Linda Sharp
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View article: How does socio-economic disadvantage influence the timeliness of lung cancer diagnosis? A systematic review and synthesis of published qualitative studies
How does socio-economic disadvantage influence the timeliness of lung cancer diagnosis? A systematic review and synthesis of published qualitative studies Open
This review identified multiple barriers that should be addressed to reduce lung cancer inequalities. This information can be used to inform future public health policies and interventions.
View article: Socio-demographic variation in symptomatic FIT return: a population-based analysis of 125,659 patients
Socio-demographic variation in symptomatic FIT return: a population-based analysis of 125,659 patients Open
Background: In the UK, patients presenting in primary care with possible symptoms of colorectal cancer complete Faecal Immunochemical Testing (FIT), as triage for (urgent) colonoscopy. Little is known about FIT completion rates or socio-de…
View article: Multimethod study of Endoscopic Retrograde Cholangio Pancreatography (ERCP) service delivery: stakeholder perspectives on opportunities for quality improvement
Multimethod study of Endoscopic Retrograde Cholangio Pancreatography (ERCP) service delivery: stakeholder perspectives on opportunities for quality improvement Open
Background and aims Endoscopic Retrograde Cholangio Pancreatography (ERCP) is a technically challenging and relatively risky procedure. The British Society of Gastroenterology ERCP Endoscopy Quality Improvement Programme was established to…
View article: Systematic Review: The Relationship Between the Faecal Microbiome and Colorectal Neoplasia in Shotgun Metagenomic Studies
Systematic Review: The Relationship Between the Faecal Microbiome and Colorectal Neoplasia in Shotgun Metagenomic Studies Open
Background The human gut microbiome is of academic and clinical interest. Associations between certain organisms and colorectal neoplasia have been reported, but findings have limited reproducibility in different populations. Methods We pe…
View article: Laryngectomy Education and Training Resources: An Environmental Scan of Resources
Laryngectomy Education and Training Resources: An Environmental Scan of Resources Open
In many settings, head and neck cancer (HNC) services are centralized in large hospitals, meaning that community input from HNC specialists can be lacking. Community healthcare professionals often require laryngectomy-specific education an…
View article: Routes to Diagnosis in Lung Cancer—Do Socio-Demographics Matter? An English Population-Based Study
Routes to Diagnosis in Lung Cancer—Do Socio-Demographics Matter? An English Population-Based Study Open
Objectives: Survival from lung cancer is worse in the UK than in some other countries, with late stage at diagnosis implicated in poor prognosis. The route and referral urgency by which patients obtain a diagnosis influence outcomes. This …
View article: Mendelian randomization analysis for identifying circulating inflammatory cytokines and risk of pancreatic cancers
Mendelian randomization analysis for identifying circulating inflammatory cytokines and risk of pancreatic cancers Open
Objectives Inflammation is intricately linked to the emergence and advancement of most cancers, playing a pivotal role in their malignant transformation. Observational evidence revealed the role of cytokines in pancreatic cancer (PC) carci…
View article: Healthcare provision for cancer survivors with chronic bowel symptoms post pelvic radiotherapy. “… and then you're kind of cast adrift”: A qualitative study
Healthcare provision for cancer survivors with chronic bowel symptoms post pelvic radiotherapy. “… and then you're kind of cast adrift”: A qualitative study Open
Our findings suggest a need for raising awareness of late-effects of pelvic-radiotherapy among patients and health professionals encompassing recognition of symptoms and awareness of treatments and support and for accelerating access to sp…
View article: Case-mix-adjusted mean number of polyps per 100 procedures: a new candidate gold standard colonoscopy key performance indicator
Case-mix-adjusted mean number of polyps per 100 procedures: a new candidate gold standard colonoscopy key performance indicator Open
Objective Adenoma detection rate (ADR) has been criticised as a colonoscopy key performance indicator (KPI), for excluding serrated polyps, requiring histological data and fostering a ‘one-and-done’ attitude. We hypothesised that a case-mi…
View article: Patient experiences and expectations of faecal immunochemical testing for investigation of colorectal cancer symptoms: a cross-sectional qualitative interview study with patients and practitioners in the UK
Patient experiences and expectations of faecal immunochemical testing for investigation of colorectal cancer symptoms: a cross-sectional qualitative interview study with patients and practitioners in the UK Open
Objectives Faecal immunochemical testing (FIT) is now commonplace in the UK to prioritise symptomatic patients for urgent gastrointestinal investigation. The test requires a stool sample to be collected at home by the patient and returned …
View article: BSG/ACPGBI guidance on the management of colorectal polyps in patients with limited life expectancy
BSG/ACPGBI guidance on the management of colorectal polyps in patients with limited life expectancy Open
Background Determining optimal management of colorectal polyps in patients with limited life expectancy of under 10 years can be difficult, due to challenges balancing an uncertain natural history of polyp progression to symptomatic malign…
View article: Deciphering the Role of Complement System Genes in Pancreatic Cancer Susceptibility and Prognosis
Deciphering the Role of Complement System Genes in Pancreatic Cancer Susceptibility and Prognosis Open
