Laura D Howe
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View article: What does "housebound" mean? Mixed methods study to develop a consensus definition
What does "housebound" mean? Mixed methods study to develop a consensus definition Open
Background Housebound patients are an under-researched group who face challenges accessing primary healthcare and have complex needs. There is no consensus definition of housebound, hindering research. Aim To develop a definition of houseb…
View article: Data Note: Social role transitions (further/higher education, employment, living situation, parenthood, and being a carer) in the G1s of the Avon Longitudinal Study of Parents and Children (ALSPAC)
Data Note: Social role transitions (further/higher education, employment, living situation, parenthood, and being a carer) in the G1s of the Avon Longitudinal Study of Parents and Children (ALSPAC) Open
Background Social roles common to adulthood (e.g. employment, parenthood) and their timing and combinations have been shown to relate to health. However, there is a lack of contemporary data to study complex patterns. We applied a pragmati…
View article: The use of Mendelian randomization to explore the causal consequences of childhood maltreatment: consideration of assumptions and challenges
The use of Mendelian randomization to explore the causal consequences of childhood maltreatment: consideration of assumptions and challenges Open
Mendelian randomization (MR) uses genetic variants as instrumental variables to enhance causal inference. Studies have identified genetic variants related to childhood maltreatment, but interpreting the effects of these variants or assessi…
View article: Weight and discrimination: evidence of intersectional effects from an ethnically diverse, UK general population survey
Weight and discrimination: evidence of intersectional effects from an ethnically diverse, UK general population survey Open
BackgroundWeight-related discrimination is widespread in society. Some US studies have suggested weight discrimination may differ between demographic groups, impacting White women more than minority women or men. However, stigma differs su…
View article: The socioeconomic trajectories followed during early adulthood contribute to inequalities in cardiometabolic health by age 24 years
The socioeconomic trajectories followed during early adulthood contribute to inequalities in cardiometabolic health by age 24 years Open
The newly identified 'Part-time Employment' trajectory showed the least healthy cardiometabolic profile. Further research should focus on this group to understand the exposures contributing to poor cardiometabolic health in this sector of …
View article: T91. CHILDHOOD MALTREATMENT AND MENTAL HEALTH PROBLEMS: A GENETICALLY INFORMED APPROACH FROM AN ADMIXED POPULATION
T91. CHILDHOOD MALTREATMENT AND MENTAL HEALTH PROBLEMS: A GENETICALLY INFORMED APPROACH FROM AN ADMIXED POPULATION Open
View article: Assessing the causal and independent impact of parity-related reproductive factors on risk of breast cancer subtypes
Assessing the causal and independent impact of parity-related reproductive factors on risk of breast cancer subtypes Open
View article: Infection and telomere length: A systematic review
Infection and telomere length: A systematic review Open
Background Infections may increase the risk of age-related diseases such as dementia. Accelerated immunological ageing, measurable by telomere length (TL), may be a potential mechanism. However, the relationship between different infection…
View article: Associations of adolescent menstrual symptoms with school absences and educational attainment: analysis of a prospective cohort study
Associations of adolescent menstrual symptoms with school absences and educational attainment: analysis of a prospective cohort study Open
Menstrual symptoms may negatively impact academic achievement, but rigorous population-based studies are lacking. 2,698 participants from the Avon Longitudinal Study of Parents and Children (ALSPAC) self-reported heavy or prolonged bleedin…
View article: Intergenerational educational mobility and mental health: Evidence from a Filipino birth cohort
Intergenerational educational mobility and mental health: Evidence from a Filipino birth cohort Open
Evidence suggests that associations between educational attainment and mental health may vary according to educational mobility (i.e., changes in educational attainment across generations). This evidence is largely limited to high-income c…
View article: Maternal social support and child developmental outcomes: an analysis of the Born in Bradford cohort
Maternal social support and child developmental outcomes: an analysis of the Born in Bradford cohort Open
Background Women lacking social support during pregnancy often have worse mental health, but we know little about the influence of social support on child development, or the impact for migrant women. We aimed to investigate the associatio…
View article: The association between adverse experiences throughout the life-course and risk of dementia in the English Longitudinal Study of Ageing
The association between adverse experiences throughout the life-course and risk of dementia in the English Longitudinal Study of Ageing Open
Introduction Studies investigating the association between adverse experiences across the life-course and dementia consider a narrow range of experiences and use sum scores, assuming each experience has the same impact on dementia risk. We…
View article: Adverse childhood experiences as a risk factor for depression-overweight comorbidity in adolescence and young adulthood
Adverse childhood experiences as a risk factor for depression-overweight comorbidity in adolescence and young adulthood Open
The comorbidity of depression and overweight is a manifestation of mental-physical multimorbidity, a marker of complex healthcare needs. We sought to examine how adverse childhood experiences (ACEs) are associated with depression-overweigh…
View article: The association between longitudinal patterns of adverse childhood experiences, and self-harm and depression in adolescence and early adulthood: findings from the Avon longitudinal study of parents and children
The association between longitudinal patterns of adverse childhood experiences, and self-harm and depression in adolescence and early adulthood: findings from the Avon longitudinal study of parents and children Open
Adverse childhood experiences (ACEs) elevate the risk of self-harm and depression, which are significant public health concerns. This study examined the association between the longitudinal co-occurrence patterns of ACEs across childhood a…
View article: Effects of alcohol consumption on employment and social outcomes: a Mendelian randomisation study
Effects of alcohol consumption on employment and social outcomes: a Mendelian randomisation study Open
Aims Alcohol consumption is associated with socioeconomic disadvantage, but causality is unclear. We used Mendelian randomisation (MR) to estimate the effect of alcohol consumption on socioeconomic and employment-related outcomes. Methods …
View article: The impact of parental intimate partner violence and abuse (IPVA) on young adult relationships: a UK general population cohort study
The impact of parental intimate partner violence and abuse (IPVA) on young adult relationships: a UK general population cohort study Open
View article: Life course trajectories of maternal cardiovascular disease risk factors by obstetric history: a UK cohort study using electronic health records
Life course trajectories of maternal cardiovascular disease risk factors by obstetric history: a UK cohort study using electronic health records Open
View article: Preterm Birth and Cardiometabolic Health Trajectories From Birth to Adulthood: The Avon Longitudinal Study of Parents and Children
Preterm Birth and Cardiometabolic Health Trajectories From Birth to Adulthood: The Avon Longitudinal Study of Parents and Children Open
Background Adults who were born prematurely (<37 weeks’ gestation) are at increased cardiovascular disease risk, but it is unclear when in the life course this risk emerges. Our aim was to compare trajectories of multiple cardiometabolic r…
View article: Adverse childhood experiences in firstborns and mental health risk and health-care use in siblings: a population-based birth cohort study of half a million children in England
Adverse childhood experiences in firstborns and mental health risk and health-care use in siblings: a population-based birth cohort study of half a million children in England Open
NIHR Policy Research Programme.
