Daniel L. Drane
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Non-invasive temporal interference stimulation of the hippocampus suppresses epileptic biomarkers in patients with Epilepsy: biophysical differences between kilohertz and amplitude modulated stimulation Open
Our findings underscore the therapeutic potential of TI as a non-invasive brain stimulation modality for epilepsy, offering significant suppression of epileptic biomarkers through subthreshold modulation of the epileptogenic zone. Furtherm…
View article: Temporal Interference Stimulation Can Enhance or Disrupt Human Memory Encoding as a Function of Brain Location and Frequency
Temporal Interference Stimulation Can Enhance or Disrupt Human Memory Encoding as a Function of Brain Location and Frequency Open
Visual memory relies on synchronized interactions and rhythms between the medial temporal lobes and neocortical brain regions. Non-invasive manipulation of memory-related brain regions, specifically deeper temporal lobe regions, has been l…
Model-Based Person Fit Statistics Applied to the Wechsler Adult Intelligence Scale IV Open
An important task in clinical neuropsychology is to evaluate whether scores obtained on a test battery, such as the Wechsler Adult Intelligence Scale Fourth Edition (WAIS-IV), can be considered “credible” or “valid” for a particular patien…
View article: Temporal Lobe Epilepsy Surgical Outcomes Can Be Inferred Based on Structural Connectome Hubs: A Machine Learning Study
Temporal Lobe Epilepsy Surgical Outcomes Can Be Inferred Based on Structural Connectome Hubs: A Machine Learning Study Open
OBJECTIVE: Medial temporal lobe epilepsy (TLE) is the most common form of medication-resistant focal epilepsy in adults. Despite removal of medial temporal structures, more than one-third of patients continue to have disabling seizures pos…
View article: Radiological identification of temporal lobe epilepsy using artificial intelligence: a feasibility study
Radiological identification of temporal lobe epilepsy using artificial intelligence: a feasibility study Open
Temporal lobe epilepsy is associated with MRI findings reflecting underlying mesial temporal sclerosis. Identifying these MRI features is critical for the diagnosis and management of temporal lobe epilepsy. To date, this process relies on …
Predictors of white matter hyperintensities in the elderly Congolese population Open
Introduction White matter hyperintensities (WMHs) are strongly linked to cardiovascular risk factors and other health conditions such as Alzheimer’s disease. However, there is a dearth of research on this topic in low-income countries and …
View article: Characterizing the Prevalence of Psychiatric Conditions and Fear-Potentiated Startle Response in Civilians with a History of Trauma and Seizures
Characterizing the Prevalence of Psychiatric Conditions and Fear-Potentiated Startle Response in Civilians with a History of Trauma and Seizures Open
Background Depression, posttraumatic stress disorder (PTSD), and suicidality are more prevalent among people with seizures, but few studies exist in low-resourced minoritized populations. Existing knowledge of the overlapping neurocircuitr…
View article: Comparative Review of Seizure and Cognitive Outcomes in Resective, Ablative, and Neuromodulatory Temporal Lobe Epilepsy Surgery
Comparative Review of Seizure and Cognitive Outcomes in Resective, Ablative, and Neuromodulatory Temporal Lobe Epilepsy Surgery Open
Resective surgery for drug-resistant temporal lobe epilepsy remains underutilized in the United States. While anteromesial temporal lobectomy consistently achieves the highest rates of long-term seizure freedom, it comes with greater risks…
View article: Non-invasive Temporal Interference Stimulation of the Hippocampus Suppresses Epileptic Biomarkers in Patients with Epilepsy: Biophysical Differences between Kilohertz and Amplitude Modulated Stimulation
Non-invasive Temporal Interference Stimulation of the Hippocampus Suppresses Epileptic Biomarkers in Patients with Epilepsy: Biophysical Differences between Kilohertz and Amplitude Modulated Stimulation Open
Medication-refractory focal epilepsy creates a significant challenge, with approximately 30% of patients ineligible for surgery due to the involvement of eloquent cortex in the epileptogenic network. For such patients with limited surgical…
Context familiarity is a third kind of episodic memory distinct from item familiarity and recollection Open
Episodic memory is accounted for with two processes: "familiarity" when generally recognizing an item and "recollection" when retrieving the full contextual details bound with the item. We tested a combination of item recognition confidenc…
Predictors of white matter hyperintensities in the elderly Congolese population Open
Background White matter hyperintensities (WMHs) are strongly linked to cardiovascular risk factors and other health conditions such as Alzheimer’s disease. However, there is a dearth of research on this topic in low-income countries and un…
A third kind of episodic memory: Context familiarity is distinct from item familiarity and recollection Open
