Lucilla Poston
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View article: Effects of lifestyle interventions in pregnancy on gestational diabetes: individual participant data and network meta-analysis
Effects of lifestyle interventions in pregnancy on gestational diabetes: individual participant data and network meta-analysis Open
Objectives To assess the effects of lifestyle interventions on gestational diabetes, determine whether the effects vary by maternal body mass index, age, parity, ethnicity, education level, or intervention, and rank interventions by effect…
View article: Cohort Profile: PRECISE-DYAD: a prospective cohort study linking maternal and infant health trajectories in sub-Saharan Africa
Cohort Profile: PRECISE-DYAD: a prospective cohort study linking maternal and infant health trajectories in sub-Saharan Africa Open
Purpose The PRECISE-DYAD study is a prospective observational cohort, designed to investigate health outcomes among mother-child pairs (dyads), over the first three years of life in two contexts from sub-Saharan Africa. The primary objecti…
Beyond Gestational Diabetes: Maternal and Offspring Health and Lifestyle 3 Years Postnatally in a Secondary Analysis of the <span>UPBEAT</span> Trial Cohort Open
Background Gestational diabetes (GDM) is associated with increased future obesity risk in affected mothers and children. Objective We assessed if dietary behaviours learnt during a GDM pregnancy positively impact maternal and child health …
Maternal Gestational Diabetes Impairs Fetoplacental Insulin-Induced Vasodilation via AKT/eNOS Pathway and Reduces Placental Efficiency Open
Gestational Diabetes Mellitus (GDM) increases the long-term risk for metabolic and cardiovascular diseases in the offspring. However, the underlying mechanisms are not well understood. This study investigates the impact of GDM on fetoplace…
View article: The effect of lifestyle intervention and depression symptoms on binge eating and relation of binge eating to gestational weight gain and child birth weight in the UPBEAT cohort of pregnant women living with obesity
The effect of lifestyle intervention and depression symptoms on binge eating and relation of binge eating to gestational weight gain and child birth weight in the UPBEAT cohort of pregnant women living with obesity Open
Binge eating is one of the most prevalent eating disorder behaviours in pregnancy, its risk factors and association with pregnancy-related outcomes has sparsely researched in this population. This study aimed to investigate: (hypothesis 1)…
View article: Mother and Infant Research Electronic Data Analysis (MIREDA): Creating a Common Data Model for Federated Analysis to Inform Policy for Improvement in Maternal and Child Outcomes.
Mother and Infant Research Electronic Data Analysis (MIREDA): Creating a Common Data Model for Federated Analysis to Inform Policy for Improvement in Maternal and Child Outcomes. Open
ObjectiveMIREDA aims to provide a harmonized UK-wide resource of restructured, routinely collected anonymised data from multiple birth cohorts using the OMOP Common Data Model (CDM). It will enable analyses across sites without sharing sen…
View article: The relationship between virtual antenatal care and pregnancy outcomes in a diverse UK inner-city population: a group-based trajectory modeling approach using routine health records
The relationship between virtual antenatal care and pregnancy outcomes in a diverse UK inner-city population: a group-based trajectory modeling approach using routine health records Open
A higher proportion of virtual care contacts in antenatal care in the second or third trimesters was associated with a greater risk of adverse pregnancy outcomes.
Metallomic profiles of pregnant women living with obesity in the UK: a secondary analysis of UPBEAT Open
Characterization of serum metal element concentrations in pregnancy enables the elucidation of relationships with maternal-fetal and neonatal health. Metal elements in the blood serve as essential cofactors for enzymatic reactions and cont…
The Influence of Snacking on Glycaemia in Women With Gestational Diabetes Mellitus: A Systematic Review Open
Gestational diabetes mellitus (GDM) is characterised by glucose intolerance identified during pregnancy, typically resolving postpartum. Globally, the standardised prevalence is 14%. Dietary management is essential in mitigating adverse ma…
Evaluating acceptability and experiences of pregnant women at high risk of developing gestational diabetes who take part in antenatal intervention trials: a qualitative systematic review Open
Background Gestational diabetes mellitus (GDM) is associated with short- and longer-term adverse outcomes for both mother and child. The success of randomised controlled trials (RCTs) assessing interventions to prevent GDM depends in part …
View article: Temporal trends in pregnancy outcomes during a health system shock: A retrospective longitudinal study
Temporal trends in pregnancy outcomes during a health system shock: A retrospective longitudinal study Open
To better understand reported COVID-19 pandemic effects on pregnancy, we examined temporal trends in pregnancy outcomes in a diverse population from South London, United Kingdom. We included 31,411 singleton pregnancies with complete regis…
View article: Do lower antenatal blood pressure cut-offs in pregnant women with obesity identify those at greater risk of adverse maternal and perinatal outcomes? A secondary analysis of data from the UK Pregnancies Better Eating and Activity Trial (UPBEAT)
Do lower antenatal blood pressure cut-offs in pregnant women with obesity identify those at greater risk of adverse maternal and perinatal outcomes? A secondary analysis of data from the UK Pregnancies Better Eating and Activity Trial (UPBEAT) Open
