Heinrich J. Audebert
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View article: Teleneurology expertise in intensive care units across Germany - a nationwide survey
Teleneurology expertise in intensive care units across Germany - a nationwide survey Open
Background Telemedicine is well established in acute stroke care and significantly contributes to widespread access to treatment. In intensive care, telemedicine is increasingly used to reduce mortality and complications. The German Societ…
View article: Revascularization Treatment of Basilar Artery Occlusion in Patients with Mild‐to‐Moderate Severe Stroke
Revascularization Treatment of Basilar Artery Occlusion in Patients with Mild‐to‐Moderate Severe Stroke Open
BACKGROUND The benefit of endovascular thrombectomy (EVT) in patients with basilar artery occlusion and severe neurological deficits is well established. However, its effectiveness in those with mild‐to‐moderate deficits remains uncertain.…
View article: Intravenous Thrombolysis Prior to Endovascular Treatment in Basilar Artery Occlusions: A Patient Pooled Analysis of Four Randomized Controlled Trials
Intravenous Thrombolysis Prior to Endovascular Treatment in Basilar Artery Occlusions: A Patient Pooled Analysis of Four Randomized Controlled Trials Open
Purpose This study assessed intravenous thrombolysis (IVT) prior to endovascular treatment (EVT) versus EVT alone in patients with basilar artery occlusions (BAO). Methods This patient-level pooled analysis included data from four randomiz…
View article: Neuroimaging Correlates of Post-Stroke Pain After Ischemic Stroke: Secondary Analysis of the INSPiRE-TMS Trial
Neuroimaging Correlates of Post-Stroke Pain After Ischemic Stroke: Secondary Analysis of the INSPiRE-TMS Trial Open
Background Post-stroke pain (PSP) affects nearly half of stroke survivors, severely compromising quality of life. The causes of PSP remain underexplored, although there is likely a complex interplay of lesion effects, psychological factors…
View article: Risk Factors Associated With Bell's Palsy: A Real‐World Analysis of 281,600 Patients
Risk Factors Associated With Bell's Palsy: A Real‐World Analysis of 281,600 Patients Open
Introduction Bell's palsy is the most common cause of peripheral facial paralysis, with an annual incidence of 5–50 per 100,000 cases worldwide. Its etiology remains largely unknown, though risk factors such as herpes simplex virus reactiv…
View article: Myocardial injury in patients with acute ischemic stroke: Prevalence and types of triggers of myocardial demand ischemia
Myocardial injury in patients with acute ischemic stroke: Prevalence and types of triggers of myocardial demand ischemia Open
Introduction: Acute myocardial injury occurs in about every fourth patient in the early phase after ischemic stroke. It may be caused by an imbalance between myocardial oxygen supply and demand, potentially leading to type 2 myocardial inf…
View article: External validation of risk prediction models for post-stroke mortality in Berlin
External validation of risk prediction models for post-stroke mortality in Berlin Open
Objectives Prediction models for post-stroke mortality can support medical decision-making. Although numerous models have been developed, external validation studies determining the models’ transportability beyond the original settings are…
View article: Off-label thrombolysis in acute ischemic stroke patients: Frequencies and outcome compared to on-label and no treatment
Off-label thrombolysis in acute ischemic stroke patients: Frequencies and outcome compared to on-label and no treatment Open
Background: Intravenous thrombolysis (IVT) is not approved for acute ischemic stroke in certain patient groups due to in- and exclusion criteria from mostly early clinical trials. In a real-life setting, we analyzed frequencies, outcomes a…
View article: The legacy of the COVID-19 pandemic for the healthcare environment: the establishment of long COVID/ Post-COVID-19 condition follow-up outpatient clinics in Germany
The legacy of the COVID-19 pandemic for the healthcare environment: the establishment of long COVID/ Post-COVID-19 condition follow-up outpatient clinics in Germany Open
Background Since 2020, several specialized follow-up outpatient clinics have been established across Germany to address the complex needs of patients with Long COVID/ Post-COVID-19 Condition (PCC). This article reviews the current landscap…
View article: Assessing non-inferiority for binary matched-pairs data with missing values: a powerful and flexible GEE approach based on the risk difference
Assessing non-inferiority for binary matched-pairs data with missing values: a powerful and flexible GEE approach based on the risk difference Open
Background Clinical studies often aim to test the non-inferiority of a treatment compared to an alternative intervention with binary matched-pairs data. These studies are often planned with methods for completely observed pairs only. Howev…
View article: Potential of transcranial ultrasound- and near-infrared spectroscopy-based acute stroke imaging for decision-making on intravenous thrombolysis treatment
