Michael Sey
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View article: <scp>IL23</scp> Receptor Polymorphism Is a Predictor of Anti‐Tumour Necrosis Factor‐α‐Induced Paradoxical Psoriasis in Inflammatory Bowel Disease
<span>IL23</span> Receptor Polymorphism Is a Predictor of Anti‐Tumour Necrosis Factor‐α‐Induced Paradoxical Psoriasis in Inflammatory Bowel Disease Open
Background Paradoxical psoriasis (PP) is an adverse drug reaction associated with anti‐tumour necrosis factor (TNF)‐α therapy leading to disfiguring skin lesions that may impact an individual's quality of life and affect their inflammatory…
View article: Canadian Association of Gastroenterology Clinical Practice Guideline for the Endoscopic Management of Nonvariceal Nonpeptic Ulcer Upper Gastrointestinal Bleeding
Canadian Association of Gastroenterology Clinical Practice Guideline for the Endoscopic Management of Nonvariceal Nonpeptic Ulcer Upper Gastrointestinal Bleeding Open
This guideline has been formally endorsed by leading international endoscopy societies: the American Society for Gastrointestinal Endoscopy, the European Society of Gastrointestinal Endoscopy, the Sociedad Interamericana de Endoscopía Dige…
View article: Day 3 Oxford criteria predict steroid non-response for acute severe ulcerative colitis in the post biologic era
Day 3 Oxford criteria predict steroid non-response for acute severe ulcerative colitis in the post biologic era Open
Background and aims Outcomes of patients admitted with acute severe ulcerative colitis (ASUC) in the post biologic era are under explored, as well as the ability of scoring indices to predict early steroid non-response. Methods This retros…
View article: Endoscopic Skipping, Stricturing, and Penetrating Complications in Crohn’s Disease on Tandem Ileo-colonoscopy and Cross-sectional Imaging: A Retrospective Cohort Study
Endoscopic Skipping, Stricturing, and Penetrating Complications in Crohn’s Disease on Tandem Ileo-colonoscopy and Cross-sectional Imaging: A Retrospective Cohort Study Open
Background Crohn’s disease (CD) is characterized by discontinuous inflammation. Failure to identify skipping lesions of the terminal ileum (TI) or transmural changes can lead to incorrect management. Methods Eligible adult patients with CD…
View article: Prevalence of stricturing, penetrating complications and extraintestinal manifestations in inflammatory bowel disease detected on cross‐sectional imaging in a tertiary care setting
Prevalence of stricturing, penetrating complications and extraintestinal manifestations in inflammatory bowel disease detected on cross‐sectional imaging in a tertiary care setting Open
Background Stricturing, penetrating complications and extraintestinal manifestations (EIMs) are frequent in patients with inflammatory bowel disease (IBD). There is limited data on the prevalence of these complications in patients with IBD…
View article: Initiation of vedolizumab did not provoke new‐onset spondylarthritis in patients with inflammatory bowel disease: A prospective 24‐week study with imaging assessments
Initiation of vedolizumab did not provoke new‐onset spondylarthritis in patients with inflammatory bowel disease: A prospective 24‐week study with imaging assessments Open
Background A temporal relationship between vedolizumab and new‐onset spondyloarthritis (SpA) has been suggested. Aims We evaluated the relationship between vedolizumab initiation and development of new‐onset SpA in patients with inflammato…
View article: Propofol sedation does not improve measures of colonoscopy quality but increase cost – findings from a large population-based cohort study