Background Obesity is a major risk-factor for adverse pregnancy outcomes. While the 2017 American College of Cardiology/American Heart Association (ACC/AHA) classification of normal and abnormal blood pressure (BP) outside pregnancy has be…
View article: The relationship between virtual antenatal care and pregnancy outcomes in a diverse UK inner-city population; A group-based trajectory modelling approach using routine health records
The relationship between virtual antenatal care and pregnancy outcomes in a diverse UK inner-city population; A group-based trajectory modelling approach using routine health records Open
Background The COVID-19 pandemic resulted in major maternity service reconfigurations, particularly an increase in virtual antenatal care (vANC). We aimed to explore the relationship between vANC trajectories over time and pregnancy outcom…
View article: PREgnancy Care Integrating translational Science, Everywhere (PRECISE): a prospective cohort study of African pregnant and non-pregnant women to investigate placental disorders – cohort profile
PREgnancy Care Integrating translational Science, Everywhere (PRECISE): a prospective cohort study of African pregnant and non-pregnant women to investigate placental disorders – cohort profile Open
Purpose The PREgnancy Care Integrating translational Science, Everywhere Network was established to investigate specific placental disorders (pregnancy hypertension, preterm birth, fetal growth restriction and stillbirth) in sub-Saharan Af…
The impact of the COVID-19 pandemic on maternal healthcare costs:a time series analysis of pregnancies of multi-ethnic mothers in South London, United Kingdom Open
Background: Due to the COVID-19 pandemic, maternity care reconfigurations disrupted in-person care, which shifted towards virtual care and self-monitoring. We assessed the impact of these changes on maternity service provision costs. Metho…
View article: <i>In vivo</i> tractography of human neonatal white-matter pathways underlying hypothalamic and reward functions to study predispositions to neurodevelopmental conditions and obesity
<i>In vivo</i> tractography of human neonatal white-matter pathways underlying hypothalamic and reward functions to study predispositions to neurodevelopmental conditions and obesity Open
White matter (WM) tracts of the reward, limbic, and autonomic systems implicate the hypothalamus, nucleus accumbens, ventral tegmental area and the amygdala and are associated with autism, ADHD, addiction and obesity. However, since most o…
View article: Diagnostic properties of differing BP thresholds for adverse pregnancy outcomes in standard-risk nulliparous women: A secondary analysis of SCOPE cohort data
Diagnostic properties of differing BP thresholds for adverse pregnancy outcomes in standard-risk nulliparous women: A secondary analysis of SCOPE cohort data Open
Background In 2017, the American College of Cardiology and American Heart Association (ACC/AHA) lowered blood pressure (BP) thresholds to define hypertension in adults outside pregnancy. If used in pregnancy, these lower thresholds may ide…
Pregnancy and postnatal outcomes for women with intellectual disability and their infants: A systematic review Open
The relative sparsity of literature in this field demonstrates the need for further focused study on the pregnancy and postnatal outcomes of women with intellectual disability and their infants. Nonetheless, findings indicate that maternit…
View article: The impact of the COVID-19 pandemic on maternal healthcare costs in a UK inner-city multi-ethnic population
The impact of the COVID-19 pandemic on maternal healthcare costs in a UK inner-city multi-ethnic population Open
Background: During the COVID-19 pandemic, maternity care reconfigurations disrupted in-person care, which shifted towards virtual care and self-monitoring. We assessed the impact of these changes on healthcare costs. Methods: Data from Oct…
Infant feeding practices: an analysis of sociodemographic characteristics and dietary patterns in early life Open
The significant rise in childhood obesity is a public health challenge, and it is estimated that nearly 25% of children in England start school with overweight or obesity 1 ; those from ethnic minorities and more disadvantaged areas are di…
View article: Mother and Infant Research Electronic Data Analysis (MIREDA): A protocol for creating a common data model for federated analysis of UK birth cohorts and the life course
Mother and Infant Research Electronic Data Analysis (MIREDA): A protocol for creating a common data model for federated analysis of UK birth cohorts and the life course Open
IntroductionBirth cohorts are valuable resources for studying early life, the determinants of health, disease, and development. They are essential for studying life course. Dynamic longitudinal electronic cohorts use routinely collected da…
Breastfeeding behaviours in women with obesity; associations with weight retention and the serum metabolome: a secondary analysis of UPBEAT Open
Background/Objectives Maternal obesity is associated with a decreased intention and initiation of breastfeeding as well as a shortened duration of breastfeeding. This analysis was undertaken to identify breastfeeding behaviours, and relati…
Maternal obesity and offspring cardiovascular remodelling — the effect of preconception and antenatal lifestyle interventions: a systematic review Open
Background Preconception or antenatal lifestyle interventions in women with obesity may prevent adverse cardiovascular outcomes in the child, including cardiac remodelling. We undertook a systematic review of the existing data to examine t…
Rethinking causal assumptions about maternal BMI, gestational weight gain, and adverse pregnancy outcomes Open
Background The aim of this study was to evaluate commonly assumed causal relationships between body mass index (BMI), gestational weight gain (GWG), and adverse pregnancy outcomes, which have formed the basis of guidelines and intervention…