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View article: A Human Milk Factor Susceptible to Cathepsin D Inhibitors Enhances Human Immunodeficiency Virus Type 1 Infectivity and Allows Virus Entry into a Mammary Epithelial Cell Line
A Human Milk Factor Susceptible to Cathepsin D Inhibitors Enhances Human Immunodeficiency Virus Type 1 Infectivity and Allows Virus Entry into a Mammary Epithelial Cell Line Open
Human immunodeficiency virus type 1 (HIV-1) growth in lymphocyte cultures was increased when the virus inoculum was incubated in breast milk. The enhancing effect of milk was abolished by anti-cathepsin D antibody or by pepstatin A, a cath…
View article: Lethal oxidative damage to human immunodeficiency virus by human recombinant myeloperoxidase
Lethal oxidative damage to human immunodeficiency virus by human recombinant myeloperoxidase Open
Human recombinant myeloperoxidase was evaluated in a cell‐free system for its inactivation properties on the replication of human immunodeficiency virus, HTLV‐III B . In the presence of a hydrogen peroxide generating system (glucose and gl…
View article: Markers of HTLV-III in patients with end stage renal failure treated by haemodialysis.
Markers of HTLV-III in patients with end stage renal failure treated by haemodialysis. Open
Patients and members of staff from a haemodialysis unit were tested for markers of infection with human T cell lymphotropic virus type III (HTLV-III), the virus associated with the acquired immune deficiency syndrome (AIDS). An enzyme link…
View article: Human syncytiotrophoblast membrane proteins defined using a heterologous antiserum.
Human syncytiotrophoblast membrane proteins defined using a heterologous antiserum. Open
Detergent extracts of human trophoblast plasma membranes (TrPM) and of other fetal tissues from the same conceptus were prepared and the proteins separated by use of isoelectric focusing. A major band of isoelectric point (pI) 4.1 was pres…
View article: Study of the expression of a glycoprotein of retroviral origin in the plasma of patients with hematologic disorders and in the plasma of normal individuals
Study of the expression of a glycoprotein of retroviral origin in the plasma of patients with hematologic disorders and in the plasma of normal individuals Open
A 74,000 molecular weight glycoprotein was purified from the plasma of a patient with chronic myelogenous leukemia in blast crisis. Monoclonal antibodies were produced in the mouse and used to characterize this protein. It was shown to con…
View article: Cell receptors for baboon endogenous virus recognized by monoclonal antibodies
Cell receptors for baboon endogenous virus recognized by monoclonal antibodies Open
Hybridomas from mice immunized with baboon endogenous virus (BaEV) from A204(M7) cells produced several antiviral monoclonal antibodies and, in addition, antibodies D-12 and E-4, which appeared to be virus specific because they reacted wit…
View article: Monoclonal antibodies against baboon endogenous virus and against host cell antigens
Monoclonal antibodies against baboon endogenous virus and against host cell antigens Open
Monoclonal antibodies were produced by murine hybridomas after immunization with semipurified baboon endogenous virus. In a solid-phase radioimmunoassay, two antibodies (F12-9 and B9-18) reacted with viral antigen only. The antibodies A6-8…
View article: The photoinactivation of an RNA animal virus, vesicular stomatitis virus, with the aid of newly synthesized psoralen derivatives
The photoinactivation of an RNA animal virus, vesicular stomatitis virus, with the aid of newly synthesized psoralen derivatives Open
The newly synthesized psoralen derivatives, 4' hydroxymethyl 4,5',8 trimethylpsoralen, 4' methoxymethyl 4,5',8 trimethylpsoralen, and 4' aminomethyl 4,5',8 trimethylpsoralen hydrochloride photoreact with the single-stranded RNA animal viru…