Daoud Sie
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View article: Barriers and facilitators for implementing a pharmacogenetic passport: lessons learned from reusing sequencing data
Barriers and facilitators for implementing a pharmacogenetic passport: lessons learned from reusing sequencing data Open
When considering the implementation of a pharmacogenetic passport, strategies can be developed to diminish barriers and strengthen facilitators. It is important to focus on data infrastructure, (visibility of) guidelines, clear division of…
View article: Extremely rare CNVs contributing to Alzheimer disease risk: a case-control association analysis of exome sequencing data from 22,319 individuals
Extremely rare CNVs contributing to Alzheimer disease risk: a case-control association analysis of exome sequencing data from 22,319 individuals Open
Rare coding single nucleotide variants (SNV) and short insertions or deletions (indels) contribute to Alzheimer disease (AD) genetic risk, from pathogenic variants in autosomal dominant genes to risk factors with diverse effects. In contra…
View article: Effect of mesenchymal stem cells on the host response in severe community-acquired pneumonia
Effect of mesenchymal stem cells on the host response in severe community-acquired pneumonia Open
Mesenchymal stem cells (MSC) have immune regulatory properties that may ameliorate pathophysiological processes in sepsis. We determined the effect of allogeneic adipose-derived MSCs (Cx611) on the host response during sepsis due to commun…
View article: Domain mapping of disease mutations supports genetic testing of specific<i>SORL1</i>variants in familial Alzheimer’s Disease
Domain mapping of disease mutations supports genetic testing of specific<i>SORL1</i>variants in familial Alzheimer’s Disease Open
Background Protein truncating variants (PTVs) in SORL1 are observed almost exclusively in Alzheimer’s Disease (AD) cases, but the effect of rare SORL1 missense variants is unclear. Methods To identify high-priority missense variants (HPVs)…
View article: False positivity in break apart fluorescence in-situ hybridization due to polyploidy
False positivity in break apart fluorescence in-situ hybridization due to polyploidy Open
In case of polyploidy there is an increased likelihood of false positivity when using break apart FISH probes. Therefore, we state that prescribing one single cut-off in FISH is inappropriate. In polyploidy, the currently proposed cut-off …
View article: Data from Search for a Gene Expression Signature of Breast Cancer Local Recurrence in Young Women
Data from Search for a Gene Expression Signature of Breast Cancer Local Recurrence in Young Women Open
Purpose: A gene expression signature, predictive for local recurrence after breast-conserving treatment, has previously been identified from a series of 165 young patients with breast cancer. We evaluated this signature on both another pla…
View article: Data from To DNA or not to DNA? That Is the Question, When It Comes to Molecular Subtyping for the Clinic!
Data from To DNA or not to DNA? That Is the Question, When It Comes to Molecular Subtyping for the Clinic! Open
Genome-wide RNA expression profiling has yielded tumor subtypes with strong predictive or prognostic value for a wide variety of cancers. Recently, for breast cancer two RNA expression classifiers have been adopted by the World Health Orga…
View article: Data from To DNA or not to DNA? That Is the Question, When It Comes to Molecular Subtyping for the Clinic!
Data from To DNA or not to DNA? That Is the Question, When It Comes to Molecular Subtyping for the Clinic! Open
Genome-wide RNA expression profiling has yielded tumor subtypes with strong predictive or prognostic value for a wide variety of cancers. Recently, for breast cancer two RNA expression classifiers have been adopted by the World Health Orga…
View article: Supplementary Methods, Figures Legends 1-4, Table 1 from To DNA or not to DNA? That Is the Question, When It Comes to Molecular Subtyping for the Clinic!
Supplementary Methods, Figures Legends 1-4, Table 1 from To DNA or not to DNA? That Is the Question, When It Comes to Molecular Subtyping for the Clinic! Open
PDF file - 91K
View article: Supplementary Tables 1-4, Figure 1 from Search for a Gene Expression Signature of Breast Cancer Local Recurrence in Young Women
Supplementary Tables 1-4, Figure 1 from Search for a Gene Expression Signature of Breast Cancer Local Recurrence in Young Women Open
PDF file - 203K
View article: Supplementary Figure 1 from To DNA or not to DNA? That Is the Question, When It Comes to Molecular Subtyping for the Clinic!
Supplementary Figure 1 from To DNA or not to DNA? That Is the Question, When It Comes to Molecular Subtyping for the Clinic! Open
PDF file - 1.94 MB
View article: Supplementary Figure 2 from To DNA or not to DNA? That Is the Question, When It Comes to Molecular Subtyping for the Clinic!
