Gitte M. Knudsen
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View article: Correction: Acute and long-term effects of psilocybin on energy balance and feeding behavior in mice
Correction: Acute and long-term effects of psilocybin on energy balance and feeding behavior in mice Open
View article: Psilocybin’s effect on human brain synaptic plasticity
Psilocybin’s effect on human brain synaptic plasticity Open
Psychedelics such as psilocybin have been linked to enhanced neuroplasticity and symptom relief in affective disorders, but the neurobiological mechanisms and impact of environmen-tal context remain unclear. Here, we tested whether a singl…
View article: Reduced ventromedial prefrontal cortex volume and impaired attention associated with past suicide attempts in patients with mood disorders
Reduced ventromedial prefrontal cortex volume and impaired attention associated with past suicide attempts in patients with mood disorders Open
Reduced vmPFC volume and deficits in attention may be associated with history of suicidal behaviors in patients with MD. These findings support previous research highlighting the role of vmPFC in suicidal behavior and suggest that there ma…
View article: Inter-individual variability of neurotransmitter receptor and transporter density in the human brain
Inter-individual variability of neurotransmitter receptor and transporter density in the human brain Open
Neurotransmitter receptors guide the propagation of signals between brain regions. Mapping receptor distributions in the brain is therefore necessary for understanding how neurotransmitter systems mediate the link between brain structure a…
View article: Preliminary First-in-Human Pharmacokinetic Evaluation, Dosimetry and Safety of 7-[<sup>18</sup>F]-Fluorotryptophan as PET Imaging Agent to Visualize Serotonin Synthesis in the Brain
Preliminary First-in-Human Pharmacokinetic Evaluation, Dosimetry and Safety of 7-[<sup>18</sup>F]-Fluorotryptophan as PET Imaging Agent to Visualize Serotonin Synthesis in the Brain Open
Tryptophan (Trp) is the precursor for serotonin synthesis and other biologically relevant metabolites. We evaluated the novel radiotracer 7-[ 18 F]Fluorotryptophan (7-[ 18 F]FTrp) to assess its biodistribution, dosimetry, and potential for…
View article: Longitudinal Trajectory of Cognition, Brain Morphometry, and Brain Predicted Age in Unaffected First‐Degree Relatives of Patients With Bipolar Disorder
Longitudinal Trajectory of Cognition, Brain Morphometry, and Brain Predicted Age in Unaffected First‐Degree Relatives of Patients With Bipolar Disorder Open
Introduction Prior research suggests structural brain abnormalities and cognitive difficulties in patients with bipolar disorder. Although there is some evidence that similar structural and cognitive changes may also be present in unaffect…
View article: Whole blood BDNF is lower in patients with depression and unchanged by escitalopram in patients and healthy controls
Whole blood BDNF is lower in patients with depression and unchanged by escitalopram in patients and healthy controls Open
wb-BDNF reflects the total blood BDNF pool and avoids platelet aggregation-related confounds seen in s-BDNF measures. wb-BDNF could be used as diagnosis but not as a prognosis biomarker, in MDD. Further research is needed to investigate ch…
View article: Neural Correlates of Cognitive Improvement After Virtual Reality‐Based Cognitive Remediation in Psychosis and Mood Disorders: A Randomized Controlled Trial
Neural Correlates of Cognitive Improvement After Virtual Reality‐Based Cognitive Remediation in Psychosis and Mood Disorders: A Randomized Controlled Trial Open
Introduction Cognitive impairment in mood disorders and schizophrenia spectrum disorders hampers patients' clinical and functional outcomes. A key challenge in pro‐cognitive treatment development is the limited insight into the underlying …
View article: Precision psychiatry roadmap: towards a biology-informed framework for mental disorders
Precision psychiatry roadmap: towards a biology-informed framework for mental disorders Open
The current classification systems for mental disorders provide a uniform symptom-based language to describe and diagnose mental disorders. Clinicians use these classifications to communicate with their patients and colleagues, to treat pa…
