L. Gayani Tillekeratne
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View article: Association of race, ethnicity, and housing stability with COVID-19 testing method by investigators in underserved populations 2020–2023
Association of race, ethnicity, and housing stability with COVID-19 testing method by investigators in underserved populations 2020–2023 Open
Background Expanding SARS-CoV-2 testing was a critical part of community-based health efforts during the COVID-19 pandemic. In the RADx-UP consortium, a large NIH-funded network of community-engaged researchers in the United States, invest…
View article: Use of the BIOFIRE® FILMARRAY® Pneumonia plus Panel to characterize the etiology of lower respiratory tract infections among hospitalized patients in Southern Province, Sri Lanka
Use of the BIOFIRE® FILMARRAY® Pneumonia plus Panel to characterize the etiology of lower respiratory tract infections among hospitalized patients in Southern Province, Sri Lanka Open
Our findings suggest that patients with LRTI in Southern Province, Sri Lanka have a high prevalence of gram-negative bacteria and antibacterial resistance in their sputum samples. However, it remains difficult to differentiate isolates tha…
View article: Association of race, ethnicity, and housing stability with COVID-19 testing method by investigators in underserved populations 2020–2023
Association of race, ethnicity, and housing stability with COVID-19 testing method by investigators in underserved populations 2020–2023 Open
Background Expanding SARS-CoV-2 testing was a critical part of community-based health efforts during the COVID-19 pandemic. In the RADx-UP consortium, a large NIH-funded network of community-engaged researchers in the United States, invest…
View article: Diverse respiratory viruses detected among hospitalized patients with pneumonia in Sri Lanka and Vietnam
Diverse respiratory viruses detected among hospitalized patients with pneumonia in Sri Lanka and Vietnam Open
The detection of a novel, possibly emerging virus, CCoV-HuPn-2018, in multiple patients in Vietnam, demonstrates the value of such periodic novel virus surveillance, especially in regions at risk for viral emergence.
View article: Academic global health collaboration: the Ruhuna-Duke partnership
Academic global health collaboration: the Ruhuna-Duke partnership Open
The role of institutional partnerships is increasingly recognized as a means of advancing our collective efficacy in improving public health. Shared challenges related to infectious and chronic diseases, as well as social determinants of h…
View article: Exploring supportive roles for global north investigators in global health research
Exploring supportive roles for global north investigators in global health research Open
Many academics are increasingly pushing for solutions to address inequitable partnership dynamics in global health research and practice. Efforts to improve equity in collaborations have prompted academic institutions to grapple with promo…
View article: Electronic Clinical Decision Support Tools to Manage Patients with Lower Respiratory Tract Infection: Clinicians’ Perspectives in Sri Lanka
Electronic Clinical Decision Support Tools to Manage Patients with Lower Respiratory Tract Infection: Clinicians’ Perspectives in Sri Lanka Open
In low-resource settings, providers often manage lower respiratory tract infections (LRTIs) without diagnostic tests, which may cause antibacterial overuse. Electronic clinical decision support tools (eCDSTs) can support evidence-based dec…
View article: Host gene expression in the Nasopharynx can discriminate microbiologically confirmed viral and bacterial lower respiratory tract infection
Host gene expression in the Nasopharynx can discriminate microbiologically confirmed viral and bacterial lower respiratory tract infection Open
Introduction: Distinguishing viral versus bacterial lower respiratory tract infection (LRTI) is challenging. We previously developed a rapid, host response-based test (Biomeme HR-B/V assay) using peripheral blood samples to identify viral …
View article: Prevalence of anxiety and depression among patients hospitalised with acute febrile illness
Prevalence of anxiety and depression among patients hospitalised with acute febrile illness Open
Introduction: Acute febrile illnesses (AFI) such as dengue, leptospirosis, and influenza result in large numbers of hospitalisation in the tropics. These illnesses may negatively impact patients’ mental health. The prevalence of anxiety an…
