Explanipedia

Dynamic immune dysregulation in severe mental illness: Exaggerated innate and attenuated adaptive immune responses following SARS-CoV-2 vaccination Open

Tim Rietberg, Kawtar El Abdellati, Alexandre Lucas, Margot Lemarinier, Steven D.E. Fried , et al. · 2025

Our findings provide in vivo evidence for exaggerated innate and attenuated adaptive immune responses to vaccination in SMI patients. The study underscores the need for longitudinal, experimental approaches in immunopsychiatry to better ch…

Psychometric properties of the 4-week version of the Borderline Personality Disorder Severity Index-5 Open

Shanna van Trigt, Mariana Mendoza Alvarez, Tanja van der Zweerde, Livia De Picker, Annemieke van Straten , et al. · 2025

This study evaluated the psychometric properties of a new version of the Borderline Personality Disorder Severity Index-5 that assesses BPD symptom severity over the course of 4 weeks instead of the standard 3 months: the BPDSI-5-4wk. Reli…

Clinical predictors of insomnia in borderline personality disorder: a polysomnographic and subjective examination Open

Mariana Mendoza Alvarez, Johan Verbraecken, Laurence Claes, Marie Vandekerckhove, Livia De Picker · 2025

Immune-neuroendocrine crosstalk in mood and psychotic disorders: A meta-analysis and systematic review Open

Minne Van Den Noortgate, Filip Van Den Eede, Violette Coppens, Erik J. Giltay, Livia De Picker , et al. · 2025

TSPO PET BRAIN INFLAMMATION IMAGING: A TRANSDIAGNOSTIC SYSTEMATIC REVIEW AND META-ANALYSIS OF 156 CASE-CONTROL STUDIES Open

Livia De Picker, Manuel Morrens, Igor Branchi, Bartholomeus C. M. Haarman, Tatsuhiro Terada , et al. · 2025

Introduction The 18-kDa translocator protein (TSPO) is increasingly recognized as a molecular target for PET imaging of inflammatory responses in various CNS disorders, but its usefulness appears to vary greatly across disorders, disease s…

THE RISK OF ANTIDEPRESSANT-INDUCED HYPONATREMIA: A META- ANALYSIS OF ANTIDEPRESSANT CLASSES AND COMPOUNDS Open

Tim Gheysens, Filip Van Den Eede, Livia De Picker · 2025

Background Hyponatremia (hypoNa) is a potentially serious adverse event of treatment with antidepressants. Previous research suggests that risk of drug-induced hyponatremia differs between antidepressants.1 This meta-analysis sought to det…

Use of psychedelic treatments in psychiatric clinical practice: an EPA policy paper Open

Marianne Destoop, Pavel Mohr, Florence Butlen‐Ducuing, Péter Kéri, Jerzy Samochowiec , et al. · 2025

Background Recent years show an exponential increased interest (“renaissance”) in the use of psychedelics for the treatment of mental disorders and broader. Some of these treatments, such as psilocybin for depression, are in the process of…

Systematic review: REM sleep, dysphoric dreams and nightmares as transdiagnostic features of psychiatric disorders with emotion dysregulation - Clinical implications Open

Mariana Mendoza Alvarez, Y Balthasar, Johan Verbraecken, Laurence Claes, Eus J.W. Van Someren , et al. · 2024

Immuno-metabolic depression: from concept to implementation Open

Brenda W.J.H. Penninx, Femke Lamers, Rick Jansen, Michael Berk, Golam M. Khandaker , et al. · 2024

Major depressive disorder is a common, disabling mental disorder characterized by extensive etiological and phenotypic heterogeneity. This heterogeneity makes treatment approaches imprecise and often ineffective. Insight into the underlyin…

Towards a consensus roadmap for a new diagnostic framework for mental disorders Open

Martien J. Kas, Steven E. Hyman, Leanne M. Williams, Diego Hidalgo‐Mazzei, Quentin J. M. Huys , et al. · 2024

Current nosology claims to separate mental disorders into distinct categories that do not overlap with each other. This nosological separation is not based on underlying pathophysiology but on convention-based clustering of qualitative sym…

Efficacy of inflammation-based stratification for add-on celecoxib or minocycline in major depressive disorder: Protocol of the INSTA-MD double-blind placebo-controlled randomised clinical trial Open

Céline Wessa, J. Janssens, Violette Coppens, Kawtar El Abdellati, Elfi Vergaelen , et al. · 2024

Immune-based Machine learning Prediction of Diagnosis and Illness State in Schizophrenia and Bipolar Disorder Open

Katrien Skorobogatov, Livia De Picker, Ching‐Lien Wu, Marianne Foiselle, Jean‐Romain Richard , et al. · 2024

This study highlights the potential of using immune-based measures to build predictive classification models in schizophrenia and bipolar disorder, with IL-6, TNF-ɑ, IFN-γ, QUINO and PICO as key candidates. While machine learning models su…

Anti-spike antibody responses to SARS-CoV-2 mRNA vaccines in people with schizophrenia and schizoaffective disorder Open

Katlyn Nemani, Livia De Picker, Faith Dickerson, Marion Leboyer, Michele Santacatterina , et al. · 2024

In this cohort study of individuals with SZ and a control group without psychiatric disorders, SZ was associated with lower SARS-CoV-2 anti-spike antibody levels following 2 doses of SARS-CoV-2 mRNA vaccination. This highlights the need fo…

The risk of antidepressant-induced hyponatremia: A meta-analysis of antidepressant classes and compounds Open

T. Gheysens, Livia De Picker, Filip Van Den Eede · 2024

Introduction Hyponatremia (hypoNa) is a potentially serious adverse event of treatment with antidepressants. Previous research suggests that risk of drug-induced hyponatremia differs between antidepressants. Objectives This meta-analysis s…