Potential of transcranial ultrasound- and near-infrared spectroscopy-based acute stroke imaging for decision-making on intravenous thrombolysis treatment Open
Background Mobile Stroke Units (MSU) shorten time to intravenous thrombolysis (IVT) and improve functional outcome, but they rely on computed tomography (CT) making them highly specialized and costly. Alternative technologies can potential…
View article: Severe subacute combined degeneration of the spinal cord resulting from nitrous oxide (N2O) abuse: a case series
Severe subacute combined degeneration of the spinal cord resulting from nitrous oxide (N2O) abuse: a case series Open
Objective To describe the demographic, clinical, laboratory, and radiological findings, and the clinical course of seven patients with severe N2O-induced subacute combined degeneration of the spinal cord (SACD). Methods Retrospective study…
View article: Time trends in mechanical thrombectomy (2017–2021): do real-world data reflect advances in evidence?
Time trends in mechanical thrombectomy (2017–2021): do real-world data reflect advances in evidence? Open
Background In recent years, we have witnessed a continuous, evidence-based expansion of indications for endovascular therapy (EVT) in the treatment of ischaemic stroke, driven by advancements in extended time windows and target vessel occl…
View article: Early Complications After Mild to Moderate Ischemic Stroke and Impact on 3‐Month Outcome: The Multicenter Prospective Stroke Unit Plus Cohort Study
Early Complications After Mild to Moderate Ischemic Stroke and Impact on 3‐Month Outcome: The Multicenter Prospective Stroke Unit Plus Cohort Study Open
Background Early stroke complications (ESCs) impair recovery and provide an important therapeutic target. Our multicenter prospective cohort study examined the prevalence and amount of poor outcomes attributable to ESCs. Methods and Result…
View article: Multi-dimensional outcomes following extracorporeal cardiopulmonary resuscitation
Multi-dimensional outcomes following extracorporeal cardiopulmonary resuscitation Open
ECPR patients showed significant improvement in left ventricular function over time but their neuropsychological and physical abilities remained compromised. Timely, multidisciplinary rehabilitation is required, starting in the intensive c…
View article: Endovascular therapy for acute vertebrobasilar occlusion (VERITAS): a systematic review and individual patient data meta-analysis
Endovascular therapy for acute vertebrobasilar occlusion (VERITAS): a systematic review and individual patient data meta-analysis Open
View article: Mobile stroke units services in Germany: A cost‐effectiveness modeling perspective on catchment zones, operating modes, and staffing
Mobile stroke units services in Germany: A cost‐effectiveness modeling perspective on catchment zones, operating modes, and staffing Open
Background and Purpose Investigating the cost‐effectiveness of future mobile stroke unit (MSU) services with respect to local idiosyncrasies is essential for enabling large‐scale implementation of MSU services. The aim of this study was to…
View article: Endovascular therapy in patients with acute intracranial non-terminal internal carotid artery occlusion (ICA-I)
Endovascular therapy in patients with acute intracranial non-terminal internal carotid artery occlusion (ICA-I) Open
Background: Acute intracranial occlusion of the internal carotid artery (ICA) can be distinguished into (a) occlusion of the terminal ICA, involving the proximal segments of the middle or anterior cerebral artery (ICA-L/-T) and (b) non-ter…
View article: VISIT STROKE: non-inferiority of telemedicine-based neurological consultation for post-acute stroke patients – protocol of a prospective observational controlled multi-center study
VISIT STROKE: non-inferiority of telemedicine-based neurological consultation for post-acute stroke patients – protocol of a prospective observational controlled multi-center study Open
View article: The legacy of the COVID-19 pandemic for the healthcare environment: The establishment of long COVID/ post-COVID-19 condition follow-up outpatient clinics in Germany
The legacy of the COVID-19 pandemic for the healthcare environment: The establishment of long COVID/ post-COVID-19 condition follow-up outpatient clinics in Germany Open
Background Since 2020, several specialized follow-up outpatient clinics have been established across Germany to address the complex needs of patients with Long COVID/ Post-COVID-19 Condition (PCC). This article reviews the current landscap…
View article: Shedding Light on Mobile Stroke Unit Dispatch Protocols
Shedding Light on Mobile Stroke Unit Dispatch Protocols Open
Background: Treatment on Mobile Stroke Units (MSU) improves outcome for patients with acute ischemic stroke, however MSU effectiveness relies on accuracy of field dispatch. We aimed at collecting representative data on dispatch infrastruct…
View article: Regarding the ESO guideline on the diagnosis and management of patent foramen ovale after stroke: Is it a matter of urgency?
