José Luís López-Campos
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View article: Evaluation of Alpha1 Antitrypsin Deficiency-Associated Mutations in People with Cystic Fibrosis
Evaluation of Alpha1 Antitrypsin Deficiency-Associated Mutations in People with Cystic Fibrosis Open
Background: Recent hypotheses suggest that mutations associated with alpha1 antitrypsin (AAT) deficiency (AATD) may influence the clinical presentation and progression of cystic fibrosis (CF). This study employs a longitudinal design to de…
View article: Characteristics of bronchiectasis in patients with different genotypes of severe alpha1-antitrypsin deficiency from the EARCO registry
Characteristics of bronchiectasis in patients with different genotypes of severe alpha1-antitrypsin deficiency from the EARCO registry Open
Background Alpha-1 antitrypsin deficiency (AATD) is a rare genetic disorder caused by mutations in the SERPINA1 gene and associated with reduced levels of alpha-1- antitrypsin (AAT). It predisposes individuals to pulmonary diseases, includ…
View article: Inflammation-adjusted optimal serum cut-off alpha-1 antitrypsin values for detecting deficient patients: a cross-sectional analysis of the AVATAR cohort
Inflammation-adjusted optimal serum cut-off alpha-1 antitrypsin values for detecting deficient patients: a cross-sectional analysis of the AVATAR cohort Open
New study establishes optimal serum AAT cut-offs for alpha-1 antitrypsin deficiency diagnosis in both stable and inflammatory conditions. Analysis of 492 patients from the AVATAR cohort provides CRP-adjusted thresholds to improve detection…
View article: Characteristics and actions in high-risk COPD in unstable patients: The EPOCONSUL audit
Characteristics and actions in high-risk COPD in unstable patients: The EPOCONSUL audit Open
Objective: To assess the clinical characteristics of high-risk COPD patients considered not stable for having had moderate or severe exacerbations of COPD in the three months prior to the audited review visit based on information extracted…
View article: Functional and structural impact of novel SERPINA1 variants on Alpha-1 Antitrypsin Deficiency
Functional and structural impact of novel SERPINA1 variants on Alpha-1 Antitrypsin Deficiency Open
Background. Mutations in the SERPINA1 gene can result in alpha-1 antitrypsin deficiency (AATD), which may be associated with lung or liver injury. Although the S and Z alleles account for over 95% of cases of AATD, a wide variety of rare v…
View article: Alpha-1 Antitrypsin Deficiency and Bronchial Asthma: Current Challenges
Alpha-1 Antitrypsin Deficiency and Bronchial Asthma: Current Challenges Open
Alpha-1 antitrypsin deficiency (AATD) is a rare genetic condition classically associated with pulmonary emphysema and liver disease. However, the potential link between AATD and other respiratory diseases, particularly bronchial asthma, re…
View article: Metabolomic Plasma Profile of Chronic Obstructive Pulmonary Disease Patients
Metabolomic Plasma Profile of Chronic Obstructive Pulmonary Disease Patients Open
The analysis of blood metabolites may help identify individuals at risk of having COPD and offer insights into its underlying pathophysiology. This study aimed to identify COPD-related metabolic alterations and generate a biological signat…
View article: Development and Validation of a Quantitative Score for the Criteria Clinical Control in Stable COPD Proposed in the Spanish COPD Guidelines (GesEPOC): Results of the EPOCONSUL Audit
Development and Validation of a Quantitative Score for the Criteria Clinical Control in Stable COPD Proposed in the Spanish COPD Guidelines (GesEPOC): Results of the EPOCONSUL Audit Open
Introduction/Objective: the concept of clinical control of COPD is a measure proposed in the Spanish COPD Guidelines (GesEPOC), which aims to help clinicians assess the clinical status in order to adapt the treatment plan at follow-up. How…
View article: Clinical control in COPD and therapeutic implications: The EPOCONSUL audit
Clinical control in COPD and therapeutic implications: The EPOCONSUL audit Open
Objective This study aimed to evaluate clinical control in chronic obstructive pulmonary disease (COPD), the consequences in terms of treatment decisions, and their potentially associated factors during follow-up of patients in real-life c…
View article: Development and Validation of a Quantitative Score for the Criteria Clinical Control in Stable COPD
Development and Validation of a Quantitative Score for the Criteria Clinical Control in Stable COPD Open
Introduction: The control of Chronic Obstructive Pulmonary Disease (COPD) introduces a novel evaluative element in the management of COPD. There is a need for promoting its evaluation through a quantitative assessment to facilitate the int…
View article: Evaluation of the Importance of Capsule Transparency in Dry Powder Inhalation Devices
Evaluation of the Importance of Capsule Transparency in Dry Powder Inhalation Devices Open
The aim of this work is to test whether the use of a transparent capsule affects the residual capsule weight after inhalation as a surrogate of the inhaled delivered dose for patients with non-reversible chronic airway disease. Researchers…
View article: A Pilot Study on Proteomic Predictors of Mortality in Stable COPD
