L. Lambourne
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View article: Widespread variation in molecular interactions and regulatory properties among transcription factor isoforms
Widespread variation in molecular interactions and regulatory properties among transcription factor isoforms Open
Summary Most human Transcription factors (TFs) genes encode multiple protein isoforms differing in DNA binding domains, effector domains, or other protein regions. The global extent to which this results in functional differences between i…
View article: Binary interactome models of inner- versus outer-complexome organisation
Binary interactome models of inner- versus outer-complexome organisation Open
Summary Hundreds of different protein complexes that perform important functions across all cellular processes, collectively comprising the “complexome” of an organism, have been identified 1 . However, less is known about the fraction of …
View article: Decision letter: Topology-driven protein-protein interaction network analysis detects genetic sub-networks regulating reproductive capacity
Decision letter: Topology-driven protein-protein interaction network analysis detects genetic sub-networks regulating reproductive capacity Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Understanding the genetic regulation of or…
View article: A reference map of the human protein interactome
A reference map of the human protein interactome Open
Global insights into cellular organization and function require comprehensive understanding of interactome networks. Similar to how a reference genome sequence revolutionized human genetics, a reference map of the human interactome network…
View article: Towards an “assayome” for binary interactome mapping
Towards an “assayome” for binary interactome mapping Open
Complementary assays are required to comprehensively map complex biological entities such as genomes, proteomes and interactome networks. However, how various assays can be optimally combined to approach completeness while maintaining high…
View article: APID database: redefining protein–protein interaction experimental evidences and binary interactomes
APID database: redefining protein–protein interaction experimental evidences and binary interactomes Open
The collection and integration of all the known protein-protein physical interactions within a proteome framework are critical to allow proper exploration of the protein interaction networks that drive biological processes in cells at mole…
View article: Domain-based prediction of the human isoform interactome provides insights into the functional impact of alternative splicing
Domain-based prediction of the human isoform interactome provides insights into the functional impact of alternative splicing Open
Alternative splicing is known to remodel protein-protein interaction networks ("interactomes"), yet large-scale determination of isoform-specific interactions remains challenging. We present a domain-based method to predict the isoform int…
View article: Upon Accounting for the Impact of Isoenzyme Loss, Gene Deletion Costs Anticorrelate with Their Evolutionary Rates
Upon Accounting for the Impact of Isoenzyme Loss, Gene Deletion Costs Anticorrelate with Their Evolutionary Rates Open
System-level metabolic network models enable the computation of growth and metabolic phenotypes from an organism's genome. In particular, flux balance approaches have been used to estimate the contribution of individual metabolic genes to …