Melissa Edwards
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View article: ACVECC Veterinary Committee on Trauma Registry Report 2022–2023
ACVECC Veterinary Committee on Trauma Registry Report 2022–2023 Open
Objective To report summative data from the American College of Veterinary Emergency and Critical Care Veterinary Committee on Trauma (ACVECC‐VetCOT) registry, with further summary reporting based on geographic region and human population …
View article: Design principles for city waste reduction: Addressing gaps in public reporting for zero waste
Design principles for city waste reduction: Addressing gaps in public reporting for zero waste Open
View article: Hybridity in Non‐profits: Innovating for Social Value Creation
Hybridity in Non‐profits: Innovating for Social Value Creation Open
Non‐profits face rising pressure to secure funding and innovate for increasingly complex social problems, while cognizant that failed innovations could produce consequential societal harm. In a longitudinal case study, we apply a social in…
View article: Comprehensive analysis of constitutional mismatch repair deficiency‐associated non‐Hodgkin lymphomas in a global cohort
Comprehensive analysis of constitutional mismatch repair deficiency‐associated non‐Hodgkin lymphomas in a global cohort Open
Background Constitutional mismatch repair deficiency syndrome (CMMRD) is a rare childhood cancer predisposition syndrome associated with a broad spectrum of malignancies, including non‐Hodgkin lymphomas (NHL). Most patients die due to canc…
View article: DNA mismatch and damage patterns revealed by single-molecule sequencing
DNA mismatch and damage patterns revealed by single-molecule sequencing Open
View article: From “business as usual” to sustainable “purpose‐driven business”: Challenges facing the purpose ecosystem in the United Kingdom and Australia
From “business as usual” to sustainable “purpose‐driven business”: Challenges facing the purpose ecosystem in the United Kingdom and Australia Open
Purpose‐driven businesses have a stated objective to contribute to the welfare of society and the planet alongside generating shareholder value. As interest in purpose‐driven businesses grows, an emerging “purpose ecosystem” of advisers, i…
View article: An integrative framework for sustainable coral reef restoration
An integrative framework for sustainable coral reef restoration Open
View article: ACVECC‐Veterinary Committee on Trauma registry report 2017–2019
ACVECC‐Veterinary Committee on Trauma registry report 2017–2019 Open
Objective To report summative data from the American College of Veterinary Emergency and Critical Care Veterinary Committee on Trauma (VetCOT) registry. Design Multi‐institutional registry data report, April 1, 2017 to December 31, 2019. S…
View article: Data from Mutations in the RAS/MAPK Pathway Drive Replication Repair–Deficient Hypermutated Tumors and Confer Sensitivity to MEK Inhibition
Data from Mutations in the RAS/MAPK Pathway Drive Replication Repair–Deficient Hypermutated Tumors and Confer Sensitivity to MEK Inhibition Open
The RAS/MAPK pathway is an emerging targeted pathway across a spectrum of both adult and pediatric cancers. Typically, this is associated with a single, well-characterized point mutation in an oncogene. Hypermutant tumors that harbor many …
View article: Supplemental-Figures-and-Legends from Mutations in the RAS/MAPK Pathway Drive Replication Repair–Deficient Hypermutated Tumors and Confer Sensitivity to MEK Inhibition
Supplemental-Figures-and-Legends from Mutations in the RAS/MAPK Pathway Drive Replication Repair–Deficient Hypermutated Tumors and Confer Sensitivity to MEK Inhibition Open
All Supplementary Figures: Fig S1: Major subtypes in 1215 pediatric cancers. Fig S2: Frequency of protein coding point mutations in 1215 pediatric tumors. Fig S3: Confirmatory tissue specific preferences for MAPK pathway mutations in cBioP…
View article: Data from Mutations in the RAS/MAPK Pathway Drive Replication Repair–Deficient Hypermutated Tumors and Confer Sensitivity to MEK Inhibition
Data from Mutations in the RAS/MAPK Pathway Drive Replication Repair–Deficient Hypermutated Tumors and Confer Sensitivity to MEK Inhibition Open
The RAS/MAPK pathway is an emerging targeted pathway across a spectrum of both adult and pediatric cancers. Typically, this is associated with a single, well-characterized point mutation in an oncogene. Hypermutant tumors that harbor many …
View article: SupplementalTables from Mutations in the RAS/MAPK Pathway Drive Replication Repair–Deficient Hypermutated Tumors and Confer Sensitivity to MEK Inhibition
SupplementalTables from Mutations in the RAS/MAPK Pathway Drive Replication Repair–Deficient Hypermutated Tumors and Confer Sensitivity to MEK Inhibition Open
Table S1: Summary of likely pathogenic mutations detected in Foundation Medicine cohort of 1215 pediatric cancers. Table S2: Summary of RAS/MAPK pathway mutations and consequences detected in 48 RRD cancers.
