David Ferguson
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View article: A divergent <i>Plasmodium</i> NEK4 acts as a key regulator driving the early events of meiosis
A divergent <i>Plasmodium</i> NEK4 acts as a key regulator driving the early events of meiosis Open
Meiosis is a conserved yet evolutionarily varied process underpinning sexual reproduction in eukaryotes. In the malaria parasite Plasmodium , meiosis is unconventional: it occurs immediately after fertilisation (post-zygotic) and must be c…
View article: Plasmodium ARK1 regulates spindle formation during atypical mitosis and forms a divergent chromosomal passenger complex
Plasmodium ARK1 regulates spindle formation during atypical mitosis and forms a divergent chromosomal passenger complex Open
Mitosis in Plasmodium spp., the causative agent of malaria, is fundamentally different from model eukaryotes, proceeding via a bipartite microtubule organising centre (MTOC) and lacking canonical regulators such as Polo and Bub1 kinases. D…
View article: <i>Plasmodium</i> ARK1 regulates spindle formation during atypical mitosis and forms a divergent chromosomal passenger complex
<i>Plasmodium</i> ARK1 regulates spindle formation during atypical mitosis and forms a divergent chromosomal passenger complex Open
Mitosis in Plasmodium spp., the causative agent of malaria, is fundamentally different from model eukaryotes, proceeding via a bipartite microtubule organising centre (MTOC) and lacking canonical regulators such as Polo and Bub1 kinases. D…
View article: Co-dependent formation of the <i>Toxoplasma gondii</i> subpellicular microtubules and inner membrane skeleton
Co-dependent formation of the <i>Toxoplasma gondii</i> subpellicular microtubules and inner membrane skeleton Open
One of the defining features of apicomplexan parasites is their cytoskeleton composed of alveolar vesicles, known as the inner membrane complex (IMC) undergirded by an intermediate filament-like protein network and an array of subpellicula…
View article: Integrated Analysis of the 2022 SARS-CoV-2 Omicron Lineage Replacement Dynamics in Connecticut, US
Integrated Analysis of the 2022 SARS-CoV-2 Omicron Lineage Replacement Dynamics in Connecticut, US Open
In 2022, consecutive sweeps of highly transmissible SARS-CoV-2 Omicron-derived lineages (B.1.1.529*) maintained viral transmission despite extensive antigen exposure from both vaccinations and infections. To better understand Omicron varia…
View article: A novel SUN1-ALLAN complex coordinates segregation of the bipartite MTOC across the nuclear envelope during rapid closed mitosis in Plasmodium berghei
A novel SUN1-ALLAN complex coordinates segregation of the bipartite MTOC across the nuclear envelope during rapid closed mitosis in Plasmodium berghei Open
Mitosis in eukaryotes involves reorganisation of the nuclear envelope (NE) and microtubule-organising centres (MTOCs). During male gametogenesis in Plasmodium , the causative agent of malaria, mitosis is exceptionally rapid and highly dive…
View article: Inactivated Viral Vaccine BBV87 Protects Against Chikungunya Virus Challenge in a Non-Human Primate Model
Inactivated Viral Vaccine BBV87 Protects Against Chikungunya Virus Challenge in a Non-Human Primate Model Open
Chikungunya virus (CHIKV) is an alphavirus transmitted by mosquitos that poses a threat to global public health and for which there is an urgent need for widespread access to globally licensed vaccines. Here, we demonstrate that an inactiv…
View article: A novel SUN1-ALLAN complex coordinates segregation of the bipartite MTOC across the nuclear envelope during rapid closed mitosis in Plasmodium
A novel SUN1-ALLAN complex coordinates segregation of the bipartite MTOC across the nuclear envelope during rapid closed mitosis in Plasmodium Open
Mitosis in eukaryotes involves reorganization of the nuclear envelope (NE) and microtubule-organizing centres (MTOCs). During male gametogenesis in Plasmodium, the causative agent of malaria, mitosis is exceptionally rapid and highly diver…
View article: A novel SUN1-ALLAN complex coordinates segregation of the bipartite MTOC across the nuclear envelope during rapid closed mitosis in Plasmodium berghei
