Luigi Grassi
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View article: Risk prediction models for depression in older adults with cancer
Risk prediction models for depression in older adults with cancer Open
Background Depression in people with cancer is common and debilitating, but few instruments exist for early identification. We aimed at developing streamlined Risk Prediction Models (Arturo RPMs) for identifying individuals at higher risk …
View article: FRIDA: A Four-Factor Adaptive Screening Tool for Demoralization, Anxiety, Irritability, and Depression in Hospital Patients
FRIDA: A Four-Factor Adaptive Screening Tool for Demoralization, Anxiety, Irritability, and Depression in Hospital Patients Open
Background: Demoralization, anxiety, irritability, and depression are common among hospital patients and are associated with poorer outcomes and greater healthcare burden. Early identification is essential, but simultaneous screening acros…
View article: Development and Piloting of Co.Ge.: A Web-Based Digital Platform for Generative and Clinical Cognitive Assessment
Development and Piloting of Co.Ge.: A Web-Based Digital Platform for Generative and Clinical Cognitive Assessment Open
Background/Objectives: This study presents Co.Ge. a Cognitive Generative digital platform for cognitive testing. We describe its architecture and report a pilot study. Methods: Co.Ge. is modular and web-based (Laravel-PHP, MySQL). It can b…
View article: Suicide risk in patients undergoing hemodialysis: a systematic review and meta-analysis of prevalence
Suicide risk in patients undergoing hemodialysis: a systematic review and meta-analysis of prevalence Open
The present systematic review and meta-analysis is a pioneering effort to identify the prevalence of suicide risk in patients on dialysis. It revealed a significant prevalence of suicide risk among hemodialysis patients, with a rate notabl…
View article: The association between cannabis use and paranoia: Meta-analysis of experimental and observational studies
The association between cannabis use and paranoia: Meta-analysis of experimental and observational studies Open
Paranoia is common and has negative implications at clinical and societal levels. Cannabis may cause paranoia, although conflicting evidence exists. We reviewed studies on the association between cannabinoid use and paranoid symptoms. PubM…
View article: Psycho-oncology as a specialty and the certification of the psycho-oncologist as a profession
Psycho-oncology as a specialty and the certification of the psycho-oncologist as a profession Open
Decades of research has confirmed that good quality comprehensive cancer care must have psycho-oncology included as an essential component of the clinical team. There are, however, issues that should be considered. First, although a number…
View article: The impact of socioeconomic factors on the incidence and characteristics of first-episode psychosis
The impact of socioeconomic factors on the incidence and characteristics of first-episode psychosis Open
Aim The environment shapes the risk of psychosis. In particular, urbanicity, deprivation or inequality, migrant density and cannabis availability may not only influence psychosis incidence, but also the characteristics of individuals who a…
View article: Reacting to Demoralization and Investigating the Experience of Dignity in Psychosis: Reflections from an Acute Psychiatric Ward
Reacting to Demoralization and Investigating the Experience of Dignity in Psychosis: Reflections from an Acute Psychiatric Ward Open
Psychotic disorders are extremely challenging for individuals and their loved ones. The experience of psychosis, as is found in schizophrenia, may subvert the foundations of the individual’s relationship with the world. Irrespective of the…
View article: Preserving Dignity and Epistemic Justice in Palliative Care for Patients with Serious Mental Health Problems
Preserving Dignity and Epistemic Justice in Palliative Care for Patients with Serious Mental Health Problems Open
Dignity and preservation of dignity have emerged as a central and mandatory aim to pursue in all the areas of medicine, including palliative care. People with severe mental disorders (SMI) who are at the end of life pose further challenges…
View article: The pleural gradient does not reflect the superimposed pressure in patients with class III obesity
The pleural gradient does not reflect the superimposed pressure in patients with class III obesity Open
In patients with class III obesity, the superimposed pressure does not approximate the pleural pressure gradient, which is higher than in patients with lower BMI. The quantity and distribution of subcutaneous and intrathoracic adiposity al…
View article: A case report of a probable drug-induced liver injury after therapy remodulation with lamotrigine, quetiapine and sertraline in an adult female with recurrent major depression using the updated RUCAM score
A case report of a probable drug-induced liver injury after therapy remodulation with lamotrigine, quetiapine and sertraline in an adult female with recurrent major depression using the updated RUCAM score Open
Background: Drug-induced Liver Injury (DILI) is a common cause of acute liver injury and can be induced by several drugs. Lamotrigine, an antiepileptic drug, and quetiapine are used also as mood stabilizer medications and both have been re…
View article: Maladaptive coping styles moderate the relationship between information on cancer treatment and psychosocial symptoms: an Italian multicenter study