View article: A Rapid Host Response Blood Test for Bacterial/Viral Infection Discrimination Using a Portable Molecular Diagnostic Platform
A Rapid Host Response Blood Test for Bacterial/Viral Infection Discrimination Using a Portable Molecular Diagnostic Platform Open
Background Difficulty discriminating bacterial versus viral etiologies of infection drives unwarranted antibacterial prescriptions and, therefore, antibacterial resistance. Methods Utilizing a rapid portable test that measures peripheral b…
View article: Prevalence and molecular epidemiology of methicillin-resistant Staphylococcus aureus in livestock farmers, livestock, and livestock products in southern Sri Lanka: A one health approach
Prevalence and molecular epidemiology of methicillin-resistant Staphylococcus aureus in livestock farmers, livestock, and livestock products in southern Sri Lanka: A one health approach Open
Methicillin-resistant Staphylococcus aureus (MRSA) colonization can lead to subsequent severe infections. Unlike community and hospital-associated types, Livestock-associated MRSA (LA-MRSA) transmits to humans through direct contact with l…
View article: Electronic Clinical Decision Support Tools: Strategies to Improve the Management of Lower Respiratory Tract Infections in Low-Resource Settings
Electronic Clinical Decision Support Tools: Strategies to Improve the Management of Lower Respiratory Tract Infections in Low-Resource Settings Open
Lower respiratory tract infection (LRTI) is a common reason for hospitalization and antibacterial use globally. There is considerable overlap in the clinical presentation of bacterial and viral LRTIs. Low- or middle-income countries (LMICs…
View article: RADx-UP Testing Core: Access to COVID-19 Diagnostics in Community-Engaged Research with Underserved Populations
RADx-UP Testing Core: Access to COVID-19 Diagnostics in Community-Engaged Research with Underserved Populations Open
Research on the COVID-19 pandemic revealed a disproportionate burden of COVID-19 infection and death among underserved populations and exposed low rates of SARS-CoV-2 testing in these communities. A landmark National Institutes of Health (…
View article: Access to COVID-19 testing by individuals with housing insecurity during the early days of the COVID-19 pandemic in the United States: a scoping review
Access to COVID-19 testing by individuals with housing insecurity during the early days of the COVID-19 pandemic in the United States: a scoping review Open
Introduction: The COVID-19 pandemic focused attention on healthcare disparities and inequities faced by individuals within marginalized and structurally disadvantaged groups in the United States. These individuals bore the heaviest burden …
View article: Prevalence and predictors of antibiotic prescription among patients hospitalized with viral lower respiratory tract infections in Southern Province, Sri Lanka
Prevalence and predictors of antibiotic prescription among patients hospitalized with viral lower respiratory tract infections in Southern Province, Sri Lanka Open
Background Antimicrobial overprescription is common for lower respiratory tract infections (LRTI), as viral and bacterial infections generally present with similar clinical features. Overprescription is associated with downstream antimicro…
View article: 854. Performance of a Nasopharyngeal-Based Host Gene Expression Classifier at Distinguishing Bacterial versus Viral Respiratory Infection
854. Performance of a Nasopharyngeal-Based Host Gene Expression Classifier at Distinguishing Bacterial versus Viral Respiratory Infection Open
Background Acute respiratory infections (ARI) present a diagnostic challenge due to overlapping clinical features of bacterial and viral infections, leading to unnecessary use of antibiotics. We have previously shown that a host-based bloo…
View article: The Antibacterial Resistance Leadership Group: Scientific Advancements and Future Directions
The Antibacterial Resistance Leadership Group: Scientific Advancements and Future Directions Open
In this overview, we describe important contributions from the Antibacterial Resistance Leadership Group (ARLG) to patient care, clinical trials design, and mentorship while outlining future priorities. The ARLG research agenda is focused …
View article: The Future Ain’t What It Used to Be…Out With the Old…In With the Better: Antibacterial Resistance Leadership Group Innovations
The Future Ain’t What It Used to Be…Out With the Old…In With the Better: Antibacterial Resistance Leadership Group Innovations Open
