Lei Zhu
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View article: Bioinformatics analysis reveals C5AR1’s impact on thyroid cancer development via immune infiltration
Bioinformatics analysis reveals C5AR1’s impact on thyroid cancer development via immune infiltration Open
Thyroid cancer (THCA) remains a prevalent endocrine malignancy, with limited molecular markers for accurate diagnosis and targeted therapy. This study aimed to identify key biomarkers and therapeutic targets for THCA using integrative bioi…
View article: Computational Study on Complex Wind Field Environments in Urban and Marine Low-Altitude Based on Multi-Wind-Turbine Coordination
Computational Study on Complex Wind Field Environments in Urban and Marine Low-Altitude Based on Multi-Wind-Turbine Coordination Open
With the rise of the low-altitude economy, there is growing demand for performance and safety evaluation of logistics drones and urban aircraft operating in complex turbulent environments. Conventional wind tunnels, however, face challenge…
View article: A catechol-modified quaternized chitosan/PEG hydrogel for diabetic wound healing: synergistic effects of TGF-β3 delivery, angiogenesis, and antibacterial activity
A catechol-modified quaternized chitosan/PEG hydrogel for diabetic wound healing: synergistic effects of TGF-β3 delivery, angiogenesis, and antibacterial activity Open
Background Diabetic foot ulcers (DFUs) represent a challenging chronic wound model, often plagued by biofilm formation that sustains inflammation and impedes healing. Transforming growth factor-beta 3 (TGF-β3) is a promising cytokine for t…
View article: Modification of Active Carbon and Expanded Graphite on SrCl <sub>2</sub> for Ammonia Adsorption in Solid Selective Catalytic Reduction
Modification of Active Carbon and Expanded Graphite on SrCl <sub>2</sub> for Ammonia Adsorption in Solid Selective Catalytic Reduction Open
Solid selective catalytic reduction (SCR) is a promising nitrogen oxides abatement technology with advantages over urea‐SCR, such as higher ammonia storage density, no low‐temperature crystallization, and no exhaust temperature limitation.…
View article: Polarized Heterojunction in a Doubly Doped Layer‐by‐Layer Structure to Obtain an Organic Photovoltaic Device of 20.5% Efficiency
Polarized Heterojunction in a Doubly Doped Layer‐by‐Layer Structure to Obtain an Organic Photovoltaic Device of 20.5% Efficiency Open
Achieving efficient double doping in organic photovoltaic (OPV) devices is hindered by parasitic interactions between p‐ and n‐type dopants, which lead to radical accumulation, deep‐level traps, and reduced device performance. Herein, we r…
View article: Non-WNT/non-SHH medulloblastoma in siblings: case report and literature review
Non-WNT/non-SHH medulloblastoma in siblings: case report and literature review Open
This first report of familial non-WNT/non-SHH MBs highlights novel somatic (NF1) and germline (KYAT3, SPATA31A6) variants, suggesting unexplored oncogenic mechanisms. The findings underscore the need for further research to elucidate drive…
View article: Characterization of pathogens and prognostic factors in cerebral infarction patients complicated by pulmonary infections
Characterization of pathogens and prognostic factors in cerebral infarction patients complicated by pulmonary infections Open
This study aimed to investigate the microbial spectrum and prognostic indicators in patients who developed pulmonary infections secondary to cerebral infarction (CI). A total of 175 retrospective cases with post-CI pneumonia were reviewed.…
View article: Maternal and protective antibody responses to E2 subunit and C-strain classical swine fever vaccines in piglets: a comparative analysis
Maternal and protective antibody responses to E2 subunit and C-strain classical swine fever vaccines in piglets: a comparative analysis Open
Classical swine fever (CSF), caused by the classical swine fever virus (CSFV), is an acute and highly contagious disease affecting swine. In clinical settings, the C- strain vaccine and the E2 subunit vaccine are commonly employed for the …
View article: Electric field calculation of transmission lines based on CSM and analysis of fiber optical cable hanging points
Electric field calculation of transmission lines based on CSM and analysis of fiber optical cable hanging points Open
To address the low accuracy in electric field calculation for complex three-dimensional transmission lines and the multi-objective cooperative optimization of cable hanging points, an improved fusion model is proposed. This model integrate…
View article: Frozen bits perturbation key transmission scheme based on subcarrier index modulation
Frozen bits perturbation key transmission scheme based on subcarrier index modulation Open
This article proposes a secure transmission method that uses grouped multicarrier modulation, embedding encryption keys directly into the transmitted signal to allow simultaneous key and data transmission. A four-dimensional hyperchaotic s…
View article: BNIP3-mediated mitophagy alleviates traumatic brain injury by inhibiting neuronal apoptosis and oxidative stress
BNIP3-mediated mitophagy alleviates traumatic brain injury by inhibiting neuronal apoptosis and oxidative stress Open
Traumatic brain injury (TBI) significantly influences neurological outcomes, and its pathogenesis is primarily attributed to neuronal apoptosis and oxidative stress. However, the precise role of Bcl2/adenovirus E1B protein-interacting prot…
View article: Systematic review of Chinese medicine for the treatment of atherosclerosis
Systematic review of Chinese medicine for the treatment of atherosclerosis Open
Introduction Atherosclerosis (AS) is a chronic inflammatory metabolic disease strongly associated with risk factors, including hypertension, hyperlipidemia, hyperglycemia, and hyperuricemia. AS serves as the pathological foundation for num…
View article: Mechanisms and potential therapeutic targets of SphK1 and SphK2 in hepatocellular carcinoma
Mechanisms and potential therapeutic targets of SphK1 and SphK2 in hepatocellular carcinoma Open
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths globally. Sphingosine-1-phosphate (S1P) is catalyzed by sphingosine kinases SphK1 and SphK2 and plays a key role in HCC progression: SphK1 can drive tumor p…
View article: Ferroptosis in Autoimmune Diseases: Research Advances and Therapeutic Strategies