A novel SUN1-ALLAN complex coordinates segregation of the bipartite MTOC across the nuclear envelope during rapid closed mitosis in Plasmodium berghei Open
Mitosis in eukaryotes involves reorganisation of the nuclear envelope (NE) and microtubule-organising centres (MTOCs). During male gametogenesis in Plasmodium , the causative agent of malaria, mitosis is exceptionally rapid and highly dive…
View article: Divergent <i>Plasmodium</i> kinases drive MTOC, kinetochore and axoneme organisation in male gametogenesis
Divergent <i>Plasmodium</i> kinases drive MTOC, kinetochore and axoneme organisation in male gametogenesis Open
Sexual development and male gamete formation of the malaria parasite in the mosquito midgut are initiated by rapid endomitosis in the activated male gametocyte. This process is highly regulated by protein phosphorylation, specifically by t…
View article: A novel SUN1-ALLAN complex coordinates segregation of the bipartite MTOC across the nuclear envelope during rapid closed mitosis in Plasmodium
A novel SUN1-ALLAN complex coordinates segregation of the bipartite MTOC across the nuclear envelope during rapid closed mitosis in Plasmodium Open
Mitosis in eukaryotes involves reorganization of the nuclear envelope (NE) and microtubule-organizing centres (MTOCs). During male gametogenesis in Plasmodium, the causative agent of malaria, mitosis is exceptionally rapid and highly diver…
View article: Divergent<i>Plasmodium</i>kinases drive MTOC, kinetochore and axoneme organisation in male gametogenesis
Divergent<i>Plasmodium</i>kinases drive MTOC, kinetochore and axoneme organisation in male gametogenesis Open
Sexual development and male gamete formation of the malaria parasite in the mosquito midgut is governed by rapid endomitosis in the activated male gametocyte. This process is highly regulated by protein phosphorylation, specifically by thr…
View article: Genome-wide association study between SARS-CoV-2 single nucleotide polymorphisms and virus copies during infections
Genome-wide association study between SARS-CoV-2 single nucleotide polymorphisms and virus copies during infections Open
Significant variations have been observed in viral copies generated during SARS-CoV-2 infections. However, the factors that impact viral copies and infection dynamics are not fully understood, and may be inherently dependent upon different…
View article: Plasmodium NEK1 coordinates MTOC organisation and kinetochore attachment during rapid mitosis in male gamete formation
Plasmodium NEK1 coordinates MTOC organisation and kinetochore attachment during rapid mitosis in male gamete formation Open
Mitosis is an important process in the cell cycle required for cells to divide. Never in mitosis (NIMA)-like kinases (NEKs) are regulators of mitotic functions in diverse organisms. Plasmodium spp., the causative agent of malaria is a dive…
View article: Design, Immunogenicity and Preclinical Efficacy of the ChAdOx1.COVconsv12 Pan-Sarbecovirus T-Cell Vaccine
Design, Immunogenicity and Preclinical Efficacy of the ChAdOx1.COVconsv12 Pan-Sarbecovirus T-Cell Vaccine Open
During the COVID-19 pandemic, antibody-based vaccines targeting the SARS-CoV-2 spike glycoprotein were the focus for development because neutralizing antibodies were associated with protection against the SARS-CoV-2 infection pre-clinicall…
View article: Design, Immunogenicity and Preclinical Efficacy of the ChAdOx1.COVconsv12 Pan-Sarbecovirus T-cell Vaccine
Design, Immunogenicity and Preclinical Efficacy of the ChAdOx1.COVconsv12 Pan-Sarbecovirus T-cell Vaccine Open
During the COVID-19 pandemic, antibody-based vaccines targeting the SARS-CoV-2 spike glycoprotein were the key focus for development because neutralizing antibodies were associated with protection against the SARS-CoV-2 infection in pre-cl…
View article: Co-dependent formation of the<i>Toxoplasma gondii</i>sub-pellicular microtubules and inner membrane skeleton
Co-dependent formation of the<i>Toxoplasma gondii</i>sub-pellicular microtubules and inner membrane skeleton Open