Propofol sedation does not improve measures of colonoscopy quality but increase cost – findings from a large population-based cohort study Open
View article: A160 A CASE OF BREAST CANCER METASTASIS MASQUERADING AS SIGNET RING CELL ADENOCARCINOMA OF THE STOMACH
A160 A CASE OF BREAST CANCER METASTASIS MASQUERADING AS SIGNET RING CELL ADENOCARCINOMA OF THE STOMACH Open
Background Gastric cancer has a poor prognosis, particularly at advanced stages. Endoscopic submucosal dissection (ESD) can be used to treat selected early-stage gastric cancers. This case study explores the challenge of diagnosing and man…
View article: A123 THE EFFECTS OF INFLAMMATORY BOWEL DISEASE ON THE MANAGEMENT AND OUTCOMES OF COMPLEX POLYPS IN PATIENTS UNDERGOING SURVEILLANCE COLONOSCOPY: A RETROSPECTIVE COHORT STUDY
A123 THE EFFECTS OF INFLAMMATORY BOWEL DISEASE ON THE MANAGEMENT AND OUTCOMES OF COMPLEX POLYPS IN PATIENTS UNDERGOING SURVEILLANCE COLONOSCOPY: A RETROSPECTIVE COHORT STUDY Open
Background The influence of inflammatory bowel disease (IBD) on the outcomes of complex polyps remains an area of uncertainty. Aims To investigate the impact of IBD on the management and outcomes of complex polyps during surveillance colon…
View article: P696 Initiation of Vedolizumab did not provoke new-onset spondylarthritis in patients with inflammatory bowel disease: A Prospective Study Including Rheumatological and Blinded Imaging Assessments
P696 Initiation of Vedolizumab did not provoke new-onset spondylarthritis in patients with inflammatory bowel disease: A Prospective Study Including Rheumatological and Blinded Imaging Assessments Open
Background Prior case series indicated a temporal relationship between use of vedolizumab and new-onset spondyloarthritis. Methods We aimed to evaluate the relationship between initiation of vedolizumab and development of new-onset spondyl…
View article: P550 Short and long-term outcomes after acute severe ulcerative colitis in adults: A 12 year Canadian experience in the post biologic era
P550 Short and long-term outcomes after acute severe ulcerative colitis in adults: A 12 year Canadian experience in the post biologic era Open
Background Patients with acute severe ulcerative colitis (ASUC) are at increased risk of colectomy following an episode of acute severe exacerbation. Medical rescue therapy in steroid non-responders has reduced the need for emergency colec…
View article: Extended delay in endoscopic mucosal resection is not associated with adverse outcomes: Findings from the COVID-19 pandemic
Extended delay in endoscopic mucosal resection is not associated with adverse outcomes: Findings from the COVID-19 pandemic Open
Background and study aims The aim of this study was to investigate the impact of delayed endoscopic mucosal resection (EMR) of colorectal polyps on health outcomes. Patients and methods A bidirectional cohort study was completed. A baselin…
View article: A140 ECTOPIC SPLEEN PRESENTING AS A GASTRIC SUBMUCOSAL LESION
A140 ECTOPIC SPLEEN PRESENTING AS A GASTRIC SUBMUCOSAL LESION Open
Background Accessory spleen is ectopic splenic tissue which can be either congenital or acquired. It is usually an asymptomatic incidental finding. In the context of known malignancy, accessory spleen can be mistaken for metastasis. Purpos…
View article: Association of Trainee Participation in Colonoscopy Procedures With Quality Metrics
Association of Trainee Participation in Colonoscopy Procedures With Quality Metrics Open
This study suggests that trainee involvement during colonoscopy was associated with reduced ssPDR but not other colonoscopy outcome measures. Extra care should be exercised when examining the right colon when trainees are involved.
