Dale L. Bailey
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View article: Confirming the normal range for Mebrofenin liver function indices
Confirming the normal range for Mebrofenin liver function indices Open
Objective(s): To establish normal ranges for [99mTc] Tc-Mebrofenin hepatobiliary scintigraphy (HBS) indices of liver function and the associated uncertainty in clinical measures due to region placement.Methods: 47 patients referred for gal…
View article: Continuous monitoring of radiation emissions from 131I thyroid cancer ablation subjects: development of a novel radiation detector system and measurement of effective retention half-time in 250 subjects
Continuous monitoring of radiation emissions from 131I thyroid cancer ablation subjects: development of a novel radiation detector system and measurement of effective retention half-time in 250 subjects Open
Objectives(s): To report methodology that has been developed to provide real-time monitoring of radiation emissions from subjects treated with radionuclide therapies and summarise the radioiodine retention profiles of 250 subjects treated …
View article: CTNI-25. MULTI-SITE, PROSPECTIVE TRIAL EVALUATING FET-PET IN GLIOBLASTOMA (FIG) STUDY (TROG 18.06): CENTRAL NUCLEAR MEDICINE AND RADIATION ONCOLOGY REVIEW OF FET-PET BIOLOGIC TARGET VOLUME DELINEATION FOR RADIATION PLANNING
CTNI-25. MULTI-SITE, PROSPECTIVE TRIAL EVALUATING FET-PET IN GLIOBLASTOMA (FIG) STUDY (TROG 18.06): CENTRAL NUCLEAR MEDICINE AND RADIATION ONCOLOGY REVIEW OF FET-PET BIOLOGIC TARGET VOLUME DELINEATION FOR RADIATION PLANNING Open
BACKGROUND The prospective multi-site trial evaluating O-(2-[18F]-fluoroethyl)-L-tyrosine Positron Emission Tomography (FET-PET) in Glioblastoma (FIG) study is currently recruiting. This abstract aims to evaluate the impact of full central…
View article: ARTnet Perspectives and Contributions to Theranostics
ARTnet Perspectives and Contributions to Theranostics Open
Theranostics is a rapidly growing field, providing new therapeutic options for cancer patients. Clinical trials have a key role in establishing the efficacy and safety of new treatments and determining impact on patient care. Multicenter c…
View article: Standardization of PET/CT Performance Requirements for Whole-Body Quantitative Imaging: An International Proposal
Standardization of PET/CT Performance Requirements for Whole-Body Quantitative Imaging: An International Proposal Open
Currently, PET scanner validation phantoms, methods, and acceptance criteria for clinical trials are not standardized. This situation generates substantial inefficiencies with many scanners being tested multiple times for different trials.…
View article: Foam-based depopulation methods of swine differ from water submersion based on computed tomography findings and postmortem lesions
Foam-based depopulation methods of swine differ from water submersion based on computed tomography findings and postmortem lesions Open
Objective To investigate the extent of fluid incursion throughout the respiratory tract of anesthetized pigs terminated using 3 different depopulation methods compared to termination by water submersion (H 2 O). Methods Inclusion criteria …
View article: Theranostic Radioembolization: Radiation Dosimetry-Guided Treatment Planning and Delivery
Theranostic Radioembolization: Radiation Dosimetry-Guided Treatment Planning and Delivery Open
Radioembolizaton of hepatic malignancy is an accepted palliative treatment option in many subjects. The process of working up an individual for a radioembolization procedure permits pretreatment radiation dosimetry to be estimated, which i…
View article: Total lesion glycolysis is a promising predictor of chemo‐response in pancreatic cancer patients treated with neoadjuvant chemotherapy prior to surgery
Total lesion glycolysis is a promising predictor of chemo‐response in pancreatic cancer patients treated with neoadjuvant chemotherapy prior to surgery Open
Background There has been increased use of neoadjuvant chemotherapy (NAC) in resectable pancreatic ductal adenocarcinoma (PDAC) patients. [ 18 F]fluoro‐2‐deoxyglucose positron emission tomography/computed tomography (FDG‐PET/CT) scan is be…
View article: Consensus Nomenclature for Radionuclide Therapy: Initial Recommendations from Nuclear Medicine Global Initiative
Consensus Nomenclature for Radionuclide Therapy: Initial Recommendations from Nuclear Medicine Global Initiative Open
Since its inception in 2012, the Nuclear Medicine Global Initiative (NMGI) of the Society of Nuclear Medicine and Molecular Imaging has played an important role in addressing significant challenges in the field of nuclear medicine and mole…
View article: [<sup>18</sup>F]FMISO PET in metastatic neuroendocrine tumours: a pilot study.
