Ludovic Desvignes
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View article: SARS-CoV-2 infection predisposes patients to coinfection with <i>Staphylococcus aureus</i>
SARS-CoV-2 infection predisposes patients to coinfection with <i>Staphylococcus aureus</i> Open
Severe COVID-19 has been associated with coinfections with bacterial and fungal pathogens. Notably, patients with COVID-19 who develop Staphylococcus aureus bacteremia exhibit higher rates of mortality than those infected with either patho…
View article: A Repurposed Drug Interferes with Nucleic Acid to Inhibit the Dual Activities of Coronavirus Nsp13
A Repurposed Drug Interferes with Nucleic Acid to Inhibit the Dual Activities of Coronavirus Nsp13 Open
The recent pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) highlighted a critical need to discover more effective antivirals. While therapeutics for SARS-CoV-2 exist, its nonstructural protein 13 (Nsp13) rem…
View article: Impaired immune responses in the airways are associated with poor outcome in critically ill COVID-19 patients
Impaired immune responses in the airways are associated with poor outcome in critically ill COVID-19 patients Open
Introduction Mounting evidence indicates that an individual's humoral adaptive immune response plays a critical role in the setting of SARS-CoV-2 infection, and that the efficiency of the response correlates with disease severity. The rela…
View article: mRNA COVID-19 vaccine elicits potent adaptive immune response without the acute inflammation of SARS-CoV-2 infection
mRNA COVID-19 vaccine elicits potent adaptive immune response without the acute inflammation of SARS-CoV-2 infection Open
View article: A neonatal mouse model characterizes transmissibility of SARS-CoV-2 variants and reveals a role for ORF8
A neonatal mouse model characterizes transmissibility of SARS-CoV-2 variants and reveals a role for ORF8 Open
View article: A neonatal mouse model characterizes transmissibility of SARS-CoV-2 variants and reveals a role for ORF8
A neonatal mouse model characterizes transmissibility of SARS-CoV-2 variants and reveals a role for ORF8 Open
Small animal models have been a challenge for the study of SARS-CoV-2 transmission, with most investigators using golden hamsters or ferrets 1, 2 . Mice have the advantages of low cost, wide availability, less regulatory and husbandry chal…
View article: Bacterial Strain–Dependent Dissociation of Cell Recruitment and Cell-to-Cell Spread in Early M. tuberculosis Infection
Bacterial Strain–Dependent Dissociation of Cell Recruitment and Cell-to-Cell Spread in Early M. tuberculosis Infection Open
Tuberculosis is a leading infectious disease killer worldwide and is caused by Mycobacterium tuberculosis . After exposure to M. tuberculosis , outcomes range from apparent elimination to active disease.
View article: Bacterial strain-dependent dissociation of cell recruitment and cell-to-cell spread in early<i>M. tuberculosis</i>infection
Bacterial strain-dependent dissociation of cell recruitment and cell-to-cell spread in early<i>M. tuberculosis</i>infection Open
In the initial stage of respiratory infection, Mycobacterium tuberculosis traverses from alveolar macrophages to phenotypically diverse monocyte-derived phagocytes and neutrophils in the lung parenchyma. Here, we compare the in vivo kineti…
View article: Microbial signatures in the lower airways of mechanically ventilated COVID-19 patients associated with poor clinical outcome
Microbial signatures in the lower airways of mechanically ventilated COVID-19 patients associated with poor clinical outcome Open
View article: mRNA COVID-19 vaccine elicits potent adaptive immune response without the persistent inflammation seen in SARS-CoV-2 infection
mRNA COVID-19 vaccine elicits potent adaptive immune response without the persistent inflammation seen in SARS-CoV-2 infection Open
SARS-CoV-2 infection and vaccination elicit potent immune responses. Our study presents a comprehensive multimodal single-cell dataset of peripheral blood of patients with acute COVID-19 and of healthy volunteers before and after receiving…
View article: Microbial signatures in the lower airways of mechanically ventilated COVID19 patients associated with poor clinical outcome
