Lia R. Bevilaqua
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View article: NMDARs control object recognition memory destabilization and reconsolidation
NMDARs control object recognition memory destabilization and reconsolidation Open
Object recognition memory (ORM) allows identification of previously encountered items and is therefore crucial for remembering episodic information. In rodents, reactivation during recall in the presence of a novel object destabilizes ORM …
View article: On the effect of hippocampal c-Jun N-terminal kinase inhibition on object recognition memory
On the effect of hippocampal c-Jun N-terminal kinase inhibition on object recognition memory Open
c-Jun N-terminal kinase (JNK) phosphorylates the transcription factor c-Jun in response to stress stimuli and contributes to both hippocampal synaptic plasticity and memory processing in mammals. Object recognition memory (ORM) is essentia…
View article: Reactivation-dependent amnesia for object recognition memory is contingent on hippocampal theta–gamma coupling during recall
Reactivation-dependent amnesia for object recognition memory is contingent on hippocampal theta–gamma coupling during recall Open
Hippocampal dopamine D1/D5 receptor-dependent destabilization is necessary for object recognition memory (ORM) updating through reconsolidation. Dopamine also regulates hippocampal theta and gamma oscillations, which are involved in novelt…
View article: Dopamine controls whether new declarative information updates reactivated memories through reconsolidation
Dopamine controls whether new declarative information updates reactivated memories through reconsolidation Open
Consolidation and reconsolidation are independent memory processes. Consolidation stabilizes new memories, whereas reconsolidation restabilizes memories destabilized when reactivated during recall. However, the biological role of the desta…
View article: mTOR inhibition impairs extinction memory reconsolidation
mTOR inhibition impairs extinction memory reconsolidation Open
Fear-motivated avoidance extinction memory is prone to hippocampal brain-derived neurotrophic factor (BDNF)-dependent reconsolidation upon recall. Here, we show that extinction memory recall activates mammalian target of rapamycin (mTOR) i…
View article: PKMζ Inhibition Disrupts Reconsolidation and Erases Object Recognition Memory
PKMζ Inhibition Disrupts Reconsolidation and Erases Object Recognition Memory Open
Object recognition memory (ORM) confers the ability to discriminate the familiarity of previously encountered items. Reconsolidation is the process by which reactivated memories become labile and susceptible to modifications. The hippocamp…
View article: PERK, mTORC1 and eEF2 interplay during long term potentiation
PERK, mTORC1 and eEF2 interplay during long term potentiation Open
This Editorial highlights a study by Zimmermann and coworkers in the current issue of Journal of Neurochemistry. The authors' link suppression of PKR‐like endoplasmatic reticulum kinase (PERK) activity to eukaryotic elongation factor 2 (eE…
View article: Prior Learning of Relevant Nonaversive Information Is a Boundary Condition for Avoidance Memory Reconsolidation in the Rat Hippocampus
Prior Learning of Relevant Nonaversive Information Is a Boundary Condition for Avoidance Memory Reconsolidation in the Rat Hippocampus Open
Reactivated memories can be modified during reconsolidation, making this process a potential therapeutic target for posttraumatic stress disorder (PTSD), a mental illness characterized by the recurring avoidance of situations that evoke tr…