Luca Fabris
YOU?
Author Swipe
View article: Cancer-associated thrombosis in cholangiocarcinoma: Exploring a phenotype of tumor aggressiveness
Cancer-associated thrombosis in cholangiocarcinoma: Exploring a phenotype of tumor aggressiveness Open
Cholangiocarcinoma (CCA) is the liver malignancy with the most rapid increase in incidence and lethality in recent years. Venous thromboembolism (VTE) is a common complication of the cancer-associated hypercoagulable state, which may incit…
View article: Case Report: jaundice in the young: the complexity of rare diseases beyond cholangiopathies
Case Report: jaundice in the young: the complexity of rare diseases beyond cholangiopathies Open
Jaundice is a common presentation of diseases of the biliary tree, which differential diagnosis can be challenging, in particular when associated to pancreas involvement. In this respect, autoimmune pancreatitis (AIP), a rare form of chron…
View article: Noninvasive Assessment of Portal Hypertension in Patients With Primary Biliary Cholangitis Is Affected by Severity of Cholestasis
Noninvasive Assessment of Portal Hypertension in Patients With Primary Biliary Cholangitis Is Affected by Severity of Cholestasis Open
Biochemical-based RESIST criteria demonstrate the highest net benefit compared with elastography-based criteria for ruling out HRV. The severity of cholestasis affects NITs performance to rule out HRV and CSPH in patients with PBC and cACL…
View article: Patient and Healthcare Provider Experience With Rheumatoid Arthritis in Northern Ontario, Canada: A Qualitative Descriptive Study
Patient and Healthcare Provider Experience With Rheumatoid Arthritis in Northern Ontario, Canada: A Qualitative Descriptive Study Open
Background Rheumatoid arthritis (RA) is a disabling common chronic inflammatory joint disease. In Ontario, the burden is higher in those aged 65 and older, in females, and in northern communities. This study examined patient disease impact…
View article: ADVANCES IN LAPAROSCOPIC SURGERY
ADVANCES IN LAPAROSCOPIC SURGERY Open
Laparoscopic surgery has established itself as an innovative and effective approach to treating acute abdominal diseases, revolutionizing traditional surgical practices. With the advancement of medical technologies and the growing demand f…
View article: Liver-related aspects of valoctocogene roxaparvovec gene therapy for hemophilia A: expert guidance for clinical practice
Liver-related aspects of valoctocogene roxaparvovec gene therapy for hemophilia A: expert guidance for clinical practice Open
Adeno-associated virus–based gene therapy (valoctocogene roxaparvovec) is an attractive treatment for hemophilia A. Careful clinical management is required to minimize the risk of hepatotoxicity, including assessment of baseline liver cond…
Procoagulant phenotype of virus-infected pericytes is associated with portal thrombosis and intrapulmonary vascular dilations in fatal COVID-19 Open
View article: Comparing Survival of Perihilar Cholangiocarcinoma After R1 Resection Versus Palliative Chemotherapy for Unresected Localized Disease
Comparing Survival of Perihilar Cholangiocarcinoma After R1 Resection Versus Palliative Chemotherapy for Unresected Localized Disease Open
View article: Sex and Gender in Ageing and Longevity: Highlights from an International Course
Sex and Gender in Ageing and Longevity: Highlights from an International Course Open
Gender medicine is a multidisciplinary science and represents an important perspective for pathophysiological and clinical studies in the third millennium. Here, it is provided an overview of the topics discussed in a recent course on the …
View article: Angiopoietin-2 and the Vascular Endothelial Growth Factor Promote Migration and Invasion in Hepatocellular Carcinoma- and Intrahepatic Cholangiocarcinoma-Derived Spheroids
Angiopoietin-2 and the Vascular Endothelial Growth Factor Promote Migration and Invasion in Hepatocellular Carcinoma- and Intrahepatic Cholangiocarcinoma-Derived Spheroids Open
Aggressive hepatocellular carcinoma (HCC) overexpressing Angiopoietin-2 (ANG-2) (a protein linked with angiogenesis, proliferation, and epithelial–mesenchymal transition (EMT)), shares 95% of up-regulated genes and a similar poor prognosis…
View article: The evil relationship between liver fibrosis and cardiovascular disease in metabolic dysfunction-associated fatty liver disease (MAFLD): Looking for the culprit
The evil relationship between liver fibrosis and cardiovascular disease in metabolic dysfunction-associated fatty liver disease (MAFLD): Looking for the culprit Open
