Magnetic-Responsive Mesoporous Silica Nanocarriers
Beyond Traditional Hyperthermia: In Vivo Cancer Treatment with Magnetic-Responsive Mesoporous Silica Nanocarriers Open
In this study, we present an innovation in the tumor treatment in vivo mediated by magnetic mesoporous silica nanoparticles. This device was built with iron oxide magnetic nanoparticles embedded in a mesoporous silica matrix and coated wit…
View article: In vitro efficacy of magnetic hyperthermia in 3D cell culture in collagen gel matrix models
In vitro efficacy of magnetic hyperthermia in 3D cell culture in collagen gel matrix models Open
Resumen del trabajo presentado a la IV Reunión de Jóvenes Investigadores en Coloides e Interfases, celebrada en Córdoba del 7 al 9 de febrero de 2018.
View article: Formation Mechanism of Maghemite Nanoflowers Synthesized by a Polyol-Mediated Process
Formation Mechanism of Maghemite Nanoflowers Synthesized by a Polyol-Mediated Process Open
Magnetic nanoparticles are being developed as structural and functional materials for use in diverse areas, including biomedical applications. Here, we report the synthesis of maghemite (γ-Fe2O3) nanoparticles with distinct morphologies: s…
View article: New Structured Materials in the Study of the Mechanobiological Processes Related to the Heart Failure
New Structured Materials in the Study of the Mechanobiological Processes Related to the Heart Failure Open
Cardiovascular diseases are the number one of death globally. According to the World Health organization 17.7 million people died from cardiovascular diseases in 2015, representing 31% of all global deaths. In these diseases the cardiac ho…
View article: Biohybrid nanoparticles for directed enzyme prodrug therapy remotely triggered by magnetic hyperthermia
Biohybrid nanoparticles for directed enzyme prodrug therapy remotely triggered by magnetic hyperthermia Open
Póster presntado a la 5th International Conference on Multifunctional, Hybrid and Nanomaterials, celebrada en Lisboa (Portugal) del 6 al 10 de marzo de 2017.
View article: Cell bystander effect induced by radiofrequency electromagnetic fields and magnetic nanoparticles
Cell bystander effect induced by radiofrequency electromagnetic fields and magnetic nanoparticles Open
Induced effects by direct exposure to ionizing radiation (IR) are a central issue in many fields like radiation protection, clinic diagnosis and oncological therapies. Direct irradiation at certain doses induce cell death, but similar effe…