[<sup>18</sup>F]FMISO PET in metastatic neuroendocrine tumours: a pilot study. Open
Only one of ten patients with DONUT lesions demonstrated increased [18F]FMISO uptake rate on delayed static imaging. In contrast, dynamic imaging demonstrated increased [18F]FMISO uptake rate in the region of [68Ga]DOTATATE photopenia on 8…
View article: The role of amino acid PET in radiotherapy target volume delineation for adult-type diffuse gliomas: A review of the literature
The role of amino acid PET in radiotherapy target volume delineation for adult-type diffuse gliomas: A review of the literature Open
AA-PET is a promising complementary tool to MRI for radiotherapy target volume delineation, with potential benefits requiring further validation including margin reduction and facilitation of dose-escalation.
View article: NIMG-41. MULTI-SITE, PROSPECTIVE TRIAL EVALUATING FET-PET IN GLIOBLASTOMA (FIG) STUDY (TROG 18.06): PRELIMINARY RESULTS OF CENTRAL NUCLEAR MEDICINE REVIEW OF FET-PET BIOLOGIC TARGET VOLUME DELINEATION FOR RADIATION PLANNING
NIMG-41. MULTI-SITE, PROSPECTIVE TRIAL EVALUATING FET-PET IN GLIOBLASTOMA (FIG) STUDY (TROG 18.06): PRELIMINARY RESULTS OF CENTRAL NUCLEAR MEDICINE REVIEW OF FET-PET BIOLOGIC TARGET VOLUME DELINEATION FOR RADIATION PLANNING Open
BACKGROUND To provide an update from the multi-site trial evaluating O-(2-[18F]-fluoroethyl)-L-tyrosine Positron Emission Tomography (FET-PET) in Glioblastoma (FIG) study and 2) assess the impact of central Nuclear Medicine physician (NMP)…
View article: Evolving SPECT-CT technology
Evolving SPECT-CT technology Open
Both hardware and software developments have seen single photon emission CT (SPECT)/X-ray CT technology grow at a rapid rate. Such growth has been fuelled by the need for clinical applications and has provided inspiration for clinical deve…
View article: P14.22.B THE ROLE OF AMINO ACID PET IN RADIOTHERAPY TARGET VOLUME DELINEATION FOR ADULT-TYPE DIFFUSE GLIOMAS: A SYSTEMATIC LITERATURE REVIEW
P14.22.B THE ROLE OF AMINO ACID PET IN RADIOTHERAPY TARGET VOLUME DELINEATION FOR ADULT-TYPE DIFFUSE GLIOMAS: A SYSTEMATIC LITERATURE REVIEW Open
BACKGROUND Amino acid positron-emission tomography (AA-PET) is an emerging tool to complement magnetic resonance imaging (MRI) in glioma management. This purpose of this review was to summarise the existing literature examining use of earl…
View article: A practical method for assessing quantitative scanner accuracy with long-lived radionuclides: The ARTnet insert.
