Explanipedia

Brain-derived neurotrophic factor prevents LPS-induced dysregulation of GABAergic interneuron markers in mouse hippocampus Open

Sara Rezaei, Mounira Banasr, Thomas D. Prévot, Yashika Bansal, Érica Leandro Marciano Vieira , et al. · 2025

Background Inflammation causes reduced markers of GABAergic interneurons and brain-derived neurotrophic factor (BDNF) in the hippocampus, features often associated with neuropsychiatric disease pathophysiology. However, the mechanism conne…

Neuronal and Astrocytic Activity Changes Induced by Acute and Chronic Stress Open

Yashika Bansal, Martin Mitchell, Sierra A. Codeluppi, Jaime Knoch, Kevan Clifford , et al. · 2025

Stress is a major risk factor for depression and exerts complex effects on brain function and behavior. In this study, we examined the neural mechanisms of stress responses in the prefrontal cortex (PFC), with particular focus on neuron–as…

Cortical GABAergic Neuron Dysregulation in Schizophrenia Is Age Dependent Open

Debra L. Kiss, Xiaolin Zhou, Nicole Endresz, Keon Arbabi, Àlex G. Segura , et al. · 2025

108. SELECTIVE POTENTIATION OF α5-GABAA RECEPTORS CONTRIBUTES TO REDUCTION OF COGNITIVE BURDEN AND NEURONAL LOSS IN AGING MICE Open

Thomas D. Prévot, Alexandra Bernardo, Carla Elena Mezo‐González, Jianmin Chen, Michael Marcotte , et al. · 2025

Background Reduced GABA/somatostatin (SST) signaling is reported in aging as well as in psychiatric, stress-related and neurodegenerative disorders. Cortical SST+ interneurons inhibit the dendrites of excitatory neurons, largely through α5…

Chronic α5‐<span>GABA</span>‐A Receptor Potentiation Promotes Mouse Adult Hippocampal Neurogenesis Open

Thomas D. Prévot, Michael Marcotte, Denis J. David, Indira Mendez‐David, Md Yeunus Mian , et al. · 2025

Several lines of evidence implicate adult hippocampal neurogenesis (AHN) in cognitive functions, in mood‐ and anxiety‐related behaviors, and in the therapeutic effects of antidepressants. Augmenting α5‐γ‐Aminobutyric acid type A (GABAA) re…

Cognitive Dysfunction in the Addictions (CDiA): protocol for a neuron-to-neighbourhood collaborative research program Open

Yuliya S. Nikolova, Anthony C. Ruocco, Daniel Felsky, Shannon Lange, Thomas D. Prévot , et al. · 2025

Substance use disorders (SUDs), including Alcohol Use Disorder, are pressing global public health problems. Executive functions (EFs) are prominently featured in mechanistic models of addiction. However, significant gaps remain in our unde…

Spine loss in depression impairs dendritic signal integration in human cortical microcircuit models Open

Heng Kang Yao, Frank Mazza, Thomas D. Prévot, Etienne Sibille, Etay Hay · 2025

Therapeutic dose prediction of α5-GABA receptor modulation from simulated EEG of depression severity Open

Alexandre Guet-McCreight, Frank Mazza, Thomas D. Prévot, Etienne Sibille, Etay Hay · 2024

Treatment for major depressive disorder (depression) often has partial efficacy and a large portion of patients are treatment resistant. Recent studies implicate reduced somatostatin (SST) interneuron inhibition in depression, and new phar…

Neurostructural and cognitive signatures of novel polygenic risk scores for molecular brain aging Open

Yuliya S. Nikolova, Kevan Clifford, Fernanda C. Dos Santos, Thomas D. Prévot, Mohamed Abdelhack , et al. · 2024

The world population is shifting sharply toward an older-age demographic. To navigate the escalating burden of physical and cognitive decline common to aging, and heightened risk of neurodegenerative and neuropsychiatric disease, we requir…

Electroencephalography Biomarkers of α5-GABA Positive Allosteric Modulators in Rodents Open

Frank Mazza, Alexandre Guet-McCreight, Thomas D. Prévot, Taufik A. Valiante, Etienne Sibille , et al. · 2024