View article: Supplemental-Figures-and-Legends from Mutations in the RAS/MAPK Pathway Drive Replication Repair–Deficient Hypermutated Tumors and Confer Sensitivity to MEK Inhibition
Supplemental-Figures-and-Legends from Mutations in the RAS/MAPK Pathway Drive Replication Repair–Deficient Hypermutated Tumors and Confer Sensitivity to MEK Inhibition Open
All Supplementary Figures: Fig S1: Major subtypes in 1215 pediatric cancers. Fig S2: Frequency of protein coding point mutations in 1215 pediatric tumors. Fig S3: Confirmatory tissue specific preferences for MAPK pathway mutations in cBioP…
View article: SupplementalTables from Mutations in the RAS/MAPK Pathway Drive Replication Repair–Deficient Hypermutated Tumors and Confer Sensitivity to MEK Inhibition
SupplementalTables from Mutations in the RAS/MAPK Pathway Drive Replication Repair–Deficient Hypermutated Tumors and Confer Sensitivity to MEK Inhibition Open
Table S1: Summary of likely pathogenic mutations detected in Foundation Medicine cohort of 1215 pediatric cancers. Table S2: Summary of RAS/MAPK pathway mutations and consequences detected in 48 RRD cancers.
View article: Data from Cancers from Novel <i>Pole</i>-Mutant Mouse Models Provide Insights into Polymerase-Mediated Hypermutagenesis and Immune Checkpoint Blockade
Data from Cancers from Novel <i>Pole</i>-Mutant Mouse Models Provide Insights into Polymerase-Mediated Hypermutagenesis and Immune Checkpoint Blockade Open
POLE mutations are a major cause of hypermutant cancers, yet questions remain regarding mechanisms of tumorigenesis, genotype–phenotype correlation, and therapeutic considerations. In this study, we establish mouse models harboring …
View article: Supplementary Table S3 from Cancers from Novel <i>Pole</i>-Mutant Mouse Models Provide Insights into Polymerase-Mediated Hypermutagenesis and Immune Checkpoint Blockade
Supplementary Table S3 from Cancers from Novel <i>Pole</i>-Mutant Mouse Models Provide Insights into Polymerase-Mediated Hypermutagenesis and Immune Checkpoint Blockade Open
POLE germline mutations from the IRRDC and literature
View article: Supplementary Table S1 from Cancers from Novel <i>Pole</i>-Mutant Mouse Models Provide Insights into Polymerase-Mediated Hypermutagenesis and Immune Checkpoint Blockade
Supplementary Table S1 from Cancers from Novel <i>Pole</i>-Mutant Mouse Models Provide Insights into Polymerase-Mediated Hypermutagenesis and Immune Checkpoint Blockade Open
CyTOF panel antibodies
View article: Data from Cancers from Novel <i>Pole</i>-Mutant Mouse Models Provide Insights into Polymerase-Mediated Hypermutagenesis and Immune Checkpoint Blockade
Data from Cancers from Novel <i>Pole</i>-Mutant Mouse Models Provide Insights into Polymerase-Mediated Hypermutagenesis and Immune Checkpoint Blockade Open
POLE mutations are a major cause of hypermutant cancers, yet questions remain regarding mechanisms of tumorigenesis, genotype–phenotype correlation, and therapeutic considerations. In this study, we establish mouse models harboring …
View article: Supplementary Table S2 from Cancers from Novel <i>Pole</i>-Mutant Mouse Models Provide Insights into Polymerase-Mediated Hypermutagenesis and Immune Checkpoint Blockade
Supplementary Table S2 from Cancers from Novel <i>Pole</i>-Mutant Mouse Models Provide Insights into Polymerase-Mediated Hypermutagenesis and Immune Checkpoint Blockade Open
Tumor incidence of Pole mutant mice
