Ludger Klimek
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View article: Allergic Rhinitis and Its Impact on Asthma ( <scp>ARIA</scp> )‐ <scp>EAACI</scp> Guidelines—2024–2025 Revision: Part I—Guidelines on Intranasal Treatments
Allergic Rhinitis and Its Impact on Asthma ( <span>ARIA</span> )‐ <span>EAACI</span> Guidelines—2024–2025 Revision: Part I—Guidelines on Intranasal Treatments Open
Background Allergic rhinitis (AR) impacts quality of life, work and school productivity. Over the last years, an important body of evidence resulting from mHealth data has led to a better understanding of AR. Such advances have motivated a…
View article: Methodology for the Development of the Allergic Rhinitis and Its Impact on Asthma ( <scp>ARIA</scp> )‐EAACI 2024–2025 Guidelines: From Evidence‐to‐Decision Frameworks to Digitalised Shared Decision‐Making Algorithms
Methodology for the Development of the Allergic Rhinitis and Its Impact on Asthma ( <span>ARIA</span> )‐EAACI 2024–2025 Guidelines: From Evidence‐to‐Decision Frameworks to Digitalised Shared Decision‐Making Algorithms Open
The Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines produced their first edition in 1999, with subsequent revisions in 2008, 2010, 2016 and 2019. A new iteration of ARIA—ARIA 2024–2025—in collaboration with EAACI is currently …
View article: Expert Opinion: A Call for Early and Appropriate Symptomatic Treatment in Acute Respiratory Infections to Prevent Escalation
Expert Opinion: A Call for Early and Appropriate Symptomatic Treatment in Acute Respiratory Infections to Prevent Escalation Open
Acute respiratory infections are highly prevalent and significantly impair quality of life and productivity. Despite their impact, they are often not managed according to best medical practice. A lack of knowledge about symptomatic therapi…
View article: Update on the Nasal Polyp Score
Update on the Nasal Polyp Score Open
View article: Comparison of Allergic Rhinitis Treatments on Patient Satisfaction: A <scp>MASK</scp> ‐air and <scp>EAACI</scp> Methodological Committee Report
Comparison of Allergic Rhinitis Treatments on Patient Satisfaction: A <span>MASK</span> ‐air and <span>EAACI</span> Methodological Committee Report Open
Introduction Satisfaction with treatments may affect medication adherence and use patterns, including the use of co‐medication. We aimed to compare different medications for allergic rhinitis (AR) on (i) patients' satisfaction and (ii) co‐…
View article: Multiomics approach to evaluating personalized biomarkers of allergen immunotherapy
Multiomics approach to evaluating personalized biomarkers of allergen immunotherapy Open
View article: Daily digital biomarkers in the follow-up and clustering of patients with asthma
Daily digital biomarkers in the follow-up and clustering of patients with asthma Open
Levels of digital biomarkers reflect asthma control patterns and might be used to monitor patients with asthma.