View article: The tumor microenvironment in hepatocarcinoma: dissecting the functions of cancer-associated fibroblasts
The tumor microenvironment in hepatocarcinoma: dissecting the functions of cancer-associated fibroblasts Open
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy, deriving from the neoplastic transformation of hepatocytes, most often forced to long-lasting regeneration by the cirrhotic background. HCC is an extremely aggress…
View article: <scp>FXR</scp> agonists <scp>INT</scp>‐787 and <scp>OCA</scp> increase <scp>RECK</scp> and inhibit liver steatosis and inflammation in diet‐induced ob/ob mouse model of <scp>NASH</scp>
<span>FXR</span> agonists <span>INT</span>‐787 and <span>OCA</span> increase <span>RECK</span> and inhibit liver steatosis and inflammation in diet‐induced ob/ob mouse model of <span>NASH</span> Open
Background and Aims We have previously shown in a model of hepatic ischaemia/reperfusion injury that the farnesoid X receptor (FXR) agonist obeticholic acid (OCA) restores reversion‐inducing‐cysteine‐rich protein with Kazal motifs (RECK), …
View article: A TGFβ-ECM-integrin signaling axis drives structural reconfiguration of the bile duct to promote polycystic liver disease
A TGFβ-ECM-integrin signaling axis drives structural reconfiguration of the bile duct to promote polycystic liver disease Open
The formation of multiple cysts in the liver occurs in a number of isolated monogenic diseases or multisystemic syndromes, during which bile ducts develop into fluid-filled biliary cysts. For patients with polycystic liver disease (PCLD), …
View article: Supplementary Figure Legends from Low-Dose Paclitaxel Reduces S100A4 Nuclear Import to Inhibit Invasion and Hematogenous Metastasis of Cholangiocarcinoma
Supplementary Figure Legends from Low-Dose Paclitaxel Reduces S100A4 Nuclear Import to Inhibit Invasion and Hematogenous Metastasis of Cholangiocarcinoma Open
The legends for the supplementary figures 1-7
View article: Supplementary Figure 5. from Low-Dose Paclitaxel Reduces S100A4 Nuclear Import to Inhibit Invasion and Hematogenous Metastasis of Cholangiocarcinoma
Supplementary Figure 5. from Low-Dose Paclitaxel Reduces S100A4 Nuclear Import to Inhibit Invasion and Hematogenous Metastasis of Cholangiocarcinoma Open
Supplementary Figure 5. Low dose PTX did not affect cytoskeletal integrity of EGI-1 cells.
View article: Supplementary Figure 7. from Low-Dose Paclitaxel Reduces S100A4 Nuclear Import to Inhibit Invasion and Hematogenous Metastasis of Cholangiocarcinoma
Supplementary Figure 7. from Low-Dose Paclitaxel Reduces S100A4 Nuclear Import to Inhibit Invasion and Hematogenous Metastasis of Cholangiocarcinoma Open
Supplementary Figure 7. LDM PTX did not affect the splenic tumor mass in SCID mice xenotransplanted with EGI-1 cells, in vivo.
View article: Supplementary Figure 7. from Low-Dose Paclitaxel Reduces S100A4 Nuclear Import to Inhibit Invasion and Hematogenous Metastasis of Cholangiocarcinoma
Supplementary Figure 7. from Low-Dose Paclitaxel Reduces S100A4 Nuclear Import to Inhibit Invasion and Hematogenous Metastasis of Cholangiocarcinoma Open
Supplementary Figure 7. LDM PTX did not affect the splenic tumor mass in SCID mice xenotransplanted with EGI-1 cells, in vivo.
View article: Supplementary Figure 4. from Low-Dose Paclitaxel Reduces S100A4 Nuclear Import to Inhibit Invasion and Hematogenous Metastasis of Cholangiocarcinoma
Supplementary Figure 4. from Low-Dose Paclitaxel Reduces S100A4 Nuclear Import to Inhibit Invasion and Hematogenous Metastasis of Cholangiocarcinoma Open
Supplementary Figure 4. Low dose PTX did not affect Rac-1 GTP levels, while it reduced the MT1-MMP membrane expression.
View article: Supplementary Figure 3 from Low-Dose Paclitaxel Reduces S100A4 Nuclear Import to Inhibit Invasion and Hematogenous Metastasis of Cholangiocarcinoma
Supplementary Figure 3 from Low-Dose Paclitaxel Reduces S100A4 Nuclear Import to Inhibit Invasion and Hematogenous Metastasis of Cholangiocarcinoma Open
Supplementary Figure 3. In contrast with high doses, low dose PTX did not affect cell proliferation, viability, and apoptosis of CCA-TV3 cells.
View article: Supplementary Figure 1 from Low-Dose Paclitaxel Reduces S100A4 Nuclear Import to Inhibit Invasion and Hematogenous Metastasis of Cholangiocarcinoma
Supplementary Figure 1 from Low-Dose Paclitaxel Reduces S100A4 Nuclear Import to Inhibit Invasion and Hematogenous Metastasis of Cholangiocarcinoma Open
Supplementary Figure 1. Schedule of treatment with low dose metronomic PTX and assessment by bioluminescence analysis in SCID mice xenografted with EGI-1 cells.
