Timothy L. Denning
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IL-36/IL-36R signaling promotes CD4+ T cell-dependent colitis via pro-inflammatory cytokine production Open
Background Inflammatory bowel disease (IBD) is a multifactorial, chronic disease that affects approximately 1.5 million people in the United States. Several important factors are implicated in the pathogenesis of IBD, one factor being dysr…
Editorial: Impact of gut ecosystem in health and diseases: microbiome, mucosal barrier and cytokine milieu Open
EDITORIAL article Front. Microbiol., 05 January 2024Sec. Microbial Symbioses Volume 14 - 2023 | https://doi.org/10.3389/fmicb.2023.1345703
View article: Double-layered protein nanoparticles conjugated with truncated flagellin induce improved mucosal and systemic immune responses in mice
Double-layered protein nanoparticles conjugated with truncated flagellin induce improved mucosal and systemic immune responses in mice Open
Intranasal immunization with HA3-tFliC/NP SDAD protein nanoparticles enhances both systemic and mucosal immunity, promoting influenza cross-protection. Sequential priming immunization further enhances GC B cells, Tfh cells, and effector T …
N-acetylglucosamine-6-O sulfation on intestinal mucins prevents obesity and intestinal inflammation by regulating gut microbiota Open
Intestinal mucins play an essential role in the defense against bacterial invasion and the maintenance of gut microbiota, which is instrumental in the regulation of host immune systems; hence, its dysregulation is a hallmark of metabolic d…
IL-36/IL-36R Signaling Promotes CD4+ T Cell-Dependent Colitis via Pro-Inflammatory Cytokine Production Open
Inflammatory bowel disease (IBD) is a multifactorial, chronic disease that affects approximately 1.5 million people in the United States [1]. It presents with inflammation of the intestine with unknown etiology and its two main forms are C…
Data from Early-Life Microbiota Exposure Restricts Myeloid-Derived Suppressor Cell–Driven Colonic Tumorigenesis Open
Gut microbiota and their metabolites are instrumental in regulating homeostasis at intestinal and extraintestinal sites. However, the complex effects of prenatal and early postnatal microbial exposure on adult health and disease outcomes r…
Data from Early-Life Microbiota Exposure Restricts Myeloid-Derived Suppressor Cell–Driven Colonic Tumorigenesis Open
Gut microbiota and their metabolites are instrumental in regulating homeostasis at intestinal and extraintestinal sites. However, the complex effects of prenatal and early postnatal microbial exposure on adult health and disease outcomes r…
Supplementary Data File from Early-Life Microbiota Exposure Restricts Myeloid-Derived Suppressor Cell–Driven Colonic Tumorigenesis Open
Complete Supplementary Data File
Supplementary Data File from Early-Life Microbiota Exposure Restricts Myeloid-Derived Suppressor Cell–Driven Colonic Tumorigenesis Open
Complete Supplementary Data File
Luminal bacteria coated with IgA and IgG during intestinal inflammation as a new and abundant stimulus for colonic macrophages Open
In the gut, secretory immunoglobulin A is the predominant humoral response against commensals, although healthy hosts also produce microbiota‐specific IgG antibodies. During intestinal inflammation, the content of IgG in the lumen increase…
Skin Vaccination with Dissolvable Microneedle Patches Incorporating Influenza Neuraminidase and Flagellin Protein Nanoparticles Induces Broad Immune Protection against Multiple Influenza Viruses Open
We generated self-adjuvanted protein nanoparticles of conserved influenza antigens and immunized mice via skin vaccination with dissolvable microneedle patches (MNPs) to increase the strength and breadth of immune responses. We produced M2…
IL‐36 cytokines and gut immunity Open
Summary Interleukin 36 (IL‐36) constitutes a group of cytokines that belong to the IL‐1 superfamily. Emerging evidence has suggested a role of IL‐36 in the pathogenesis of many inflammatory disorders. Intriguingly, in the gastrointestinal …
METHYLTRANSFERASE SMYD5 EXAGGERATES INFLAMMATORY BOWEL DISEASE BY REGULATING PPAR-γ COACTIVATOR 1-α STABILITY Open
Background and Aims The expression and role of methyltransferase SET and MYND domain-containing protein 5 (SMYD5) in inflammatory bowel diseases (IBD) is completely unknown. Here, we investigated the role and the underlying mechanism of ep…
View article: Inhalation of Nicotine-containing Electronic Cigarette Vapor Exacerbates the Features of COPD in βENaC-overexpressing Mice.
