Explanipedia

Interpregnancy Weight Gain and Risks of Perinatal Death: A Systematic Review and Meta‐Analysis Open

Yu Tang, Nabil Islam, Rong Luo, Shi Wu Wen, Desheng Zhai , et al. · 2025

The link between interpregnancy weight gain (IPWG) and perinatal death remains unclear. This meta‐analysis examines the impact of interpregnancy body mass index (BMI) increase on perinatal mortality. A comprehensive search was conducted in…

P-775 Multifetal pregnancy reduction and ensuing severe maternal and neonatal morbidity and mortality: a population-based cohort study Open

Ellen Richmond, Joel G. Ray, Laura Gaudet, M. Vélez, Jessica Pudwell , et al. · 2025

Study question How does early multifetal pregnancy reduction impact risk of severe maternal morbidity or mortality (SMM-M) and severe neonatal morbidity or mortality (SNM-M) later in pregnancy? Summary answer Multifetal pregnancy reduction…

Risk associated with planned mode of delivery in women with obesity: a large population-based retrospective cohort study Open

Geneviève Horwood, Erica Erwin, Yanfang Guo, Brian C. Aston, Sara C. S. Souza , et al. · 2025

Neonates With In-Utero SSRI Exposure (NeoWISE): a retrospective cohort study examining the effect of newborn feeding method on newborn withdrawal Open

Christina Cantin, Wen‐Bin Li, Erna Snelgrove‐Clarke, Daniel J. Corsi, Cindy‐Lee Dennis , et al. · 2024

IntroductionUp to 30% of newborns with in-utero selective serotonin reuptake inhibitor (SSRI) exposure experience withdrawal symptoms. The impact of newborn feeding method on alleviating withdrawal has not been investigated. We examined th…

Risk related to gestational weight loss among individuals with obesity: a population‐based cohort study Open

Yanfang Guo, Sara C. S. Souza, Liam Bruce, Rong Luo, Darine El‐Chaâr , et al. · 2024

Objective There is no clear evidence on the risk of gestational weight loss (GWL) for individuals with obesity. Our study aimed to assess the association between GWL and adverse perinatal outcomes among individuals with obesity. Methods Th…

Multifetal Pregnancy After Implementation of a Publicly Funded Fertility Program Open

Maria P. Vélez, Allison Soule, Laura Gaudet, Jessica Pudwell, Paul Nguyen , et al. · 2024

Importance A publicly funded fertility program was introduced in Ontario, Canada, in 2015 to increase access to fertility treatment. For in vitro fertilization (IVF), the program mandated an elective single-embryo transfer (eSET) policy. H…

Type III Vasa Previa Associated with Resolution of a Low-Lying Placenta: Case Report and Literature Review Open

Joanna J. Kim, Katherine Bonhomme, Lawrence Oppenheimer, Laura Gaudet · 2024

Vasa previa occurs when fetal vessels lie above the cervical os. A novel type of vasa previa, known as type III, is characterized by an abnormal branching of fetal vessels from the placenta in the absence of velamentous cord insertion (as …

The impact of isolated obesity compared with obesity and other risk factors on risk of stillbirth: a retrospective cohort study Open

Naila Ramji, Daniel J. Corsi, M.D. MOHAMED R.M. ABO SHADY AHMED M. GAD, Sheryll Dimanlig-Cruz, Qun Miao , et al. · 2024

Maternal obesity alone and obesity with other risk factors are associated with an increased risk of stillbirth. This risk increases with gestational age, especially at term.

Gestational weight loss and fetal growth in uncomplicated pregnancies among women with obesity: a population-based retrospective cohort study Open

Yanfang Guo, Sara C. S. Souza, Liam Bruce, Rong Luo, Darine El‐Chaâr , et al. · 2023

Objective The impact of gestational weight loss (GWL) on fetal growth among women with obesity remains unclear. This study aimed to examine the association between weight loss during pregnancy among women with body mass index (BMI) ≥ 30 kg…

Maternal weight and paediatric health use: mediating role of adverse birth outcomes: a retrospective cohort study Open

Lisa Currie, Hilary K. Brown, Beth K. Potter, Steven Hawken, Doug Coyle , et al. · 2023

Background Maternal pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) above or below recommendations have been associated with increased paediatric health service utilization as well as increased risk of adverse birth o…

Persisting risk factors for preeclampsia among high-risk pregnancies already using prophylactic aspirin: a multi-country retrospective investigation Open

Katherine A. Muldoon, Cheynne McLean, Darine El‐Chaâr, Daniel J. Corsi, Natalie Rybak , et al. · 2023

