Rui Wang
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View article: Sleep characteristics and dementia: a multivariate Mendelian randomization study
Sleep characteristics and dementia: a multivariate Mendelian randomization study Open
Background Observational studies have provided inconsistent association between sleep characteristics and dementia, and the causal nature of this relationship remains unclear. This study aimed to investigate the comprehensive relationship …
View article: Global, regional and national burden of neck pain in children and adolescents: GBD 2021 systematic analysis
Global, regional and national burden of neck pain in children and adolescents: GBD 2021 systematic analysis Open
Background Neck pain (NP) has emerged as a significant health concern among children and adolescents, with potential lifelong consequences. This study aimed to comprehensively assess the global, regional, and national burden of NP among th…
View article: Posterior-stabilized vs cruciate-retaining TKA in osteoarthritic patients with genu recurvatum: a 2-year comparative analysis
Posterior-stabilized vs cruciate-retaining TKA in osteoarthritic patients with genu recurvatum: a 2-year comparative analysis Open
Introduction Pre-operative genu recurvatum (GR) in patients with knee osteoarthritis (OA) presents a surgical challenge during total knee arthroplasty (TKA). It remains unclear whether cruciate-retaining (CR) or posterior-stabilized (PS) T…
View article: TROP2‐guided aggregation‐induced emission‐luminogen nanoparticles overcome sacituzumab govitecan resistance via mitochondrial oxidative stress and immunogenic cell death in triple‐negative breast cancer
TROP2‐guided aggregation‐induced emission‐luminogen nanoparticles overcome sacituzumab govitecan resistance via mitochondrial oxidative stress and immunogenic cell death in triple‐negative breast cancer Open
Chemoresistance and immune evasion constitute formidable obstacles in triple‐negative breast cancer (TNBC) therapy, exacerbated by the suboptimal pharmacokinetics and acquired resistance of antibody–drug conjugates (ADCs). Herein, we descr…
View article: How urban versus rural residency relates to basic activities of daily living among older people in Central China
How urban versus rural residency relates to basic activities of daily living among older people in Central China Open
Although basic activities of daily living (BADL) have been associated with quality of life in older adults, the differences in BADL between urban and rural residency in Central China are not fully clear. This study aimed to assess and comp…
View article: Potential mechanisms of acupuncture treatment for rheumatoid arthritis: a study based on network topology and machine learning
Potential mechanisms of acupuncture treatment for rheumatoid arthritis: a study based on network topology and machine learning Open
Background Rheumatoid arthritis (RA) is a systemic autoimmune disease that requires multitarget therapeutic strategies. Acupuncture, an integrative therapy of traditional Chinese medicine (TCM), has shown efficacy in the clinical treatment…
View article: Pulsed field ablation for atrial fibrillation: clinical applications and research advances
Pulsed field ablation for atrial fibrillation: clinical applications and research advances Open
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, associated with increased risks of stroke, heart failure, and mortality. With the advancement of catheter ablation technology, pulsed field ablation (PFA), a novel n…
View article: Long-term simultaneous 2.25/8.60~GHz monitoring of the newly-discovered repeating FRB~20240114A
Long-term simultaneous 2.25/8.60~GHz monitoring of the newly-discovered repeating FRB~20240114A Open
We report on the simultaneous monitoring of the repeating fast radio burst (FRB) 20240114A at 2.25 and 8.60~GHz, conducted 66 times between 2024 January 29 and 2025 February 15 with the Shanghai Tianma Radio Telescope (TMRT). In about 180 …
View article: Defaunation erodes the diversity of rodent personality traits in fragmented forests
Defaunation erodes the diversity of rodent personality traits in fragmented forests Open
Habitat fragmentation is a primary driver of biodiversity loss globally. One impact of habitat fragmentation is the resultant decline and loss of large and medium mammal populations (also known as defaunation). While the effects of habitat…
View article: Instruments for measuring fatigue in patients with brain tumours: protocol for a COSMIN-based systematic review
Instruments for measuring fatigue in patients with brain tumours: protocol for a COSMIN-based systematic review Open
Introduction Cancer-related fatigue occurs at high rates and can harm patients’ quality of life and even reduce survival, especially in patients with brain tumours. Many measures have been developed to assess this condition, but there have…
View article: Potential Mechanisms of Acupuncture Treatment for Rheumatoid Arthritis: A Study Based on Network Topology and Machine Learning
Potential Mechanisms of Acupuncture Treatment for Rheumatoid Arthritis: A Study Based on Network Topology and Machine Learning Open
Objective: Rheumatoid arthritis (RA) is a systemic autoimmune disease requiring multi-target therapeutic strategies. Acupuncture, a holistic therapy in traditional Chinese medicine (TCM), has shown clinical efficacy in RA, yet its molecula…
View article: Neuroprotective Effects of Qi Jing Wan and Its Active Ingredient Diosgenin Against Cognitive Impairment in Plateau Hypoxia
Neuroprotective Effects of Qi Jing Wan and Its Active Ingredient Diosgenin Against Cognitive Impairment in Plateau Hypoxia Open
Background/Objectives: High-altitude environments have a significant detrimental impact on the cognitive functions of the brain. Qi Jing Wan (QJW), a traditional herbal formula composed of Angelica sinensis, Astragalus membranaceus, and Rh…
View article: Association Between Sleep Duration and Anxiety in US Adults: A Nationally Representative Cross-Sectional Study
Association Between Sleep Duration and Anxiety in US Adults: A Nationally Representative Cross-Sectional Study Open
Short sleep duration is associated with an increased risk of anxiety, with the strength of this association differing notably across demographic subgroups. Long sleep duration is associated with higher anxiety risk exclusively in specific …
View article: Reliability and validity of the Geriatric Self-Care Scale among Chinese older adults
Reliability and validity of the Geriatric Self-Care Scale among Chinese older adults Open
The GSS showed good reliability and validity among community-dwelling older adults in China.
