Lars Barregård
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View article: The variability of selenium and sulphur and the impact of creatinine in blood and urine of humans
The variability of selenium and sulphur and the impact of creatinine in blood and urine of humans Open
The urinary S and Se ER were highly associated with Crea ER, which has previously not been shown. This suggests that Crea corrected values should be interpreted with caution. Biomarkers of Se in blood had the highest ICC, while ICCs for S …
View article: Review: Strategies for limiting dietary cadmium in cereals
Review: Strategies for limiting dietary cadmium in cereals Open
Cadmium (Cd) is a toxic metal, which in some production areas reaches levels above allowed limits in cereals. Thus, reducing its concentration in cereals is crucial for mitigating health risks and complying with food safety regulations. Th…
View article: Exposure to Lead and Coronary Artery Atherosclerosis: A Swedish Cross‐Sectional Population‐Based Study
Exposure to Lead and Coronary Artery Atherosclerosis: A Swedish Cross‐Sectional Population‐Based Study Open
Background Lead is an established causal risk factor for coronary heart disease. Atherosclerosis may be the key mediator for this association, but evidence from studies in humans is limited. Our objective was to test the hypothesis that en…
View article: Risk assessment of complex organoarsenic species in food
Risk assessment of complex organoarsenic species in food Open
The European Commission asked EFSA for a risk assessment on complex organoarsenic species in food. They are typically found in marine foods and comprise mainly arsenobetaine (AsB), arsenosugars and arsenolipids. For AsB, no reference point…
View article: Cancer incidence in Swedish oil refinery workers exposed to benzene
Cancer incidence in Swedish oil refinery workers exposed to benzene Open
The present study indicated an increased risk of leukaemia in male oil refinery workers with low to moderate exposure to benzene.
View article: Risk assessment of small organoarsenic species in food
Risk assessment of small organoarsenic species in food Open
The European Commission asked EFSA for a risk assessment on small organoarsenic species in food. For monomethylarsonic acid MMA(V), decreased body weight resulting from diarrhoea in rats was identified as the critical endpoint and a BMDL10…
View article: Annex D1 - Exposure estimates and transformations (w-tiAs studies)
Annex D1 - Exposure estimates and transformations (w-tiAs studies) Open
Annex D1 includes conversion of water iAs concentrations to iAs exposures, as well as transformations of relative risk estimates to quantal data.
View article: Annex C - Risk of bias analysis
Annex C - Risk of bias analysis Open
Annex C contains the harmonised outcome of the two independent RoB analyses.
View article: Annex D2 - Exposure estimates and transformations (u-tiAs studies)
Annex D2 - Exposure estimates and transformations (u-tiAs studies) Open
Annex D2 includes conversion of urine iAs concentrations to iAs exposures, as well as transformations of relative risk estimates to quantal data.
View article: Annex D2 - Exposure estimates and transformations (u-tiAs studies)
Annex D2 - Exposure estimates and transformations (u-tiAs studies) Open
Annex D2 includes conversion of urine iAs concentrations to iAs exposures, as well as transformations of relative risk estimates to quantal data.
View article: Annex F - BMD summary table
Annex F - BMD summary table Open
Annex F presents a summary of the BMD analyses (BMRs of 1, 5, 10, and 50% as relative increase of the background incidence after adjustment for confounders). It includes important modelling outcomes such as BMD, BMDL, and BMDU values, and …
View article: Annex F - BMD summary table
Annex F - BMD summary table Open
Annex F presents a summary of the BMD analyses (BMRs of 1, 5, 10, and 50% as relative increase of the background incidence after adjustment for confounders). It includes important modelling outcomes such as BMD, BMDL, and BMDU values, and …
View article: Annex D1 - Exposure estimates and transformations (w-tiAs studies)
Annex D1 - Exposure estimates and transformations (w-tiAs studies) Open
Annex D1 includes conversion of water iAs concentrations to iAs exposures, as well as transformations of relative risk estimates to quantal data.
View article: Annex C - Risk of bias analysis
Annex C - Risk of bias analysis Open
Annex C contains the harmonised outcome of the two independent RoB analyses.
