Lin Sun
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View article: The HG domain is the key factor responsible for antioxidant activity of pectin polysaccharides from Polygonum aviculare L.
The HG domain is the key factor responsible for antioxidant activity of pectin polysaccharides from Polygonum aviculare L. Open
In this study, we purified two pectin macromolecules designated as WPAP-Aa (59.9 kDa) and WPAP-Ab (83.8 kDa) from Polygonum aviculare L. by using hot water extraction, ethanol precipitation and chromatographic purification. Through enzymat…
View article: The CCR5/ROS/NRF2 axis Mediates Dihydrotanshinone I-Induced oxidative stress and apoptosis in hepatocellular carcinoma
The CCR5/ROS/NRF2 axis Mediates Dihydrotanshinone I-Induced oxidative stress and apoptosis in hepatocellular carcinoma Open
Despite therapeutic advances, hepatocellular carcinoma (HCC) remains a leading cause of cancer mortality worldwide. While dihydrotanshinone I (DHT) shows promising anticancer potential, its molecular mechanisms in HCC remain unexplored. He…
View article: Selective utilization of medicinal polysaccharides by human gut Bacteroides and Parabacteroides species
Selective utilization of medicinal polysaccharides by human gut Bacteroides and Parabacteroides species Open
View article: A Simple Colorimetric Receptor for High-Affinity Aqueous Anion Recognition via Hydrogen Bonding
A Simple Colorimetric Receptor for High-Affinity Aqueous Anion Recognition via Hydrogen Bonding Open
View article: Utilization of medicinal polysaccharides by human gut Bacteroides and Parabacteroides species
Utilization of medicinal polysaccharides by human gut Bacteroides and Parabacteroides species Open
Human gut Bacteroides and Parabacteroides species play crucial roles in human health and are known for their capacity to utilize diverse polysaccharides. Understanding how these bacteria utilize medicinal polysaccharides is foundational fo…
View article: Application of a Novel Α-Galactosidase from Bacteroides Fragilis on Structural Analysis of Raffinose Family Oligosaccharides
Application of a Novel Α-Galactosidase from Bacteroides Fragilis on Structural Analysis of Raffinose Family Oligosaccharides Open
View article: Preparation and structural analysis of fucomannogalactan and β-1,6-glucan from Grifola frondosa mycelium
Preparation and structural analysis of fucomannogalactan and β-1,6-glucan from Grifola frondosa mycelium Open
Introduction: Polysaccharides, key components present in Grifola frondosa , can be divided into those derived from fruiting bodies, mycelium, and fermentation broth based on their source. The structure of G. frondosa fruiting body-derived …
View article: Structural characterization and antioxidant activity of pectic polysaccharides from Veronica peregrina L.
Structural characterization and antioxidant activity of pectic polysaccharides from Veronica peregrina L. Open
Background Pectins are a class of acidic polysaccharides with complex structures. Different pectin molecules are composed of different domains, which have an important impact on their biological activity. Objective This study aimed to dete…
View article: Structural characterization of water-soluble polysaccharides isolated from leaves of Hedera nepalensis
Structural characterization of water-soluble polysaccharides isolated from leaves of Hedera nepalensis Open
Background Hedera nepalensis is a traditional medicinal plants, and the dried leaves of it are generally used for the cure and treatment of many diseases, also widely known as Chang-Chun-Teng in Chinese. Until now, structural characterizat…
View article: Purification and identification of oligosaccharides from Cimicifuga heracleifolia Kom. rhizomes
Purification and identification of oligosaccharides from Cimicifuga heracleifolia Kom. rhizomes Open
Even though Cimicifuga sp. is widely used in functional foods around the world, the content and structure of its oligosaccharides remain unclear. Here, we isolated a mixture of oligosaccharides from Cimicifuga heracleifolia K…
View article: Structural characterization and anti-oxidation activity evaluation of pectin from Lonicera japonica Thunb.
Structural characterization and anti-oxidation activity evaluation of pectin from Lonicera japonica Thunb. Open
Pectins are nutrient components of plants and are widely used in the food industry. In this study, one major pectin fraction (WLJP-A0.2b) with Mw of 40.6 kDa was purified from Lonicera japonica Thunb. The structural feature and antioxidant…
View article: Determining Methyl-Esterification Patterns in Plant-Derived Homogalacturonan Pectins
Determining Methyl-Esterification Patterns in Plant-Derived Homogalacturonan Pectins Open
Homogalacturonan (HG)-type pectins are nutrient components in plants and are widely used in the food industry. The methyl-esterification pattern is a crucial structural parameter used to assess HG pectins in terms of their nutraceutical ac…
View article: β-1,6-Glucan From Pleurotus eryngii Modulates the Immunity and Gut Microbiota
β-1,6-Glucan From Pleurotus eryngii Modulates the Immunity and Gut Microbiota Open
Polysaccharides from Pleurotus eryngii exhibit a variety of biological activities. Here, we obtained a homogeneous branched β-1,6-glucan (APEP-A-b) from the fruiting bodies of P. eryngii and investigated its effect on immunity and gut micr…
View article: Bee Pollen Polysaccharide From Rosa rugosa Thunb. (Rosaceae) Promotes Pancreatic β-Cell Proliferation and Insulin Secretion
Bee Pollen Polysaccharide From Rosa rugosa Thunb. (Rosaceae) Promotes Pancreatic β-Cell Proliferation and Insulin Secretion Open
Insufficient pancreatic β-cell or insulin-producing β-cell are implicated in all types of diabetes mellitus. Our previous studies showed bee pollen polysaccharide RBPP-P improves insulin resistance in type 2 diabetic mice by inhibiting liv…