View article: Artificial Intelligence and the Promise of Expediting and Standardizing the Reviewing and Reporting of Capsule Endoscopy Videos
Artificial Intelligence and the Promise of Expediting and Standardizing the Reviewing and Reporting of Capsule Endoscopy Videos Open
Xia Xie, MD, PhD; Yu-Feng Xiao, MD, PhD; Xiao-Yan Zhao, MD, PhD; Jian-Jun Li, MB; Qiang-Qiang Yang, MM; Xue Peng, MB; Xu-Biao Nie, MM; Jian-Yun Zhou, MD, PhD; Yong-Bing Zhao, MM; Huan Yang, MM; Xi Liu, MD, PhD; En Liu, MD, PhD; Yu-Yang Che…
View article: Comparison of Risk Scores for Lower Gastrointestinal Bleeding
Comparison of Risk Scores for Lower Gastrointestinal Bleeding Open
The Oakland score was the most discriminative LGIB risk score for predicting safe discharge, major bleeding, and need for transfusion, whereas the Strate score was best for predicting need for hemostasis. This study suggests that these sco…
View article: A106 THE EPIDEMIOLOGY OF COMPLEX COLONIC POLYPS: A POPULATION BASED STUDY OF THE SOUTHWEST ONTARIO COLONOSCOPY COHORT
A106 THE EPIDEMIOLOGY OF COMPLEX COLONIC POLYPS: A POPULATION BASED STUDY OF THE SOUTHWEST ONTARIO COLONOSCOPY COHORT Open
Background Complex polyps are well recognized amongst endoscopists, but its definition varies in the literature and from one endoscopist to another. Despite its clinical importance, the epidemiology of complex polyps is poorly understood. …
View article: A71 POLYP TO ADENOMA CONVERSION FACTOR AS A SURROGATE FOR ADENOMA DETECTION RATE-– FINDINGS FROM THE SOUTHWEST ONTARIO COLONOSCOPY COHORT
A71 POLYP TO ADENOMA CONVERSION FACTOR AS A SURROGATE FOR ADENOMA DETECTION RATE-– FINDINGS FROM THE SOUTHWEST ONTARIO COLONOSCOPY COHORT Open
Background The adenoma detection rate (ADR) is one of the main quality indicators of a colonoscopy but requires combining endoscopic and histologic data. However, the polyp detection rate (PDR) requires only endoscopic assessment and has b…
View article: A142 IMPACT OF <i>HLADQA1*05G&gt;A</i> GENETIC-SCREENING FOR OPTIMAL ANTI-TNF THERAPY IN INFLAMMATORY BOWEL DISEASE: A PRELIMINARY REPORT
A142 IMPACT OF <i>HLADQA1*05G>A</i> GENETIC-SCREENING FOR OPTIMAL ANTI-TNF THERAPY IN INFLAMMATORY BOWEL DISEASE: A PRELIMINARY REPORT Open
Background Genetic variation in the human leukocyte antigen ( HLA) gene is strongly associated with the formation of anti-drug antibodies to tumor necrosis factor-alpha antagonists (anti-TNF) in inflammatory bowel disease (IBD). It is also…
View article: High oncostatin M predicts lack of clinical remission for patients with inflammatory bowel disease on tumor necrosis factor α antagonists
High oncostatin M predicts lack of clinical remission for patients with inflammatory bowel disease on tumor necrosis factor α antagonists Open
The interleukin-6 family cytokine, oncostatin-M (OSM) has been associated with response to tumor necrosis factor-α antagonists (anti-TNFs) in small cohorts of patients with inflammatory bowel disease (IBD). We aimed to evaluate the associa…
View article: Recurrent Hepatocellular Carcinoma After Liver Transplantation: Validation of a Pathologic Risk Score on Explanted Livers to Predict Recurrence
Recurrent Hepatocellular Carcinoma After Liver Transplantation: Validation of a Pathologic Risk Score on Explanted Livers to Predict Recurrence Open
Our pathologic risk score accurately risks stratified patients for HCC recurrence after liver transplant. It can be used to tailor surveillance strategies for those deemed to be at elevated risk for recurrence.
View article: Reliability of the Endoscopic Ultrasound Ulcerative Colitis (EUS-UC) score for assessment of inflammation in patients with ulcerative colitis
Reliability of the Endoscopic Ultrasound Ulcerative Colitis (EUS-UC) score for assessment of inflammation in patients with ulcerative colitis Open
Background and study aims Endoscopic ultrasound (EUS) may be a useful modality for disease assessment and risk stratification in ulcerative colitis. We assessed the reliability of a newly developed EUS index of inflammation called the EUS-…
