Jin Li
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View article: Precise species identification and whole-genome sequencing analysis of <i>Enterobacter cloacae</i> complex causing bloodstream infections in China
Precise species identification and whole-genome sequencing analysis of <i>Enterobacter cloacae</i> complex causing bloodstream infections in China Open
The Enterobacter cloacae complex (ECC) is one of the major causes of hospital-acquired infections. However, achieving accurate species identification and comprehensive resistance profiling remains difficult in clinical practice, with a lim…
View article: Identification of serum MicroRNAs associated with hepatic immunoinflammatory injury in chronic hepatitis B: implications for non-invasive diagnosis
Identification of serum MicroRNAs associated with hepatic immunoinflammatory injury in chronic hepatitis B: implications for non-invasive diagnosis Open
Background and aims Hepatitis B virus (HBV) causes chronic hepatic infection, leading to various advanced liver diseases. Currently, there is still a lack of effective non-invasive biomarkers for evaluating hepatic inflammation and fibrosi…
View article: Integrative genomics characterizes HCC eRNAs for prognosis and targeted therapy
Integrative genomics characterizes HCC eRNAs for prognosis and targeted therapy Open
Hepatocellular carcinoma (HCC), a leading cause of cancer-related mortality globally, exhibits limited diagnostic and therapeutic biomarkers despite its clinical significance. Emerging evidence has positioned enhancer RNAs (eRNAs) as pivot…
View article: Genomic evolution of enteric pathogens: mechanisms of pathogenicity and diagnostic innovations
Genomic evolution of enteric pathogens: mechanisms of pathogenicity and diagnostic innovations Open
Genomic evolution serves as a pivotal driver of pathogenicity and host adaptation in intestinal pathogens. This review systematically dissects, from a phylogenetic perspective, the key genomic evolutionary mechanisms underpinning pathogene…
View article: Phlorest phylogeny derived from Zhang et al 2019 'Phylogenetic evidence for Sino-Tibetan origin in northern China in the Late Neolithic'
Phlorest phylogeny derived from Zhang et al 2019 'Phylogenetic evidence for Sino-Tibetan origin in northern China in the Late Neolithic' Open
Cite the source of the dataset as: Zhang M, Yan S, Pan W, & Jin L. 2019. Phylogenetic evidence for Sino-Tibetan origin in northern China in the Late Neolithic. Nature, 569, 112–115.
View article: A Residual Approach to Estimate Biological Age from Gompertz Modeling
A Residual Approach to Estimate Biological Age from Gompertz Modeling Open
Biological age (BA) and its residual relative to chronological age are popularly used to quantify individual aging. Although these residuals independently predict age-related health outcomes, conventional BA measures often lack robustness …
View article: A bibliographic database of Chinese translations of foreign literature in modern periodicals (1896–1949)
A bibliographic database of Chinese translations of foreign literature in modern periodicals (1896–1949) Open
This study examines the archival materials of Chinese translations of foreign literature (CTFL) published in modern periodicals, highlighting the pervasive issue of ‘different names for the same entity’ that obstructs effective retrieval t…
View article: Determinants of intertransfusion interval in children with transfusion-dependent thalassemia: a retrospective single-center cohort study in China
Determinants of intertransfusion interval in children with transfusion-dependent thalassemia: a retrospective single-center cohort study in China Open
Genotype severity and RBC product type significantly affect intertransfusion intervals in pediatric TDT. Personalized strategies considering these factors may optimize transfusion efficacy and reduce complications.
View article: Expert consensus statement for basic research of animal exercise intervention studies in chronic disease prevention and treatment: A joint position paper of the Exercise Science branch of the Biophysical Society of China and the Metabolism and Genetics branch of the Genetics Society of China
Expert consensus statement for basic research of animal exercise intervention studies in chronic disease prevention and treatment: A joint position paper of the Exercise Science branch of the Biophysical Society of China and the Metabolism and Genetics branch of the Genetics Society of China Open
Chronic diseases, broadly defined as long-duration conditions that require sustained medical care and/or limit activities of daily living, are a major problem that threatens human health and imposes large social and economic burdens. Physi…
View article: Immune, blood-brain barrier, and metabolic biomarkers mediate gut-brain axis crosstalk in alzheimer’s disease
Immune, blood-brain barrier, and metabolic biomarkers mediate gut-brain axis crosstalk in alzheimer’s disease Open
Background Gut microbiota may influence Alzheimer’s disease (AD) pathogenesis by modulating host homeostasis. However, population-based causal evidence linking gut dysbiosis to Alzheimer’s disease pathogenesis, especially via immune, vascu…
View article: Model-Assisted Process Optimization for Trivalent Ligand-siRNA Conjugation via CuAAC Click Chemistry
Model-Assisted Process Optimization for Trivalent Ligand-siRNA Conjugation via CuAAC Click Chemistry Open
Small interfering RNA (siRNA) represents a potent gene therapy tool, playing pivotal roles in treating cancers and genetic disorders due to its unique advantages. Chemical modifications of nucleic acids serve as critical strategies to enha…
View article: Surgical treatment and outcomes in feline aortic thromboembolism: a retrospective study of 13 cats
Surgical treatment and outcomes in feline aortic thromboembolism: a retrospective study of 13 cats Open
Objectives This study aimed to evaluate the survival and survivor characteristics in cats diagnosed with feline aortic thromboembolism (FATE) who underwent surgical aortic thrombectomy. Methods Medical records from 2021 to 2023 were retros…
View article: Measuring customer-perceived service quality in the ride-hailing industry: a generic approach for the development and validation of a multidimensional scale