View article: Supplementary Table S2 from Cancers from Novel <i>Pole</i>-Mutant Mouse Models Provide Insights into Polymerase-Mediated Hypermutagenesis and Immune Checkpoint Blockade
Supplementary Table S2 from Cancers from Novel <i>Pole</i>-Mutant Mouse Models Provide Insights into Polymerase-Mediated Hypermutagenesis and Immune Checkpoint Blockade Open
Tumor incidence of Pole mutant mice
View article: Supplementary Table S1 from Cancers from Novel <i>Pole</i>-Mutant Mouse Models Provide Insights into Polymerase-Mediated Hypermutagenesis and Immune Checkpoint Blockade
Supplementary Table S1 from Cancers from Novel <i>Pole</i>-Mutant Mouse Models Provide Insights into Polymerase-Mediated Hypermutagenesis and Immune Checkpoint Blockade Open
CyTOF panel antibodies
View article: Supplementary Table S3 from Cancers from Novel <i>Pole</i>-Mutant Mouse Models Provide Insights into Polymerase-Mediated Hypermutagenesis and Immune Checkpoint Blockade
Supplementary Table S3 from Cancers from Novel <i>Pole</i>-Mutant Mouse Models Provide Insights into Polymerase-Mediated Hypermutagenesis and Immune Checkpoint Blockade Open
POLE germline mutations from the IRRDC and literature
View article: Supplementary Data Figures 1-8 from Cancers from Novel <i>Pole</i>-Mutant Mouse Models Provide Insights into Polymerase-Mediated Hypermutagenesis and Immune Checkpoint Blockade
Supplementary Data Figures 1-8 from Cancers from Novel <i>Pole</i>-Mutant Mouse Models Provide Insights into Polymerase-Mediated Hypermutagenesis and Immune Checkpoint Blockade Open
Supplementary Figure S1 (related to Figure 1): PoleP286R mouse model design, validation, and tumor findings. Supplementary Figure S2 (related to Figure 1): PoleS459F mouse model design, validation, and tumor findings. Supplementary Figure …
View article: Supplementary Data from Cancers from Novel <i>Pole</i>-Mutant Mouse Models Provide Insights into Polymerase-Mediated Hypermutagenesis and Immune Checkpoint Blockade
Supplementary Data from Cancers from Novel <i>Pole</i>-Mutant Mouse Models Provide Insights into Polymerase-Mediated Hypermutagenesis and Immune Checkpoint Blockade Open
Supplemental Titles and Figure Legends
View article: Supplementary Data from Cancers from Novel <i>Pole</i>-Mutant Mouse Models Provide Insights into Polymerase-Mediated Hypermutagenesis and Immune Checkpoint Blockade
Supplementary Data from Cancers from Novel <i>Pole</i>-Mutant Mouse Models Provide Insights into Polymerase-Mediated Hypermutagenesis and Immune Checkpoint Blockade Open
Supplemental Titles and Figure Legends
View article: Supplementary Data Figures 1-8 from Cancers from Novel <i>Pole</i>-Mutant Mouse Models Provide Insights into Polymerase-Mediated Hypermutagenesis and Immune Checkpoint Blockade
Supplementary Data Figures 1-8 from Cancers from Novel <i>Pole</i>-Mutant Mouse Models Provide Insights into Polymerase-Mediated Hypermutagenesis and Immune Checkpoint Blockade Open
Supplementary Figure S1 (related to Figure 1): PoleP286R mouse model design, validation, and tumor findings. Supplementary Figure S2 (related to Figure 1): PoleS459F mouse model design, validation, and tumor findings. Supplementary Figure …
View article: Future sustainability trends
Future sustainability trends Open
View article: The sustainability imperative in business
The sustainability imperative in business Open
View article: The sustainability imperative in practice
The sustainability imperative in practice Open
View article: Introduction to Sustainability
Introduction to Sustainability Open