Jiunn‐Liang Ko
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View article: <i>Ganoderma microsporum</i> Immunomodulatory Protein (GMI) Enhances Phagocytosis by Suppressing STAT3/CD47 Signaling in EGFR-Mutant NSCLC Resistant to Gefitinib and Osimertinib
<i>Ganoderma microsporum</i> Immunomodulatory Protein (GMI) Enhances Phagocytosis by Suppressing STAT3/CD47 Signaling in EGFR-Mutant NSCLC Resistant to Gefitinib and Osimertinib Open
View article: Fungal immunomodulatory protein FIP-fve mitigates airway inflammation and metabolic dysfunction in an obese allergic asthma model
Fungal immunomodulatory protein FIP-fve mitigates airway inflammation and metabolic dysfunction in an obese allergic asthma model Open
Obesity is a growing global health concern that exacerbates the risk and severity of allergic asthma, yet effective therapies and mechanistic understanding remain limited. This study investigates the therapeutic potential of Flammulina vel…
View article: Clinical Efficacy of Topical Ziyun Ointment in Improving Skin Hydration and Reducing Transepidermal Water Loss in Psoriasis
Clinical Efficacy of Topical Ziyun Ointment in Improving Skin Hydration and Reducing Transepidermal Water Loss in Psoriasis Open
Ziyun Ointment retains the hydration in the skin and reduces the loss of moisture from the skin. We also suggest that Ziyun Ointment be used for at least 12 weeks to observe significant improvements. Ziyun Ointment has a physiological sign…
View article: The Protective Effects of <scp><i>Lactobacillus reuteri</i></scp> Combined With <scp><i>Clostridium butyricum</i></scp> Miyairi 588 on Intestinal Barrier Function, Water Transport, and Oxidative Stress in a Rat Model of <scp>5FU</scp>‐Induced Diarrhea
The Protective Effects of <span><i>Lactobacillus reuteri</i></span> Combined With <span><i>Clostridium butyricum</i></span> Miyairi 588 on Intestinal Barrier Function, Water Transport, and Oxidative Stress in a Rat Model of <span>5FU</span>‐Induced Diarrhea Open
5‐Fluorouracil (5FU) is a commonly employed and highly effective chemotherapeutic agent in clinical oncology. Nevertheless, one of the most frequent and debilitating adverse effects associated with 5FU treatment is diarrhea. These gastroin…
View article: Cyanidin 3-O glucoside Ameliorate Nickel Chloride-induced VEGF and Interleukin-8 in Retinal Pigment Epithelial Cells
Cyanidin 3-O glucoside Ameliorate Nickel Chloride-induced VEGF and Interleukin-8 in Retinal Pigment Epithelial Cells Open
The mechanisms of age-related macular degeneration (AMD) are complex and challenging to treat. Clinically, it is classified into two types: dry and wet. Typically, oxidative stress, inflammation, or angiogenesis are key pathogenic factors.…
View article: Targeted inhibition of integrin αVβ3 induces cytotoxicity and suppresses migration ability in ovarian cancer cells and tumor spheroids
Targeted inhibition of integrin αVβ3 induces cytotoxicity and suppresses migration ability in ovarian cancer cells and tumor spheroids Open
Ovarian cancer is a gynecological malignancy that has poor prognosis and high lethality. Integrin αVβ3 is highly expressed in solid cancer cells, including ovarian cancer, and is important in proliferation and cell migration. In this study…
View article: Butyrate modulates gut microbiota and anti-inflammatory response in attenuating cisplatin-induced kidney injury
Butyrate modulates gut microbiota and anti-inflammatory response in attenuating cisplatin-induced kidney injury Open
In our previous research, we reported that administering probiotics Lactobacillus reuteri and Clostridium butyricum (LCs) before cisplatin treatment effectively modifies structures of the gut microbiota and restore ecological balance and s…
View article: Genistein inhibited endocytosis and fibrogenesis in keloid via CTGF signaling pathways
Genistein inhibited endocytosis and fibrogenesis in keloid via CTGF signaling pathways Open