View article: Molecular, haemodynamic and functional effects of LSD in the human brain
Molecular, haemodynamic and functional effects of LSD in the human brain Open
In this study, we provide the first study to integrate molecular and functional neuroimaging during psychedelic drug effects in humans. Using simultaneous PET-MRI technology, we describe multiple brain actions of lysergic acid diethylamide…
View article: Network-wide aberrancies in neuronal activity during working memory in a large cohort of patients with mood disorders: associations with cognitive impairment and functional disability
Network-wide aberrancies in neuronal activity during working memory in a large cohort of patients with mood disorders: associations with cognitive impairment and functional disability Open
View article: Connecting the dots: approaching a standardized nomenclature for molecular connectivity in positron emission tomography
Connecting the dots: approaching a standardized nomenclature for molecular connectivity in positron emission tomography Open
Positron emission tomography (PET)-based connectivity analysis provides a molecular perspective that complements fMRI-derived functional connectivity. However, lack of standardized terminology and diverse methodologies in PET connectivity …
View article: Computational modelling and neural correlates of reinforcement learning following three-week escitalopram: a double-blind, placebo-controlled semi-randomised study
Computational modelling and neural correlates of reinforcement learning following three-week escitalopram: a double-blind, placebo-controlled semi-randomised study Open
View article: Pitfalls of mapping functional and molecular human brain imaging data from separate cohorts
Pitfalls of mapping functional and molecular human brain imaging data from separate cohorts Open
It has become increasingly common to probe correlations between human brain imaging measures of receptor/protein binding and function using population-level brain maps drawn from independent cohorts, estimating correlations across regions.…
View article: Aging predominates over an MFGM/EV-rich supplement in modulating the brain lipidome and cognitive decline of aged rats
Aging predominates over an MFGM/EV-rich supplement in modulating the brain lipidome and cognitive decline of aged rats Open
View article: Cigarette smoking is associated with levels of the serotonin transporter in the brain: a [11C]DASB PET Study
Cigarette smoking is associated with levels of the serotonin transporter in the brain: a [11C]DASB PET Study Open
Background Preclinical work suggests that chronic nicotine/tobacco use is associated with reductions in serotonin within the hippocampus, yet no research has yet shown an association of smoking behaviors and alterations in brain serotonin …
View article: Independent Evaluation of Deep Learning Models for Detecting Focal Cortical Dysplasia
Independent Evaluation of Deep Learning Models for Detecting Focal Cortical Dysplasia Open
Objective The objective of this study is to perform an independent assessment of the diagnostic utility of three state-of-the-art tools for the detection of focal cortical dysplasia (FCD) from Magnetic Resonance images (MRI). These tools i…
View article: Neuroanatomical dimensions in major depression: external validation and links with cognition, adverse life events, self-harm, metabolomics and genetics
Neuroanatomical dimensions in major depression: external validation and links with cognition, adverse life events, self-harm, metabolomics and genetics Open
Major depressive disorder (MDD) is a leading cause of disability worldwide, yet its diagnosis relies on clinical symptoms alone. Using machine learning applied to deeply phenotyped, medication-free participants with MDD, we identified two …
View article: Blood phosphatidylethanol measurements indicate <scp>GLP</scp>‐1 receptor stimulation causes delayed decreases in alcohol consumption
Blood phosphatidylethanol measurements indicate <span>GLP</span>‐1 receptor stimulation causes delayed decreases in alcohol consumption Open
Background The investigation of glucagon‐like peptide 1 (GLP‐1) receptor agonists (GLP‐1RA) as a potential treatment for individuals with alcohol use disorder (AUD) and obesity is currently underway. In this secondary analysis of a randomi…