Episodic memory is accounted for with two processes: ‘familiarity’ when generally recognizing an item and ‘recollection’ when retrieving the full contextual details bound with the item. Paradoxically, people sometimes report contextual inf…
View article: An ordinal clinical score predicts seizure freedom after minimally invasive epilepsy surgery
An ordinal clinical score predicts seizure freedom after minimally invasive epilepsy surgery Open
Objective To predict one‐year seizure freedom, using a combination of relevant clinical variables, following stereotactic laser amygdalohippocampotomy for mesial temporal lobe epilepsy in a series of 101 patients. Methods Eight predictors …
View article: Selective Posterior Cerebral Artery Wada Better Predicts Good Memory and Naming Outcomes Following Selective Stereotactic Thermal Ablation for Medial Temporal Lobe Epilepsy Than Internal Carotid Artery Wada
Selective Posterior Cerebral Artery Wada Better Predicts Good Memory and Naming Outcomes Following Selective Stereotactic Thermal Ablation for Medial Temporal Lobe Epilepsy Than Internal Carotid Artery Wada Open
The conventional intracarotid amobarbital (Wada) test has been used to assess memory function in patients being considered for temporal lobe epilepsy (TLE) surgery. Minimally invasive approaches that target the medial temporal lobe (MTL) a…
View article: The Voice Inside Your Head: Intracranial Examination of High Frequency Activity and Phase Amplitude Coupling During Natural Language
The Voice Inside Your Head: Intracranial Examination of High Frequency Activity and Phase Amplitude Coupling During Natural Language Open
Many studies have investigated brain network dynamics involved in language, but most have done so from the scalp and focused on discrete components of language. Functional mapping using stereoelectroencephalography (SEEG) offers a unique o…
Improved Temporal and Spatial Focality of Non-invasive Deep-brain Stimulation using Multipolar Single-pulse Temporal Interference with Applications in Epilepsy Open
Temporal Interference (TI) is an emerging method to non-invasively stimulate deep brain structures. This innovative technique is increasingly recognized for its potential applications in the treatment of various neurological disorders, inc…
View article: Impact of white matter networks on risk for memory decline following resection versus ablation in temporal lobe epilepsy
Impact of white matter networks on risk for memory decline following resection versus ablation in temporal lobe epilepsy Open
Background With expanding neurosurgical options in epilepsy, it is important to characterise each options’ risk for postoperative cognitive decline. Here, we characterise how patients’ preoperative white matter (WM) networks relates to pos…
View article: Adding the third dimension: 3D convolutional neural network diagnosis of temporal lobe epilepsy
Adding the third dimension: 3D convolutional neural network diagnosis of temporal lobe epilepsy Open
Convolutional neural networks (CNN) show great promise for translating decades of research on structural abnormalities in temporal lobe epilepsy into clinical practice. Three-dimensional CNNs typically outperform two-dimensional CNNs in me…
View article: 25 High-resolution MRI Reveals Selective Patterns of Hippocampal Subfield Atrophy in Focal Epilepsy
25 High-resolution MRI Reveals Selective Patterns of Hippocampal Subfield Atrophy in Focal Epilepsy Open
Objective: Hippocampal pathology is a consistent feature in persons with temporal lobe epilepsy (TLE) and a strong biomarker of memory impairment. Histopathological studies have identified selective patterns of cell loss across hippocampal…
94 Associations Between African Neuropsychological Tests of Memory and Medial Temporal Lobe Structures in Older Congolese Adults with Suspected Dementia Open
Objective: Hippocampal and medial temporal lobe structure atrophy is commonly observed in patients with mild neurocognitive disorders and dementias of various neurodegenerative conditions, with the degree of atrophy in these regions correl…
View article: 43 Laterality of Hippocampal Volume Differentially Predicts Verbal Versus Nonverbal Memory Performance
43 Laterality of Hippocampal Volume Differentially Predicts Verbal Versus Nonverbal Memory Performance Open
Objective: Epilepsy is a chronic neurological disease, and surgery is a common treatment option for persons who do not respond to medication. Neuropsychology plays an important role in the epilepsy presurgical workup, characterizing the co…
Association Between Hippocampal Volume and African Neuropsychology Memory Tests in Adult Individuals with Probable Alzheimer’s Disease in Democratic Republic of Congo Open
Background: Western studies indicate potential associations between hippocampal volume and memory in the trajectory of Alzheimer’s disease (AD). However, limited availability of neuroimaging technology and neuropsychological tests appropri…
Computerized adaptive test strategies for the matrix reasoning subtest of the Wechsler Adult Intelligence Scale, 4th Edition (WAIS-IV) Open
Objective: Most neuropsychological tests were developed without the benefit of modern psychometric theory. We used item response theory (IRT) methods to determine whether a widely used test – the 26-item Matrix Reasoning subtest of the WAI…