View article: Data from Low-Dose Paclitaxel Reduces S100A4 Nuclear Import to Inhibit Invasion and Hematogenous Metastasis of Cholangiocarcinoma
Data from Low-Dose Paclitaxel Reduces S100A4 Nuclear Import to Inhibit Invasion and Hematogenous Metastasis of Cholangiocarcinoma Open
Nuclear expression of the calcium-binding protein S100A4 is a biomarker of increased invasiveness in cholangiocarcinoma, a primary liver cancer with scarce treatment opportunities and dismal prognosis. In this study, we provide evidence th…
View article: Supplementary Figure 3 from Low-Dose Paclitaxel Reduces S100A4 Nuclear Import to Inhibit Invasion and Hematogenous Metastasis of Cholangiocarcinoma
Supplementary Figure 3 from Low-Dose Paclitaxel Reduces S100A4 Nuclear Import to Inhibit Invasion and Hematogenous Metastasis of Cholangiocarcinoma Open
Supplementary Figure 3. In contrast with high doses, low dose PTX did not affect cell proliferation, viability, and apoptosis of CCA-TV3 cells.
View article: Supplementary methods from Low-Dose Paclitaxel Reduces S100A4 Nuclear Import to Inhibit Invasion and Hematogenous Metastasis of Cholangiocarcinoma
Supplementary methods from Low-Dose Paclitaxel Reduces S100A4 Nuclear Import to Inhibit Invasion and Hematogenous Metastasis of Cholangiocarcinoma Open
Supplementary file containing the supplementary methods
View article: Supplementary Figure Legends from Low-Dose Paclitaxel Reduces S100A4 Nuclear Import to Inhibit Invasion and Hematogenous Metastasis of Cholangiocarcinoma
Supplementary Figure Legends from Low-Dose Paclitaxel Reduces S100A4 Nuclear Import to Inhibit Invasion and Hematogenous Metastasis of Cholangiocarcinoma Open
The legends for the supplementary figures 1-7
View article: Supplementary Figure 2 from Low-Dose Paclitaxel Reduces S100A4 Nuclear Import to Inhibit Invasion and Hematogenous Metastasis of Cholangiocarcinoma
Supplementary Figure 2 from Low-Dose Paclitaxel Reduces S100A4 Nuclear Import to Inhibit Invasion and Hematogenous Metastasis of Cholangiocarcinoma Open
Supplementary Figure 2. Low dose PTX reduced motility and invasiveness of CCA-TV3 cells.
View article: Supplementary Figure 4. from Low-Dose Paclitaxel Reduces S100A4 Nuclear Import to Inhibit Invasion and Hematogenous Metastasis of Cholangiocarcinoma
Supplementary Figure 4. from Low-Dose Paclitaxel Reduces S100A4 Nuclear Import to Inhibit Invasion and Hematogenous Metastasis of Cholangiocarcinoma Open
Supplementary Figure 4. Low dose PTX did not affect Rac-1 GTP levels, while it reduced the MT1-MMP membrane expression.
View article: Supplementary Figure 5. from Low-Dose Paclitaxel Reduces S100A4 Nuclear Import to Inhibit Invasion and Hematogenous Metastasis of Cholangiocarcinoma
Supplementary Figure 5. from Low-Dose Paclitaxel Reduces S100A4 Nuclear Import to Inhibit Invasion and Hematogenous Metastasis of Cholangiocarcinoma Open
Supplementary Figure 5. Low dose PTX did not affect cytoskeletal integrity of EGI-1 cells.
View article: Data from Low-Dose Paclitaxel Reduces S100A4 Nuclear Import to Inhibit Invasion and Hematogenous Metastasis of Cholangiocarcinoma
Data from Low-Dose Paclitaxel Reduces S100A4 Nuclear Import to Inhibit Invasion and Hematogenous Metastasis of Cholangiocarcinoma Open
Nuclear expression of the calcium-binding protein S100A4 is a biomarker of increased invasiveness in cholangiocarcinoma, a primary liver cancer with scarce treatment opportunities and dismal prognosis. In this study, we provide evidence th…
View article: Supplementary Figure 2 from Low-Dose Paclitaxel Reduces S100A4 Nuclear Import to Inhibit Invasion and Hematogenous Metastasis of Cholangiocarcinoma
Supplementary Figure 2 from Low-Dose Paclitaxel Reduces S100A4 Nuclear Import to Inhibit Invasion and Hematogenous Metastasis of Cholangiocarcinoma Open
Supplementary Figure 2. Low dose PTX reduced motility and invasiveness of CCA-TV3 cells.