Lu Yang
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View article: Decoding GDF15: Impact on prostate cancer metabolism, chemoresistance, and clinical applications
Decoding GDF15: Impact on prostate cancer metabolism, chemoresistance, and clinical applications Open
Prostate cancer (PCa) presents a significant global health challenge, and cachexia in end-stage PCa further reduces survival time and deteriorates patient quality of life. This necessitates nuanced approaches to prevention, diagnosis, and …
View article: Integrated machine learning survival framework for consensus modeling in a large multicenter cohort of NSCLC resistant to aumolertinib
Integrated machine learning survival framework for consensus modeling in a large multicenter cohort of NSCLC resistant to aumolertinib Open
Patients with advanced non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutations often benefit from third-generation tyrosine kinase inhibitors (TKIs), such as aumolertinib (AUM). However, the developme…
View article: Advances in Genetic Engineering Techniques for Improved Forest Trees: Applications in Biomass, Stress Resilience and Carbon Sequestration
Advances in Genetic Engineering Techniques for Improved Forest Trees: Applications in Biomass, Stress Resilience and Carbon Sequestration Open
Forest biotechnology is rapidly advancing from conventional breeding toward molecular design, enabling the development of genetically modified trees (GMTs) with traits such as accelerated growth, stress resilience, and improved wood proper…
View article: Rational engineering of degradation tail-driven CELMoD–antibody conjugates for precision malignancy therapy
Rational engineering of degradation tail-driven CELMoD–antibody conjugates for precision malignancy therapy Open
View article: Identifying Key Genes of Proanthocyanidin Intervention in Fluoride-Induced Liver Injury: Integrated Molecular Docking and Experimental Validation
Identifying Key Genes of Proanthocyanidin Intervention in Fluoride-Induced Liver Injury: Integrated Molecular Docking and Experimental Validation Open
Objectives: The objectives of this study are to investigate the therapeutic targets and mechanisms of proanthocyanidins in alleviating fluoride-induced liver injury through network pharmacology and animal experimental validation and to exp…
View article: A surgical strategy-based nomogram for primary pulmonary mucoepidermoid carcinoma
A surgical strategy-based nomogram for primary pulmonary mucoepidermoid carcinoma Open
Background Primary pulmonary mucoepidermoid carcinoma (PMEC) is a rare malignancy with no standardized prognostic tools. This study aimed to investigate whether specific surgical approaches significantly impact survival outcomes and to dev…
View article: Research on application of multiparametric MRI to predict FNCLCC grading and ki67 expression in soft tissue sarcoma biopsy pathology: Based on a CT-MRI fusion image registration method
Research on application of multiparametric MRI to predict FNCLCC grading and ki67 expression in soft tissue sarcoma biopsy pathology: Based on a CT-MRI fusion image registration method Open
Objective To investigate an in vivo biopsy method based on CT-MRI fusion image registration and evaluate its value for improving the accuracy of preoperative core needle biopsies(CNBs) histological grading in soft tissue sarcoma (STS)and d…
View article: Prognosis Prediction and Surgical Benefit Subgroup Analysis in Anal Squamous Cell Carcinoma Patients Undergoing Concurrent Chemoradiotherapy
Prognosis Prediction and Surgical Benefit Subgroup Analysis in Anal Squamous Cell Carcinoma Patients Undergoing Concurrent Chemoradiotherapy Open
Background This study aimed to develop a nomogram to predict overall survival in anal squamous cell carcinoma (ASCC) patients undergoing chemoradiotherapy and to identify patients who may benefit from surgery. Methods Data from 4697 ASCC p…
View article: Projected future changes in extreme climate indices affecting rice production in China using a multi-model ensemble of CMIP6 projections
Projected future changes in extreme climate indices affecting rice production in China using a multi-model ensemble of CMIP6 projections Open
Assessing and predicting the spatial-temporal characteristics of extreme climate events can effectively identify the impacts of climate change on crop production and propose targeted measures. This study systematically evaluates the intens…
View article: Exploring a circulating circRNA and miRNA biomarker panel for early detection of ovarian cancer through multiple omics analysis
Exploring a circulating circRNA and miRNA biomarker panel for early detection of ovarian cancer through multiple omics analysis Open
View article: Associations of different insulin resistance-related indices with the incidence and progression trajectory of cardiometabolic multimorbidity: a prospective cohort study from UK biobank
Associations of different insulin resistance-related indices with the incidence and progression trajectory of cardiometabolic multimorbidity: a prospective cohort study from UK biobank Open
Our findings highlight the critical role of IR-related indices, particularly TyG-WHtR and TyG-WC, in the incidence, progression, and prevention of CMM. The mediation effects of biomarkers indicate the potential for targeted interventions t…
View article: Sage Deer: A Super-Aligned Driving Generalist Is Your Copilot
Sage Deer: A Super-Aligned Driving Generalist Is Your Copilot Open