Supplementary Figure 2 from To DNA or not to DNA? That Is the Question, When It Comes to Molecular Subtyping for the Clinic! Open
PDF file - 2.45 MB
View article: Supplementary Figure 4 from To DNA or not to DNA? That Is the Question, When It Comes to Molecular Subtyping for the Clinic!
Supplementary Figure 4 from To DNA or not to DNA? That Is the Question, When It Comes to Molecular Subtyping for the Clinic! Open
PDF file - 3.65 MB
View article: Supplementary Figure 1 from To DNA or not to DNA? That Is the Question, When It Comes to Molecular Subtyping for the Clinic!
Supplementary Figure 1 from To DNA or not to DNA? That Is the Question, When It Comes to Molecular Subtyping for the Clinic! Open
PDF file - 1.94 MB
View article: Supplementary Figure 4 from To DNA or not to DNA? That Is the Question, When It Comes to Molecular Subtyping for the Clinic!
Supplementary Figure 4 from To DNA or not to DNA? That Is the Question, When It Comes to Molecular Subtyping for the Clinic! Open
PDF file - 3.65 MB
View article: Supplementary Figure 2 from To DNA or not to DNA? That Is the Question, When It Comes to Molecular Subtyping for the Clinic!
Supplementary Figure 2 from To DNA or not to DNA? That Is the Question, When It Comes to Molecular Subtyping for the Clinic! Open
PDF file - 2.45 MB
View article: Supplementary Tables 1-4, Figure 1 from Search for a Gene Expression Signature of Breast Cancer Local Recurrence in Young Women
Supplementary Tables 1-4, Figure 1 from Search for a Gene Expression Signature of Breast Cancer Local Recurrence in Young Women Open
PDF file - 203K
View article: Supplementary Methods, Figures Legends 1-4, Table 1 from To DNA or not to DNA? That Is the Question, When It Comes to Molecular Subtyping for the Clinic!
Supplementary Methods, Figures Legends 1-4, Table 1 from To DNA or not to DNA? That Is the Question, When It Comes to Molecular Subtyping for the Clinic! Open
PDF file - 91K
View article: Data from Search for a Gene Expression Signature of Breast Cancer Local Recurrence in Young Women
Data from Search for a Gene Expression Signature of Breast Cancer Local Recurrence in Young Women Open
Purpose: A gene expression signature, predictive for local recurrence after breast-conserving treatment, has previously been identified from a series of 165 young patients with breast cancer. We evaluated this signature on both another pla…
View article: Supplementary Figure 3 from To DNA or not to DNA? That Is the Question, When It Comes to Molecular Subtyping for the Clinic!
Supplementary Figure 3 from To DNA or not to DNA? That Is the Question, When It Comes to Molecular Subtyping for the Clinic! Open
PDF file - 7.64 MB
View article: Supplementary Figure 3 from To DNA or not to DNA? That Is the Question, When It Comes to Molecular Subtyping for the Clinic!
Supplementary Figure 3 from To DNA or not to DNA? That Is the Question, When It Comes to Molecular Subtyping for the Clinic! Open
PDF file - 7.64 MB
View article: Supplementary Figure Legends 1-3 from Insertional Mutagenesis in Mice Deficient for <i>p15<sup>Ink4b</sup>, p16<sup>Ink4a</sup>, p21<sup>Cip1</sup></i>, and <i>p27<sup>Kip1</sup></i> Reveals Cancer Gene Interactions and Correlations with Tumor Phenotypes
Supplementary Figure Legends 1-3 from Insertional Mutagenesis in Mice Deficient for <i>p15<sup>Ink4b</sup>, p16<sup>Ink4a</sup>, p21<sup>Cip1</sup></i>, and <i>p27<sup>Kip1</sup></i> Reveals Cancer Gene Interactions and Correlations with Tumor Phenotypes Open
Supplementary Figure Legends 1-3 from Insertional Mutagenesis in Mice Deficient for p15Ink4b, p16Ink4a, p21Cip1, and p27Kip1 Reveals Cancer Gene Interactions and Correlations with Tumor Phenotypes
View article: Supplementary Figure Legends 1-3 from Insertional Mutagenesis in Mice Deficient for <i>p15<sup>Ink4b</sup>, p16<sup>Ink4a</sup>, p21<sup>Cip1</sup></i>, and <i>p27<sup>Kip1</sup></i> Reveals Cancer Gene Interactions and Correlations with Tumor Phenotypes