View article: A randomized controlled trial of high volume simethicone to improve visualization during capsule endoscopy
A randomized controlled trial of high volume simethicone to improve visualization during capsule endoscopy Open
Background The optimal dose of simethicone before capsule endoscopy is unknown. Prior studies have reported inconsistent cleansing, with some showing improved visualization only in the proximal small intestine. We hypothesized a higher vol…
View article: Pretreatment HLADQA1-HLADRB1 Testing for the Prevention of Azathioprine-Induced Pancreatitis in Inflammatory Bowel Disease: A Prospective Cohort Study
Pretreatment HLADQA1-HLADRB1 Testing for the Prevention of Azathioprine-Induced Pancreatitis in Inflammatory Bowel Disease: A Prospective Cohort Study Open
INTRODUCTION: Azathioprine-induced pancreatitis is an idiosyncratic and unpredictable response, occurring in up to 7% of azathioprine-exposed patients with inflammatory bowel disease (IBD). The haplotype HLADQA1-HLADRB1*07:01A>C is strongl…
View article: A108 ARE INPATIENTS STILL MORE LIKELY TO FAIL BOWEL PREPARATION IN THE SPLIT-DOSE ERA? FINDINGS FROM 47, 292 COLONOSCOPIES IN THE SOUTHWEST ONTARIO COLONOSCOPY COHORT
A108 ARE INPATIENTS STILL MORE LIKELY TO FAIL BOWEL PREPARATION IN THE SPLIT-DOSE ERA? FINDINGS FROM 47, 292 COLONOSCOPIES IN THE SOUTHWEST ONTARIO COLONOSCOPY COHORT Open
Background Prior studies before the widespread use of split-dose bowel preparation have shown a high rate of inadequate bowel preparation in hospitalized patients. Whether this is still true in the era of split-dose bowel preparation is un…
View article: A117 PROPOFOL SEDATION DOES NOT IMPROVE MEASURES OF COLONOSCOPY QUALITY – FINDINGS FROM THE SOUTHWEST ONTARIO COLONOSCOPY COHORT
A117 PROPOFOL SEDATION DOES NOT IMPROVE MEASURES OF COLONOSCOPY QUALITY – FINDINGS FROM THE SOUTHWEST ONTARIO COLONOSCOPY COHORT Open
Background The use of propofol during colonoscopy has gained increased popularity due to deeper anesthesia compared to conscious sedation. Prior studies examining the use of propofol sedation during colonoscopy have primarily focused on an…
View article: A115 A SYSTEMATIC REVIEW AND META-ANALYSIS OF LOWER GASTROINTESTINAL BLEEDING RISK SCORES TO PREDICT ADVERSE OUTCOMES
A115 A SYSTEMATIC REVIEW AND META-ANALYSIS OF LOWER GASTROINTESTINAL BLEEDING RISK SCORES TO PREDICT ADVERSE OUTCOMES Open
Background Acute lower gastrointestinal bleeding (LGIB) is a common reason for emergency hospitalization. In most patients, bleeding resolves spontaneously but some cases can be fatal. Risk prediction scores can be useful in risk stratifyi…
View article: A12 PRE-TREATMENT HLADQA1-HLADRB1 TESTING FOR THE PREVENTION OF AZATHIOPRINE-INDUCED PANCREATITIS IN INFLAMMATORY BOWEL DISEASE: A PROSPECTIVE COHORT STUDY
A12 PRE-TREATMENT HLADQA1-HLADRB1 TESTING FOR THE PREVENTION OF AZATHIOPRINE-INDUCED PANCREATITIS IN INFLAMMATORY BOWEL DISEASE: A PROSPECTIVE COHORT STUDY Open
Background Azathioprine (AZA) therapy has a long history of use in IBD. The need to promote its safe use in this population is ensured by governmental health policy requiring IBD patients to fail low cost drugs, such as AZA, prior to appro…
View article: A113 ANNUAL COLONOSCOPY VOLUME IS NOT PREDICTIVE OF COLONOSCOPY QUALITY - FINDINGS FROM THE SOUTHWEST ONTARIO COLONOSCOPY COHORT
A113 ANNUAL COLONOSCOPY VOLUME IS NOT PREDICTIVE OF COLONOSCOPY QUALITY - FINDINGS FROM THE SOUTHWEST ONTARIO COLONOSCOPY COHORT Open
Background Performing a minimum number of colonoscopies annually has been proposed by some jurisdictions as a requirement for maintaining privileges. However, this practice is supported by limited evidence. Aims The objective of this study…
View article: A120 NO EVIDENCE OF A FRIDAY EFFECT ON COLONOSCOPY QUALITY OUTCOMES
A120 NO EVIDENCE OF A FRIDAY EFFECT ON COLONOSCOPY QUALITY OUTCOMES Open
Background Colonoscopy quality may be influenced by operator fatigue. Prior studies have shown lower adenoma detection rates for procedures performed at the end of the day. However, it is unknown if colonoscopy quality is impaired at the e…