The risk of antidepressant-induced hyponatremia: A meta-analysis of antidepressant classes and compounds Open

Tim Gheysens, Filip Van Den Eede, Livia De Picker · 2024

Background Hyponatremia (hypoNa) is a potentially serious adverse event of antidepressant treatment. Previous research suggests the risk of drug-induced hyponatremia differs between antidepressants. This meta-analysis sought to determine t…

Benchmarking Psychiatry in Europe and beyond: The European Board Exam of Psychiatry Open

Andrew Brittlebank, Livia De Picker, K. Krysta, Asilay Şeker, Ilaria Riboldi , et al. · 2024

Higher Covid-19 exposure and lower vaccine response in patients with psychosis spectrum disorders Open

Kawtar El Abdellati, Katlyn Nemani, Alexandre Lucas, Robert H. Yolken, Marion Leboyer , et al. · 2024

High unrecognized SARS-CoV-2 exposure of newly admitted and hospitalized psychiatric patients Open

Kawtar El Abdellati, Alexandre Lucas, Hervé Perron, Ryad Tamouza, Irène Nkam , et al. · 2023

Our work demonstrated a very high unrecognized exposure to SARS-CoV-2 among newly admitted and hospitalized psychiatric inpatients, which is cause for concern in the context of highly robust evidence of adverse outcomes following COVID-19 …

TSPO PET brain inflammation imaging: A transdiagnostic systematic review and meta-analysis of 156 case-control studies Open

Livia De Picker, Manuel Morrens, Igor Branchi, Bartholomeus C. M. Haarman, Tatsuhiro Terada , et al. · 2023

This study is the first overarching transdiagnostic meta-analysis of case-control TSPO PET findings in humans across several brain regions. We observed robust increases in the TSPO signal for specific types of disorders, which were widespr…

Patients with psychosis spectrum disorders hospitalized during the COVID-19 pandemic unravel overlooked SARS-CoV-2 past infection clustering with HERV-W ENV expression and chronic inflammation Open

Ryad Tamouza, Urs Meyer, Alexandre Lucas, Jean‐Romain Richard, Irène Nkam , et al. · 2023

Epidemiology has repeatedly associated certain infections with a risk of further developing psychiatric diseases. Such infections can activate retro-transposable genetic elements (HERV) known to trigger immune receptors and impair synaptic…

Choice of Outcome Measure Predicts Anti-Inflammatory Treatment Efficacy in Major Depressive Disorder [Letter] Open

Céline Wessa, Manuel Morrens, Livia De Picker · 2023

Kynurenine pathway abnormalities are state-specific but not diagnosis-specific in schizophrenia and bipolar disorder Open

Katrien Skorobogatov, Valérie Autier, Marianne Foiselle, Jean‐Romain Richard, Wahid Boukouaci , et al. · 2023

Cov-N-Psy: Neurobiological underpinnings of long Covid neuropsychological consequences Open

Katrien Skorobogatov, Livia De Picker, Manuel Morrens, Kurt Beeckmans, Filip Van Den Eede · 2023

Improving mental health care in depression: A call for action Open

Julia Eder, Geert Dom, Philip Gorwood, Hilkka Kärkkäinen, Andre Decraene , et al. · 2023

Depressive disorders have one of the highest disability-adjusted life years (DALYs) of all medical conditions, which led the European Psychiatric Association to propose a policy paper, pinpointing their unmet health care and research needs…

Association between gender ratio and inflammatory biomarkers in major depressive disorder: a systematic review and meta-analysis Open

Jonathan Janssens, L. De Ketelaere, Livia De Picker, Manuel Morrens · 2023

Ethical dilemmas in contemporary psychiatry: Findings from a survey of National Psychiatric Associations in Europe Open

Jerzy Samochowiec, Dorota Frydecka, Karolina Skonieczna‐Żydecka, Meryam Schouler‐Ocak, Bernardo Carpinello , et al. · 2023

Background The European Psychiatric Association (EPA) is an organization that speaks on behalf of its individual members and members of National Psychiatric Associations (NPAs). The aim of this study to identify and investigate current con…

REM sleep fragmentation and the overnight downregulation of distress: a “neglected” symptom of Borderline Personality Disorder? Open

Marcos M. Alvarez, Livia De Picker, Marie Vandekerckhove, Van Audekerke Johan, Laurence Claes · 2023

The relationship between immune and cognitive dysfunction in mood and psychotic disorder: a systematic review and a meta-analysis Open

Manuel Morrens, C. Overloop, Violette Coppens, Elke Loots, Minne Van Den Noortgate , et al. · 2022

Background In psychotic and mood disorders, immune alterations are hypothesized to underlie cognitive symptoms, as they have been associated with elevated blood levels of inflammatory cytokines, kynurenine metabolites, and markers of micro…

Association between serum lithium level and incidence of COVID-19 infection Open

Livia De Picker, Marion Leboyer, John Geddes, Manuel Morrens, Paul J. Harrison , et al. · 2022

Summary An antiviral effect of lithium has been proposed, but never investigated for coronavirus disease 2019 (COVID-19). Using electronic health records of 26 554 patients with documented serum lithium levels during the pandemic, we show …

Psychiatric training in perinatal mental health across Europe Open

Marisa Casanova Dias, Ekin Sönmez Güngör, Sean Naughton, Howard Ryland, Thomas Gargot , et al. · 2022

Perinatal mental illness is associated with considerable maternal and infant morbidity and mortality. However, there are currently no specific guidelines on the standards and structure of postgraduate perinatal psychiatric training in Euro…

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