One of the defining features of apicomplexan parasites is their cytoskeleton composed of alveolar vesicles, known as the inner membrane complex (IMC) undergirded by intermediate-like filament network and an array of subpellicular microtubu…
View article: Intranasal neomycin evokes broad-spectrum antiviral immunity in the upper respiratory tract
Intranasal neomycin evokes broad-spectrum antiviral immunity in the upper respiratory tract Open
Respiratory virus infections in humans cause a broad-spectrum of diseases that result in substantial morbidity and mortality annually worldwide. To reduce the global burden of respiratory viral diseases, preventative and therapeutic interv…
View article: Linking Women Farmer Perceptions and Knowledge of Soil Health to Climate-Smart Coffee Cropping Management
Linking Women Farmer Perceptions and Knowledge of Soil Health to Climate-Smart Coffee Cropping Management Open
Coffee cropping is very sensitive to global warming, thus affecting coffee growers, particularly women farmers and their economies. As unpredictable weather continues to limit the suitability of the majority of traditional coffee-growing r…
View article: Genome-wide association study between SARS-CoV-2 single nucleotide polymorphisms and virus copies during infections
Genome-wide association study between SARS-CoV-2 single nucleotide polymorphisms and virus copies during infections Open
Significant variations have been observed in viral copies generated during SARS-CoV-2 infections. However, the factors that impact viral copies and infection dynamics are not fully understood, and may be inherently dependent upon different…
View article: <i>Plasmodium</i> NEK1 coordinates MTOC organisation and kinetochore attachment during rapid mitosis in male gamete formation
<i>Plasmodium</i> NEK1 coordinates MTOC organisation and kinetochore attachment during rapid mitosis in male gamete formation Open
Mitosis is an important process in the cell cycle required for cells to divide. Never in mitosis (NIMA)-like kinases (NEKs) are regulators of mitotic functions in diverse organisms. Plasmodium spp , the causative agent of malaria is a dive…
View article: DNA-binding protein PfAP2-P regulates parasite pathogenesis during malaria parasite blood stages
DNA-binding protein PfAP2-P regulates parasite pathogenesis during malaria parasite blood stages Open
Malaria-associated pathogenesis such as parasite invasion, egress, host cell remodelling and antigenic variation requires concerted action by many proteins, but the molecular regulation is poorly understood. Here we have characterized an e…
View article: Evaluation of the cross reactivity of neutralising antibody response in vaccinated human and convalescent hamster sera against SARS-CoV-2 variants up to and including JN.1 using an authentic virus neutralisation assay
Evaluation of the cross reactivity of neutralising antibody response in vaccinated human and convalescent hamster sera against SARS-CoV-2 variants up to and including JN.1 using an authentic virus neutralisation assay Open
New vaccines, therapeutics and immunity elicited by natural infection create evolutionary pressure on SARS-CoV-2 to evolve and adapt to evade vaccine-induced and infection-elicited immunity. Vaccine and therapeutics developers thus find th…
View article: PfAP2-MRP DNA-binding protein is a master regulator of parasite pathogenesis during malaria parasite blood stages
PfAP2-MRP DNA-binding protein is a master regulator of parasite pathogenesis during malaria parasite blood stages Open
Malaria pathogenicity results from the parasite’s ability to invade, multiply within and then egress from the host red blood cell (RBC). Infected RBCs are remodeled, expressing antigenic variant proteins (such as PfEMP1, coded by the var g…
View article: Radial spoke protein 9 is necessary for axoneme assembly in <i>Plasmodium</i> but not in trypanosomatid parasites
Radial spoke protein 9 is necessary for axoneme assembly in <i>Plasmodium</i> but not in trypanosomatid parasites Open
Flagella are important for eukaryote cell motility, including in sperm, and are vital for life cycle progression of many unicellular eukaryotic pathogens. The ‘9+2’ axoneme in most motile flagella comprises nine outer doublet and two centr…