View article: Alert Card for Patients on Biologicals and Immunosuppressives: An <scp>EAACI</scp> Position Paper
Alert Card for Patients on Biologicals and Immunosuppressives: An <span>EAACI</span> Position Paper Open
the EAACI Working Group on Biologicals developed a compact, customizable, wallet- friendly PAC, con- taining concise information for patients and medical staff, treatment details, travel certificate, and physician or hospital contacts
View article: Consensus from European experts on severe eosinophilic asthma and chronic rhinosinusitis with nasal polyps: Results from the OverSEA Delphi study
Consensus from European experts on severe eosinophilic asthma and chronic rhinosinusitis with nasal polyps: Results from the OverSEA Delphi study Open
The OverSEA study is the largest European initiative providing recommendations for optimizing the management of patients with SEA and comorbid CRSwNP. It underscores the importance of evaluating patients with SEA for comorbid upper airways…
View article: Multi-centric real-world effectiveness of mepolizumab in severe chronic rhinosinusitis with nasal polyps in Germany
Multi-centric real-world effectiveness of mepolizumab in severe chronic rhinosinusitis with nasal polyps in Germany Open
Background: Within the last years, monoclonal antibodies (biologicals) have revolutionized the treatment of chronic rhinosinusitis with nasal polyps (CRSwNP) and significantly improved symptom control in otherwise refractory cases. The eff…
View article: S2k-Leitlinie Fachärztliche Diagnostik und Therapie von erwachsenen Patienten mit Husten
S2k-Leitlinie Fachärztliche Diagnostik und Therapie von erwachsenen Patienten mit Husten Open
Zusammenfassung Die vorliegende 4. Ausgabe der deutschen fachärztlichen S2k-Leitlinie wurde im Auftrag der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin unter Teilnahme von – durch die jeweiligen Gesellschaften akkreditierten…
View article: Otitis Media With Effusion (<scp>OME</scp>) and Eustachian Tube Dysfunction: The Role of Allergy and Immunity—An <scp>EAACI</scp> Position Paper
Otitis Media With Effusion (<span>OME</span>) and Eustachian Tube Dysfunction: The Role of Allergy and Immunity—An <span>EAACI</span> Position Paper Open
IgE‐mediated allergies play a significant role in respiratory diseases. Given the similar mucosal epithelium of the upper and lower respiratory tracts and their shared (patho)physiological immune responses, the “unified airways” concept vi…
View article: WAO - ARIA consensus on chronic cough: Executive summary
WAO - ARIA consensus on chronic cough: Executive summary Open
View article: Adherence to Treatment in Allergic Rhinitis During the Pollen Season in Europe: A MASK‐air Study
Adherence to Treatment in Allergic Rhinitis During the Pollen Season in Europe: A MASK‐air Study Open
Background Adherence to rhinitis treatment has been insufficiently assessed. We aimed to use data from the MASK‐air mHealth app to assess adherence to oral antihistamines (OAH), intra‐nasal corticosteroids (INCS) or azelastine‐fluticasone …
View article: Six Injections of Modified Adjuvanted <scp>PQ</scp> Grass Is Effective and Well‐Tolerated in a Pivotal Phase <scp>III</scp> Trial
Six Injections of Modified Adjuvanted <span>PQ</span> Grass Is Effective and Well‐Tolerated in a Pivotal Phase <span>III</span> Trial Open
Background PQ Grass 27600 SU (PQ Grass) cumulative dose is a pre‐seasonal, six‐injection, aluminium‐free, modified subcutaneous immunotherapy product under development for the treatment of allergic rhinitis (AR). A pivotal Phase III random…
View article: Allergic Rhinitis and its Impact on Asthma (ARIA) Classes in MASK-air Users
Allergic Rhinitis and its Impact on Asthma (ARIA) Classes in MASK-air Users Open
Background: The Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines classify rhinitis as "intermittent" or "persistent" and "mild" or "moderate-severe". Objectives: To assess ARIA classes in a real-world study in terms of phenotyp…
View article: Determination of the Bioavailability of 3 Intranasal Formulations of Azelastine Hydrochloride in Healthy Male Volunteers
Determination of the Bioavailability of 3 Intranasal Formulations of Azelastine Hydrochloride in Healthy Male Volunteers Open
The primary objective of the study was to determine the bioavailability of 2 new formulations of azelastine (AZE) hydrochloride (0.10% and 0.15% AZE) containing sorbitol and sucralose compared with the commercially available 0.10% AZE. Thi…
View article: Pivotal role of the optimal dose in allergen immunotherapy
Pivotal role of the optimal dose in allergen immunotherapy Open
The transitioning of named patient products (NPPs) of therapy allergens is regulated under the German therapy allergen ordinance (TAO) since 2008. The establishment of a sound dose–response relationship constitutes a pivotal aspect in clin…
View article: In perennial allergic rhinitis, RQLQ is improved similarly by Azelastine 0.15 and mometasone furoate