Supplementary Figure Legends 1-3 from Insertional Mutagenesis in Mice Deficient for <i>p15<sup>Ink4b</sup>, p16<sup>Ink4a</sup>, p21<sup>Cip1</sup></i>, and <i>p27<sup>Kip1</sup></i> Reveals Cancer Gene Interactions and Correlations with Tumor Phenotypes Open
Supplementary Figure Legends 1-3 from Insertional Mutagenesis in Mice Deficient for p15Ink4b, p16Ink4a, p21Cip1, and p27Kip1 Reveals Cancer Gene Interactions and Correlations with Tumor Phenotypes
View article: Supplementary Figure 3 from MicroRNA Sequence and Expression Analysis in Breast Tumors by Deep Sequencing
Supplementary Figure 3 from MicroRNA Sequence and Expression Analysis in Breast Tumors by Deep Sequencing Open
Supplementary Figure 3 from MicroRNA Sequence and Expression Analysis in Breast Tumors by Deep Sequencing
View article: Supplementary Table 1 from Insertional Mutagenesis in Mice Deficient for <i>p15<sup>Ink4b</sup>, p16<sup>Ink4a</sup>, p21<sup>Cip1</sup></i>, and <i>p27<sup>Kip1</sup></i> Reveals Cancer Gene Interactions and Correlations with Tumor Phenotypes
Supplementary Table 1 from Insertional Mutagenesis in Mice Deficient for <i>p15<sup>Ink4b</sup>, p16<sup>Ink4a</sup>, p21<sup>Cip1</sup></i>, and <i>p27<sup>Kip1</sup></i> Reveals Cancer Gene Interactions and Correlations with Tumor Phenotypes Open
Supplementary Table 1 from Insertional Mutagenesis in Mice Deficient for p15Ink4b, p16Ink4a, p21Cip1, and p27Kip1 Reveals Cancer Gene Interactions and Correlations with Tumor Phenotypes
View article: Supplementary Table 8 from Insertional Mutagenesis in Mice Deficient for <i>p15<sup>Ink4b</sup>, p16<sup>Ink4a</sup>, p21<sup>Cip1</sup></i>, and <i>p27<sup>Kip1</sup></i> Reveals Cancer Gene Interactions and Correlations with Tumor Phenotypes
Supplementary Table 8 from Insertional Mutagenesis in Mice Deficient for <i>p15<sup>Ink4b</sup>, p16<sup>Ink4a</sup>, p21<sup>Cip1</sup></i>, and <i>p27<sup>Kip1</sup></i> Reveals Cancer Gene Interactions and Correlations with Tumor Phenotypes Open
Supplementary Table 8 from Insertional Mutagenesis in Mice Deficient for p15Ink4b, p16Ink4a, p21Cip1, and p27Kip1 Reveals Cancer Gene Interactions and Correlations with Tumor Phenotypes
View article: Supplementary Table 6 from Insertional Mutagenesis in Mice Deficient for <i>p15<sup>Ink4b</sup>, p16<sup>Ink4a</sup>, p21<sup>Cip1</sup></i>, and <i>p27<sup>Kip1</sup></i> Reveals Cancer Gene Interactions and Correlations with Tumor Phenotypes
Supplementary Table 6 from Insertional Mutagenesis in Mice Deficient for <i>p15<sup>Ink4b</sup>, p16<sup>Ink4a</sup>, p21<sup>Cip1</sup></i>, and <i>p27<sup>Kip1</sup></i> Reveals Cancer Gene Interactions and Correlations with Tumor Phenotypes Open
Supplementary Table 6 from Insertional Mutagenesis in Mice Deficient for p15Ink4b, p16Ink4a, p21Cip1, and p27Kip1 Reveals Cancer Gene Interactions and Correlations with Tumor Phenotypes
View article: Supplementary Table 7 from Insertional Mutagenesis in Mice Deficient for <i>p15<sup>Ink4b</sup>, p16<sup>Ink4a</sup>, p21<sup>Cip1</sup></i>, and <i>p27<sup>Kip1</sup></i> Reveals Cancer Gene Interactions and Correlations with Tumor Phenotypes
Supplementary Table 7 from Insertional Mutagenesis in Mice Deficient for <i>p15<sup>Ink4b</sup>, p16<sup>Ink4a</sup>, p21<sup>Cip1</sup></i>, and <i>p27<sup>Kip1</sup></i> Reveals Cancer Gene Interactions and Correlations with Tumor Phenotypes Open
Supplementary Table 7 from Insertional Mutagenesis in Mice Deficient for p15Ink4b, p16Ink4a, p21Cip1, and p27Kip1 Reveals Cancer Gene Interactions and Correlations with Tumor Phenotypes
View article: Supplementary Figure 2B from MicroRNA Sequence and Expression Analysis in Breast Tumors by Deep Sequencing
Supplementary Figure 2B from MicroRNA Sequence and Expression Analysis in Breast Tumors by Deep Sequencing Open
Supplementary Figure 2B from MicroRNA Sequence and Expression Analysis in Breast Tumors by Deep Sequencing