Cristobalina Mayorga
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Long‐Term Effect of Allergen Immunotherapy in Responder Local Allergic Rhinitis Patients: Symptom Control, and Prevention of Asthma and Allergic Sensitizations Open
Background Clinical trials (CTs) have shown that allergen immunotherapy (AIT) is effective for local allergic rhinitis (LAR) while treatment is ongoing. However, its long‐term effects remain unknown. This study investigates the long‐term c…
The Use of Omics Sciences in Allergic Diseases From Bench to Bedside: An EAACI Position Paper Open
Omics have revolutionized our understanding of allergic diseases, with increasingly more studies adopting techniques like genomics, proteomics, and metabolomics over the years. Integrating high‐dimensional omics data with clinical features…
View article: Drug hypersensitivity reactions in children in clinical practice: A WAO Statement
Drug hypersensitivity reactions in children in clinical practice: A WAO Statement Open
Drug hypersensitivity reactions (DHRs) in children and adolescents are less common than in adults but can have serious consequences if mismanaged. Mislabeling children as drug-allergic due to incomplete diagnostic evaluations leads to unne…
Multi-omics analysis of a prebiotic intervention with pectin in lipid transfer proteins (LTPs) allergic patients Open
Currently, there is great interest in the use of pectins for prebiotic treatment of food allergy. Hence, the effects of two different esterified pectins - low methoxyl citrus-derived pectin (CP-DElow) and high methoxyl apple-derived pectin…
The Use of Omics Sciences in Allergic Diseases From Bench to Bedside: An <span>EAACI</span> Position Paper Open
Omics have revolutionized our understanding of allergic diseases, with increasingly more studies adopting techniques like genomics, proteomics, and metabolomics over the years. Integrating high‐dimensional omics data with clinical features…
View article: Basophil Activation Test: Bridging Allergy and Oncology for Diagnostic, Therapeutic and Prognostic Applications in <scp>AllergoOncology</scp>: An <scp>EAACI</scp> Position Paper
Basophil Activation Test: Bridging Allergy and Oncology for Diagnostic, Therapeutic and Prognostic Applications in <span>AllergoOncology</span>: An <span>EAACI</span> Position Paper Open
The basophil activation test (BAT) is gaining increasing relevance as an ex vivo functional assay in allergy to evaluate IgE‐mediated hypersensitivity reactions to food allergens, venoms, and drugs and to monitor tolerance induction. Estab…
<span>IgG</span> Removal Enhances the Sensitivity of Amoxicillin‐Specific <span>IgE</span> Detection in <span>ImmunoCAP</span> and Radioallergosorbent Test Open
Funding for open access charge: Universidad de Málaga / CBUA
Direct Single‐Dose Drug‐Provocation Test Is Safe for Delabelling Penicillin Low‐Risk Reactions in Adults Open
Background Penicillins (PENs) are the most frequent drug‐allergic reactions trigger. However, diagnostic work‐up is complex and time‐consuming: it requires skin testing (ST) and drug‐provocation test (DPT), needing faster delabelling strat…
View article: Endotypes in Immune Mediated Drug Reactions: Present and Future of Relevant Biomarkers. An <scp>EAACI</scp> Task Force Report
Endotypes in Immune Mediated Drug Reactions: Present and Future of Relevant Biomarkers. An <span>EAACI</span> Task Force Report Open
Drug‐induced immune reactions are an important burden for patients and health systems. They can be classified into immediate‐drug hypersensitivity reactions (IDHRs) and delayed‐DHRs (DDHRs) based on their phenotype. Drugs do not always beh…
Reverse vaccinology-based multi-epitope COVID-19 vaccine targeting SARS-CoV-2 structural and non-structural proteins induces immune responses in mice Open
Vaccination is effective to end pandemics, including the Coronavirus disease-2019 (COVID-19). However, the evolution of Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) which is characterized by the emergence of the virus varia…
Ovalbumin-loaded mesoporous silica nanoparticles for allergen specific immunotherapy Open
Allergic diseases are caused by an unnecessary immune response against harmless external substances (allergens), and they pose an important economic burden for healthcare systems with a large impact on the quality of life of patients. Alle…
Dissolving microneedle array patches containing mesoporous silica nanoparticles of different pore sizes as a tunable sustained release platform Open
Dissolving microneedle array patches (DMAP) enable efficient and painless delivery of therapeutic molecules across the stratum corneum and into the upper layers of the skin. Furthermore, this delivery strategy can be combined with the sust…