View article: Update of the risk assessment of inorganic arsenic in food
Update of the risk assessment of inorganic arsenic in food Open
The European Commission asked EFSA to update its 2009 risk assessment on arsenic in food carrying out a hazard assessment of inorganic arsenic (iAs) and using the revised exposure assessment issued by EFSA in 2021. Epidemiological studies …
View article: Long-term exposure to air pollution and coronary atherosclerosis, calcification, and non-calcified plaques – results from the Swedish SCAPIS study
Long-term exposure to air pollution and coronary atherosclerosis, calcification, and non-calcified plaques – results from the Swedish SCAPIS study Open
BACKGROUND AND AIM: Despite firm evidence for an association between long-term air pollution exposure and cardiovascular events also at low exposure levels, previous epidemiological studies on the association with atherosclerosis have been…
View article: Long-term ambient air pollution and venous thromboembolism in a population-based Swedish cohort
Long-term ambient air pollution and venous thromboembolism in a population-based Swedish cohort Open
Air pollution is a major contributor to the global burden of disease and has been linked to several diseases and conditions, including cardiovascular disease. The biological mechanisms are related to inflammation and increased coagulabilit…
View article: The variability of arsenic in blood and urine of humans
The variability of arsenic in blood and urine of humans Open
The study suggests that C-As is the most reliable biomarker for use in exposure assessment of individual exposure. Morning urine samples have low reliability for such use. No apparent diurnal variation was observed in the urinary As excret…
View article: Urinary iodine excretion and optimal time point for sampling when estimating 24-h urinary iodine
Urinary iodine excretion and optimal time point for sampling when estimating 24-h urinary iodine Open
Iodine deficiency may cause thyroid dysfunction. The iodine intake in a population is measured by urinary iodine concentration (UIC) in spot samples or 24-h urinary iodine excretion (24UIE). 24UIE is considered the gold standard and may be…
View article: Long-Term Exposure to Transportation Noise and Ischemic Heart Disease: A Pooled Analysis of Nine Scandinavian Cohorts
Long-Term Exposure to Transportation Noise and Ischemic Heart Disease: A Pooled Analysis of Nine Scandinavian Cohorts Open
Exposure to road, railway, and aircraft noise in the prior 5 y was associated with an increased risk of IHD, particularly after exclusion of angina pectoris cases, which are less well identified in the registries. https://doi.org/10.1289/E…
View article: Diesel exhaust particles affected heart rate variability but not endothelial function – results from a controlled chamber study
Diesel exhaust particles affected heart rate variability but not endothelial function – results from a controlled chamber study Open
Background Adverse cardiovascular effects have been associated with exposure to both diesel exhaust and road traffic noise. Effects of these highly correlated exposures are hard to disentangle in epidemiological studies, but effects on int…
View article: Low-level cadmium exposure and atherosclerosis in the carotid arteries: results from the Swedish population-based cohort SCAPIS
Low-level cadmium exposure and atherosclerosis in the carotid arteries: results from the Swedish population-based cohort SCAPIS Open
Background and aim: Cadmium exposure is associated with atherosclerosis and cardiovascular mortality. Few studies have, however, examined how cadmium affects the atherosclerotic burden. We investigated the association between cadmium expos…
View article: Air pollution and Venous Thromboembolism in the Malmö Diet and Cancer cohort
Air pollution and Venous Thromboembolism in the Malmö Diet and Cancer cohort Open
Background: Air pollution is a major contributor to the global burden of disease and has been linked to several diseases and conditions. The mechanisms are related to inflammation and increased coagulability, factors that play an important…
View article: Does low-level cadmium exposure affect cognitive functions? Results from the Malmö Diet and Cancer Study
Does low-level cadmium exposure affect cognitive functions? Results from the Malmö Diet and Cancer Study Open
Background and aim: Elevated cadmium exposure is toxic for the brain, but it is unclear if low-level exposure is a risk factor for cognitive impairment. We aim at examining the association between blood cadmium and cognitive functions in a…
View article: Variability of lead in urine and blood in healthy individuals
Variability of lead in urine and blood in healthy individuals Open
In addition to BPb, UPb adjusted for creatinine or SG seems to be a useful biomarker for exposure assessment in epidemiological studies.
View article: A controlled chamber study of effects of exposure to diesel exhaust particles and noise on heart rate variability and endothelial function
A controlled chamber study of effects of exposure to diesel exhaust particles and noise on heart rate variability and endothelial function Open
Three-hour exposure to diesel exhaust, but not noise, was associated with decreased HRV in the high frequency band. This indicates activation of irritant receptor-mediated autonomic reflexes, a possible mechanism for the cardiovascular ris…
View article: Low-level exposure to lead, cadmium and mercury, and histopathological findings in kidney biopsies
Low-level exposure to lead, cadmium and mercury, and histopathological findings in kidney biopsies Open
The results suggest that even low levels of Cd in the kidney can induce a mild degree of tubular atrophy. This is in line with previous findings at high-level Cd exposure. The association between kidney Hg and renal arteriosclerosis was un…