Valina L. Dawson
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View article: Neurotropic Alphaviruses activate PARP-1 Dependent Cell Death Mechanisms in Infected Motor Neurons 9207
Neurotropic Alphaviruses activate PARP-1 Dependent Cell Death Mechanisms in Infected Motor Neurons 9207 Open
Description Alphaviruses are arthropod-borne viruses that are known to cause neurological sequalae following infection, including encephalomyelitis, headaches, ataxia, seizures, paralysis, cognitive impairment, and neurodegeneration. Sever…
View article: Multicenter Stroke Preclinical Assessment Network Analysis of Cardiovascular Risk Factor Subgroups Treated With the Poly(ADP‐Ribose) Polymerase Inhibitor Veliparib
Multicenter Stroke Preclinical Assessment Network Analysis of Cardiovascular Risk Factor Subgroups Treated With the Poly(ADP‐Ribose) Polymerase Inhibitor Veliparib Open
Background The Stroke Preclinical Assessment Network tested 6 therapeutic interventions initiated at the time of reperfusion after focal ischemic stroke in young mice, aging mice, obese mice, and spontaneously hypertensive rats. This rando…
View article: Poly(ADP-ribose) Polymerase 1 Deficiency Attenuates Amyloid Pathology, Neurodegeneration, and Cognitive Decline in a Familial Alzheimer’s Disease Model
Poly(ADP-ribose) Polymerase 1 Deficiency Attenuates Amyloid Pathology, Neurodegeneration, and Cognitive Decline in a Familial Alzheimer’s Disease Model Open
Poly(ADP-ribose) (PAR) polymerase-1 (PARP1) has been implicated in DNA damage responses and neuroinflammation in Alzheimer’s disease (AD), yet its role in amyloid-β (Aβ) pathology remains unclear. Here, we show that PARP1 activation drives…
View article: Differential Expression of the Synapse Regulatory Proteins Neurexins in Early Diabetic Retinal Disease
Differential Expression of the Synapse Regulatory Proteins Neurexins in Early Diabetic Retinal Disease Open
Our findings suggest that NRXNs may play cell-type-specific roles in the inner retina and associate decreased Nrxn3β expression in RGCs with inner retinal dysfunction in early DRD.
View article: From metabolism to mind: The expanding role of the GLP-1 receptor in neurotherapeutics
From metabolism to mind: The expanding role of the GLP-1 receptor in neurotherapeutics Open
GLP-1 receptor agonists (GLP-1RAs), initially approved for diabetes and obesity, are now under investigation for neuroprotective effects in a range of neurological disorders. These agents, whose receptors are widely expressed in brain regi…
View article: Deep-learning Saturation Transfer Magnetic Resonance Fingerprinting (ST-MRF) in Patients with Parkinson’s Disease
Deep-learning Saturation Transfer Magnetic Resonance Fingerprinting (ST-MRF) in Patients with Parkinson’s Disease Open
Parkinson’s disease (PD) is marked by progressive neurodegeneration in the substantia nigra (SN). This study evaluated deep-learning saturation transfer magnetic resonance fingerprinting (ST-MRF) to quantify molecular and microstructural c…
View article: Copper-Containing ROS-Scavenging Nanozyme Paradoxically Drives Alpha-Synucleinopathy by Amplifying Nitrosative Stress
Copper-Containing ROS-Scavenging Nanozyme Paradoxically Drives Alpha-Synucleinopathy by Amplifying Nitrosative Stress Open
Reactive oxygen and nitrogen species (RO/NS) are implicated in neurodegeneration, but their roles remain unclear. Here, we identify RNS as the dominant driver of alpha-synucleinopathy. Systematic nanozyme screening identified iridium (Ir) …
View article: Spatially Organized IGF1-mTOR Signaling Controls Human Forebrain Progenitor Fate Through Coordinated Transcriptional and Translational Programs
Spatially Organized IGF1-mTOR Signaling Controls Human Forebrain Progenitor Fate Through Coordinated Transcriptional and Translational Programs Open
The specification and maintenance of human forebrain neural progenitor cells (NPCs) depend on both intrinsic gene networks and spatially localized niche signals, but the interplay between these cues remains incompletely understood. Here, w…
View article: APOE genotype confers context dependent neurovascular vulnerability in immune-vascularized human forebrain organoids
APOE genotype confers context dependent neurovascular vulnerability in immune-vascularized human forebrain organoids Open