Procognitive and neurotrophic benefits of α5-GABA-A receptor positive allosteric modulation in a β-amyloid deposition mouse model of Alzheimer’s disease pathology Open

Ashley Bernardo, Michael Marcotte, Kayla Wong, Dishary Sharmin, Kamal Prakash Pandey , et al. · 2024

Reduced somatostatin (SST) and SST-expressing GABAergic neurons are well-replicated findings in Alzheimer's disease (AD) and are associated with cognitive deficits. SST cells inhibit pyramidal cell dendrites through α5-GABA-A receptors (α5…

Restoring Cognitive functions: Unveiling the Procognitive and Neurotrophic Impact of Chronic Administration of a Selective A5‐GABAA Receptor Positive Allosteric Modulator in Mouse Models of Amyloid Load and Tau Phosphorylation Open

Thomas D. Prévot, Ashley D Bernardo, Kayla Wong, Celeste Pina‐Leblanc, Michael Marcotte , et al. · 2024

Background Dysregulated GABA/somatostatin (SST) signaling has been implicated in psychiatric and neurodegenerative disorders. The inhibition of excitatory neurons by SST+ interneurons, particularly through α5‐containing GABAA receptors (α5…

Neurostructural and cognitive signatures of novel polygenic risk scores for molecular brain aging Open

Kevan Clifford, Fernanda C. Dos Santos, Mohamed Abdelhack, Daniel Felsky, Etienne Sibille , et al. · 2024

The world population is shifting sharply toward an older-age demographic. To navigate the escalating burden of physical and cognitive decline common to aging, and heightened risk of neurodegenerative and neuropsychiatric disease, we requir…

Etienne Sibille: Investigating the cellular and molecular bases of depression and aging for innovative therapeutics Open

Etienne Sibille · 2024

Etienne Sibille, a pioneering figure in neuropsychiatric research, has yet to follow conventional paths. From his early days as a photojournalist editor in New York to becoming one of neuroscience's most innovative voices, his journey refl…

Lived Experience and Family Engagement in Mental Health and Substance use Health Research: Case Profiles of Five Studies Open

Lisa D. Hawke, Lena C. Quilty, Branka Agic, Darren Courtney, Gray Liddell , et al. · 2024

Introduction People with lived and living experience (PWLLE) and family members (F) can engage in mental health and substance use health research beyond participant roles, as advisors, co‐researchers, equal partners and research leads. How…

Cortical GABAergic neuron dysregulation in schizophrenia is age dependent Open

Debra L. Kiss, Xiaolin Zhou, Keon Arbabi, Àlex G. Segura, Nicole Endresz , et al. · 2024

Cortical GABAergic neuron dysregulation is implicated in schizophrenia (SCZ), but it remains unclear if these changes are due to altered cell proportions or per-cell mRNA changes. We analyzed bulk and cell type-specific RNAseq data from 1,…

Spine loss in depression impairs dendritic signal integration in human cortical microcircuit models Open

Heng Kang Yao, Frank Mazza, Thomas D. Prévot, Etienne Sibille, Etay Hay · 2024

Major depressive disorder (depression) is associated with altered dendritic structure and function in excitatory cortical pyramidal neurons, due to decreased inhibition from somatostatin interneurons and loss of spines and associated synap…

Therapeutic dose prediction of α5-GABA receptor modulation from simulated EEG of depression severity Open

Alexandre Guet-McCreight, Frank Mazza, Thomas D. Prévot, Etienne Sibille, Etay Hay · 2024

Treatment for major depressive disorder (depression) often has partial efficacy and a large portion of patients are treatment resistant. Recent studies implicate reduced somatostatin (SST) interneuron inhibition in depression, and new phar…

EEG biomarkers of α5-GABA positive allosteric modulators in rodents Open

Frank Mazza, Alexandre Guet-McCreight, Thomas D. Prévot, Taufik A. Valiante, Etienne Sibille , et al. · 2024

Reduced cortical inhibition mediated by gamma-aminobutyric acid (GABA) is reported in depression, anxiety disorders, and aging. Novel positive allosteric modulator that specifically target α5-GABA A receptor subunit (α5-PAM), ligand GL-II-…