View article: Weight and discrimination: evidence of intersectional effects from an ethnically diverse, UK general population survey
Weight and discrimination: evidence of intersectional effects from an ethnically diverse, UK general population survey Open
BackgroundWeight-related discrimination is widespread in society. Some US studies have suggested weight discrimination may differ between demographic groups, impacting White women more than minority women or men. However, stigma differs su…
View article: Assessing the impact of paternal emigration on children ‘left-behind’—A cohort analysis
Assessing the impact of paternal emigration on children ‘left-behind’—A cohort analysis Open
View article: Data Note: Social role transitions (further/higher education, employment, living situation, parenthood, and being a carer) in the G1s of the Avon Longitudinal Study of Parents and Children (ALSPAC)
Data Note: Social role transitions (further/higher education, employment, living situation, parenthood, and being a carer) in the G1s of the Avon Longitudinal Study of Parents and Children (ALSPAC) Open
Background Social roles common to adulthood (e.g. employment, parenthood) and their timing and combinations have been shown to relate to health. However, there is a lack of contemporary data to study complex patterns. We applied a pragmati…
View article: The association between socioeconomic position and depression or suicidal ideation in low- and middle-income countries in Southeast Asia: a systematic review and meta-analysis
The association between socioeconomic position and depression or suicidal ideation in low- and middle-income countries in Southeast Asia: a systematic review and meta-analysis Open
View article: Exploring genetic confounding of the associations between excessive screen time and depressive symptoms in adolescence and early adulthood
Exploring genetic confounding of the associations between excessive screen time and depressive symptoms in adolescence and early adulthood Open
Background Digital devices have become a major aspect of children’s life. Associations between screen time and mental health have been observed, but the causality remains unclear. This study aimed to investigate the associations between ex…
View article: Demographic, socioeconomic and lifecourse risk-factors for internalized weight stigma
Demographic, socioeconomic and lifecourse risk-factors for internalized weight stigma Open
Background Obesity is highly stigmatized, with negative obesity-related stereotypes widespread across society. Internalized weight stigma (IWS) is linked to negative outcomes including poor mental health and disordered eating. Previous evi…
View article: Social inequalities in child mental health trajectories: a longitudinal study using birth cohort data 12 countries
Social inequalities in child mental health trajectories: a longitudinal study using birth cohort data 12 countries Open
View article: Early adulthood socioeconomic trajectories contribute to inequalities in adult diet quality, independent of childhood and adulthood socioeconomic position
Early adulthood socioeconomic trajectories contribute to inequalities in adult diet quality, independent of childhood and adulthood socioeconomic position Open
Background Diet is an important risk factor for cardiovascular disease and shows well-established socioeconomic patterning among adults. However, less clear is how socioeconomic inequalities in diet develop across the life course. This stu…
View article: Does maternal education moderate the relationship between adolescent cannabis use and mental health in early adulthood?
Does maternal education moderate the relationship between adolescent cannabis use and mental health in early adulthood? Open
Introduction Socioeconomic disadvantage has been associated with cannabis use and poor mental health. It is therefore hypothesised that lower maternal education, a proxy for socioeconomic disadvantage, may increase the risk of cannabis‐rel…
View article: The association between poverty and longitudinal patterns of adverse childhood experiences across childhood and adolescence: Findings from a prospective population-based cohort study in the UK
The association between poverty and longitudinal patterns of adverse childhood experiences across childhood and adolescence: Findings from a prospective population-based cohort study in the UK Open
A multifactorial approach to preventing ACEs is needed - including support for parents facing financial and material hardship, at-risk families, and timely interventions for those experiencing ACEs.
View article: How do socioeconomic trajectories experienced during early adulthood contribute to the development of cardiometabolic health in young adults?
How do socioeconomic trajectories experienced during early adulthood contribute to the development of cardiometabolic health in young adults? Open
Introduction Socioeconomic position has been strongly associated with cardiovascular health. However, little is known about the short-term health impacts of socioeconomic exposures during early adulthood. In this study we describe distinct…