The APOE gene is a major genetic determinant of neurovascular and immune function, yet the mechanisms by which its isoforms modulate brain vulnerability to pathogenic stress remain incompletely understood. Here, we employ isogenic human iP…
View article: Empty pelvis syndrome as a cause of major morbidity after pelvic exenteration: validation of a core data set
Empty pelvis syndrome as a cause of major morbidity after pelvic exenteration: validation of a core data set Open
Background Pelvic exenteration (PE) is a potentially curative treatment for advanced pelvic cancers. However, PE procedures are associated with empty pelvis syndrome (EPS), a spectrum of complications including pelvic sepsis, sinus formati…
View article: Exploring [11C]CPPC as a CSF1R-targeted PET imaging marker for early Parkinson’s disease severity
Exploring [11C]CPPC as a CSF1R-targeted PET imaging marker for early Parkinson’s disease severity Open
BACKGROUNDMicroglia-mediated brain immune changes play a role in the pathogenesis of Parkinson's disease (PD), but imaging microglia in living people with PD has relied on positron emission tomography (PET) ligands that lack specificity in…
View article: Proteome-wide microarray-based screening of PAR-binding proteins
Proteome-wide microarray-based screening of PAR-binding proteins Open
Poly (ADP-ribose) (PAR) plays a crucial role in intracellular signaling and scaffolding through covalent modification or non-covalent binding to target proteins. The non-covalent PAR binding proteome (PARylome) has not been extensively cha…
View article: Preclinical studies and transcriptome analysis in a model of Parkinson’s disease with dopaminergic ZNF746 expression
Preclinical studies and transcriptome analysis in a model of Parkinson’s disease with dopaminergic ZNF746 expression Open
Background The parkin-interacting substrate (PARIS, also known as ZNF746) is a transcriptional repressor, whose accumulation and phosphorylation play central pathological roles in Parkinson’s disease (PD). PARIS-induced transcriptional rep…
View article: Emerging targets of α-synuclein spreading in α-synucleinopathies: a review of mechanistic pathways and interventions
Emerging targets of α-synuclein spreading in α-synucleinopathies: a review of mechanistic pathways and interventions Open
View article: Neuronal LAG3 facilitates pathogenic α-synuclein neuron-to-neuron propagation
Neuronal LAG3 facilitates pathogenic α-synuclein neuron-to-neuron propagation Open
Lymphocyte activation gene 3 (LAG3) is a key receptor involved in the propagation of pathological proteins in Parkinson disease (PD). This study investigates the role of neuronal LAG3 in mediating the binding, uptake, and propagation of al…
View article: Cryo-EM structure of AAA + ATPase thorase reveals novel helical filament formation
Cryo-EM structure of AAA + ATPase thorase reveals novel helical filament formation Open
The AAA+ (ATPases associated with a variety of cellular activities) ATPase, Thorase, also known as ATAD1, plays multiple roles in synaptic plasticity, mitochondrial quality control and mTOR signaling through disassembling protein complexes…
View article: Elucidating metabolite and pH variations in stroke through guanidino, amine and amide CEST MRI: A comparative multi-field study at 9.4T and 3T
Elucidating metabolite and pH variations in stroke through guanidino, amine and amide CEST MRI: A comparative multi-field study at 9.4T and 3T Open
This study aims to investigate the variations in guanidino (Guan), amine and amide chemical exchange saturation transfer (CEST) contrasts in ischemic stroke using permanent middle cerebral artery occlusion (pMCAO) and transient MCAO (tMCAO…
View article: Cryo-EM Structure of AAA + ATPase Thorase Reveals Novel Helical Filament Formation
Cryo-EM Structure of AAA + ATPase Thorase Reveals Novel Helical Filament Formation Open
The AAA+ ( A TPases a ssociated with a variety of cellular a ctivities) ATPase, Thorase, also known as ATAD1, plays multiple roles in synaptic plasticity, mitochondrial quality control and mTOR signaling through disassembling protein compl…
View article: CalDAG-GEFI acts as a guanine nucleotide exchange factor for LRRK2 to regulate LRRK2 function and neurodegeneration
CalDAG-GEFI acts as a guanine nucleotide exchange factor for LRRK2 to regulate LRRK2 function and neurodegeneration Open