View article: Acute psilocybin and ketanserin effects on cerebral blood flow: 5-HT2AR neuromodulation in healthy humans
Acute psilocybin and ketanserin effects on cerebral blood flow: 5-HT2AR neuromodulation in healthy humans Open
Psilocin, the active metabolite of psilocybin, is a psychedelic and agonist at the serotonin 2A receptor (5-HT2AR) that has shown positive therapeutic effects for brain disorders such as depression. To elucidate the brain effects of psiloc…
View article: Relation Between Brain Morphological Features and Psychiatric Hospitalization Risk in Major Depressive and Bipolar Disorders
Relation Between Brain Morphological Features and Psychiatric Hospitalization Risk in Major Depressive and Bipolar Disorders Open
Introduction Patients with mood disorders, especially, major depressive disorder (MDD) and bipolar disorder (BD), are at heightened risk of relapse and psychiatric rehospitalizations. Therefore, there is an urgent need to identify modifiab…
View article: Effects of GLP‐1 Receptor Agonists in Alcohol Use Disorder
Effects of GLP‐1 Receptor Agonists in Alcohol Use Disorder Open
In the search for novel treatment strategies for alcohol use disorder (AUD), glucagon‐like peptide‐1 (GLP‐1) receptor agonists (GLP‐1RAs) approved for treating Type 2 diabetes and obesity have caught much attention. GLP‐1 is a naturally oc…
View article: Multivariate patterns among multimodal neuroimaging and clinical, cognitive, and daily functioning characteristics in bipolar disorder
Multivariate patterns among multimodal neuroimaging and clinical, cognitive, and daily functioning characteristics in bipolar disorder Open
View article: Structure activity investigations of substituted quinazolines in the pursuit of a selective PDE1 PET ligand
Structure activity investigations of substituted quinazolines in the pursuit of a selective PDE1 PET ligand Open
View article: Poststroke Translocator Protein Expression Dynamics and Correlations to Chronic Infarction: A <sup>[123I]</sup> ‐CLINDE‐SPECT Study
Poststroke Translocator Protein Expression Dynamics and Correlations to Chronic Infarction: A <sup>[123I]</sup> ‐CLINDE‐SPECT Study Open
Background and Purpose This study aims to investigate the longitudinal changes in translocator protein (TSPO) following stroke in different brain regions and potential associations with chronic brain infarction. Methods Twelve patients und…
View article: Functional connectivity differences in patients with mood disorders: an exploratory fMRI study comparing electroconvulsive therapy with pharmacological treatment
Functional connectivity differences in patients with mood disorders: an exploratory fMRI study comparing electroconvulsive therapy with pharmacological treatment Open
Electroconvulsive therapy (ECT) has been shown to induce widespread dysregulation of network connectivity in patients with mood disorders. Nevertheless, the extent to which these functional changes contribute to patients’ cognitive side-ef…
View article: Sex hormones and serotonin 4 receptor brain binding in men with and without major depressive disorder
Sex hormones and serotonin 4 receptor brain binding in men with and without major depressive disorder Open
View article: Neuroinflammation and TSPO-Targeted Imaging Before and After Meningioma Surgery
Neuroinflammation and TSPO-Targeted Imaging Before and After Meningioma Surgery Open
View article: Development of β-arrestin biased positron emission tomography radioligands for the cerebral serotonin 2A receptor
Development of β-arrestin biased positron emission tomography radioligands for the cerebral serotonin 2A receptor Open
View article: Does semaglutide reduce alcohol intake in Danish patients with alcohol use disorder and comorbid obesity? Trial protocol of a randomised, double-blinded, placebo-controlled clinical trial (the SEMALCO trial)
Does semaglutide reduce alcohol intake in Danish patients with alcohol use disorder and comorbid obesity? Trial protocol of a randomised, double-blinded, placebo-controlled clinical trial (the SEMALCO trial) Open
Introduction Alcohol use disorder (AUD) is a massive burden for the individual, relatives and society. Despite this, the treatment gap is wide compared with other mental health disorders. Treatment options are sparse, with only three Food …