Microbial signatures in the lower airways of mechanically ventilated COVID19 patients associated with poor clinical outcome Open
Mortality among patients with COVID-19 and respiratory failure is high and there are no known lower airway biomarkers that predict clinical outcome. We investigated whether bacterial respiratory infections and viral load were associated wi…
View article: Antibody isotype diversity against SARS-CoV-2 is associated with differential serum neutralization capacities
Antibody isotype diversity against SARS-CoV-2 is associated with differential serum neutralization capacities Open
Understanding antibody responses to SARS-CoV-2 is indispensable for the development of containment measures to overcome the current COVID-19 pandemic. Recent studies showed that serum from convalescent patients can display variable neutral…
View article: Microbial signatures in the lower airways of mechanically ventilated COVID19 patients associated with poor clinical outcome
Microbial signatures in the lower airways of mechanically ventilated COVID19 patients associated with poor clinical outcome Open
Mortality among patients with COVID-19 and respiratory failure is high and there are no known lower airway biomarkers that predict clinical outcome. We investigated whether bacterial respiratory infections and viral load were associated wi…
View article: A Comparative Analysis of SARS-CoV-2 Antivirals Characterizes 3CL <sup>pro</sup> Inhibitor PF-00835231 as a Potential New Treatment for COVID-19
A Comparative Analysis of SARS-CoV-2 Antivirals Characterizes 3CL <sup>pro</sup> Inhibitor PF-00835231 as a Potential New Treatment for COVID-19 Open
The arsenal of SARS-CoV-2 specific antiviral drugs is extremely limited. Only one direct-acting antiviral drug is currently approved, the viral polymerase inhibitor remdesivir, and it has limited efficacy.
View article: A comparative analysis of SARS-CoV-2 antivirals in human airway models characterizes 3CL(pro) inhibitor PF-00835231 as a potential new treatment for COVID-19
A comparative analysis of SARS-CoV-2 antivirals in human airway models characterizes 3CL(pro) inhibitor PF-00835231 as a potential new treatment for COVID-19 Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of Coronavirus Disease 2019 (COVID-19). There is a dire need for novel effective antivirals to treat COVID-19, as the only approved direct-acting antivir…
View article: Discrete Immune Response Signature to SARS-CoV-2 mRNA Vaccination Versus Infection
Discrete Immune Response Signature to SARS-CoV-2 mRNA Vaccination Versus Infection Open
View article: A comparative analysis of SARS-CoV-2 antivirals in human airway models characterizes 3CL<sup>pro</sup>inhibitor PF-00835231 as a potential new treatment for COVID-19
A comparative analysis of SARS-CoV-2 antivirals in human airway models characterizes 3CL<sup>pro</sup>inhibitor PF-00835231 as a potential new treatment for COVID-19 Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of Coronavirus Disease 2019 (COVID-19). There is a dire need for novel effective antivirals to treat COVID-19, as the only approved direct-acting antivir…
View article: Evidenced-based guidelines for tuberculosis screening before biologic treatment initiation
Evidenced-based guidelines for tuberculosis screening before biologic treatment initiation Open
View article: Limited Antimycobacterial Efficacy of Epitope Peptide Administration Despite Enhanced Antigen-Specific CD4 T-Cell Activation
Limited Antimycobacterial Efficacy of Epitope Peptide Administration Despite Enhanced Antigen-Specific CD4 T-Cell Activation Open
Further studies revealed that CD4 T cells in lung lesions are distant from the infected cells, suggesting that, even if they can be activated, the positioning of CD4 T cells and their direct interactions with infected cells may be limiting…
View article: STIM1 controls T cell–mediated immune regulation and inflammation in chronic infection
STIM1 controls T cell–mediated immune regulation and inflammation in chronic infection Open
Chronic infections induce a complex immune response that controls pathogen replication, but also causes pathology due to sustained inflammation. Ca2+ influx mediates T cell function and immunity to infection, and patients with inherited mu…