Luke Esposito
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View article: Integrated Classification of Cortical Cells and Quantitative Projectomic Mapping Unveil Organizational Principles of Brain-Wide Connectomes at Single Cell Level
Integrated Classification of Cortical Cells and Quantitative Projectomic Mapping Unveil Organizational Principles of Brain-Wide Connectomes at Single Cell Level Open
Molecularly defined cortical cell types have recently been linked to whole neuronal morphology (WNM), particularly those characterized by whole-brain-wide projections, such as intratelencephalic (IT), extratelencephalic (ET), and corticoth…
View article: Risk for Unplanned Pregnancy Among Survivors of Childhood Cancer
Risk for Unplanned Pregnancy Among Survivors of Childhood Cancer Open
The purpose of this study was to identify factors associated with risk for unplanned pregnancy in sexually active female survivors using self‐report survey data. Risk for unplanned pregnancy was defined as using less effective/no contracep…
View article: Brain-wide cell-type-specific transcriptomic signatures of healthy ageing in mice
Brain-wide cell-type-specific transcriptomic signatures of healthy ageing in mice Open
View article: Integrated multimodal cell atlas of Alzheimer’s disease
Integrated multimodal cell atlas of Alzheimer’s disease Open
Alzheimer’s disease (AD) is the leading cause of dementia in older adults. Although AD progression is characterized by stereotyped accumulation of proteinopathies, the affected cellular populations remain understudied. Here we use multiomi…
View article: A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain
A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain Open
View article: Signature morphoelectric properties of diverse GABAergic interneurons in the human neocortex
Signature morphoelectric properties of diverse GABAergic interneurons in the human neocortex Open
Human cortex transcriptomic studies have revealed a hierarchical organization of γ-aminobutyric acid–producing (GABAergic) neurons from subclasses to a high diversity of more granular types. Rapid GABAergic neuron viral genetic labeling pl…
View article: Morphoelectric and transcriptomic divergence of the layer 1 interneuron repertoire in human versus mouse neocortex
Morphoelectric and transcriptomic divergence of the layer 1 interneuron repertoire in human versus mouse neocortex Open
Neocortical layer 1 (L1) is a site of convergence between pyramidal-neuron dendrites and feedback axons where local inhibitory signaling can profoundly shape cortical processing. Evolutionary expansion of human neocortex is marked by disti…
View article: Signature morpho-electric properties of diverse GABAergic interneurons in the human neocortex
Signature morpho-electric properties of diverse GABAergic interneurons in the human neocortex Open
Human cortical interneurons have been challenging to study due to high diversity and lack of mature brain tissue platforms and genetic targeting tools. We employed rapid GABAergic neuron viral labeling plus unbiased Patch-seq sampling in b…
View article: Morpho-electric and transcriptomic divergence of the layer 1 interneuron repertoire in human versus mouse neocortex
Morpho-electric and transcriptomic divergence of the layer 1 interneuron repertoire in human versus mouse neocortex Open
Neocortical layer 1 (L1) is a site of convergence between pyramidal neuron dendrites and feedback axons where local inhibitory signaling can profoundly shape cortical processing. Evolutionary expansion of human neocortex is marked by disti…
View article: Local connectivity and synaptic dynamics in mouse and human neocortex
Local connectivity and synaptic dynamics in mouse and human neocortex Open
We present a unique, extensive, and open synaptic physiology analysis platform and dataset. Through its application, we reveal principles that relate cell type to synaptic properties and intralaminar circuit organization in the mouse and h…
View article: Morphological diversity of single neurons in molecularly defined cell types
Morphological diversity of single neurons in molecularly defined cell types Open
Dendritic and axonal morphology reflects the input and output of neurons and is a defining feature of neuronal types 1,2 , yet our knowledge of its diversity remains limited. Here, to systematically examine complete single-neuron morpholog…
View article: Enhancer viruses for combinatorial cell-subclass-specific labeling
Enhancer viruses for combinatorial cell-subclass-specific labeling Open
View article: Survey of spiking in the mouse visual system reveals functional hierarchy
Survey of spiking in the mouse visual system reveals functional hierarchy Open
View article: Integrated Morphoelectric and Transcriptomic Classification of Cortical GABAergic Cells
Integrated Morphoelectric and Transcriptomic Classification of Cortical GABAergic Cells Open
View article: Brain-wide single neuron reconstruction reveals morphological diversity in molecularly defined striatal, thalamic, cortical and claustral neuron types
Brain-wide single neuron reconstruction reveals morphological diversity in molecularly defined striatal, thalamic, cortical and claustral neuron types Open
Ever since the seminal findings of Ramon y Cajal, dendritic and axonal morphology has been recognized as a defining feature of neuronal types. Yet our knowledge concerning the diversity of neuronal morphologies, in particular distal axonal…
View article: Toward an integrated classification of neuronal cell types: morphoelectric and transcriptomic characterization of individual GABAergic cortical neurons
Toward an integrated classification of neuronal cell types: morphoelectric and transcriptomic characterization of individual GABAergic cortical neurons Open
Neurons are frequently classified into distinct groups or cell types on the basis of structural, physiological, or genetic attributes. To better constrain the definition of neuronal cell types, we characterized the transcriptomes and intri…
View article: Toward an Integrated Classification of Cell Types: Morphoelectric and Transcriptomic Characterization of Individual GABAergic Cortical Neurons
Toward an Integrated Classification of Cell Types: Morphoelectric and Transcriptomic Characterization of Individual GABAergic Cortical Neurons Open
View article: Brain-wide single neuron reconstruction reveals morphological diversity in molecularly defined striatal, thalamic, cortical and claustral neuron types
Brain-wide single neuron reconstruction reveals morphological diversity in molecularly defined striatal, thalamic, cortical and claustral neuron types Open
Ever since the seminal findings of Ramon y Cajal, dendritic and axonal morphology has been recognized as a defining feature of neuronal types. Yet our knowledge concerning the diversity of neuronal morphologies, in particular distal axonal…
View article: Enhancer viruses and a transgenic platform for combinatorial cell subclass-specific labeling
Enhancer viruses and a transgenic platform for combinatorial cell subclass-specific labeling Open
Summary The rapid pace of cell type identification by new single-cell analysis methods has not been met with efficient experimental access to the newly discovered types. To enable flexible and efficient access to specific neural population…
View article: Complete Whole-Brain Single Neuron Reconstruction Reveals Morphological Diversity in Molecularly Defined Claustral and Cortical Neuron Types
Complete Whole-Brain Single Neuron Reconstruction Reveals Morphological Diversity in Molecularly Defined Claustral and Cortical Neuron Types Open