Venkatesh L. Murthy
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View article: Non-Linear Size Effects and Episodic Progression in the Ascending Aorta
Non-Linear Size Effects and Episodic Progression in the Ascending Aorta Open
Background Predicting ascending aortic (AsAo) growth is challenging. Conventional paradigms often assume a linear and monotonic relationship between baseline size and future growth that occurs continuously–assumptions that may oversimplify…
View article: A Metabolite Score of Unintentional Weight Loss Explained a Substantial Proportion of Associated Mortality and Mobility Limitation Risk in a Biracial Older Cohort
A Metabolite Score of Unintentional Weight Loss Explained a Substantial Proportion of Associated Mortality and Mobility Limitation Risk in a Biracial Older Cohort Open
Unintentional weight loss (UWL) is related to mortality and mobility limitation. Here, we aimed to develop a metabolite‐based score for UWL and evaluate its prediction performance and explanation value for UWL‐related health outcomes. Part…
View article: No Evidence of Metabolomic Disruptions From Real‐World Intakes of Aspartame or Saccharin: The Coronary Artery Risk Development in Young Adults Study
No Evidence of Metabolomic Disruptions From Real‐World Intakes of Aspartame or Saccharin: The Coronary Artery Risk Development in Young Adults Study Open
Background Artificial sweeteners have become ubiquitous additives in the food supply, and yet the safety of their regular consumption remains controversial. The present study examined whether intakes of aspartame or saccharin are related t…
View article: Dietary metabolic signatures and cardiometabolic risk
Dietary metabolic signatures and cardiometabolic risk Open
AIMS: Observational studies of diet in cardiometabolic-cardiovascular disease (CM-CVD) focus on self-reported consumption of food or dietary pattern, with limited information on individual metabolic responses to dietary intake linked to CM…
View article: Proteomic Signatures as Biomarkers of Atherosclerosis Burden
Proteomic Signatures as Biomarkers of Atherosclerosis Burden Open
View article: Simultaneous <scp> T <sub>1</sub> </scp> , <scp> T <sub>2</sub> </scp> , and T <sub>1ρ</sub> mapping of the myocardium using cardiac <scp>MR</scp> fingerprinting with a deep image prior reconstruction
Simultaneous <span> T <sub>1</sub> </span> , <span> T <sub>2</sub> </span> , and T <sub>1ρ</sub> mapping of the myocardium using cardiac <span>MR</span> fingerprinting with a deep image prior reconstruction Open
Purpose To develop a cardiac MR fingerprinting (cMRF) approach using deep image prior reconstruction (DIP) to simultaneously map T 1 , T 2 , and T 1ρ , and assess T 1ρ in healthy subjects and patients with areas of enhancement on late gado…
View article: Human Physiologic Responses to Insulin in Indigenous Americans Identify a Metabolic Susceptibility Profile Linked to Diabetes
Human Physiologic Responses to Insulin in Indigenous Americans Identify a Metabolic Susceptibility Profile Linked to Diabetes Open
OBJECTIVE To identify metabolic signatures of insulin action/secretion in Indigenous Americans (IAs) and their association with diabetes. RESEARCH DESIGN AND METHODS We defined circulating metabolomic signatures of insulin action/secretion…
View article: Human physiologic responses to insulin in Indigenous Americans identify a metabolic susceptibility profile linked to diabetes
Human physiologic responses to insulin in Indigenous Americans identify a metabolic susceptibility profile linked to diabetes Open
Objective: To identify a metabolic signature of insulin action/secretion in Indigenous Americans (IAs) and its association with diabetes. Research Design and Methods: We defined circulating metabolomic signatures of insulin action/secretio…
View article: Human physiologic responses to insulin in Indigenous Americans identify a metabolic susceptibility profile linked to diabetes
Human physiologic responses to insulin in Indigenous Americans identify a metabolic susceptibility profile linked to diabetes Open
Objective: To identify a metabolic signature of insulin action/secretion in Indigenous Americans (IAs) and its association with diabetes. Research Design and Methods: We defined circulating metabolomic signatures of insulin action/secretio…
View article: Metabolic Markers Demonstrate the Heterogeneity of Walking Ability in Non-Disabled Community-Dwelling Older Adults
Metabolic Markers Demonstrate the Heterogeneity of Walking Ability in Non-Disabled Community-Dwelling Older Adults Open
Background: Walking ability is important for the quality of life of older adults. A self-reported walking ability index (WAI) covering the difficulty and ease of walking captures a broader spectrum of walking ability in healthy older perso…
View article: Human Plasma Proteomics Links Modifiable Lifestyle Exposome to Disease Risk
Human Plasma Proteomics Links Modifiable Lifestyle Exposome to Disease Risk Open
Environmental exposures influence disease risk, yet their underlying biological mechanisms remain poorly understood. We present the Human Exposomic Architecture of the Proteome (HEAP), a framework and resource integrating genetic, exposomi…
View article: FDA Approval of<sup>18</sup>F-Flurpiridaz for PET: Stepping into a New Era of Myocardial Perfusion Imaging?