Maladaptive coping styles moderate the relationship between information on cancer treatment and psychosocial symptoms: an Italian multicenter study Open
Objectives Disclosing information on diagnosis, prognosis and treatment is a delicate process in oncology, although awareness levels have over time increased in people with cancer. However, individual characteristics should be considered w…
View article: Communication and support of patients and caregivers in chronic cancer care: ESMO Clinical Practice Guideline
Communication and support of patients and caregivers in chronic cancer care: ESMO Clinical Practice Guideline Open
• ESMO Clinical Practice Guideline with key recommendations for communication and support of cancer patients and caregivers. • The guideline discusses training in communication of oncology clinicians and research on communication in cancer…
View article: First episode psychoses in people over-35 years old: uncovering potential actionable targets for early intervention services
First episode psychoses in people over-35 years old: uncovering potential actionable targets for early intervention services Open
The traditional youth-oriented design of Early Intervention Services (EIS) may lead to the exclusion of patients who have their psychotic onset later in life. A retrospective study was conducted to compare first-episode psychosis (FEP) pat…
View article: Dignity in Medicine: Definition, Assessment and Therapy
Dignity in Medicine: Definition, Assessment and Therapy Open
Purpose of Review Over the last 20 years, dignity and dignity-conserving care have become the center of investigation, in many areas of medicine, including palliative care, oncology, neurology, geriatrics, and psychiatry. We summarized pee…
View article: The Italian adaptation of the <scp>Mini‐SIPS</scp>, a tool for early detection of individuals at clinical high risk and first episode of psychosis: A preliminary study of implementation in an Italian <scp>FEP</scp> program
The Italian adaptation of the <span>Mini‐SIPS</span>, a tool for early detection of individuals at clinical high risk and first episode of psychosis: A preliminary study of implementation in an Italian <span>FEP</span> program Open
Aims The study aims are to present the Italian adaptation of the Abbreviated Clinical Structured Interview for DSM‐5 Attenuated Psychosis Syndrome (Mini‐SIPS) and illustrate its implementation in a clinical setting. Methods The Mini‐SIPS w…
View article: Tolerability of vortioxetine compared to selective serotonin reuptake inhibitors in older adults with major depressive disorder (VESPA): a randomised, assessor-blinded and statistician-blinded, multicentre, superiority trial
Tolerability of vortioxetine compared to selective serotonin reuptake inhibitors in older adults with major depressive disorder (VESPA): a randomised, assessor-blinded and statistician-blinded, multicentre, superiority trial Open
The study was funded by the Italian Medicines Agency within the "2016 Call for Independent Drug Research".
View article: Effects of electroconvulsive therapy on cortical thickness in depression: a systematic review
Effects of electroconvulsive therapy on cortical thickness in depression: a systematic review Open
Objective: Electroconvulsive therapy (ECT) is one of the most studied and validated available treatments for severe or treatment-resistant depression. However, little is known about the neural mechanisms underlying ECT. This systematic rev…
View article: Action prediction in psychosis
Action prediction in psychosis Open
Aberrant motor-sensory predictive functions have been linked to symptoms of psychosis, particularly reduced attenuation of self-generated sensations and misattribution of self-generated actions. Building on the parallels between prediction…
View article: Establishment of a Public Mental Health Database for Research Purposes in the Ferrara Province: Development and Preliminary Evaluation Study
Establishment of a Public Mental Health Database for Research Purposes in the Ferrara Province: Development and Preliminary Evaluation Study Open
Background The immediate use of data exported from electronic health records (EHRs) for research is often limited by the necessity to transform data elements into an actual data set. Objective This paper describes the methodology for estab…
View article: Illness Management and Recovery (IMR): Implementation in an Italian Department of Mental Health and Pathological Addictions
Illness Management and Recovery (IMR): Implementation in an Italian Department of Mental Health and Pathological Addictions Open
Illness Management and Recovery (IMR) is a manualized psychosocial intervention developed to guide patients towards their recovery. This study presents the implementation of IMR within the Integrated Department of Mental Health and Patholo…
View article: Psychosocial determinants of healthcare use costs in kidney transplant recipients
Psychosocial determinants of healthcare use costs in kidney transplant recipients Open
Introduction Psychosocial factors frequently occur in kidney transplant recipients (KTRs), leading to behavioral alterations and reduced therapeutic adherence. However, the burden of psychosocial disorders on costs for KTRs is unknown. The…
View article: Linguistic markers of demoralization improvement in schizophrenia: A pilot study
Linguistic markers of demoralization improvement in schizophrenia: A pilot study Open
Background and objectives: Individuals with schizophrenia display language impairments involving pragmatics, semantics and syntax. Language impairments may show diagnostic specificity and could relate to the ability of engaging in psychoth…