Regarding the ESO guideline on the diagnosis and management of patent foramen ovale after stroke: Is it a matter of urgency? Open
View article: Pre-Hospital Stroke Care beyond the MSU
Pre-Hospital Stroke Care beyond the MSU Open
View article: Telemedicine quality and outcomes in stroke: A scientific statement for healthcare professionals from the American Heart Association/American Stroke Association
Telemedicine quality and outcomes in stroke: A scientific statement for healthcare professionals from the American Heart Association/American Stroke Association Open
Purpose - Telestroke is one of the most frequently used and rapidly expanding applications of telemedicine, delivering much-needed stroke expertise to hospitals and patients. This document reviews the current status of telestroke and sugge…
View article: Characteristics associated with occurrence of stroke in patients with infective endocarditis – a retrospective cohort study
Characteristics associated with occurrence of stroke in patients with infective endocarditis – a retrospective cohort study Open
Background Stroke is a severe complication of infective endocarditis (IE), associated with high rates of mortality. Data on how IE patients with and without stroke differ may help to improve understanding contributing mechanisms. Methods A…
View article: Randomized controlled double-blind trial of methylprednisolone versus placebo in patients with post-COVID-19 syndrome and cognitive deficits: study protocol of the post-corona-virus immune treatment (PoCoVIT) trial
Randomized controlled double-blind trial of methylprednisolone versus placebo in patients with post-COVID-19 syndrome and cognitive deficits: study protocol of the post-corona-virus immune treatment (PoCoVIT) trial Open
View article: Sex Differences in Outcomes of Acute Myocardial Injury After Stroke
Sex Differences in Outcomes of Acute Myocardial Injury After Stroke Open
Background Sex differences in presentation, treatment, and prognosis of cardiovascular disorders are well recognized. Although an association between acute myocardial injury and mortality after ischemic stroke has been demonstrated, it is …
View article: Pre-hospital telestroke and expanded hyper-acute telestroke network solutions to reduce geographic inequities: a brief review from the South Pacific
Pre-hospital telestroke and expanded hyper-acute telestroke network solutions to reduce geographic inequities: a brief review from the South Pacific Open
Hyper-acute stroke treatments are time sensitive, and decision-making is complex. Telemedicine has been highly effective in breaking down regional access barriers by providing front line rural hospital clinicians with remote telemedicine d…
View article: Optimization of sensitivity and specificity of a biomarker-based blood test (LVOCheck-Opti): A protocol for a multicenter prospective observational study of patients suspected of having a stroke
Optimization of sensitivity and specificity of a biomarker-based blood test (LVOCheck-Opti): A protocol for a multicenter prospective observational study of patients suspected of having a stroke Open
Introduction Acute ischemic stroke (AIS) is a time-critical medical emergency. For patients with large-vessel occlusions (LVO), mechanical thrombectomy (MT) is the gold-standard treatment. Mobile Stroke Units (MSUs) provide on-site diagnos…
View article: Effect of Asymptomatic and Symptomatic COVID-19 on Acute Ischemic Stroke Revascularization Outcomes
Effect of Asymptomatic and Symptomatic COVID-19 on Acute Ischemic Stroke Revascularization Outcomes Open
BACKGROUND: The association of COVID-19 with higher bleeding risk and worse outcomes in acute ischemic stroke (AIS) undergoing revascularization may be related to the presence of infection symptoms. We aimed to assess the safety and outcom…