Li Ding
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View article: Longitudinal profiling of tumor and immune compartments uncovers patterns of dysregulation and associations with response in multiple myeloma
Longitudinal profiling of tumor and immune compartments uncovers patterns of dysregulation and associations with response in multiple myeloma Open
Multiple myeloma (MM) is a malignancy of clonally expanded plasma cells shaped by complex interactions with the immune microenvironment. To investigate immune correlates of treatment response and disease progression, we conducted multi-omi…
View article: Table S1 from Single-Cell Discovery and Multiomic Characterization of Therapeutic Targets in Multiple Myeloma
Table S1 from Single-Cell Discovery and Multiomic Characterization of Therapeutic Targets in Multiple Myeloma Open
Clinical information of patients in scRNA-seq discovery cohort, flow cytometry validation cohort and proteomics validation cohort, including age, gender, race, ISS stage, time to disease progression (TTPD). Disease stage for WashU cohort 1.
View article: Table S3 from Single-Cell Discovery and Multiomic Characterization of Therapeutic Targets in Multiple Myeloma
Table S3 from Single-Cell Discovery and Multiomic Characterization of Therapeutic Targets in Multiple Myeloma Open
Batch specific co-expression analysis.
View article: Table S5 from Single-Cell Discovery and Multiomic Characterization of Therapeutic Targets in Multiple Myeloma
Table S5 from Single-Cell Discovery and Multiomic Characterization of Therapeutic Targets in Multiple Myeloma Open
List of recurrent mutations with potential utility as neoantigens
View article: Correction: Flash pulmonary edema caused by paroxysmal supraventricular tachycardia in a patient with preserved ejection fraction
Correction: Flash pulmonary edema caused by paroxysmal supraventricular tachycardia in a patient with preserved ejection fraction Open
View article: Utility of Quantitative Parameters From Triple‐Phase Contrast Enhanced Dual‐Energy <scp>CT</scp> for Predicting Immunohistochemical Biomarkers in Invasive Breast Cancer
Utility of Quantitative Parameters From Triple‐Phase Contrast Enhanced Dual‐Energy <span>CT</span> for Predicting Immunohistochemical Biomarkers in Invasive Breast Cancer Open
Purpose To investigate the value of quantitative parameters derived from triple‐phase dual‐energy CT (DECT) for the discrimination of immunohistochemical biomarkers in invasive breast cancer. Material and Methods From March 2022 to May 202…
View article: Parameter-driven habitat imaging based on intravoxel incoherent motion MRI for preoperative prediction of muscle invasion in bladder cancer
Parameter-driven habitat imaging based on intravoxel incoherent motion MRI for preoperative prediction of muscle invasion in bladder cancer Open
View article: Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer
Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer Open
View article: Investigation of lncRNA expression in newly diagnosed multiple myeloma reveals a LINC01432-CELF2 axis as an inhibitor of apoptosis
Investigation of lncRNA expression in newly diagnosed multiple myeloma reveals a LINC01432-CELF2 axis as an inhibitor of apoptosis Open
Multiple myeloma (MM) is an incurable malignancy of plasma cells, with over 35,000 new cases diagnosed annually in the United States. Despite an expanding arsenal of approved therapies, nearly all patients relapse, and mechanisms underlyin…
View article: Left Upper Lobectomy After Coronary Artery Bypass Grafting: A National Analysis of Postoperative Outcomes
Left Upper Lobectomy After Coronary Artery Bypass Grafting: A National Analysis of Postoperative Outcomes Open
View article: Association between peripheral thyroid sensitivity defined by the FT3/FT4 ratio and composite adverse outcome among inpatients with heart failure
Association between peripheral thyroid sensitivity defined by the FT3/FT4 ratio and composite adverse outcome among inpatients with heart failure Open
Objective The free triiodothyronine to free thyroxine (FT3/FT4) ratio is an indicator of peripheral thyroid hormone sensitivity. However, its prognostic value in heart failure (HF) remains unclear. Methods This single center prospective co…
View article: The correlation between economic development and suicide rate — based on the global WHO and WB database
The correlation between economic development and suicide rate — based on the global WHO and WB database Open
Background Although some studies have reported correlations between economic factors and suicide rates, there is a lack of systematic analysis from a global data perspective. Methods The most recent suicide rates (from 2017 to 2019) were o…
View article: Enhanced YOLOv5 with ECA Module for Vision-Based Apple Harvesting Using a 6-DOF Robotic Arm in Occluded Environments
Enhanced YOLOv5 with ECA Module for Vision-Based Apple Harvesting Using a 6-DOF Robotic Arm in Occluded Environments Open
Accurate target recognition and localization remain significant challenges for robotic fruit harvesting in unstructured orchard environments characterized by branch occlusion and leaf clutter. To address the difficulty in identifying and l…
View article: Integrative analysis of lung adenocarcinoma across diverse ethnicities and exposures
Integrative analysis of lung adenocarcinoma across diverse ethnicities and exposures Open
Lung adenocarcinomas (LUAD) are a pressing global health problem with enduring lethality and rapidly shifting epidemiology. Proteogenomic studies integrating proteomics and post-translational modifications with genomics can identify clinic…
View article: Germline genetic variation impacts clonal hematopoiesis landscape and progression to malignancy
Germline genetic variation impacts clonal hematopoiesis landscape and progression to malignancy Open