LPS-induced inflammation reduces GABAergic interneuron markers and brain-derived neurotrophic factor in mouse prefrontal cortex and hippocampus Open

Sara Rezaei, Thomas D. Prévot, Érica Leandro Marciano Vieira, Etienne Sibille · 2024

Inflammation, reduced gamma-aminobutyric acidergic (GABAergic) function and altered neuroplasticity are co-occurring pathophysiologies in major depressive disorder (MDD). However, the link between these biological changes remains unclear. …

Extrasynaptic Localization Is Essential for α5GABA <sub>A</sub> Receptor Modulation of Dopamine System Function Open

Alexandra M. McCoy, Thomas D. Prévot, Md Yeunus Mian, Dishary Sharmin, Adeeba N. Ahmad , et al. · 2024

Dopamine system dysfunction, observed in animal models with psychosis-like symptomatology, can be restored by targeting gamma-aminobutyric acid type A receptors (GABA A Rs) containing the α5, but not α1, subunit in the ventral hippocampus …

In-silico testing of new pharmacology for restoring inhibition and human cortical function in depression Open

Alexandre Guet-McCreight, Homeira Moradi Chameh, Frank Mazza, Thomas D. Prévot, Taufik A. Valiante , et al. · 2024

Modeling elevated MAO-A activity in mice: role in emotionality and antidepressant treatment response Open

R Lebeau, Rong Zhou, Etienne Sibille, Jeffrey H. Meyer, Toshifumi Tomoda , et al. · 2024

Improvement of Cognitive Functions And Neurotrophic Effects through by Α5‐GABAA Receptor Positive Allosteric Modulation in Animal Models of Risk for Alzheimer’s Disease Open

Thomas D. Prévot, Ashley D Bernardo, Michael Marcotte, Kayla Wong, Md Yeunus Mian , et al. · 2023

Background Reduced GABA/somatostatin (SST) signaling is reported in psychiatric, stress‐related and neurodegenerative disorders. SST+ interneurons from cortical layers and the hippocampus inhibit the dendrites of excitatory neurons, largel…

LPS-Induced Inflammation Reduces GABAergic Interneuron markers and Brain-derived Neurotrophic Factor in Mouse Prefrontal Cortex and Hippocampus Open

Sara Rezaei, Thomas D. Prévot, Érica Leandro Marciano Vieira, Etienne Sibille · 2023

Inflammation, reduced gamma-aminobutyric acidergic (GABAergic) function and altered neuroplasticity are co-occurring pathophysiologies in major depressive disorder (MDD). However, the link between these biological changes remains unclear. …

Transcriptomic pathology of neocortical microcircuit cell types across psychiatric disorders Open

Keon Arbabi, Dwight F. Newton, Hyunjung Oh, Melanie Davie, David A. Lewis , et al. · 2023

Background Psychiatric disorders like major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SCZ) are characterized by altered cognition and mood, brain functions that depend on information processing by cortical microc…

GABAergic signaling in alcohol use disorder and withdrawal: pathological involvement and therapeutic potential Open

Ravinder Naik Dharavath, Celeste Pina‐Leblanc, Victor M. Tang, Matthew E. Sloan, Yuliya S. Nikolova , et al. · 2023

Alcohol is one of the most widely used substances. Alcohol use accounts for 5.1% of the global disease burden, contributes substantially to societal and economic costs, and leads to approximately 3 million global deaths yearly. Alcohol use…

Ribosomal dysregulation: A conserved pathophysiological mechanism in human depression and mouse chronic stress Open

Xiaolu Zhang, Mahmoud Ali Eladawi, William G. Ryan, Xiaoming Fan, Stephen Prevoznik , et al. · 2023

The underlying biological mechanisms that contribute to the heterogeneity of major depressive disorder (MDD) presentation remain poorly understood, highlighting the need for a conceptual framework that can explain this variability and brid…

Prefrontal cortex astroglia modulate anhedonia-like behavior Open

Sierra A. Codeluppi, Meiyu Xu, Yashika Bansal, Ashley E. Lepack, Vanja Đurić , et al. · 2023

GABAA receptors as targets for treating affective and cognitive symptoms of depression Open

Bernhard Lüscher, Jamie Maguire, Uwe Rudolph, Etienne Sibille · 2023

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