Mutations in LRRK2 are the most common genetic cause of Parkinson’s disease (PD). LRRK2 protein contains two enzymatic domains: a GTPase (Roc-COR) and a kinase domain. Disease-causing mutations are found in both domains. Now, studies have …
View article: α-Synuclein Strain Dynamics Correlate with Cognitive Shifts in Parkinson’s Disease
α-Synuclein Strain Dynamics Correlate with Cognitive Shifts in Parkinson’s Disease Open
α-Synuclein (α-syn) strains can serve as discriminators between Parkinson’s disease (PD) from other α-synucleinopathies. The relationship between α-syn strain dynamics and clinical performance as patients transition from normal cognition (…
View article: α-Synuclein pathology disrupts mitochondrial function in dopaminergic and cholinergic neurons at-risk in Parkinson’s disease
α-Synuclein pathology disrupts mitochondrial function in dopaminergic and cholinergic neurons at-risk in Parkinson’s disease Open
View article: Poly ADP-ribose signaling is dysregulated in Huntington disease
Poly ADP-ribose signaling is dysregulated in Huntington disease Open
Huntington disease (HD) is a genetic neurodegenerative disease caused by cytosine, adenine, guanine (CAG) expansion in the Huntingtin ( HTT ) gene, translating to an expanded polyglutamine tract in the HTT protein. Age at disease onset cor…
View article: Mature microRNA-binding protein QKI suppresses extracellular microRNA let-7b release
Mature microRNA-binding protein QKI suppresses extracellular microRNA let-7b release Open
Argonaute (AGO), a component of RNA-induced silencing complexes (RISCs), is a representative RNA-binding protein (RBP) known to bind with mature microRNAs (miRNAs) and is directly involved in post-transcriptional gene silencing. However, d…
View article: Author Correction: Aplp1 interacts with Lag3 to facilitate transmission of pathologic α-synuclein
Author Correction: Aplp1 interacts with Lag3 to facilitate transmission of pathologic α-synuclein Open
The original version of this Article contained an error in Fig. 4, in which the statistical significance for conditions 410C9 versus Lag3 -
View article: Enhancing mitochondrial proteolysis alleviates alpha-synuclein-mediated cellular toxicity
Enhancing mitochondrial proteolysis alleviates alpha-synuclein-mediated cellular toxicity Open
View article: Aplp1 interacts with Lag3 to facilitate transmission of pathologic α-synuclein
Aplp1 interacts with Lag3 to facilitate transmission of pathologic α-synuclein Open
View article: Gut-Initiated Alpha Synuclein Fibrils Drive Parkinson's Disease Phenotypes: Temporal Mapping of non-Motor Symptoms and REM Sleep Behavior Disorder
Gut-Initiated Alpha Synuclein Fibrils Drive Parkinson's Disease Phenotypes: Temporal Mapping of non-Motor Symptoms and REM Sleep Behavior Disorder Open
Parkinson's disease (PD) is characterized by progressive motor as well as less recognized non-motor symptoms that arise often years before motor manifestation, including sleep and gastrointestinal disturbances. Despite the heavy burden on …
View article: Lymphocyte‐Activation Gene 3 Facilitates Pathological Tau Neuron‐to‐Neuron Transmission (Adv. Sci. 16/2024)
Lymphocyte‐Activation Gene 3 Facilitates Pathological Tau Neuron‐to‐Neuron Transmission (Adv. Sci. 16/2024) Open
Tau preformed Fibrils The pathological tau transmission mechanism was elusive. Despite known neuronal uptake pathways, tau‐fibril‐specific receptor‐mediated uptake routes remained obscure, akin to the “maze”. In article number 2303775, Val…
View article: Poly( <scp>ADP</scp> ‐ribose) mediates bioenergetic defects and redox imbalance in neurons following oxygen and glucose deprivation
Poly( <span>ADP</span> ‐ribose) mediates bioenergetic defects and redox imbalance in neurons following oxygen and glucose deprivation Open
PARP‐1 over‐activation results in cell death via excessive PAR generation in different cell types, including neurons following brain ischemia. Glycolysis, mitochondrial function, and redox balance are key cellular processes altered in brai…
View article: Stereotaxic α-Syn PFF injection into mouse striatum v1
Stereotaxic α-Syn PFF injection into mouse striatum v1 Open
For stereotaxic injection of α-Syn PFF into the mouse striatum using 2-3 month old mice. This forked protocol has slight variations in anesthesia solution and injection coordinations.