Catharine West
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Using machine learning to predict patient-reported symptom clusters in prostate cancer patients receiving radiotherapy Open
Purpose/objective Prostate cancer (PC) survivors frequently experience multiple co-occurring symptoms that adversely affect health-related quality of life (HRQoL). Identifying symptom clusters (SCs) may help to improve symptom management a…
View article: Intra-voxel incoherent motion biomarker repeatability in healthy volunteers and sensitivity to chemoradiotherapy-induced changes in patients with uterine cervical cancer
Intra-voxel incoherent motion biomarker repeatability in healthy volunteers and sensitivity to chemoradiotherapy-induced changes in patients with uterine cervical cancer Open
Intra-voxel incoherent motion (IVIM) biomarkers require validation for translation into clinical practice. This work evaluates repeatability and sensitivity to treatment of IVIM biomarkers in the uterine cervix, and assesses suitability of…
View article: Integration of Dose Surface Maps and Genetic Data Identifies the Lower Posterior Rectum as a Key Region for Toxicity after Prostate Cancer Radiotherapy
Integration of Dose Surface Maps and Genetic Data Identifies the Lower Posterior Rectum as a Key Region for Toxicity after Prostate Cancer Radiotherapy Open
Purpose: Genome-wide association studies are the gold standard for identifying SNP associated with rectal toxicity after prostate cancer radiotherapy. However, they often neglect the radiotherapy dose distribution, which is a key contribut…
View article: Gene Expression in Muscle-Invasive and Non-Muscle-Invasive Bladder Cancer Cells Exposed to Hypoxia
Gene Expression in Muscle-Invasive and Non-Muscle-Invasive Bladder Cancer Cells Exposed to Hypoxia Open
Introduction: Hypoxic cancers are radioresistant, but biomarkers based on expression of multiple genes can identify patients who will benefit from hypoxia modification. Most studies identifying relevant genes exposed cells in culture to 1%…
View article: Radiation-induced extracellular matrix remodelling drives prognosis and predicts radiotherapy response in muscle-invasive bladder cancer
Radiation-induced extracellular matrix remodelling drives prognosis and predicts radiotherapy response in muscle-invasive bladder cancer Open
Muscle-invasive bladder cancer (MIBC) is a prevalent disease that can be treated with radiotherapy, but has a poor prognosis. Radiation-induced extracellular matrix (ECM) remodelling and fibrosis can induce tumour resistance and recurrence…
Integrating genetic polymorphisms and clinical data to develop predictive models for skin toxicity in breast cancer radiation therapy Open
Our findings highlight the importance of combining clinical data with genetic markers to enhance the accuracy of models predicting RT toxicity in BC.
View article: Supplementary Table S3 from A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer
Supplementary Table S3 from A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer Open
Table S3 shows bivariate associations of patient, cancer, and treatment factors with hematuria
View article: Supplementary Table S1 from A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer
Supplementary Table S1 from A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer Open
Table S1 lists the SNVs included in the PRS
View article: Supplementary Figure S1 from A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer
Supplementary Figure S1 from A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer Open
Figure S1 shows principal components analysis of participants from the RGC and REQUITE+URWCI cohorts.
View article: Supplementary Figure S3 from A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer
Supplementary Figure S3 from A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer Open
Figure S3 shows a Manhattan plot from the GWAS
View article: Supplementary Table S4 from A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer
Supplementary Table S4 from A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer Open
Table S4 shows a multivariable model of hematuria including the PRS, rare variants, and clinical factors
View article: Supplementary Figure S2 from A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer
Supplementary Figure S2 from A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer Open
Figure S2 shows a quantile-quantile plot from the GWAS
View article: Data from A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer
Data from A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer Open
Background:Late bladder toxicity is a concern for patients receiving prostate cancer radiotherapy and negatively affects survivors. Few risk factors are known beyond the radiation dose and volume of bladder exposed. A polygenic risk score …
View article: Supplementary Table S2 from A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer
Supplementary Table S2 from A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer Open
Table S2 shows the association of known prognostic factors with time to biochemical recurrence
View article: Fractionated radiation alters the extracellular matrix produced by muscle-invasive bladder cancer cells
Fractionated radiation alters the extracellular matrix produced by muscle-invasive bladder cancer cells Open
Muscle-invasive bladder cancer (MIBC) is a prevalent disease that can be treated with radiotherapy, but has a poor prognosis. Radiation-induced extracellular matrix (ECM) remodelling and fibrosis can induce tumour resistance and recurrence…
View article: Hypoxia-induced extracellular matrix changes are conserved in cancer and directly impact radiotherapy benefit
Hypoxia-induced extracellular matrix changes are conserved in cancer and directly impact radiotherapy benefit Open
Our overarching aim was to determine how hypoxia affects the extracellular matrix (ECM). Transcriptomic analysis (21,941 patients; 10 cancer types) identified ECM remodelling as the predominant pathway affected by hypoxia. Multi-omics conf…
View article: A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer
A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer Open
Background: Late bladder toxicity is a concern for patients receiving prostate cancer radiotherapy and negatively affects survivors. Few risk factors are known beyond the radiation dose and volume of bladder exposed. A polygenic risk score…
View article: Association of radiation-induced normal tissue toxicity with a high genetic risk for rheumatoid arthritis
Association of radiation-induced normal tissue toxicity with a high genetic risk for rheumatoid arthritis Open
Background Overlapping genes are involved with rheumatoid arthritis (RA) and DNA repair pathways. Therefore, we hypothesized that patients with a high polygenic risk score for RA will have an increased risk of radiotherapy toxicity given t…
View article: From a genomic risk model to clinical trial implementation in a learning health system: the ProGRESS Study
From a genomic risk model to clinical trial implementation in a learning health system: the ProGRESS Study Open
Background As healthcare moves from a one-size-fits-all approach towards precision care, individual risk prediction is an important step in disease prevention and early detection. Biobank-linked healthcare systems can generate knowledge ab…
View article: Genome sequence of WestPM, a phage infecting Microbacterium foliorum isolated from beach environmental samples
Genome sequence of WestPM, a phage infecting Microbacterium foliorum isolated from beach environmental samples Open
Bacteriophage WestPM is a siphoviral-like phage infecting Microbacterium foliorum isolated from environmental samples collected on Pensacola Beach, FL. The genome of this phage is 39,693 bp long and contains 59 predicted protein-coding gen…