Clinical research networks conduct important studies that would not otherwise be performed by other entities. In the case of the Antibacterial Resistance Leadership Group (ARLG), such studies include diagnostic studies using master protoco…
View article: Priorities and Progress in Diagnostic Research by the Antibacterial Resistance Leadership Group
Priorities and Progress in Diagnostic Research by the Antibacterial Resistance Leadership Group Open
The advancement of infectious disease diagnostics, along with studies devoted to infections caused by gram-negative and gram-positive bacteria, is a top scientific priority of the Antibacterial Resistance Leadership Group (ARLG). Diagnosti…
View article: Access to COVID-19 testing by individuals with housing insecurity during the early days of the COVID-19 pandemic in the United States: a scoping review
Access to COVID-19 testing by individuals with housing insecurity during the early days of the COVID-19 pandemic in the United States: a scoping review Open
Introduction The COVID-19 pandemic focused attention on healthcare disparities and inequities faced by individuals within marginalized and structurally disadvantaged groups in the United States. These individuals bore the heaviest burden a…
View article: Antibacterial Utilization for Febrile Illnesses and Laboratory-Confirmed Bloodstream Infections in Northern Tanzania
Antibacterial Utilization for Febrile Illnesses and Laboratory-Confirmed Bloodstream Infections in Northern Tanzania Open
Background We describe antibacterial use in light of microbiology data and treatment guidelines for common febrile syndromes in Moshi, Tanzania. Methods We compared data from 2 hospital-based prospective cohort studies, cohort 1 (2011–2014…
View article: RADx-UP Testing Core: Access to COVID-19 Diagnostics in Community-Engaged Research with Underserved Populations
RADx-UP Testing Core: Access to COVID-19 Diagnostics in Community-Engaged Research with Underserved Populations Open
Research on the COVID-19 pandemic revealed a disproportionate burden of COVID-19 infection and death among underserved populations and exposed low rates of SARS-CoV-2 testing in these communities. A landmark National Institutes of Health (…
View article: Comprehensive diagnostic testing identifies diverse aetiologies of acute febrile illness among hospitalised children and adults in Sri Lanka: a prospective cohort study
Comprehensive diagnostic testing identifies diverse aetiologies of acute febrile illness among hospitalised children and adults in Sri Lanka: a prospective cohort study Open
Introduction Acute febrile illness (AFI) is a common cause of hospital admissions in tropical settings. Identifying AFI aetiology is essential for guiding clinicians’ diagnoses and developing diagnostic and management guidelines. We used r…
View article: Influenza Vaccination Implementation in Sri Lanka: A Cost-Effectiveness Analysis
Influenza Vaccination Implementation in Sri Lanka: A Cost-Effectiveness Analysis Open
Influenza causes an estimated 3 to 5 million cases of severe illness annually, along with substantial morbidity and mortality, particularly in low- and middle-income countries (LMICs). Currently, Sri Lanka has no influenza vaccination poli…
View article: Host-response Transcriptional Biomarkers Accurately Discriminate Bacterial and Viral Infections of Global Relevance
Host-response Transcriptional Biomarkers Accurately Discriminate Bacterial and Viral Infections of Global Relevance Open
Limited diagnostics challenge management of acute febrile illness and sepsis (AFI/sepsis) globally. We generated transcriptomes for a 294-participant (USA, Sri Lanka) discovery cohort with AFI/sepsis. We used lasso to derive gene expressio…
View article: Correction: Outcomes among children and adults at risk of severe dengue in Sri Lanka: Opportunity for outpatient case management in countries with high disease burden
Correction: Outcomes among children and adults at risk of severe dengue in Sri Lanka: Opportunity for outpatient case management in countries with high disease burden Open
[This corrects the article DOI: 10.1371/journal.pntd.0010091.].
View article: Direct and indirect costs for hospitalized patients with dengue in Southern Sri Lanka
Direct and indirect costs for hospitalized patients with dengue in Southern Sri Lanka Open
Background The Southern Province of Sri Lanka is endemic with dengue, with frequent outbreaks and occurrence of severe disease. However, the economic burden of dengue is poorly quantified. Therefore, we conducted a cost analysis to assess …