In perennial allergic rhinitis, RQLQ is improved similarly by Azelastine 0.15 and mometasone furoate Open
View article: Double-blind, placebo-controlled trial of the efficacy and safety of azelastine hydrochloride in children with perennial allergic rhinitis
Double-blind, placebo-controlled trial of the efficacy and safety of azelastine hydrochloride in children with perennial allergic rhinitis Open
Background: Allergic rhinitis (AR) affects up to 40% of the pediatric population. The US practice parameter recommends the use of INAH or INCS as first-line therapy for the treatment of AR. Although not directly targeted to children, the r…
View article: Antibiotics Usage and Avoidance in Germany and Poland: Attitudes and Knowledge of Patients, Physicians, and Pharmacists
Antibiotics Usage and Avoidance in Germany and Poland: Attitudes and Knowledge of Patients, Physicians, and Pharmacists Open
Introduction: Antimicrobial resistance poses a significant global health threat, partly due to the overprescription of antibiotics. Understanding prescribers’ behaviors and identifying knowledge gaps and misconceptions are essential for ad…
View article: Endotyping in Chronic Rhinosinusitis—An <scp>EAACI</scp> Task Force Report
Endotyping in Chronic Rhinosinusitis—An <span>EAACI</span> Task Force Report Open
Chronic rhinosinusitis (CRS) is a clinical syndrome defined by typical sinonasal symptoms persisting for at least 12 weeks. CRS is divided into two distinct phenotypes, CRS with nasal polyps (CRSwNP) and without (CRSsNP). The aim of the re…
View article: Multiomics approaches disclose very-early molecular and cellular switches during insect-venom allergen-specific immunotherapy: an observational study
Multiomics approaches disclose very-early molecular and cellular switches during insect-venom allergen-specific immunotherapy: an observational study Open
Allergen-specific immunotherapy (AIT) induces immune tolerance, showing the highest success rate (>95%) for insect venom while a much lower chance for pollen allergy. However, the molecular switches leading to successful durable tolerance …
View article: One‐strength dose escalation of house dust mite depot product for subcutaneous immunotherapy is safe and tolerable
One‐strength dose escalation of house dust mite depot product for subcutaneous immunotherapy is safe and tolerable Open
Background Allergen immunotherapy (AIT) aims at modulating the immune response by administration of allergen preparations at regular intervals over several years (1). For subcutaneous AIT (SCIT), the treatment is initiated with a dose esca…
View article: Short‐course subcutaneous treatment with birch pollen allergoids greatly improves symptom and medication scores in birch allergy
Short‐course subcutaneous treatment with birch pollen allergoids greatly improves symptom and medication scores in birch allergy Open
Background Subcutaneous immunotherapy has emerged as an effective option for treating allergic diseases. Here, we assessed the clinical impact of the mannan‐conjugated birch pollen polymerized allergoid T502 in birch pollen‐induced allergi…
View article: IgE immunoadsorption: technical background, functionality, and first clinical experience
IgE immunoadsorption: technical background, functionality, and first clinical experience Open
Summary Background The prevalence of allergic diseases has risen in the 21st century, drawing attention to specific therapeutic and preventive strategies. Due to the key role of immunoglobulin E (IgE) in the development of allergic reactio…
View article: Discharge management after anaphylaxis
Discharge management after anaphylaxis Open
People who have suffered from anaphylaxis often experience far-reaching consequences in everyday life. Unfortunately, discharge management after successful acute treatment is often still inadequate. In order to prevent further reactions in…
View article: Peak nasal inspiratory flow assessment of polyp size and response from SYNAPSE
Peak nasal inspiratory flow assessment of polyp size and response from SYNAPSE Open
View article: Real‐world data show sustained therapeutic effects of dupilumab in chronic rhinosinusitis with nasal polyps (<scp>CRSwNP</scp>) over 3 years
Real‐world data show sustained therapeutic effects of dupilumab in chronic rhinosinusitis with nasal polyps (<span>CRSwNP</span>) over 3 years Open
Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is a prevalent chronic inflammatory condition affecting the nose and paranasal sinuses, posing a significant socio‐economic impact with substantial challenges in management. Biol…
View article: Physician’s perspectives on skin prick testing and allergy diagnostics in Germany
Physician’s perspectives on skin prick testing and allergy diagnostics in Germany Open
Summary Purpose Novel technologies standardising the testing process of immediate hypersensitivities have been developed and validated in recent years. Meanwhile, challenges with regard to availability of testing agents and shortage of tra…