View article: Comparison of Analytical Methods for Determining Methylesterification and Acetylation of Pectin
Comparison of Analytical Methods for Determining Methylesterification and Acetylation of Pectin Open
The esterification of galacturonic acid with methanol and/or acetic acid is important for the structural analysis of pectin. Although several methods have been reported for determining the degree of methylesterification (DM) and acetylatio…
View article: Structural analysis and macrophage activation of a novel β‑glucan isolated from <i>Cantharellus cibarius</i>
Structural analysis and macrophage activation of a novel β‑glucan isolated from <i>Cantharellus cibarius</i> Open
The present study was designed to investigate the structure and immunomodulatory activity of a polysaccharide. A novel acidic β‑glucan (WCCP‑A‑b; molecular weight, 7.3 kDa) was purified from the fruiting bodies of the edible mushroom Ca…
View article: Engineering of a bona fide light-operated calcium channel
Engineering of a bona fide light-operated calcium channel Open
View article: Citrus-derived DHCP inhibits mitochondrial complex II to enhance TRAIL sensitivity via ROS-induced DR5 upregulation
Citrus-derived DHCP inhibits mitochondrial complex II to enhance TRAIL sensitivity via ROS-induced DR5 upregulation Open
Heat-modified citrus pectin, a water-soluble indigestible polysaccharide fiber derived from citrus fruits and modified by temperature treatment, has been reported to exhibit anticancer effects. However, the bioactive fractions and their me…
View article: Structural Characterization of Pectic Polysaccharides From <i>Bupleurum chinense</i> DC
Structural Characterization of Pectic Polysaccharides From <i>Bupleurum chinense</i> DC Open
Bupleurum chinense DC, a traditional medicinal plant in China that has many pharmacological effects, contains polysaccharide as one of its active components. In this study, we isolated and structurally characterized the polysaccharide from…
View article: CED-4 CARD domain residues can modulate non-apoptotic neuronal regeneration functions independently from apoptosis
CED-4 CARD domain residues can modulate non-apoptotic neuronal regeneration functions independently from apoptosis Open
A major challenge in regenerative medicine is the repair of injured neurons. Regeneration of laser-cut C . elegans neurons requires early action of core apoptosis activator CED-4/Apaf1 and CED-3/caspase. While testing models for CED-4 as a…
View article: Structural characterization of alkali-soluble polysaccharides from <i>Panax ginseng</i> C. A. Meyer
Structural characterization of alkali-soluble polysaccharides from <i>Panax ginseng</i> C. A. Meyer Open
Panax ginseng C. A. Meyer (ginseng) has been widely used as a herb and functional food in the world. Polysaccharides are the main active components of ginseng. In this paper, the polysaccharides were sequentially extracted by 50 mM Na 2 CO…
View article: Supplementary material from "Structural characterization of alkali-soluble polysaccharides from <i>Panax ginseng</i> C. A. Meyer"
Supplementary material from "Structural characterization of alkali-soluble polysaccharides from <i>Panax ginseng</i> C. A. Meyer" Open
Panax ginseng C. A. Meyer (Ginseng) has been widely used as a herb and functional food in the world. Polysaccharide is a main active component of ginseng. In this paper, the polysaccharide was sequentially extracted by 50 mM Na…
View article: The roles and mechanisms of homogalacturonan and rhamnogalacturonan I pectins on the inhibition of cell migration
The roles and mechanisms of homogalacturonan and rhamnogalacturonan I pectins on the inhibition of cell migration Open
View article: Structural Characterization of a Rhamnogalacturonan I Domain from Ginseng and Its Inhibitory Effect on Galectin-3
Structural Characterization of a Rhamnogalacturonan I Domain from Ginseng and Its Inhibitory Effect on Galectin-3 Open
A rhamnogalacturonan I domain, named RG-I-3A, was prepared from ginseng pectin by pectinase digestion and chromatography separation. Monosaccharide composition analysis revealed that it was mainly composed of galacturonic acid, rhamnose, g…
View article: Potential lipase inhibitors from Chinese medicinal herbs
Potential lipase inhibitors from Chinese medicinal herbs Open
20(S)-ginsenoside Rg3 and honokiol might be suitable candidates for the treatment of obesity.
View article: Synthesis and anticancer activities of diquinazoline diselenides compounds
Synthesis and anticancer activities of diquinazoline diselenides compounds Open
A series of novel diquinazoline diselenide compounds was designed and synthesized with substituted 4-chloroquinazoline and sodium diselenide. Their structures were confirmed by IR, 1H NMR, 13C NMR, and elemental analyses.The antitumor acti…
View article: One New Conjugate of a Secoiridoid Glucoside with a Sesquiterpene Glucoside from the Flower Buds of <i>Lonicera japonica</i>
One New Conjugate of a Secoiridoid Glucoside with a Sesquiterpene Glucoside from the Flower Buds of <i>Lonicera japonica</i> Open
Secosesquside (1), a new secoiridoid glucoside-sesquiterpene conjugate, together with three known secoiridoid derivatives, were isolated from flower buds of Lonicera japonica. The isolated compounds were elucidated by extensive spectroscop…
View article: Casitas B-Lineage Lymphoma RING Domain Inhibitors Protect Mice against High-Fat Diet-Induced Obesity and Insulin Resistance
Casitas B-Lineage Lymphoma RING Domain Inhibitors Protect Mice against High-Fat Diet-Induced Obesity and Insulin Resistance Open
The casitas b-lineage lymphoma (c-Cbl) is an important adaptor protein with an intrinsic E3 ubiquitin ligase activity that interacts with E2 proteins such as UbCH7. c-Cbl plays a vital role in regulating receptor tyrosine kinase signaling.…