Lois M. Ednie
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Antistaphylococcal Activities of Telavancin Tested Alone and in Combination by Time-Kill Assay Open
Synergy time-kill studies against 40 methicillin-resistant Staphylococcus aureus (MRSA) strains of differing resistance phenotypes were conducted. Subinhibitory concentrations of telavancin were combined with sub-MIC concentrations of othe…
Antistaphylococcal Activity of ACHN-490 Tested Alone and in Combination with Other Agents by Time-Kill Assay Open
Synergy time-kill studies of 47 methicillin-resistant Staphylococcus aureus strains with differing resistance phenotypes showed that combinations of subinhibitory concentrations of ACHN-490 and daptomycin yielded synergy against 43/47 stra…
Comparative Antipneumococcal Activities of Sulopenem and Other Drugs Open
For 297 penicillin-susceptible, -intermediate, and -resistant pneumococcal strains, the sulopenem MIC 50 s were 0.008, 0.06, and 0.25, respectively, and the sulopenem MIC 90 s were 0.016, 0.25, and 0.5 μg/ml, respectively. The MIC 50 s of …
Antianaerobic Activity of Sulopenem Compared to Six Other Agents Open
Agar dilution MIC methodology was used to compare the activity of sulopenem with those of amoxicillin/clavulanate, ampicillin/sulbactam, piperacillin-tazobactam, imipenem, clindamycin, and metronidazole against 431 anaerobes. Overall, MIC …
Antistaphylococcal Activity of Dihydrophthalazine Antifolates, a Family of Novel Antibacterial Drugs Open
For a panel of 153 Staphylococcus aureus clinical isolates (including 13 vancomycin-intermediate or heterogeneous vancomycin-intermediate and 4 vancomycin-resistant strains), MIC 50 s and MIC 90 s of three novel dihydrophthalazine antifola…
Incidence and Characteristics of Vancomycin Nonsusceptible Strains of Methicillin-Resistant<i>Staphylococcus aureus</i>at Hershey Medical Center Open
All 982 methicillin-resistant Staphylococcus aureus strains collected from August 2006 to December 2007 were tested for vancomycin susceptibility by using 3-μg/ml vancomycin brain heart infusion screening plates, a vancomycin Etest, and a …
Antistreptococcal Activity of AR-709 Compared to That of Other Agents Open
Against 300 strains of pneumococci and 100 group A streptococci of differing β-lactam, macrolide, and quinolone resistance phenotypes, AR-709 was very active, with all MICs being ≤2 μg/ml. Furthermore, AR-709 was active against strains tha…
In Vitro Capability of Faropenem To Select for Resistant Mutants of <i>Streptococcus pneumoniae</i> and <i>Haemophilus influenzae</i> Open
When tested against nine strains of pneumococci and six of Haemophilus influenzae of various resistotypes, faropenem failed to select for resistant mutants after 50 days of consecutive subculture in subinhibitory concentrations. Faropenem …
In Vitro Activity of DC-159a, a New Broad-Spectrum Fluoroquinolone, Compared with That of Other Agents against Drug-Susceptible and -Resistant Pneumococci Open
DC-159a yielded MICs of ≤1 μg/ml against 316 strains of both quinolone-susceptible and -resistant pneumococci (resistance was defined as a levofloxacin MIC ≥4 μg/ml). Although the MICs for DC-159a against quinolone-susceptible pneumococci …
Comparative Antianaerobic Activities of Doripenem Determined by MIC and Time-Kill Analysis Open
Against 447 anaerobe strains, the investigational carbapenem doripenem had an MIC 50 of 0.125 μg/ml and an MIC 90 of 1 μg/ml. Results were similar to those for imipenem, meropenem, and ertapenem. Time-kill studies showed that doripenem had…
Capability of 11 Antipneumococcal Antibiotics To Select for Resistance by Multistep and Single-Step Methodologies Open
Testing of 12 pneumococcal strains with differing resistotypes [including tet (M) positive] showed that tigecycline, amoxicillin-clavulanate, imipenem, and ceftriaxone did not select for resistant clones after 50 sequential subcultures. By…
Characterization of a Daptomycin-Nonsusceptible Vancomycin-Intermediate <i>Staphylococcus aureus</i> Strain in a Patient with Endocarditis Open
We analyzed the emergence of daptomycin nonsusceptibility in a patient with persistent vancomycin-intermediate Staphylococcus aureus (VISA) bacteremia. The daptomycin-nonsusceptible VISA's cell wall demonstrated a reduction in muramic acid…
Activity of DX-619 Compared to Other Agents against Viridans Group Streptococci, <i>Streptococcus bovis</i> , and <i>Cardiobacterium hominis</i> Open
Against 198 viridans group streptococci, 25 Streptococcus bovis strains, and 5 Cardiobacterium hominis strains, MICs of DX-619, a des-F(6)-quinolone, were between 0.004 and 0.25 μg/ml. These MICs were lower than those of other quinolones (…
Activities of Ceftobiprole, a Novel Broad-Spectrum Cephalosporin, against <i>Haemophilus influenzae</i> and <i>Moraxella catarrhalis</i> Open
Ceftobiprole, a broad-spectrum pyrrolidinone-3-ylidenemethyl cephem currently in phase III clinical trials, had MICs between 0.008 μg/ml and 8.0 μg/ml for 321 clinical isolates of Haemophilus influenzae and between ≤0.004 μg/ml and 1.0 μg/…
Antipneumococcal Activity of Dalbavancin Compared to Other Agents Open
