Explanipedia

Allosteric activators of cystathionine γ lyase to augment endogenous hydrogen sulfide and inhibit pathologic calcification Open

Sonia Nasi, Driss Ehirchiou, Cindy Blatter, Véronique Chobaz, Stefan Germann , et al. · 2025

OP0127 DEVELOPMENT OF ALLOSTERIC ACTIVATORS OF CYSTATHIONINE G LYASE (CSE) TO AUGMENT HYDROGEN SULFIDE (H2S) AND INHIBIT PATHOLOGIC CARTILAGE CALCIFICATION Open

Driss Ehirchiou, Sonia Nasi, Véronique Chobaz, Rainer Riedl, Stefan Germann , et al. · 2025

Phytochemical constituents, GC-MS profiling and In-vitro antioxidant activity of jinja™ herbal extract (JHE) Open

Shijin Bu, Eme Asuquo, Alexander So, Ammar Ad, Jaboro GA , et al. · 2025

Toxicological evaluation of Jinja™: A Local Herbal Mixture (LHM) Open

Alexander So, Shemishere UB, Jaboro GA, E Asuquo, Turaki AA · 2025

Publisher Correction: A genome-wide association analysis reveals new pathogenic pathways in gout Open

Tanya J. Major, Riku Takei, Hirotaka Matsuo, Megan Leask, Nicholas A. Sumpter , et al. · 2024

The 15th European Crystal Network (ECN) Workshop—2024 ECN Abstract Proceedings Open

Frédéric Lioté, Fernando Pérez-Ruiz, Hang‐Korng Ea, Tristan Pascart, Tony R. Merriman , et al. · 2024

15th Anniversary this year: the ECN workshop is set up in Paris, down town. Every year ECN workshop offers a unique opportunity for clinicians and researchers interested in crystals, inflammation, crystal-induced diseases including gout, t…

Features Associated With Different Inflammatory Phenotypes of Calcium Pyrophosphate Deposition Disease: A Study Using Data From the International American College of Rheumatology/EULAR Calcium Pyrophosphate Deposition Classification Criteria Cohort Open

Tristan Pascart, Augustin Latourte, Sara K. Tedeschi, Nicola Dalbeth, Tuhina Neogi , et al. · 2024

Objective The study objective was to examine the disease, demographic, and imaging features associated with different inflammatory phenotypes of calcium pyrophosphate deposition (CPPD) disease, ie, recurrent acute calcium pyrophosphate (CP…

14th European Crystal Network (ECN) Workshop—Abstract Proceedings Open

Frédéric Lioté, Fernando Pérez-Ruiz, Hang‐Korng Ea, Tony R. Merriman, Tristan Pascart , et al. · 2024

The 14th annual international European Crystal Network was held in Paris on 2 and 3 March 2023. This in-person meeting was attended by 93 participants. Over 40 research abstract submissions were received from investigators, ranging from ea…

The 2023 ACR/<span>EULAR</span> Classification Criteria for Calcium Pyrophosphate Deposition Disease Open

Abhishek Abhishek, Sara K. Tedeschi, Tristan Pascart, Augustin Latourte, Nicola Dalbeth , et al. · 2023

Objective Calcium pyrophosphate deposition (CPPD) disease is prevalent and has diverse presentations, but there are no validated classification criteria for this symptomatic arthritis. The American College of Rheumatology (ACR) and EULAR h…

The 2023 ACR/EULAR classification criteria for calcium pyrophosphate deposition disease Open

Abhishek Abhishek, Sara K. Tedeschi, Tristan Pascart, Augustin Latourte, Nicola Dalbeth , et al. · 2023

A genome-wide association analysis of 2,622,830 individuals reveals new pathogenic pathways in gout Open

Tanya J. Major, Riku Takei, Hirotaka Matsuo, Megan Leask, Ruth Topless , et al. · 2022

Gout is a chronic disease of monosodium urate crystal deposition in the setting of hyperuricemia that typically presents with recurrent flares of acute inflammatory arthritis that occur due to innate immune response to deposited crystals. …

Association of Gout Polygenic Risk Score With Age at Disease Onset and Tophaceous Disease in European and Polynesian Men With Gout Open

Nicholas A. Sumpter, Riku Takei, Murray Cadzow, Ruth Topless, Amanda Phipps‐Green , et al. · 2022

Objective To determine whether a gout polygenic risk score (PRS) is associated with age at gout onset and tophaceous disease in European, East Polynesian, and West Polynesian men and women with gout. Methods A 19‐variant gout PRS was produ…

Fibrin deposition associates with cartilage degeneration in arthritis Open

Thomas Hügle, Sonia Nasi, Driss Ehirchiou, Patrick Omoumi, Alexander So , et al. · 2022

The Gasotransmitter Hydrogen Sulfide (H2S) Prevents Pathologic Calcification (PC) in Cartilage Open

Sonia Nasi, Driss Ehirchiou, Jessica Bertrand, Mariela Castelblanco, James R. Mitchell , et al. · 2021

Pathologic calcification (PC) is a painful and disabling condition whereby calcium-containing crystals deposit in tissues that do not physiologically calcify: cartilage, tendons, muscle, vessels and skin. In cartilage, compression and infl…

POS0041 THE GASOTRANSMITTER HYDROGEN SULFIDE (H2S) IS PROTECTIVE AGAINST CALCIFIC TENDINOPATHY (CT) Open

Ilaria Bernabei, Daniel Kronenberg, Richard Stange, Jessica Bertrand, Thomas Hügle , et al. · 2021