View article: Genistein inhibited endocytosis and fibrogenesis in transforming growth factor-β1-stimulated keloid via CTGF signaling pathways
Genistein inhibited endocytosis and fibrogenesis in transforming growth factor-β1-stimulated keloid via CTGF signaling pathways Open
Background: This study aimed to evaluate soy isoflavones' effect and potential use—specifically genistein—in treating human keloid fibroblast cell lines (KFs) and in a keloid tissue culture model. Methods: to investigate the effects of gen…
View article: β‐catenin inhibitor ICG‐001 suppress cell cycle progression and induce autophagy in endometrial cancer cells
β‐catenin inhibitor ICG‐001 suppress cell cycle progression and induce autophagy in endometrial cancer cells Open
The incidence of endometrial cancer has been rising in recent years. Gene mutation and high protein expression of β‐catenin are commonly detected in endometrioid endometrial cancer. ICG‐001 is a β‐catenin inhibitor via blocking the complex…
View article: Experiences in reverse sequence esophagectomy: a promising alternative for esophageal cancer surgery
Experiences in reverse sequence esophagectomy: a promising alternative for esophageal cancer surgery Open
View article: Polysaccharide of Ganoderma lucidum Ameliorates Cachectic Myopathy Induced by the Combination Cisplatin plus Docetaxel in Mice
Polysaccharide of Ganoderma lucidum Ameliorates Cachectic Myopathy Induced by the Combination Cisplatin plus Docetaxel in Mice Open
Cachexia is a multifactorial syndrome driven by metabolic dysregulation, anorexia, systemic inflammation, and insulin resistance. Approximately 80% of patients with advanced cancer have cachexia, and cachexia is the cause of death in 30% o…
View article: Supplementary Methods from Glutathione <i>S</i>-Transferase Mu2 Suppresses Cancer Cell Metastasis in Non–Small Cell Lung Cancer
Supplementary Methods from Glutathione <i>S</i>-Transferase Mu2 Suppresses Cancer Cell Metastasis in Non–Small Cell Lung Cancer Open
PDF file - 154K
View article: Data from Glutathione <i>S</i>-Transferase Mu2 Suppresses Cancer Cell Metastasis in Non–Small Cell Lung Cancer
Data from Glutathione <i>S</i>-Transferase Mu2 Suppresses Cancer Cell Metastasis in Non–Small Cell Lung Cancer Open
Glutathione S-transferase mu2 (GST-M2) is a phase II detoxification enzyme. Low expression of GST-M2 in lung cancers is due to hypermethylation of its promoter. Lung cancer with the GST mu-null genotype is associated with shorter su…
View article: Supplementary Figure Legend from Glutathione <i>S</i>-Transferase Mu2 Suppresses Cancer Cell Metastasis in Non–Small Cell Lung Cancer
Supplementary Figure Legend from Glutathione <i>S</i>-Transferase Mu2 Suppresses Cancer Cell Metastasis in Non–Small Cell Lung Cancer Open
PDF file - 81K
View article: Supplementary Methods from Glutathione <i>S</i>-Transferase Mu2 Suppresses Cancer Cell Metastasis in Non–Small Cell Lung Cancer
Supplementary Methods from Glutathione <i>S</i>-Transferase Mu2 Suppresses Cancer Cell Metastasis in Non–Small Cell Lung Cancer Open
PDF file - 154K
View article: Supplementary Figure 1 from Glutathione <i>S</i>-Transferase Mu2 Suppresses Cancer Cell Metastasis in Non–Small Cell Lung Cancer
Supplementary Figure 1 from Glutathione <i>S</i>-Transferase Mu2 Suppresses Cancer Cell Metastasis in Non–Small Cell Lung Cancer Open
PDF file - 636K, Supplementary Figure 1. Expression was analyzed by RT-PCR of total RNA (2 μg) amplified by RT-PCR.
View article: Supplementary Figure 1 from Glutathione <i>S</i>-Transferase Mu2 Suppresses Cancer Cell Metastasis in Non–Small Cell Lung Cancer
Supplementary Figure 1 from Glutathione <i>S</i>-Transferase Mu2 Suppresses Cancer Cell Metastasis in Non–Small Cell Lung Cancer Open
PDF file - 636K, Supplementary Figure 1. Expression was analyzed by RT-PCR of total RNA (2 μg) amplified by RT-PCR.
