Q. L. Niu
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View article: Investigation on the knowledge-attitude-practice of medical students in controlling emerging infectious diseases: A case study of COVID-19
Investigation on the knowledge-attitude-practice of medical students in controlling emerging infectious diseases: A case study of COVID-19 Open
Objective Investigate the Knowledge-Attitude-Practice (KAP) of students from Medical College towards emerging infectious diseases, and assess their impact, can provide a scientific basis and practical guidance for enhancing medico’s preven…
View article: Ecotoxicological assessment of p-benzoquinone oxidation byproducts in water treatment systems: oxidative stress responses and mechanisms
Ecotoxicological assessment of p-benzoquinone oxidation byproducts in water treatment systems: oxidative stress responses and mechanisms Open
p-Benzoquinone analogues, a class of ubiquitous oxidation byproducts, are increasingly detected in effluents from various oxidative treatment systems. While halogenated derivatives have received substantial research attention, the ecotoxic…
View article: MUC1 drives ferroptosis resistance in ICC via Src‐mediated FSP1 deubiquitination and myristoylation
MUC1 drives ferroptosis resistance in ICC via Src‐mediated FSP1 deubiquitination and myristoylation Open
Background Intrahepatic cholangiocarcinoma (ICC) exhibits poor prognosis and limited therapeutic options. Ferroptosis represents a promising therapeutic strategy, yet resistance mechanisms remain poorly understood. This study investigated …
View article: The role of REST in regulating the BDNF/TrkB signalling pathway in nano-alumina induced cognitive dysfunction in zebrafish
The role of REST in regulating the BDNF/TrkB signalling pathway in nano-alumina induced cognitive dysfunction in zebrafish Open
Synaptic plasticity is fundamental for cognitive development and brain function. Aluminium nanoparticles (AlNPs), widely used in industrial and consumer products, pose potential neurotoxic risks, particularly during early neurodevelopment.…
View article: Association of Prenatal Polycyclic Aromatic Hydrocarbons Exposure, DNA Hydroxymethylation, and Neurodevelopment at 0 and 2 Years of Age
Association of Prenatal Polycyclic Aromatic Hydrocarbons Exposure, DNA Hydroxymethylation, and Neurodevelopment at 0 and 2 Years of Age Open
Maternal exposure to polycyclic aromatic hydrocarbons (PAHs) during pregnancy may have effects on the offspring epigenome. And the change in onset epigenome may be associated with children’s neurodevelopment. The current study investigated…
View article: Therapeutic strategies for low anterior resection syndrome: an umbrella review of systematic reviews
Therapeutic strategies for low anterior resection syndrome: an umbrella review of systematic reviews Open
TAI and PFR are recommended as first-line therapies for LARS, while SNS or PTNS may be considered for refractory cases, especially those with predominant fecal incontinence. Future research should focus on standardizing protocols, improvin…
View article: Computational-aided understanding of metabolic mechanism: A case study
Computational-aided understanding of metabolic mechanism: A case study Open
This study presents an innovative computational method, combined with experimental validation, to predict and elucidate the metabolic pathways of SILA-123, a novel FLT3 inhibitor. Using UFLC/Q-TOF MS, we identified 21 metabolites generated…
View article: Exploring pesticide risk in autism via integrative machine learning and network toxicology
Exploring pesticide risk in autism via integrative machine learning and network toxicology Open
View article: Alumina nanoparticles induce learning and memory impairment in a particle size-dependent and time-dependent manner
Alumina nanoparticles induce learning and memory impairment in a particle size-dependent and time-dependent manner Open
The study investigates the influence of alumina nanoparticles (Al2O3 NPs) at varying sizes on the learning and memory of adult ICR mice over different exposure durations. The mice were administered saline or Al2<…
View article: [Allergens in occupational allergy: risk management]
[Allergens in occupational allergy: risk management] Open
The first essential aspect for the prevention of occupational allergy is related to the accurate allergen identification and characterization. At present many efforts are made to characterize the potential for a chemical to be a sensitizin…
View article: Metabolomic insights into pathogenesis and therapeutic potential in adult acute lymphoblastic leukemia
Metabolomic insights into pathogenesis and therapeutic potential in adult acute lymphoblastic leukemia Open
Acute lymphoblastic leukemia (ALL) poses challenges in adult patients, considering its heterogeneous nature and often suboptimal treatment outcomes. Here, we performed a study on 201 newly diagnosed adult ALL cases (age ≥ 15 y) to generate…
View article: Alterations of gray matter volume and functional connectivity in patients with cognitive impairment induced by occupational aluminum exposure: a case-control study
Alterations of gray matter volume and functional connectivity in patients with cognitive impairment induced by occupational aluminum exposure: a case-control study Open
Background Cognitive impairment (CI) is a condition in which an individual experiences noticeable impairment in thinking abilities. Long-term exposure to aluminum (Al) can cause CI. This study aimed to determine the relationship between CI…
View article: Ecotoxicological Assessment of P-Benzoquinone Oxidation Byproducts in Water Treatment Systems: Oxidative Stress Responses and Radical-Mediated Toxicological Mechanisms
Ecotoxicological Assessment of P-Benzoquinone Oxidation Byproducts in Water Treatment Systems: Oxidative Stress Responses and Radical-Mediated Toxicological Mechanisms Open
View article: Computational-Aided Understanding of Metabolic Mechanism: A Case Study