Background & Aims Pancreatic ductal adenocarcinoma (PDAC) genetic susceptibility is partially identified. The complement system (CS) influences carcinogenesis and participates in immunological defense and homeostasis; however, its role in …
View article: Interventions to increase uptake in a fecal‐immunochemical test population‐based colorectal cancer screening program: A quasi‐experimental study of first‐time invitees
Interventions to increase uptake in a fecal‐immunochemical test population‐based colorectal cancer screening program: A quasi‐experimental study of first‐time invitees Open
Background Many countries have established organized colorectal cancer screening programs because they can reduce mortality and incidence from the disease; however, they rely on high participation rates, which are often suboptimal. This st…
View article: A network approach to addressing the needs of patients with incurable head and neck cancer and their families
A network approach to addressing the needs of patients with incurable head and neck cancer and their families Open
Background Patients with incurable head and neck cancer have considerable unmet needs and complex symptom burden, with evidence of substantial geographical and/or socioeconomic inequalities. Accurate information on healthcare needs, resour…
View article: Development of a patient-reported outcome measure for gastrointestinal recovery after surgery (PRO-diGI)
Development of a patient-reported outcome measure for gastrointestinal recovery after surgery (PRO-diGI) Open
Background After major abdominal surgery, patients may experience significant gastrointestinal dysfunction, including postoperative ileus. Many clinical tools are used to measure this dysfunction, but there is no patient-reported outcome m…
View article: Practitioner perspectives on symptomatic faecal immunochemical testing in the UK: a qualitative interview study
Practitioner perspectives on symptomatic faecal immunochemical testing in the UK: a qualitative interview study Open
Background Faecal immunochemical testing (FIT) is now core to the management of patients presenting in primary care with symptoms of possible colorectal cancer. Patients with a positive FIT (≥10 μg haemoglobin [Hb]/g faeces) qualify for an…
View article: Co-development of a programme to improve physical activity support for women after breast cancer treatment: a pre-protocol for PURE-EX
Co-development of a programme to improve physical activity support for women after breast cancer treatment: a pre-protocol for PURE-EX Open
Background Breast cancer and its treatment can have long-term adverse effects on physical and mental health. Evidence-based guidelines recommend that healthcare professionals (HCPs) advise women with breast cancer to engage in physical ac…
View article: “After the horrible cancer…” Post-traumatic growth through the lens of head and neck cancer survivors
“After the horrible cancer…” Post-traumatic growth through the lens of head and neck cancer survivors Open
Background: This qualitative study aimed to enhance understanding of the psychosocial processes underlying post-traumatic growth (PTG) following head and neck cancer (HNC) by exploring survivors' experiences following completion of treatme…
View article: Irish Prostate Cancer Outcomes Research (IPCOR) registry: cohort profile
Irish Prostate Cancer Outcomes Research (IPCOR) registry: cohort profile Open
Purpose To describe the Irish Prostate Cancer Outcomes Research (IPCOR) registry. The cohort was collected to inform and improve the prostate cancer journey of men in Ireland. Participants Established in 2015, IPCOR was a unique large-scal…
View article: Tea and other diet-related practices in relation to sleep health in midlife women from Mexico City: qualitative and quantitative findings
Tea and other diet-related practices in relation to sleep health in midlife women from Mexico City: qualitative and quantitative findings Open
Purpose Little is known regarding women's lived experiences of how diet impacts sleep. Based on ethnographic interviews among working-class women from Mexico City, our primary aim was to identify themes related to diet and sleep among midl…
View article: Are we there yet? Closing the gap of prostate cancer presentation disparities in Ireland
Are we there yet? Closing the gap of prostate cancer presentation disparities in Ireland Open
By addressing these nuanced differences in access to healthcare, socioeconomic status, and urban versus rural residence and implementing tailored strategies, we can work towards closing disparity gaps in PC, ultimately leading to improved …
View article: “It’s a delicate dance”: How informal caregivers experience the role and responsibilities of supporting someone living with a lower-grade glioma
“It’s a delicate dance”: How informal caregivers experience the role and responsibilities of supporting someone living with a lower-grade glioma Open
Background People with lower-grade gliomas (LGG) often require long-term support with a condition that causes substantial symptom burden and is likely to progress. Partners, family, and friends often become informal caregivers (IC), but th…
View article: Table 2 from Sociodemographic Disparities in HER2<sup>+</sup> Breast Cancer Trastuzumab Receipt: An English Population-Based Study
Table 2 from Sociodemographic Disparities in HER2<sup>+</sup> Breast Cancer Trastuzumab Receipt: An English Population-Based Study Open
Early-stage disease: likelihood (OR with 95% CI and P values from logistic regression) of receiving trastuzumab by deprivation and adjusted for age, ethnicity, rural/urban residence, government region, stage at diagnosis, whether received …
View article: Table 1 from Sociodemographic Disparities in HER2<sup>+</sup> Breast Cancer Trastuzumab Receipt: An English Population-Based Study
Table 1 from Sociodemographic Disparities in HER2<sup>+</sup> Breast Cancer Trastuzumab Receipt: An English Population-Based Study Open
Demographic and clinical characteristics of women with stage I–IV HER2+ breast cancer diagnosed between January 01, 2012 and December 31, 2017 (n = 36,985).