POS1124 IDENTIFYING POTENTIAL CLASSIFICATION CRITERIA FOR CALCIUM PYROPHOSPHATE DEPOSITION DISEASE (CPPD): RESULTS FROM THE INITIAL PHASES Open

Sara K. Tedeschi, Tristan Pascart, Augustin Latourte, Cattleya Godsave, Burak Kundaki , et al. · 2021

Identifying Potential Classification Criteria for Calcium Pyrophosphate Deposition Disease: Item Generation and Item Reduction Open

Sara K. Tedeschi, Tristan Pascart, Augustin Latourte, Cattleya Godsave, Burak Kundakci , et al. · 2021

Objective Classification criteria for calcium pyrophosphate deposition (CPPD) disease will facilitate clinical research on this common crystalline arthritis. Our objective was to report on the first 2 phases of a 4‐phase process for develo…

A Randomized, Phase II Study Evaluating the Efficacy and Safety of Anakinra in the Treatment of Gout Flares Open

Kenneth G. Saag, Puja Khanna, Robert T. Keenan, S. Ohlman, Lisa Osterling Koskinen , et al. · 2021

Objective To evaluate the efficacy and safety of anakinra compared to triamcinolone in the treatment of gout flares. Methods Patients for whom nonsteroidal antiinflammatory drugs and colchicine were not suitable treatments were enrolled in…

Xanthine Oxidoreductase Is Involved in Chondrocyte Mineralization and Expressed in Osteoarthritic Damaged Cartilage Open

Sonia Nasi, Mariela Castelblanco, Véronique Chobaz, Driss Ehirchiou, Alexander So , et al. · 2021

Pathologic calcification of cartilage consists of the formation of basic calcium phosphate (BCP) and/or calcium pyrophosphate dihydrate (CPPD) containing calcium crystals in mature hyaline or articular cartilage and is associated with agin…

Multi-energy photon-counting computed tomography versus other clinical imaging techniques for the identification of articular calcium crystal deposition Open

Ilaria Bernabei, Yann Sayous, Aamir Raja, Maya R. Amma, Anaïs Viry , et al. · 2021

International audience

CD11b Signaling Prevents Chondrocyte Mineralization and Attenuates the Severity of Osteoarthritis Open

Driss Ehirchiou, Ilaria Bernabei, Véronique Chobaz, Mariela Castelblanco, Thomas Hügle , et al. · 2020

Osteoarthritis (OA) is a progressive joint disease that is strongly associated with calcium-containing crystal formation (mineralization) by chondrocytes leading ultimately to cartilage calcification. However, this calcification process is…

Current understanding of gout and optimal management strategies Open

Alexander So · 2020

The protective role of the 3-mercaptopyruvate sulfurtransferase (3-MST)-hydrogen sulfide (H2S) pathway against experimental osteoarthritis Open

Sonia Nasi, Driss Ehirchiou, Athanasia Chatzianastasiou, Noriyuki Nagahara, Andreas Papapetropoulos , et al. · 2020

Background Osteoarthritis (OA) is characterized by the formation and deposition of calcium-containing crystals in joint tissues, but the underlying mechanisms are poorly understood. The gasotransmitter hydrogen sulfide (H 2 S) has been imp…

Pleiotropic effect of the ABCG2 gene in gout: involvement in serum urate levels and progression from hyperuricemia to gout Open

Rebekah Wrigley, Amanda Phipps‐Green, Ruth Topless, Tanya J. Major, Murray Cadzow , et al. · 2020

Pleiotropic effect of ABCG2 in gout: involvement in serum urate levels and progression from hyperuricemia to gout Open

Rebekah Wrigley, Amanda Phipps‐Green, Ruth Topless, Tanya J. Major, Murray Cadzow , et al. · 2020

Background The ABCG2 Q141K ( rs2231142 ) and rs10011796 variants associate with hyperuricaemia (HU). The effect size of ABCG2 rs2231142 on urate is ∼60% that of SLC2A9 , yet the effect size on gout is greater. We tested the hypothesis that…

Febuxostat, a Xanthine Oxidoreductase Inhibitor, Decreases NLRP3-dependent Inflammation in Macrophages by Activating the Purine Salvage Pathway and Restoring Cellular Bioenergetics Open

Johji Nomura, Tsunefumi Kobayashi, Alexander So, Nathalie Busso · 2019

The nucleotide-binding oligomerization domain–like receptor family, pyrin domain–containing 3 (NLRP3) inflammasome mediates caspase-1 activation and IL-1β processing and is implicated in autoinflammatory as well as other chronic inflammato…

IL1 inhibition in gout—where are we a decade on? Open

Alexander So · 2019

Targeted knock-in mice expressing the oxidase-fixed form of xanthine oxidoreductase favor tumor growth Open

Teruo Kusano, Driss Ehirchiou, Tomohiro Matsumura, Véronique Chobaz, Sonia Nasi , et al. · 2019

Efficacité de l’anakinra dans les poussées articulaires aiguës de rhumatisme à hydroxyapatite : étude rétrospective de 23 cas Open

Pascal Zufferey, Roxana Valcov, M. Thomas, Alexandre Dumusc, Marine Forien , et al. · 2019

La calcification de cristaux d’hydroxyapatite (HA) intra- ou péri-articulaires peut provoquer des poussées aiguës hyperalgiques. Une étude pilote a suggéré que l’inhibiteur de l’interleukine-1β (IL-1β) anakinra était un traitement efficace…

Gout, Hyperuricaemia and Crystal-Associated Disease Network (G-CAN) consensus statement regarding labels and definitions of disease states of gout Open

David Bursill, William J. Taylor, Robert Terkeltaub, Abhishek Abhishek, Alexander So , et al. · 2019

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