These findings suggest that individuals with twin pregnancies, a history of preeclampsia, or hypertension may not benefit from aspirin to the same extent as those with other complications such as obesity or diabetes. Careful clinical monit…

Relationships of First-Trimester Body Mass Index and Weight Change with Persistent Organic Pollutant Concentrations in Pregnant Canadian Individuals Open

Marianne Levesque, Mariame Ouedraogo, Romina Fakhraei, Alysha L. J. Dingwall‐Harvey, Elizabeth Bratton , et al. · 2023

Persistent organic pollutants (POPs) are toxic chemicals with demonstrable effects on pregnancy and neonatal outcomes. The associations of early pregnancy body mass index (BMI) and antenatal weight changes with circulating POP concentratio…

The use, perceptions and knowledge of safety of over-the-counter medications during pregnancy in a Canadian population Open

Eoin Casey, Maria P. Vélez, Laura Gaudet, Susan B. Brogly · 2023

Background: The prevalence of prenatal over-the-counter medication use in Canadian women is unknown. Methods: A cross-sectional study of prenatal over-the-counter medication use and safety knowledge was conducted among pregnant and post-pa…

Intentional gestational weight loss among women with obesity and fetal growth: a population-based retrospective cohort study Open

Yanfang Guo, Sara C. S. Souza, Liam Bruce, Rong Luo, Darine El‐Chaâr , et al. · 2022

Objective The impact of intentional gestational weight loss (GWL) on fetal growth among women with obesity remains unclear. This study aimed to examine the association between women with body mass index (BMI) ≥ 30 kg/m² who expe…

Management of gestational weight gain in obese or overweight women based on resting energy expenditure: A pilot cohort study Open

Xiuling Zhao, Shi Wu Wen, Wei Ma, Pili Xu, Chunmei Zhang , et al. · 2022

Resting energy expenditure (REE) comprises 60% of total energy expenditure and variations may be associated with gestational weight gain (GWG). This study aims to explore the usability and feasibility of REE guided intervention for GWG in …

Cannabis Use in Pregnancy and Downstream effects on maternal and infant health (CUPiD): a protocol for a birth cohort pilot study Open

Serine Ramlawi, Malia S. Q. Murphy, Alysha L. J. Dingwall‐Harvey, Ruth Rennicks White, Laura Gaudet , et al. · 2022

Introduction Cannabis use in pregnancy and post partum is increasing. Accessibility to cannabis has expanded due to the legalisation of cannabis in Canada. Therefore, there is a critical need to monitor the impact of cannabis on pregnancy …

Trends and characteristics of Tdap vaccination during pregnancy in Ontario, Canada: a retrospective cohort study Open

Romina Fakhraei, Stephen Fung, William Petrcich, Natasha S. Crowcroft, Shelly Bolotin , et al. · 2022

During pregnancy, Tdap vaccination coverage increased substantially in Ontario between 2011/12 and 2019/20, most notably after recommendations for universal Tdap vaccination during pregnancy began in Canada. To further improve vaccine cove…

Optimal Plan for Delivery in Women with Obesity: A Large Population-based Retrospective Cohort Study Using the Better Outcomes Registry and Network (BORN) Database Open

Geneviève Horwood, Erica Erwin, Yanfang Guo, Laura Gaudet · 2022

Objective: To discern the optimal plan for delivery in nulliparous women with obesity at term gestation. Subjects/Methods: This was a large population-based retrospective cohort study. It included nulliparous women with obesity (BMI>30) gi…

Exploring weight bias internalization in pregnancy Open

Taniya S. Nagpal, Ximena Ramos Salas, Michael Vallis, Helena Piccinini‐Vallis, Angela S. Alberga , et al. · 2022

Background Recent research has shown that pregnant individuals experience weight stigma throughout gestation, including negative comments and judgement associated with gestational weight gain (GWG). Weight bias internalization (WBI) is oft…

Maternal Immune Cell and Cytokine Profiles to Predict Cardiovascular Risk Six Months after Preeclampsia Open

Malia S. Q. Murphy, Samantha J. Benton, Brian Cox, Kara Nerenberg, Scott McComb , et al. · 2022

Women who develop preeclampsia (PE) are at high risk for cardiovascular disease (CVD). Early identification of women with PE who may benefit the most from early cardiovascular risk screening and interventions remains challenging. Our objec…

Association between maternal adiposity measures and infant health outcomes: A systematic review and meta‐analysis Open