A Pilot Study on Proteomic Predictors of Mortality in Stable COPD Open
Chronic Obstructive Pulmonary Disease (COPD) is the third leading cause of global mortality. Despite clinical predictors (age, severity, comorbidities, etc.) being established, proteomics offers comprehensive biological profiling to obtain…
View article: Clinical control in COPD and therapeutic implications: The EPOCONSUL audit
Clinical control in COPD and therapeutic implications: The EPOCONSUL audit Open
Objective: The aim of the study was to evaluate the clinical control in chronic obstructive pulmonary disease (COPD), the consequences in terms of treatment decisions and their potentially associated factors during follow-up of patients in…
View article: COPD: systemic proteomic profiles in frequent and infrequent exacerbators
COPD: systemic proteomic profiles in frequent and infrequent exacerbators Open
Background Some patients with COPD suffer frequent exacerbations (FE). We hypothesised that their systemic proteomic profile would be different from that of non-frequent exacerbators (NFE). The objective of the present study was to contras…
View article: Occult cancer in patients with unprovoked venous thromboembolism: A nested case-control study
Occult cancer in patients with unprovoked venous thromboembolism: A nested case-control study Open
Objectives Detecting occult cancer in patients with unprovoked venous thromboembolism (VTE) remains a significant challenge. Our objective was to investigate the potential predictive role of coagulation-related biomarkers in the diagnosis …
View article: Detection of Alpha-1 Antitrypsin Levels in Chronic Obstructive Pulmonary Disease in Respiratory Clinics in Spain: Results of the EPOCONSUL 2021 Audit
Detection of Alpha-1 Antitrypsin Levels in Chronic Obstructive Pulmonary Disease in Respiratory Clinics in Spain: Results of the EPOCONSUL 2021 Audit Open
Background: Alpha-1 antitrypsin deficiency (AATD) is an underdiagnosed condition despite being one of the most common inherited disorders in adults that is associated with an increased risk of developing chronic obstructive pulmonary disea…
View article: Global mortality and readmission rates following COPD exacerbation-related hospitalisation: a meta-analysis of 65 945 individual patients
Global mortality and readmission rates following COPD exacerbation-related hospitalisation: a meta-analysis of 65 945 individual patients Open
Background Exacerbations of COPD (ECOPD) have a major impact on patients and healthcare systems across the world. Precise estimates of the global burden of ECOPD on mortality and hospital readmission are needed to inform policy makers and …
View article: Untargeted Metabolomic Study of Lung Cancer Patients after Surgery with Curative Intent
Untargeted Metabolomic Study of Lung Cancer Patients after Surgery with Curative Intent Open
Lung cancer (LC) is a leading cause of mortality, claiming more than 1.8 million deaths per year worldwide. Surgery is one of the most effective treatments when the disease is in its early stages. The study of metabolic alterations after s…
View article: Metallomic Signatures of Lung Cancer and Chronic Obstructive Pulmonary Disease
Metallomic Signatures of Lung Cancer and Chronic Obstructive Pulmonary Disease Open
Lung cancer (LC) is the leading cause of cancer deaths, and chronic obstructive pulmonary disease (COPD) can increase LC risk. Metallomics may provide insights into both of these tobacco-related diseases and their shared etiology. We condu…
View article: Evaluation of Different Doses in Inhaled Therapy: A Comprehensive Analysis
Evaluation of Different Doses in Inhaled Therapy: A Comprehensive Analysis Open
Background. Currently, there is a considerable degree of confusion over the dosage of inhaled medications. Here, we carried out a review of all the doses used for the devices used in inhalation therapy. Methods. We first performed a system…
View article: Exploring Current Concepts and Challenges in the Identification and Management of Early-Stage COPD
Exploring Current Concepts and Challenges in the Identification and Management of Early-Stage COPD Open
The need to improve health outcomes, as well as disease prognosis, has led clinicians and researchers to propose new ways of identifying COPD in its earliest forms. This initiative is based on the hypothesis that an earlier intervention wo…
View article: Recommendations for the Implementation of the Self-Administration of Alpha-1 Antitrypsin
Recommendations for the Implementation of the Self-Administration of Alpha-1 Antitrypsin Open
We expect this proposal to increase awareness of this therapeutic alternative and facilitate the implementation of self-administration programs, thus contributing to optimizing the patient experience with AAT therapy. Further research on t…
View article: Smoking and COPD Knowledge in the General Spanish Population: A CONOCEPOC Study
Smoking and COPD Knowledge in the General Spanish Population: A CONOCEPOC Study Open
Background: The objective of this analysis is to evaluate tobacco use and the level of chronic obstructive pulmonary disease (COPD) knowledge among the general adult population in Spain and to compare these results to those obtained in the…