FDA Approval of<sup>18</sup>F-Flurpiridaz for PET: Stepping into a New Era of Myocardial Perfusion Imaging? Open
View article: Metabolomic insight into the link of intermuscular fat with cognitive performance: the Health ABC Study
Metabolomic insight into the link of intermuscular fat with cognitive performance: the Health ABC Study Open
View article: Comprehensive coronary CT angiography in people living with HIV: a systematic review and meta-analysis
Comprehensive coronary CT angiography in people living with HIV: a systematic review and meta-analysis Open
Objectives People living with HIV (PLWH) were previously shown to have a higher prevalence of non-calcified coronary plaque with discrepant results for coronary stenosis and any plaque prevalence. This systematic review and meta-analysis s…
View article: Circulating metabolomic biomarkers of 5-year body weight and composition change in a biracial cohort of community-dwelling older adults
Circulating metabolomic biomarkers of 5-year body weight and composition change in a biracial cohort of community-dwelling older adults Open
View article: Impact of magnetization transfer effects on T1 and T2 measurements using cardiac magnetic resonance fingerprinting
Impact of magnetization transfer effects on T1 and T2 measurements using cardiac magnetic resonance fingerprinting Open
View article: The potential of Generative Pre-trained Transformer 4 (GPT-4) to analyse medical notes in three different languages: a retrospective model-evaluation study
The potential of Generative Pre-trained Transformer 4 (GPT-4) to analyse medical notes in three different languages: a retrospective model-evaluation study Open
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View article: Human metabolic chambers reveal a coordinated metabolic-physiologic response to nutrition
Human metabolic chambers reveal a coordinated metabolic-physiologic response to nutrition Open
Human studies linking metabolism with organism-wide physiologic function have been challenged by confounding, adherence, and precisionHere, we united physiologic and molecular phenotypes of metabolism during controlled dietary intervention…
View article: INTER-RELATIONSHIPS OF CIRCULATING PLASMA METABOLITES, INTERMUSCULAR FAT, AND PROCESSING SPEED: HEALTH ABC STUDY
INTER-RELATIONSHIPS OF CIRCULATING PLASMA METABOLITES, INTERMUSCULAR FAT, AND PROCESSING SPEED: HEALTH ABC STUDY Open
Higher intermuscular fat (IMF) is associated with worse processing speed, measured by the digit symbol substitution test (DSST) in older adults. However, the underlying biological mechanisms are not well understood. Since muscles and the b…
View article: METABOLOMIC CHARACTERIZATION OF UNINTENTIONAL WEIGHT LOSS AMONG COMMUNITY-DWELLING OLDER ADULTS
METABOLOMIC CHARACTERIZATION OF UNINTENTIONAL WEIGHT LOSS AMONG COMMUNITY-DWELLING OLDER ADULTS Open
Unintentional weight loss is associated with higher mortality and impaired mobility in older adults. Metabolomics can provide insight into yet unknown pathways of unintentional weight loss and inform its early prediction and targets for in…
View article: Human metabolic chambers reveal a coordinated metabolic-physiologic response to nutrition
Human metabolic chambers reveal a coordinated metabolic-physiologic response to nutrition Open
Human studies linking metabolism with organism-wide physiologic function have been challenged by confounding, adherence, and precisionHere, we united physiologic and molecular phenotypes of metabolism during controlled dietary intervention…
View article: Metabolomic characterization of unintentional weight loss among community‐dwelling older Black and White men and women