Ferroptosis in Autoimmune Diseases: Research Advances and Therapeutic Strategies Open
Ferroptosis, an iron-dependent programmed cell death driven by lipid peroxidation, plays a critical role in autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, and psoriasis. This review systematically explores …
View article: Dynamic noise-masked 3D constellation encryption scheme based on gated recurrent unit networks
Dynamic noise-masked 3D constellation encryption scheme based on gated recurrent unit networks Open
We propose a dynamic noise-masked three-dimensional constellation encryption scheme based on a gated recurrent unit (GRU) neural network. A three-dimensional six-row stacking (SRS) structure is employed for constellation shaping to enhance…
View article: GaN high electron mobility transistors with a breakdown voltage over 2500 V achieved by low temperature MBE growth, subdivision of channel, and single field plate structure
GaN high electron mobility transistors with a breakdown voltage over 2500 V achieved by low temperature MBE growth, subdivision of channel, and single field plate structure Open
GaN power high electron mobility transistors (HEMTs) with a breakdown voltage (BV) exceeding 2500 V at I DSS leakage of 1 μ A mm −1 grown by plasma-assisted MBE (PA-MBE) on sapphire was demonstrated with a single field plate structure. Sub…
View article: Efficient FPGA implementation of polar codes-based information reconciliation for quantum key distribution
Efficient FPGA implementation of polar codes-based information reconciliation for quantum key distribution Open
Quantum key distribution (QKD) leverages the principles of quantum mechanics to generate unconditionally secure keys for remote communication, even in the presence of an eavesdropper with unlimited computational power. A critical component…
View article: Fertility, gonadal and sexual function in survivors of nasopharyngeal carcinoma patients
Fertility, gonadal and sexual function in survivors of nasopharyngeal carcinoma patients Open
Purpose Therapy with radiotherapy in the head and neck, can be associated with gonadal damage in male survivors of cancer. To the authors’s knowledge the effect of treatments on testicular reproductive and endocrine function in nasopharyng…
View article: The impact of high-intensity interval training on cerebrovascular function in the APP/PS1 mice
The impact of high-intensity interval training on cerebrovascular function in the APP/PS1 mice Open
Alzheimer’s disease (AD), the most commonly diagnosed form of senile dementia worldwide, is closely associated with aging and distinct neuropathological features. Recent studies highlight that up to 90% of individuals, either preclinical o…
View article: The construction of placeness in traditional opera from the perspective of structuration theory: A case study of Huangmei Opera in Anqing, China
The construction of placeness in traditional opera from the perspective of structuration theory: A case study of Huangmei Opera in Anqing, China Open
Traditional opera is continuously involved in the construction of placeness because of its close connection with local culture, and the flow of the meaning of placeness has become a hot spot of cultural geography research. This study exami…
View article: DNA-based prediction of external ear morphology in the Chinese population: an exploratory study
DNA-based prediction of external ear morphology in the Chinese population: an exploratory study Open
Background The external human ear is a polymorphic and polygenic structure with individual uniqueness, making it a valuable target in forensic DNA phenotyping (FDP) studies. Previous genome-wide association studies have identified multiple…
View article: BigCodeArena: Unveiling More Reliable Human Preferences in Code Generation via Execution
BigCodeArena: Unveiling More Reliable Human Preferences in Code Generation via Execution Open
Crowdsourced model evaluation platforms, such as Chatbot Arena, enable real-time evaluation from human perspectives to assess the quality of model responses. In the coding domain, manually examining the quality of LLM-generated content is …
View article: Compare of the scleral morphology between healthy populations and keratoconus patients using optical coherence tomography
Compare of the scleral morphology between healthy populations and keratoconus patients using optical coherence tomography Open
The sclera is generally irregular in shape, especially extremely asymmetric in the horizontal direction. Moreover, as the chord length increases, this irregularity becomes more obvious. Compared with healthy eyes, the scleral morphology of…
View article: Addressing Data Imbalance in Hydrological Machine Learning: Impact of Advanced Sampling Methods on Performance and Interpretability
Addressing Data Imbalance in Hydrological Machine Learning: Impact of Advanced Sampling Methods on Performance and Interpretability Open
Data imbalance poses a severe challenge in hydrological machine learning (ML) applications by limiting model performance and interpretability, whereas solutions remain limited. This study evaluates the impact of advanced sampling methods, …
View article: Assessing engineering thinking in the context of biology among senior high school students in mainland China: development and validation of a two-tier assessment scale and the relationship between self-efficacy and practical performance
Assessing engineering thinking in the context of biology among senior high school students in mainland China: development and validation of a two-tier assessment scale and the relationship between self-efficacy and practical performance Open
This study designed and validated the Engineering Thinking Assessment Scale (ETAS) to assess the engineering thinking of senior high school students in mainland China and to explore the correlation between their self-efficacy in different …
View article: Improving Competitive Advantage from Costumer Perspective: Strategic Approaches in Indonesia’s Telecom Sector
Improving Competitive Advantage from Costumer Perspective: Strategic Approaches in Indonesia’s Telecom Sector Open
This study examines Smartfren’s market position, competitive advantage, and growth prospects amid Telkomsel’s market dominance. It employs primary survey data from users and professionals and secondary industry reports, analyzed through a …