Entre aguas y fábricas: transformaciones en el paisaje industrial del río Magdalena Open
This article explores the transformation of the industrial cultural landscape along the Magdalena River, specifically from Girardot to Honda, with the aim of characterizing this change and highlighting the relationship between the valley, …
Basophil Activation Test Positivity Decreases With Time in Immediate Allergic Reactions to Proton Pump Inhibitors Open
Omeprazole is a widely prescribed proton pump inhibitor [1], with 1%–3% of adverse reactions being reported. Up to 86% of these reactions are IgE mediated [2] and half of them anaphylaxis [1]. An accurate diagnosis is essential, with skin …
Investigation of the diagnostic accuracy of basophil activation test for allergic phenotypes of rhinitis Open
Introduction Basophil activation test (BAT) might be an alternative to nasal allergen challenge (NAC) to identify the allergic etiology in rhinitis patients. Here, we investigate the diagnostic performance of BAT for allergic phenotypes of…
An algorithm for the diagnosis of beta‐lactam allergy, 2024 update Open
Open access publishing facilitated by Universidad de Málaga/CBUA This study has been supported by the Institute of Health “Carlos III” of the Ministry of Economy and Competitiveness (grants cofounded by European Regional Development Fund: …
Basophil activation test is a complementary tool in the diagnosis of immediate reactions to platinum salts and taxanes Open
Background Delabelling pathways offer confirmatory diagnosis and can prevent unnecessary second‐line therapies or drug desensitization procedures after chemotherapeutic hypersensitivity reactions (CHT‐HSRs). However, these pathways rely on…
New Approaches for Basophil Activation Tests Employing Dendrimeric Antigen–Silica Nanoparticle Composites Open
In vitro cell activation through specific IgE bound to high-affinity receptors on the basophil surface is a widely used strategy for the evaluation of IgE-mediated immediate hypersensitivity reactions to betalactams. Cellular activation re…
View article: Granulocytes and mast cells in AllergoOncology—Bridging allergy to cancer: An <scp>EAACI</scp> position paper
Granulocytes and mast cells in AllergoOncology—Bridging allergy to cancer: An <span>EAACI</span> position paper Open
Derived from the myeloid lineage, granulocytes, including basophils, eosinophils, and neutrophils, along with mast cells, play important, often disparate, roles across the allergic disease spectrum. While these cells and their mediators ar…
Reaction severity and peach threshold amount during oral challenge in nonspecific lipid transfer protein allergy Open
Figure S1. Figure S2. Figure S3. Figure S4. Table S1. Data S1. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) s…
Genomic variants association with selective hypersensitivity reactions to amoxicillin and clavulanic acid Open
In summary, there are rare variants found in our patients that could be related to the development of AX or CLV- induced IDHRs. Interestingly, some of these rare variants could be associated with selective response to AX, such as the proap…
Lipopolysaccharides in combination with amoxicillin increases basophil activation test sensitivity to amoxicillin <span>IgE</span>‐mediated hypersensitivity Open
β-lactams (BLs), and among them, amoxicillin (AX) are the most current prescribed antibiotics to treat bacterial infections,1 and their use is related to an increasing prevalence of drug hypersensitivity reactions (DHRs),2 being mainly imm…
View article: Nasal allergen‐neutralizing antibodies correlate closely with tolerated intranasal allergen challenge dose following grass pollen subcutaneous immunotherapy in patients with local allergic rhinitis
Nasal allergen‐neutralizing antibodies correlate closely with tolerated intranasal allergen challenge dose following grass pollen subcutaneous immunotherapy in patients with local allergic rhinitis Open
Background Local allergic rhinitis (LAR) is defined by chronic nasal symptoms, absence of atopy, positive nasal allergen challenge (NAC) and a good response to subcutaneous allergen immunotherapy (SCIT). We sought to investigate SCIT capac…
Cytometer harmonization, through BAT, as part of IVDR and key to conduct multicentre studies Open
Supplementary Figure 1.Study design.Basophil activation test was performed to 40 drugallergic individuals toamoxicillin, clavulanic acid, cefuroxime, ceftriaxone, dipyrone or azithromycin.with a total of 430 measurements Samples were analy…