A practical method for assessing quantitative scanner accuracy with long-lived radionuclides: The ARTnet insert. Open
The "ARTnet Insert" is simple to use, inexpensive, compatible with current phantoms and is suitable for both PET and SPECT systems. It does not suffer from significant partial volume losses permitting its use even with the poor spatial res…
View article: [<sup>18</sup>F]FDG PET/CT–Avid Discordant Volume as a Biomarker in Patients with Gastroenteropancreatic Neuroendocrine Neoplasms: A Multicenter Study
[<sup>18</sup>F]FDG PET/CT–Avid Discordant Volume as a Biomarker in Patients with Gastroenteropancreatic Neuroendocrine Neoplasms: A Multicenter Study Open
[18F]FDG PET/CT and [68Ga]Ga-DOTATATE PET/CT are both used to predict tumor biology in neuroendocrine neoplasms. Although the presence of discordant ([18F]FDG-avid/non-[68Ga]Ga-DOTATATE-avid) disease predicts poor prognosis, the significan…
View article: The MANGO study: a prospective investigation of oxygen enhanced and blood-oxygen level dependent MRI as imaging biomarkers of hypoxia in glioblastoma
The MANGO study: a prospective investigation of oxygen enhanced and blood-oxygen level dependent MRI as imaging biomarkers of hypoxia in glioblastoma Open
Background Glioblastoma (GBM) is the most aggressive type of brain cancer, with a 5-year survival rate of ~5% and most tumours recurring locally within months of first-line treatment. Hypoxia is associated with worse clinical outcomes in G…
View article: Abstracts
Abstracts Open
The Nuclear Medicine Department at RPA was fondly known as 'the pie factory', which indeed it was before it was converted, with very little renovation, to accommodate this relatively new modality.They had just acquired their first Nuclear …
View article: [ <sup>18</sup> F]-fluoroethyl-L-tyrosine (FET) in glioblastoma (FIG) TROG 18.06 study: protocol for a prospective, multicentre PET/CT trial
[ <sup>18</sup> F]-fluoroethyl-L-tyrosine (FET) in glioblastoma (FIG) TROG 18.06 study: protocol for a prospective, multicentre PET/CT trial Open
Introduction Glioblastoma is the most common aggressive primary central nervous system cancer in adults characterised by uniformly poor survival. Despite maximal safe resection and postoperative radiotherapy with concurrent and adjuvant te…
View article: Not All Gatekeepers Are Theranostics
Not All Gatekeepers Are Theranostics Open
TO THE EDITOR: Sometimes we need to challenge the views of colleagues and friends, especially when their thinking has the effect of muddying the waters rather than providing greater insight and clarity. I believe this to be the case with t…
View article: Radiopharmaceutical Extravasations Can Have Consequences
Radiopharmaceutical Extravasations Can Have Consequences Open
TO THE EDITOR: Regarding “Adverse Clinical Events at the Injection Site Are Exceedingly Rare After Reported Radiopharmaceutical Extravasation in Patients Undergoing 99mTc-MDP Whole-Body Bone Scintigraphy: A 12-Year Experience” ([1][1]), I …
View article: Investigation and optimization of PET-guided SPECT reconstructions for improved radionuclide therapy dosimetry estimates
Investigation and optimization of PET-guided SPECT reconstructions for improved radionuclide therapy dosimetry estimates Open
Introduction To investigate and optimize the SPECTRE (Single Photon Emission Computed Theranostic REconstruction) reconstruction approach, using the hybrid kernelised expectation maximization (HKEM) algorithm implemented in the software fo…
View article: V/Q SPECT and SPECT/CT in Pulmonary Embolism
V/Q SPECT and SPECT/CT in Pulmonary Embolism Open
Ventilation and perfusion (V/Q) lung scintigraphy has been used in the assessment of patients with suspected pulmonary embolism for more than 50 y. Advances in imaging technology make SPECT and SPECT/CT feasible. This article will examine …
View article: Partial volume effect in SPECT & PET imaging and impact on radionuclide dosimetry estimates.
Partial volume effect in SPECT & PET imaging and impact on radionuclide dosimetry estimates. Open
The partial volume effect remains a significant factor when estimating radionuclide uptake in vivo, especially in small volumes. Accurate estimates of absorbed dose from radionuclide therapy will be particularly challenging until robust so…
View article: <sup>64</sup>Cu Treatment Planning and<sup>67</sup>Cu Therapy with Radiolabeled [<sup>64</sup>Cu/<sup>67</sup>Cu]MeCOSar-Octreotate in Subjects with Unresectable Multifocal Meningioma: Initial Results for Human Imaging, Safety, Biodistribution, and Radiation Dosimetry
<sup>64</sup>Cu Treatment Planning and<sup>67</sup>Cu Therapy with Radiolabeled [<sup>64</sup>Cu/<sup>67</sup>Cu]MeCOSar-Octreotate in Subjects with Unresectable Multifocal Meningioma: Initial Results for Human Imaging, Safety, Biodistribution, and Radiation Dosimetry Open
Our aim was to report the use of 64Cu and 67Cu as a theranostic pair of radionuclides in human subjects. An additional aim was to measure whole-organ dosimetry of 64Cu and 67Cu attached to the somatostatin analog octreotate using the sarco…