Giang Nguyễn, Louise Hayes, Lem Ngongalah, Theophile Bigirumurame, Laura Gaudet , et al. · 2022

Summary Maternal obesity increases risks of adverse fetal and infant outcomes. Guidelines use body mass index to diagnose maternal obesity. Evidence suggests body fat distribution might better predict individual risk, but there is a lack o…

Association between maternal adiposity measures and adverse maternal outcomes of pregnancy: Systematic review and meta‐analysis Open

Nicola Heslehurst, Lem Ngongalah, Theophile Bigirumurame, Giang Nguyễn, Adefisayo Odeniyi , et al. · 2022

Summary Maternal obesity increases pregnancy‐related risks. Women with a body mass index (BMI) ≥ 30 kg/m 2 are considered to be at risk and should receive additional care, although approximately half will have uncomplicated pregnancies. Th…

Optimal Plan for Delivery in Women with Obesity: A Large Population-based Retrospective Cohort Study Using the Better Outcomes Registry and Network (BORN) Database Open

Geneviève Horwood, Erica Erwin, Yanfang Guo, Laura Gaudet · 2022

Objective: To discern the optimal plan for delivery in nulliparous women with obesity at term gestation. Design: Large population-based retrospective cohort study Setting: Maternity hospitals in Ontario, Canada Population: Nulliparous wome…

Placental Pathology as a Tool to Identify Women for Postpartum Cardiovascular Risk Screening following Preeclampsia: A Preliminary Investigation Open

Samantha J. Benton, Erika Mery, David Grynspan, Laura Gaudet, Graeme N. Smith , et al. · 2022

Preeclampsia (PE) is associated with an increased risk of cardiovascular disease (CVD) in later life. Postpartum cardiovascular risk screening could identify patients who would benefit most from early intervention and lifestyle modificatio…

Predictors of Adverse Pregnancy Outcomes in Pregnant Women Living with Obesity: A Systematic Review Open

Romina Fakhraei, Kathryn M. Denize, Alexandre Simon, Ayni Sharif, Julia Zhu-Pawlowsky , et al. · 2022

Obesity is a well-recognized risk factor for pregnancy complications. Most studies to date are in large cohorts, with results presented in a way that assumes all women living with obesity are at equal risk. This study investigates which wo…

Mode of Conception and Risk of Spontaneous vs. Provider-Initiated Preterm Birth: Population-based cohort study Open

Yimin Wang, Joel G. Ray, Jessica Pudwell, Laura Gaudet, Yingwei Peng , et al. · 2022

Objective: To study the association between mode of conception and risk of preterm birth (PTB), including, spontaneous and provide-initiated PTB. Design: Retrospective cohort study Setting and Population: Population-based cohort included a…

Placental Pathology as a Tool to Identify Women for Postpartum Cardiovascular Risk Screening Following Preeclampsia: A Preliminary Investigation Open

Samantha J. Benton, Erika Mery, David Grynspan, Laura Gaudet, Graeme N. Smith , et al. · 2022

Preeclampsia (PE) is associated with an increased risk of cardiovascular disease (CVD) in later life. Postpartum cardiovascular risk screening could identify patients who would benefit most from lifestyle interventions. However, there are …

Caesarean birth in women with infertility: population‐based cohort study Open

Ellen Richmond, J. G. Ray, Jessica Pudwell, Maya Djerboua, Laura Gaudet , et al. · 2021

Objective Caesarean section (CS) is more common following infertility treatment (IT) but the reasons why remain unclear and confounded. The Robson 10‐Group Classification System (TGCS) may further explain variation in CS rates. We assessed…

Relationships of First Trimester Body Mass Index and Weight Change with Persistent Organic Pollutants Concentrations in Canadian Pregnant Women Open

Marianne Lévesque, Mariame Ouedraogo, Romina Fakhraei, Alysha L. J. Dingwall‐Harvey, Elizabeth Bratton , et al. · 2021

Background Persistent organic pollutants (POPs) are toxic chemicals with demonstrable effects on pregnancy and neonatal outcomes. The associations of early pregnancy body mass index (BMI) and antenatal weight changes with circulating POP c…

Association of placental pathology and postpartum cardiovascular risk screening following preeclampsia: an observational cohort study Open

Samantha J. Benton, Erika Mery, David Grynspan, Laura Gaudet, Graeme N. Smith , et al. · 2021

Objective: To determine the association between placental lesions and lifetime cardiovascular disease (CVD) risk screening at 6 months postpartum following preeclampsia (PE). Design: Observational cohort study. Setting: Tertiary care centr…

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