Metabolomic characterization of unintentional weight loss among community‐dwelling older Black and White men and women Open
This study aims to understand the metabolic mechanisms of unintentional weight loss in older adults. We investigated plasma metabolite associations of subsequent weight change over 2 years in 1536 previously weight stable participants (mea…
View article: Associations of exposure to PM2.5 and its compounds with carotid intima-media thickness among middle-aged adults
Associations of exposure to PM2.5 and its compounds with carotid intima-media thickness among middle-aged adults Open
View article: The complete blood count and cardiovascular disease: analyses across six cohorts of 23,370 adults
The complete blood count and cardiovascular disease: analyses across six cohorts of 23,370 adults Open
Background The complete blood count (CBC) is one of the most performed laboratory studies. However, the CBC and its components are not commonly used to understand and quantify cardiovascular disease (CVD) risk. Objective We sought to defin…
View article: Development and validation of a machine learning model to predict myocardial blood flow and clinical outcomes from patients’ electrocardiograms
Development and validation of a machine learning model to predict myocardial blood flow and clinical outcomes from patients’ electrocardiograms Open
View article: Choline metabolites and 15-year risk of incident diabetes in a prospective cohort of adults: Coronary Artery Risk Development in Young Adults (CARDIA) Study
Choline metabolites and 15-year risk of incident diabetes in a prospective cohort of adults: Coronary Artery Risk Development in Young Adults (CARDIA) Study Open
Objective The potential for choline metabolism to influence the development of diabetes has received increased attention. Previous studies on circulating choline metabolites and incident diabetes have been conducted samples of older age ad…
View article: Choline Metabolites and 15-Year Risk of Incident Diabetes in a Prospective Cohort of Adults: Coronary Artery Risk Development in Young Adults (CARDIA) Study
Choline Metabolites and 15-Year Risk of Incident Diabetes in a Prospective Cohort of Adults: Coronary Artery Risk Development in Young Adults (CARDIA) Study Open
OBJECTIVE The potential for choline metabolism to influence the development of diabetes has received increased attention. Previous studies on circulating choline metabolites and incident diabetes have been conducted in samples of older adu…
View article: Recommendations for Multimodality Imaging of Patients With Left Ventricular Assist Devices and Temporary Mechanical Support: Updated Recommendations from the American Society of Echocardiography
Recommendations for Multimodality Imaging of Patients With Left Ventricular Assist Devices and Temporary Mechanical Support: Updated Recommendations from the American Society of Echocardiography Open
View article: Projected Changes in Statin and Antihypertensive Therapy Eligibility With the AHA PREVENT Cardiovascular Risk Equations
Projected Changes in Statin and Antihypertensive Therapy Eligibility With the AHA PREVENT Cardiovascular Risk Equations Open
Importance Since 2013, the American College of Cardiology (ACC) and American Heart Association (AHA) have recommended the pooled cohort equations (PCEs) for estimating the 10-year risk of atherosclerotic cardiovascular disease (ASCVD). An …
View article: Impact of Social Determinants of Health and Lifestyle on Association Between Lipoprotein(a) and Cardiovascular Events
Impact of Social Determinants of Health and Lifestyle on Association Between Lipoprotein(a) and Cardiovascular Events Open