View article: Supplementary Figure Legend from Glutathione <i>S</i>-Transferase Mu2 Suppresses Cancer Cell Metastasis in Non–Small Cell Lung Cancer
Supplementary Figure Legend from Glutathione <i>S</i>-Transferase Mu2 Suppresses Cancer Cell Metastasis in Non–Small Cell Lung Cancer Open
PDF file - 81K
View article: Data from Glutathione <i>S</i>-Transferase Mu2 Suppresses Cancer Cell Metastasis in Non–Small Cell Lung Cancer
Data from Glutathione <i>S</i>-Transferase Mu2 Suppresses Cancer Cell Metastasis in Non–Small Cell Lung Cancer Open
Glutathione S-transferase mu2 (GST-M2) is a phase II detoxification enzyme. Low expression of GST-M2 in lung cancers is due to hypermethylation of its promoter. Lung cancer with the GST mu-null genotype is associated with shorter su…
View article: AGR2 expression as a predictive biomarker for therapy response in esophageal squamous cell carcinoma
AGR2 expression as a predictive biomarker for therapy response in esophageal squamous cell carcinoma Open
Despite multidisciplinary therapy, the prognosis is poor for esophageal squamous cell carcinoma (ESCC). In the locally advanced stage, neoadjuvant chemoradiotherapy (nCRT) followed by surgery could provide survival benefits to some patient…
View article: Chloroquine alleviates the heat-induced to injure via autophagy and apoptosis mechanisms in skin cell and mouse models
Chloroquine alleviates the heat-induced to injure via autophagy and apoptosis mechanisms in skin cell and mouse models Open
Burns can cause cell death and irreversible tissue damage. We examined the pathway of human dermis fibroblasts cell death caused by skin burns and the roles of chloroquine in human skin keratinocytes HaCaT wound healing. Western blot assay…
View article: Worsening Quality of Life in Young Adult, Highly Educated, and Married Female Patients with Vitiligo: A Hospital-Based Case Control Study in Taiwan
Worsening Quality of Life in Young Adult, Highly Educated, and Married Female Patients with Vitiligo: A Hospital-Based Case Control Study in Taiwan Open
Vitiligo is an acquired chronic depigmentation disorder that can have a negative impact on the quality of life (QoL). This is especially true for patients with non-white skin. Only few studies have investigated the QoL of Asian patients wi…
View article: Effect of combination treatment with Lactobacillus rhamnosus and corticosteroid in reducing airway inflammation in a mouse asthma model
Effect of combination treatment with Lactobacillus rhamnosus and corticosteroid in reducing airway inflammation in a mouse asthma model Open
View article: Integrated OMICs Approach for the Group 1 Protease Mite-Allergen of House Dust Mite Dermatophagoides microceras
Integrated OMICs Approach for the Group 1 Protease Mite-Allergen of House Dust Mite Dermatophagoides microceras Open
House dust mites (HDMs) are one of the most important allergy-causing agents of asthma. In central Taiwan, the prevalence of sensitization to Dermatophagoides microceras (Der m), a particular mite species of HDMs, is approximately 80% and …
View article: Genistein protects against ultraviolet B–induced wrinkling and photoinflammation in in vitro and in vivo models
Genistein protects against ultraviolet B–induced wrinkling and photoinflammation in in vitro and in vivo models Open
View article: Systematic Characterization of the Group 2 House Dust Mite Allergen in Dermatophagoides microceras
Systematic Characterization of the Group 2 House Dust Mite Allergen in Dermatophagoides microceras Open
Background Allergic asthma, a chronic airway inflammatory disease, is a critical public health problem. Indoor house dust mites (HDMs) could cause allergic asthma. The prevalence of sensitization to Dermatophagoides microceras ( Der m ) wa…
View article: Pilot production of a sensitive ELISA kit and an immunochromatographic strip for rapid detecting citrinin in fermented rice
Pilot production of a sensitive ELISA kit and an immunochromatographic strip for rapid detecting citrinin in fermented rice Open
Rapid detection of citrinin in red yeast fermented products with ELISA kit and immunostrip and confirmed with HPLC.
View article: Early Bronchiolitis Contributes to Preschool Asthma
Early Bronchiolitis Contributes to Preschool Asthma Open
This study aims to analyze whether bronchiolitis in children younger than one-year-old contributes to subsequent asthma. Medical data were retrieved from the National Health Insurance Research Database of Taiwan. Participants were divided …
View article: Plasma Endoglin is Associated with Favorable Outcome for Pemetrexed-Based Therapy in Advanced Non-Small Cell Lung Cancer
Plasma Endoglin is Associated with Favorable Outcome for Pemetrexed-Based Therapy in Advanced Non-Small Cell Lung Cancer Open
Che-Hsing Li,1,2,* Jiunn-Liang Ko,1,3,4,* Yu-Ping Hsiao,5,6 Ming-Hung Tsai,7 Yen-Chein Lai,8 I-Lun Hsin,3,4 Yu-Ting Kang,3,4 Gwo-Tarng Sheu,1,3,4 Wea-Lung Lin,6,9 Ming-Fang Wu1,4,6 1Divisions of Medical Oncology and Pulmona…