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View article: Identification of CDC25 as a Common Therapeutic Target for Triple-Negative Breast Cancer
Identification of CDC25 as a Common Therapeutic Target for Triple-Negative Breast Cancer Open
View article: <scp>TFEB</scp> and <scp>TFE3</scp> drive kidney cystogenesis and tumorigenesis
<span>TFEB</span> and <span>TFE3</span> drive kidney cystogenesis and tumorigenesis Open
Birt‐Hogg‐Dubé (BHD) syndrome is an inherited familial cancer syndrome characterized by the development of cutaneous lesions, pulmonary cysts, renal tumors and cysts and caused by loss‐of‐function pathogenic variants in the gene encoding t…
View article: Targeting the USP7/RRM2 axis drives senescence and sensitizes melanoma cells to HDAC/LSD1 inhibitors
Targeting the USP7/RRM2 axis drives senescence and sensitizes melanoma cells to HDAC/LSD1 inhibitors Open
View article: ShcD Binds DOCK4, Promotes Ameboid Motility and Metastasis Dissemination, Predicting Poor Prognosis in Melanoma
ShcD Binds DOCK4, Promotes Ameboid Motility and Metastasis Dissemination, Predicting Poor Prognosis in Melanoma Open
Metastases are the primary cause of cancer-related deaths. The underlying molecular and biological mechanisms remain, however, elusive, thus preventing the design of specific therapies. In melanomas, the metastatic process is influenced by…
View article: A Na <sup>+</sup> /Ca <sup>2+</sup> exchanger of the olive pathogen <i>Pseudomonas savastanoi</i> pv. <i>savastanoi</i> is critical for its virulence
A Na <sup>+</sup> /Ca <sup>2+</sup> exchanger of the olive pathogen <i>Pseudomonas savastanoi</i> pv. <i>savastanoi</i> is critical for its virulence Open
Summary In a number of compatible plant‐bacterium interactions, a rise in apoplastic Ca 2+ levels is observed, suggesting that Ca 2+ represents an important environmental clue, as reported for bacteria infecting mammalians. We demonstrate …
View article: CDC25 as a common therapeutic target for triple-negative breast cancer - the challenges ahead
CDC25 as a common therapeutic target for triple-negative breast cancer - the challenges ahead Open
The dual phosphatase CDC25 has recently been identified as a target for diverse triple-negative breast cancers including RB1/PTEN/P53-deficient tumors. Moreover, CDC25 inhibitors effectively synergize with PI3K inhibitors to suppres…
View article: Identification of CDC25 as a Common Therapeutic Target for Triple-Negative Breast Cancer
Identification of CDC25 as a Common Therapeutic Target for Triple-Negative Breast Cancer Open
CDK4/6 inhibitors are effective against cancer cells expressing the tumor suppressor RB1, but not RB1-deficient cells, posing the challenge of how to target RB1 loss. In triple-negative breast cancer (TNBC), RB1 and PTEN are frequently ina…
View article: A case report of unacknowledged hypercalcemia in emergency
A case report of unacknowledged hypercalcemia in emergency Open
View article: Chelating properties of beer: Implications on calcium homeostasis in PE/CA-PJ15 cells
Chelating properties of beer: Implications on calcium homeostasis in PE/CA-PJ15 cells Open
Beer contains a large variety of different molecules, of which some can chelate Ca2+. Here, we show that in PE/CA-PJ15 cells, an experimental model previously employed to investigate Ca2+ homeostasis, chemical entities with Ca2+-chelating …
View article: Aquaporin-4 antibody titration in NMO patients treated with rituximab
Aquaporin-4 antibody titration in NMO patients treated with rituximab Open
Titration of AQP4-Abs could be useful in the clinical management of patients with NMO treated with RTX: titration before each reinfusion and 3 months after each reinfusion may provide information about responsiveness to RTX. Although a rel…
View article: Antioxidant and antiproliferative activities of methanolic extracts of beer
Antioxidant and antiproliferative activities of methanolic extracts of beer Open
The beneficial effects of beer on human health, such as reduced risk of heart diseases and certain types of cancer, has been associated to its polyphenolic content and resulting antioxidant activity. The aim of this study was to verify the…
View article: Multicentre comparison of a diagnostic assay: aquaporin-4 antibodies in neuromyelitis optica
Multicentre comparison of a diagnostic assay: aquaporin-4 antibodies in neuromyelitis optica Open
The cell-based assays were most sensitive and specific overall, but immunohistochemistry or flow cytometry could be equally accurate in specialist centres. Since patients with AQP4-Ab negative NMO/SD require different management, the use o…
View article: High-throughput drug library screening identifies colchicine as a thyroid cancer inhibitor
High-throughput drug library screening identifies colchicine as a thyroid cancer inhibitor Open
We employed a high-throughput drug library screening platform to identify novel agents affecting thyroid cancer cells. We used human thyroid cancer cell lines to screen a collection of approximately 5200 small molecules with biological and…
View article: Antagonistic Effect of a Salivary Proline-Rich Peptide on the Cytosolic Ca2+ Mobilization Induced by Progesterone in Oral Squamous Cancer Cells
Antagonistic Effect of a Salivary Proline-Rich Peptide on the Cytosolic Ca2+ Mobilization Induced by Progesterone in Oral Squamous Cancer Cells Open
A salivary proline-rich peptide of 1932 Da showed a dose-dependent antagonistic effect on the cytosolic Ca2+ mobilization induced by progesterone in a tongue squamous carcinoma cell line. Structure-activity studies showed that the activity…
View article: Immune and Epstein-Barr virus gene expression in cerebrospinal fluid and peripheral blood mononuclear cells from patients with relapsing-remitting multiple sclerosis
Immune and Epstein-Barr virus gene expression in cerebrospinal fluid and peripheral blood mononuclear cells from patients with relapsing-remitting multiple sclerosis Open
Analysis of multiple cellular and EBV genes in paired CSF cell and PBMC samples using PreAmp RT-PCR may yield new information on the complex interplay between biological processes underlying MS and help in biomarker identification.