Explanipedia

Serum microRNA-24-based nomogram predicts prognosis for patients with resected pancreatic cancer Open

Jing Huang, Qian Zhang, Yang Ge, Zheng Ren, Minwei Yang , et al. · 2025

Development of a Serum-Based MicroRNA Signature for Early Detection of Pancreatic Cancer: A Multicenter Cohort Study Open

Jing Huang, Ge Gao, Yang Ge, Jianzhou Liu, Hongtu Cui , et al. · 2024

A panel of four serum miRNAs was developed showing remarkably discriminative ability of early stage PCa from either healthy controls or other pancreatic diseases, suggesting it may be developed as a novel, noninvasive approach for early sc…

Development of a serum-based miRNA signature for early detection of pancreatic cancer: a multicenter cohort study Open

Jing Huang, Ge Gao, Jianzhou Liu, Yang Ge, Hongtu Cui , et al. · 2023

Background A grim prognosis of pancreatic cancer (PCa) was attributed to the difficulty in early diagnosis of the disease. Identifying novel biomarkers for early detection of PCa is thus urgent to improve the overall survival rates of pati…

Early Detection of Pancreatic Cancer Open

Barbara Kenner, Natalie Abrams, Suresh T. Chari, Bruce F. Field, Ann Goldberg , et al. · 2021

The potential of artificial intelligence (AI) applied to clinical data from electronic health records (EHRs) to improve early detection for pancreatic and other cancers remains underexplored. The Kenner Family Research Fund, in collaborati…

Artificial Intelligence and Early Detection of Pancreatic Cancer Open

Barbara Kenner, Suresh T. Chari, David P. Kelsen, David S. Klimstra, Stephen J. Pandol , et al. · 2021

Despite considerable research efforts, pancreatic cancer is associated with a dire prognosis and a 5-year survival rate of only 10%. Early symptoms of the disease are mostly nonspecific. The premise of improved survival through early detec…

Serotonin-RhoA/ROCK axis promotes acinar-to-ductal metaplasia in caerulein-induced chronic pancreatitis Open

Xufeng Tao, Qing Chen, Ning Li, Hong Xiang, Yue Pan , et al. · 2020

Proceedings of the 3rd International Conference for Cancer Metabolism and Therapy, October 12–14, 2018, Shanghai, China Open

Gary Guishan Xiao, Zhigang Zhang, Bin Lü, Hongyang Wang, Teresa W.‐M. Fan , et al. · 2020

The 3 rd International Conference for Cancer Metabolism and Therapy was successfully held at the South Hospital Conference Center of Shanghai First People's Hospital, nearly 200 international experts from the field of cancer metabolism and…

Proceedings of the 2nd International Conference for Cancer Metabolism and Therapy, October 13–15, 2017, Wenzhou, China Open

Gary Guishan Xiao, Mengtao Zhou, Bin Lv, B Chen, Hongxia Wang , et al. · 2018

The 3 International Conference for Cancer Metabolism and Therapy was successfully held at the South Hospital Conference Center of Shanghai First People's Hospital, nearly 200 international experts from the field of cancer metabolism and th…

Early Detection of Pancreatic Cancer Open

Barbara Kenner, Vay Liang W. Go, Suresh T. Chari, Ann Goldberg, Laura J. Rothschild · 2017

A diagnosis of pancreatic cancer is devastating owing to its poor prognosis, with a 5-year survival rate of only 9%. Currently, most individuals are diagnosed at a late stage when treatment options are limited. Early detection of pancreati…

Incidence of pancreatic cancer is dramatically increased by a high fat, high calorie diet in KrasG12D mice Open

Hui-Hua Chang, Aune Moro, Kazuki Takakura, Hsin‐Yuan Su, Allen Mo , et al. · 2017

Epidemiologic data has linked obesity to a higher risk of pancreatic cancer, but the underlying mechanisms are poorly understood. To allow for detailed mechanistic studies in a relevant model mimicking diet-induced obesity and pancreatic c…

Proceedings of the 1st International Conference for Cancer Metabolism and Therapy, October 14–17, 2016, Dalian, China Open

Gary Guishan Xiao, Hongyang Wang, Lei Wang, Wei Zhang, Ge Gao , et al. · 2017

The first International Conference for Cancer Metabolism and Therapy was held in Dalian, China from October 14 to October 17, 2016 at the New World Hotel. The conference was organized by Dalian University of Technology with sponsorship fro…

Cadherin-11 Is a Cell Surface Marker Up-Regulated in Activated Pancreatic Stellate Cells and Is Involved in Pancreatic Cancer Cell Migration Open

Chiara Birtolo, Hung Pham, Susan Morvaridi, Chintan Chheda, Vay Liang W. Go , et al. · 2016

Advance in microRNA as a potential biomarker for early detection of pancreatic cancer Open

Jing Huang, Jianzhou Liu, Kevin Chen-Xiao, Xuemei Zhang, W. N. Paul Lee , et al. · 2016

Pancreatic cancer is characterized as a disease with low survival and high mortality because of no effective diagnostic and therapeutic strategies available in clinic. Conventional clinical diagnostic methods including serum markers and ra…

Early Detection of Pancreatic Cancer—a Defined Future Using Lessons From Other Cancers Open

Barbara Kenner, Suresh T. Chari, Anirban Maitra, Sudhir Srivastava, Deborah Cleeter , et al. · 2016

The implementation of effective early detection programs has significantly improved treatment, prognosis, and life expectancy in breast, prostate, and colorectal cancers. Early-detection methods need to be developed for pancreatic ductal a…

Phosphatidylinositol 3-Kinase Open

Chiara Birtolo, Vay Liang W. Go, Andrzej Ptasznik, Guido Eibl, Stephen J. Pandol · 2015

Even though a strong association between inflammation and cancer has been widely accepted, the underlying precise molecular mechanisms are still largely unknown. A complex signaling network between tumor and stromal cells is responsible fo…

Early Detection of Sporadic Pancreatic Cancer Open

Barbara Kenner, Suresh T. Chari, Deborah Cleeter, Vay Liang W. Go · 2015

Innovation leading to significant advances in research and subsequent translation to clinical practice is urgently necessary in early detection of sporadic pancreatic cancer. Addressing this need, the Early Detection of Sporadic Pancreatic…

Early Detection of Sporadic Pancreatic Cancer Open

Suresh T. Chari, Kimberly M. Kelly, Michael A. Hollingsworth, Sarah P. Thayer, David A. Ahlquist , et al. · 2015

Pancreatic cancer (PC) is estimated to become the second leading cause of cancer death in the United States by 2020. Early detection is the key to improving survival in PC. Addressing this urgent need, the Kenner Family Research Fund condu…

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