With age, clonal expansions occur pervasively across normal tissues yet only in rare instances lead to cancer, despite being driven by well-established cancer drivers. Characterization of the factors that influence clonal progression is ne…
View article: Heart rate variability (HRV) changes during the fatigue progression of manual material handling in acute hypobaric hypoxia environments
Heart rate variability (HRV) changes during the fatigue progression of manual material handling in acute hypobaric hypoxia environments Open
To support National Aeronautics and Space Administration's (NASA) lunar habitat plans utilizing hypobaric hypoxia (HH) environments, this study investigated the combined effects of acute hypoxia severity and physical fatigue on astronauts'…
View article: The impact of ESG performance on cost of equity capital
The impact of ESG performance on cost of equity capital Open
This paper analyzes the relationship between ESG performance and the cost of equity financing from the perspective of the three dimensions of ESG. On the basis of MSCI ESG, this paper makes an innovative selection of 50 U. S. companies bas…
View article: Periplocin induces necroptosis in papillary thyroid carcinoma through DR4 mediated RIPK3 and MLKL signaling
Periplocin induces necroptosis in papillary thyroid carcinoma through DR4 mediated RIPK3 and MLKL signaling Open
View article: SPAG6 Promotes Multiple Myeloma Through Activation of the MAPK/ERK Signaling Pathway
SPAG6 Promotes Multiple Myeloma Through Activation of the MAPK/ERK Signaling Pathway Open
Background Sperm - associated antigen 6 (SPAG6), a member of the cancer/testis antigen (CTA) family, has been linked to multiple hematologic malignancies. Nevertheless, its role in multiple myeloma (MM) remains unclear. Methods Bioinformat…
View article: Knowledge, Attitude, and Practice Toward Hyperuricemia Among Patients Diagnosed with Hyperuricemia
Knowledge, Attitude, and Practice Toward Hyperuricemia Among Patients Diagnosed with Hyperuricemia Open
Patients with hyperuricemia have insufficient knowledge but a positive attitude and proactive practice toward hyperuricemia. Educational and motivational interventions should be designed to improve practice.
View article: Multi-omic and spatial analysis of mouse kidneys highlights sex-specific differences in gene regulation across the lifespan
Multi-omic and spatial analysis of mouse kidneys highlights sex-specific differences in gene regulation across the lifespan Open
There is a sex bias in the incidence and progression of many kidney diseases. To better understand such sexual dimorphism, we integrated data from six platforms, characterizing 76 kidney samples from 68 mice at six developmental and adult …
View article: PRC1 as an independent adverse prognostic factor in Wilms tumor via integrated bioinformatics and experimental validation
PRC1 as an independent adverse prognostic factor in Wilms tumor via integrated bioinformatics and experimental validation Open
View article: The signature based on interleukin family and receptors identified IL19 and IL20RA in promoting nephroblastoma progression through STAT3 pathway
The signature based on interleukin family and receptors identified IL19 and IL20RA in promoting nephroblastoma progression through STAT3 pathway Open
View article: The histone modifier KAT2A presents a selective target in a subset of well-differentiated microsatellite-stable colorectal cancers
The histone modifier KAT2A presents a selective target in a subset of well-differentiated microsatellite-stable colorectal cancers Open
Lysine acetyltransferase 2 A (KAT2A) plays a pivotal role in epigenetic gene regulation across various types of cancer. In colorectal cancer (CRC), increased KAT2A expression is associated with a more aggressive phenotype. Our study aims t…
View article: The impact of ESG performance on cost of equity capital
The impact of ESG performance on cost of equity capital Open
This paper analyzes the relationship between ESG performance and the cost of equity financing from the perspective of the three dimensions of ESG. On the basis of MSCI ESG, this paper makes an innovative selection of 50 U.S. companies base…
View article: Snoring Sounds Classification of OSAHS Patients Based on Model Fusion
Snoring Sounds Classification of OSAHS Patients Based on Model Fusion Open
Obstructive sleep apnea hypopnea syndrome (OSAHS) is a prevalent and detrimental chronic condition. The conventional diagnostic approach for OSAHS is intricate and costly. Snoring is one of the most typical and easily obtained symptom of O…
View article: The spatial landscape of cancer hallmarks reveals patterns of tumor ecological dynamics and drug sensitivity
The spatial landscape of cancer hallmarks reveals patterns of tumor ecological dynamics and drug sensitivity Open
Tumors are complex ecosystems of interacting cell types. The concept of cancer hallmarks distills this complexity into underlying principles that govern tumor growth. Here, we explore the spatial distribution of cancer hallmarks across 63 …
View article: RSK1 is an exploitable dependency in myeloproliferative neoplasms and secondary acute myeloid leukemia
RSK1 is an exploitable dependency in myeloproliferative neoplasms and secondary acute myeloid leukemia Open
View article: Collaborative Scheduling Strategy for Computation and Power among Multiple Data Centers Based on New Energy State Recognition
Collaborative Scheduling Strategy for Computation and Power among Multiple Data Centers Based on New Energy State Recognition Open
View article: Nitrogen Determination in Solid-State Materials with Libs Using a Fiber Laser Free of Influence from the Ambient Gas
Nitrogen Determination in Solid-State Materials with Libs Using a Fiber Laser Free of Influence from the Ambient Gas Open