Inhalation of Nicotine-containing Electronic Cigarette Vapor Exacerbates the Features of COPD in βENaC-overexpressing Mice. Open
Background Chronic obstructive pulmonary disease (COPD) is currently listed as the 3rd leading cause of death in the United States. COPD is marked by limitations in expiratory airflow, emphysematous destruction of the lungs, bronchitis, an…
Methyltransferase SMYD5 Exaggerates IBD by Downregulating Mitochondrial Functions via Post-translational Control of PGC-1α Stability Open
Background and Aims The expression and role of methyltransferase SET and MYND domain-containing protein 5 (SMYD5) in inflammatory bowel diseases (IBD) is completely unknown. Here, we investigated the role and the underlying mechanism of ep…
IL-36R signaling integrates innate and adaptive immune-mediated protection against enteropathogenic bacteria Open
Significance Upon enteropathogenic bacterial infection, cytokines orchestrate innate and adaptive immune activation that promotes barrier protection and pathogen control. Using Citrobacter rodentium , we defined a critical role for IL-36R …
Internalization of Garlic-Derived Nanovesicles on Liver Cells is Triggered by Interaction With CD98 Open
The mechanism of how plant-derived nanovesicles are uptaken by cells remains unknown. In this study, the garlic-derived nanovesicles (GDVs) were isolated and digested with trypsin to remove all surface proteins. Digested GDVs showed less u…
View article: Combined IL-2 Immunocomplex and Anti-IL-5 mAb Treatment Expands Foxp3+ Treg Cells in the Absence of Eosinophilia and Ameliorates Experimental Colitis
Combined IL-2 Immunocomplex and Anti-IL-5 mAb Treatment Expands Foxp3+ Treg Cells in the Absence of Eosinophilia and Ameliorates Experimental Colitis Open
Interleukin (IL)-2 is expressed during T cell activation and induces the proliferation and differentiation of T cells. CD4+Foxp3+ regulatory T cells (Tregs) constitutively express the high affinity IL-2 receptor (CD25/IL-2Rα) and rapidly r…
Early-Life Microbiota Exposure Restricts Myeloid-Derived Suppressor Cell–Driven Colonic Tumorigenesis Open
Gut microbiota and their metabolites are instrumental in regulating homeostasis at intestinal and extraintestinal sites. However, the complex effects of prenatal and early postnatal microbial exposure on adult health and disease outcomes r…
Epithelial Traffic Control: IL22 Gives TA Cells the Green Light Open
The intestinal epithelial barrier is instrumental in the physical separation of gut microbiota from underlying innate and adaptive immune cells and stromal cells.1Turner J.R. Intestinal mucosal barrier function in health and disease.Nat Re…
Segmented filamentous bacteria‐induced immune responses: a balancing act between host protection and autoimmunity Open
Summary Segmented filamentous bacteria ( SFB ) are Gram‐positive, spore‐forming, bacteria that primarily colonize the ileum of the small intestine. Upon direct adherence to intestinal epithelial cells, SFB actively stimulate innate and ada…
View article: A cytokine network involving IL-36γ, IL-23, and IL-22 promotes antimicrobial defense and recovery from intestinal barrier damage
A cytokine network involving IL-36γ, IL-23, and IL-22 promotes antimicrobial defense and recovery from intestinal barrier damage Open
Significance Cytokines are produced in response to microbial threat and aid in the recruitment and activation of immune cells to protect the host. Using complementary in vitro and in vivo approaches, we have defined a cytokine network invo…