View article: Coupled hydraulic and whole‐plant economic strategies in twenty warm‐temperate woody species
Coupled hydraulic and whole‐plant economic strategies in twenty warm‐temperate woody species Open
The iso‐ to anisohydric continuum describes how plant regulate water potential and has been used to classify species hydraulic strategies. The slow to fast continuum is a whole‐plant strategy for resource acquisition and utilization. The r…
View article: Do Large Language Models Truly Understand Geometric Structures?
Do Large Language Models Truly Understand Geometric Structures? Open
Geometric ability is a significant challenge for large language models (LLMs) due to the need for advanced spatial comprehension and abstract thinking. Existing datasets primarily evaluate LLMs on their final answers, but they cannot truly…
View article: Left atrial appendage occlusion and radiofrequency ablation in a patient with atrial fibrillation and dextrocardia: a case report
Left atrial appendage occlusion and radiofrequency ablation in a patient with atrial fibrillation and dextrocardia: a case report Open
Background Dextrocardia is a rare congenital condition, affecting approximately 1 in 10,000–12,000 individuals. When combined with atrial fibrillation (AF), it becomes even rarer. “One-stop” surgery, including combined radiofrequency ablat…
View article: Neuroimaging Correlates of 3 Distinct Physical-Cognitive Phenotypes in Cognitively Normal Older Adults
Neuroimaging Correlates of 3 Distinct Physical-Cognitive Phenotypes in Cognitively Normal Older Adults Open
This study highlights the variability in physical and cognitive performance among older adults and suggests that neuroimaging markers of neurodegeneration, cSVD, and microstructural WM integrity may account for these variations. Our findin…
View article: causal effects of air pollution on dementia: a mendelian randomized study
causal effects of air pollution on dementia: a mendelian randomized study Open
Background The 2017 Lancet Commission on Dementia Prevention, Intervention and Care included air pollution in the list of potential risk factors for dementia. Air pollution has been associated with an increased risk of dementia in observat…
View article: Hemorrhages and risk factors in patients undergoing thromboprophylaxis in a respiratory critical care unit: a secondary data analysis of a cohort study
Hemorrhages and risk factors in patients undergoing thromboprophylaxis in a respiratory critical care unit: a secondary data analysis of a cohort study Open
Objective To verify whether the bleeding risk assessment guidelines from the 9th American College of Chest Physicians (ACCP) are prognostic for respiratory intensive care unit (RICU) patients and to explore risk factors for hemorrhages, we…
View article: Immune response induced by the Recombinant Novel Coronavirus Vaccine (Adenovirus Type 5 Vector) (Ad5-nCoV) in persons living with HIV (PLWH)
Immune response induced by the Recombinant Novel Coronavirus Vaccine (Adenovirus Type 5 Vector) (Ad5-nCoV) in persons living with HIV (PLWH) Open
Summary Background Despite higher risk of poorer outcomes and potential sub-optimal vaccine effectiveness, people living with HIV (PLWH) are underrepresented in SARS-CoV-2 vaccine trials. We evaluated the safety and immunogenicity of the A…
View article: Does sedentary time and physical activity predict chronic back pain and morphological brain changes? A UK biobank cohort study in 33,402 participants
Does sedentary time and physical activity predict chronic back pain and morphological brain changes? A UK biobank cohort study in 33,402 participants Open
Prolonged sedentary time is associated with heightened risks of chronic back pain and deterioration in brain health.