Computational-Aided Understanding of Metabolic Mechanism: A Case Study Open
View article: Down-Regulation of Vps34 Gene in the Autophagy Pathway Attenuates Alnp-Induced Neurodevelopmental Toxicity in Zebrafish Larvae
Down-Regulation of Vps34 Gene in the Autophagy Pathway Attenuates Alnp-Induced Neurodevelopmental Toxicity in Zebrafish Larvae Open
View article: 3mfc: Improved Flow Correlation Attacks on Tor Via Multimodal Triplet Network with Missing Data
3mfc: Improved Flow Correlation Attacks on Tor Via Multimodal Triplet Network with Missing Data Open
View article: Systemic and dynamic immune landscape of Omicron-infected subjects treated with Lianhua Qingwen capsules
Systemic and dynamic immune landscape of Omicron-infected subjects treated with Lianhua Qingwen capsules Open
View article: Miniaturized spectrometer based on MLP neural networks and a frosted glass encoder
Miniaturized spectrometer based on MLP neural networks and a frosted glass encoder Open
Computational spectrometers are explored to overcome the disadvantages of large size, narrow bandwidth and low spectral resolution suffered by conventional spectrometers. However, expensive spectral encoders and unstable algorithms impede …
View article: Cholesterol efflux from C1QB-expressing macrophages is associated with resistance to chimeric antigen receptor T cell therapy in primary refractory diffuse large B cell lymphoma
Cholesterol efflux from C1QB-expressing macrophages is associated with resistance to chimeric antigen receptor T cell therapy in primary refractory diffuse large B cell lymphoma Open
View article: Whole-transcriptome analysis of aluminum-exposed rat hippocampus and identification of ceRNA networks to investigate neurotoxicity of Al
Whole-transcriptome analysis of aluminum-exposed rat hippocampus and identification of ceRNA networks to investigate neurotoxicity of Al Open
View article: A Bayesian network for estimating hypertension risk due to occupational aluminum exposure
A Bayesian network for estimating hypertension risk due to occupational aluminum exposure Open
Background The correlation between metals and hypertension, such as sodium, zinc, potassium, and magnesium, has been confirmed, while the relationship between aluminum and hypertension is not very clear. This study aimed to evaluate the co…
View article: Necroptosis in aluminum-induced neural cells and animal models of Alzheimer's disease
Necroptosis in aluminum-induced neural cells and animal models of Alzheimer's disease Open
Introduction: Progressive neural cell loss is a pathological hallmark of Alzheimer's disease (AD). Environmental factors should be taken into consideration due to their epigenetic link to AD, and also because most of the causal environment…
View article: LNC000152 Mediates Aluminum-Induced Proliferation of Reactive Astrocytes
LNC000152 Mediates Aluminum-Induced Proliferation of Reactive Astrocytes Open
Aluminum is a metal element with significant neurotoxicity, and there is a substantial correlation between aluminum exposure and cognitive dysfunction. Glial fibrillary acidic protein (GFAP) is widely used as a marker of reactive astrocyte…
View article: Aging and comprehensive molecular profiling in acute myeloid leukemia
Aging and comprehensive molecular profiling in acute myeloid leukemia Open
Acute myeloid leukemia (AML) is an aging-related and heterogeneous hematopoietic malignancy. In this study, a total of 1,474 newly diagnosed AML patients with RNA sequencing data were enrolled, and targeted or whole exome sequencing data w…
View article: miR-128-3p is involved in aluminum-induced cognitive impairment by regulating the Sirt1-Keap1/Nrf2 pathway
miR-128-3p is involved in aluminum-induced cognitive impairment by regulating the Sirt1-Keap1/Nrf2 pathway Open
Aluminum (Al) is a common neurotoxicant in the environment, but the molecular mechanism of its toxic effects is still unclear. Studies have shown that aluminum exposure causes an increase in neuronal apoptosis. The aim of this study was to…
View article: Study on the mechanism of zinc finger proteins ROCK1 and DMD in zinc-mediated cognitive impairment caused by aluminum exposure
Study on the mechanism of zinc finger proteins ROCK1 and DMD in zinc-mediated cognitive impairment caused by aluminum exposure Open
Background : Aluminum (Al) exposure was implicated in neurodegenerative diseases and cognitive impairment, yet the involvement of zinc (Zn) and its mechanism in Al-induced mild cognitive impairment (MCI) remains poorly understood. Objectiv…
View article: Progressive Learning and Memory Impairment in Mice Induced by Alumina Nanoparticles in Particle Size-Dependent and Time-Dependent Manners
Progressive Learning and Memory Impairment in Mice Induced by Alumina Nanoparticles in Particle Size-Dependent and Time-Dependent Manners Open
View article: Role of the RIP3-PGAM5-Drp1 pathway in aluminum-induced PC12 cells necroptosis
Role of the RIP3-PGAM5-Drp1 pathway in aluminum-induced PC12 cells necroptosis Open
Epidemiological studies from diverse global regions suggest a correlation between the accumulation of aluminum in the brain and the onset of various neurodegenerative diseases, including Alzheimer's disease, of which, neuronal cells death …
View article: The molecular mechanism of miRNA-195-5p regulating ERK involvement in abnormal phosphorylation of Tau protein by aluminum maltol in PC12 cells
The molecular mechanism of miRNA-195-5p regulating ERK involvement in abnormal phosphorylation of Tau protein by aluminum maltol in PC12 cells Open
Although aluminum is ubiquitously present on Earth, it is not necessary for life. Aluminum is a metal element that can induce neurotoxicity. The neurotoxicity of aluminum is mainly caused by the aggregation of abnormally phosphorylated tau…
View article: Dual metabolic platform to analyze differential metabolites in hepatitis B virus-related liver cirrhosis patients with pre-sarcopenia
Dual metabolic platform to analyze differential metabolites in hepatitis B virus-related liver cirrhosis patients with pre-sarcopenia Open