Against 307 pneumococci of various resistotypes, dalbavancin MICs were 0.008 to 0.125 μg/ml. All strains were susceptible to vancomycin, teicoplanin, linezolid, and quinupristin-dalfopristin. Dalbavancin at 2× MIC was bactericidal against …
Antistaphylococcal Activity of Ceftobiprole, a New Broad-Spectrum Cephalosporin Open
Ceftobiprole (formerly BAL9141), the active component of the prodrug BAL5788 (ceftobiprole medocaril), is a novel cephalosporin with expanded activity against gram-positive bacteria. Among 152 Staphylococcus aureus isolates, including 5 va…
Antistaphylococcal Activity of DX-619, a New Des-F(6)-Quinolone, Compared to Those of Other Agents Open
The in vitro activity of DX-619, a new des-F(6)-quinolone, was tested against staphylococci and compared to those of other antimicrobials. DX-619 had the lowest MIC ranges/MIC 50 s/MIC 90 s (μg/ml) against 131 Staphylococcus aureus strains…
Antistaphylococcal Activity of Dalbavancin, an Experimental Glycopeptide Open
Dalbavancin, tested against 146 staphylococci, was more potent than other drugs tested, with an MIC at which 50% of staphylococci were inhibited of 0.03 μg/ml and an MIC at which 90% of staphylococci were inhibited of 0.06 μg/ml by microdi…
Derivatives of a Vancomycin-Resistant<i>Staphylococcus aureus</i>Strain Isolated at Hershey Medical Center Open
Antimicrobial susceptibilities and genetic relatedness of the vancomycin-resistant Staphylococcus aureus strain (VRSA) isolated at Hershey, Pa. (VRSA Hershey), and its vancomycin-susceptible and high-level-resistant derivatives were studie…
Antipneumococcal Activities of Two Novel Macrolides, GW 773546 and GW 708408, Compared with Those of Erythromycin, Azithromycin, Clarithromycin, Clindamycin, and Telithromycin Open
The MICs of GW 773546, GW 708408, and telithromycin for 164 macrolide-susceptible and 161 macrolide-resistant pneumococci were low. The MICs of GW 773546, GW 708408, and telithromycin for macrolide-resistant strains were similar, irrespect…
Antistaphylococcal Activity of LBM415, a New Peptide Deformylase Inhibitor, Compared with Those of Other Agents Open
The MICs of LBM415, a new peptide diformylase inhibitor, were ≤0.06 to 4.0 μg/ml for 258 isolates of Staphylococcus aureus and coagulase-negative staphylococci. LBM415 MICs were similar irrespective of whether the strains were methicillin …
Antipneumococcal Activity of LBM415, a New Peptide Diformylase Inhibitor, Compared with Those of Other Agents Open
The MICs of LBM415, a new peptide diformylase inhibitor, were evaluated and ranged from 0.03 to 4.0 μg/ml for 300 pneumococci, irrespective of their β-lactam, macrolide, and quinolone susceptibilities. By comparison, vancomycin, teicoplani…
Antipneumococcal Activity of DK-507k, a New Quinolone,Compared with the Activities of 10 OtherAgents Open
Agar dilution MIC determination was used to compare the activity of DK-507k with those of ciprofloxacin, levofloxacin, gatifloxacin, moxifloxacin, sitafloxacin, amoxicillin, cefuroxime, erythromycin, azithromycin, and clarithromycin agains…
Antimicrobial Susceptibility and Macrolide Resistance Inducibility of <i>Streptococcus pneumoniae</i> Carrying <i>erm</i> (A), <i>erm</i> (B), or <i>mef</i> (A) Open
Erythromycin-resistant Streptococcus pneumoniae isolates from young carriers were tested for their antimicrobial susceptibility; additionally, inducibility of macrolide and clindamycin resistance was investigated in pneumococci carrying er…
Antianaerobe Activity of RBX 7644 (Ranbezolid), a New Oxazolidinone, Compared with Those of Eight Other Agents Open
The activity of ranbezolid (RBX 7644), a new oxazolidinone, against 306 anaerobes was compared with those of 11 other agents. The MICs at which 50% of the isolates tested are inhibited and those at which 90% of the isolates tested are inhi…
Antipneumococcal and Antistaphylococcal Activities of Ranbezolid (RBX 7644), a New Oxazolidinone, Compared to Those of Other Agents Open
For 260 pneumococcal and 266 staphylococcal strains, ranbezolid MICs ranged from ≤0.06 to 4 μg/ml. The MICs for pneumococci were similar irrespective of the strains' β-lactam, macrolide, or quinolone susceptibilities, and ranbezolid MICs f…
Antistreptococcal Activity of Telithromycin Compared with Seven Other Drugs in Relation to Macrolide Resistance Mechanisms in Russia Open
The susceptibilities of 468 recent Russian clinical Streptococcus pneumoniae isolates and 600 Streptococcus pyogenes isolates, from 14 centers in Russia, to telithromycin, erythromycin, azithromycin, clarithromycin, clindamycin, levofloxac…
Anti-anaerobic activity of AZD2563, a new oxazolidinone, compared with eight other agents Open
The anti-anaerobic activity of AZD2563, a new oxazolidinone, was compared with that of eight other agents against 201 Gram-positive and 99 Gram-negative anaerobes. MIC(50) and MIC(90) values (mg/L) for the 201 Gram-positive organisms were …
In Vitro Antianaerobic Activity of Ertapenem (MK-0826) Compared to Seven Other Compounds Open
Ertapenem, imipenem, meropenem, ceftriaxone, piperacillin, piperacillin-tazobactam, clindamycin, and metronidazole were agar dilution MIC tested against 431 anaerobes. Imipenem, meropenem, and ertapenem were the most active β-lactams (MICs…