Measuring customer-perceived service quality in the ride-hailing industry: a generic approach for the development and validation of a multidimensional scale Open
Service issues and limitations of generic measures (scales, instruments) necessitate well-developed customized measures to evaluate service quality. Against methodological limitations that grounded in researchers’ thoughts and second-hand …
View article: Enabling Open Machine Learning of Deoxyribonucleic Acid-Encoded Library Selections to Accelerate the Discovery of Small Molecule Protein Binders
Enabling Open Machine Learning of Deoxyribonucleic Acid-Encoded Library Selections to Accelerate the Discovery of Small Molecule Protein Binders Open
Machine learning (ML) is increasingly used in DNA-encoded library (DEL) screening for ligand discovery, but its success depends on access to suitable data sets, which are often proprietary and costly. To overcome this, we present the first…
View article: <scp>TRPM7</scp> Deficiency Accelerates Vascular Senescence by Inhibiting <scp>H3K18</scp> Lactylation
<span>TRPM7</span> Deficiency Accelerates Vascular Senescence by Inhibiting <span>H3K18</span> Lactylation Open
Blood vessels exhibit a pronounced vulnerability to aging and are often at the forefront of systemic aging processes. Vascular endothelial cells, which line blood vessels and directly contact blood flow, are susceptible to damage and play …
View article: Bayesian parametric estimation shows the effects of social prestige and bilingualism on reshaping language competition
Bayesian parametric estimation shows the effects of social prestige and bilingualism on reshaping language competition Open
Understanding the mechanisms of language competition is crucial for mitigating language extinction and promoting cultural sustainability. Nevertheless, how to quantify the effects of socio-linguistic factors, such as social prestige and bi…
View article: Unveiling Forest Density Dynamics in Saihanba Forest Farm by Integrating Airborne LiDAR and Landsat Satellites
Unveiling Forest Density Dynamics in Saihanba Forest Farm by Integrating Airborne LiDAR and Landsat Satellites Open
Forest density is a key parameter in forestry research, and its variation can significantly impact ecosystems. Saihanba, as a focal site for afforestation and restoration, offers an ideal case for monitoring these dynamics. In this study, …
View article: Regular versus Irregular Exercise Differentially Modulates Hippocampal‐Hepatic Acetylcholine Flux to Coordinate Fear Memory Extinction and Liver Inflammation
Regular versus Irregular Exercise Differentially Modulates Hippocampal‐Hepatic Acetylcholine Flux to Coordinate Fear Memory Extinction and Liver Inflammation Open
Despite the known benefits of exercise, an in‐depth comparison of the effects of regular versus irregular exercise on brain–body interactions and molecular mechanisms remains lacking. This study demonstrates that regular exercise robustly …
View article: Different responses of luminal and glandular epithelium during mouse embryo implantation
Different responses of luminal and glandular epithelium during mouse embryo implantation Open
Introduction Embryo implantation, a crucial process for establishing and maintaining a successful pregnancy, involves the attachment and invasion of the embryo into the endometrium. The glandular epithelium (GE) within endometrial glands s…
View article: Dramatic decline of wild apple population: Evidence from long-term monitoring and modelling
Dramatic decline of wild apple population: Evidence from long-term monitoring and modelling Open
Successful forest restoration and species conservation require an in-depth understanding of demographic processes across life history stages. Yet, for many tree species, such understanding is limited by the lack of long-term population mon…
View article: <b>Multi-omics integration of epigenetics, proteomics, and metabolomics identifies putative drug targets and improves early prediction for diabetes</b>
<b>Multi-omics integration of epigenetics, proteomics, and metabolomics identifies putative drug targets and improves early prediction for diabetes</b> Open
Diabetes holds significant social importance due to its high incidence rate and the multitude of associated complications. The identification of diabetes biomarkers and the understanding of the intricate biological mechanisms underlying di…
View article: <b>Multi-omics integration of epigenetics, proteomics, and metabolomics identifies putative drug targets and improves early prediction for diabetes</b>
<b>Multi-omics integration of epigenetics, proteomics, and metabolomics identifies putative drug targets and improves early prediction for diabetes</b> Open
Diabetes holds significant social importance due to its high incidence rate and the multitude of associated complications. The identification of diabetes biomarkers and the understanding of the intricate biological mechanisms underlying di…
View article: Reveals meat quality and muscle metabolism characteristics in naturally grazed Sunit sheep at different ages
Reveals meat quality and muscle metabolism characteristics in naturally grazed Sunit sheep at different ages Open
This study aimed to explore the effects of different ages on muscle metabolism and its association with meat quality in naturally grazed Sunit sheep using non-targeted and targeted metabolomics. The results indicated that meat quality para…
View article: Research on Scale Prevention and Removal System
Research on Scale Prevention and Removal System Open
This article focuses on the problem of scaling on the inner wall of the drill pipe during the diamond rope coring drilling process, which affects the smooth salvage of the core. Based on the research results of predecessors at home and abr…
View article: The genomic history of East Asian Middle Neolithic millet- and rice-agricultural populations
The genomic history of East Asian Middle Neolithic millet- and rice-agricultural populations Open
The Yellow and Yangtze river basins in China are among the world's oldest independent agricultural centers, known for the domestication of millet and rice, respectively, yet their genetic history is poorly understood. Here, we present geno…