The intelligent driving cockpit, an important part of intelligent driving, needs to match different users' comfort, interaction, and safety needs. This paper aims to build a Super-Aligned and GEneralist DRiving agent, SAGE DeeR. Sage Deer …
View article: Decrease in Caveolae-Gαq Interaction Mediates Pressure Overload-Induced Cardiac Remodeling in Rats
Decrease in Caveolae-Gαq Interaction Mediates Pressure Overload-Induced Cardiac Remodeling in Rats Open
Despite its significant clinical implications, pressure overload-induced cardiac remodeling is poorly understood. This study aimed to investigate the role of Caveolae-Gαq interaction in the pathophysiology of pressure overload-induced card…
View article: RNA-binding protein gene NOP58 exhibits crucial prognostic and therapeutic value in Ewing sarcoma
RNA-binding protein gene NOP58 exhibits crucial prognostic and therapeutic value in Ewing sarcoma Open
Background Our aim was to identify crucial RNA-binding proteins (RBP) genes associated with Ewing sarcoma (EwS) in order to provide valuable insights into its mechanisms of tumorigenesis and to enhance therapeutic intervention. Results Dif…
View article: Integrated machine learning survival framework for consensus modeling in a large multicenter cohort of NSCLC resistant to aumolertinib
Integrated machine learning survival framework for consensus modeling in a large multicenter cohort of NSCLC resistant to aumolertinib Open
Patients with advanced non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutations often benefit from third-generation tyrosine kinase inhibitors (TKIs), such as aumolertinib (AUM). However, the developme…
View article: Promoting the sustainable development of the provincial electricity spot market: supervision obstacle identification, analysis, and solutions based on the ISM-DEMATEL model
Promoting the sustainable development of the provincial electricity spot market: supervision obstacle identification, analysis, and solutions based on the ISM-DEMATEL model Open
As a pivotal element of the power market system, the provincial electricity spot market has a critical foundation for effectively improving the efficiency of electricity resource consumption and promoting the clean energy transformation of…
View article: Molecular Insights Into Salt Stress Adaptation in Plants
Molecular Insights Into Salt Stress Adaptation in Plants Open
The significant rise in soil salinity has had detrimental effects on global agricultural production, negatively impacting overall plant health and leading to a decline in productivity. As a protective response, plants have developed divers…
View article: Evaluating the predictive value of clinical models for HBV-related hepatocellular carcinoma: A meta-analysis
Evaluating the predictive value of clinical models for HBV-related hepatocellular carcinoma: A meta-analysis Open
Objectives Chronic viral hepatitis B (CHB) is a prevalent liver disease with primary hepatic carcinoma (HCC) as a severe complication. Clinical prediction models have gained attention for predicting HBV-related HCC (HBV-HCC). This study ai…
View article: Clinical study on low-energy semiconductor laser treatment in the promotion of wound healing after maxillofacial fracture surgery.
Clinical study on low-energy semiconductor laser treatment in the promotion of wound healing after maxillofacial fracture surgery. Open
For facial skin wounds in maxillofacial fracture surgery, low-energy semiconductor laser treatment can effectively promote wound healing, improve wound healing quality, fade scars, and relieve wound pain.
View article: The Relationship Between Postpartum Social Support, Postpartum Depression, and Quality of Lifeduring the Puerperium A Study of Primiparas
The Relationship Between Postpartum Social Support, Postpartum Depression, and Quality of Lifeduring the Puerperium A Study of Primiparas Open
Objective This study aims to investigate the interrelationship between postpartum social support, postpartum depression, and quality of life during the puerperium, with a specific focus on primiparas.Methods A cross-sectional survey employ…
View article: Genome-Wide Analysis of the Cis-Prenyltransferase (CPT) Gene Family in Taraxacum kok-saghyz Provides Insights into Its Expression Patterns in Response to Hormonal Treatments
Genome-Wide Analysis of the Cis-Prenyltransferase (CPT) Gene Family in Taraxacum kok-saghyz Provides Insights into Its Expression Patterns in Response to Hormonal Treatments Open
Taraxacum kok-saghyz (TKS) is a natural rubber (NR)-producing plant with great development prospects. Accurately understanding the molecular mechanism of natural rubber biosynthesis is of great significance. Cis-prenyltransferase (CPT) and…
View article: Giant Dentigerous Cyst in a Child Treated with Minimally Modified Invasive Marsupialization and Decompression: A Case Report with 30 months Follow-up
Giant Dentigerous Cyst in a Child Treated with Minimally Modified Invasive Marsupialization and Decompression: A Case Report with 30 months Follow-up Open
Background Dentigerous cysts are a type of inflammatory odontogenic cyst that arises from tissues surrounding an unerupted or impacted tooth. If left untreated, they can grow into a substantial size, resulting in cortical expansion and fac…
View article: Photothermal-enhanced silver nanocluster bioactive glass hydrogels for synergistic antimicrobial and promote wound healing
Photothermal-enhanced silver nanocluster bioactive glass hydrogels for synergistic antimicrobial and promote wound healing Open
View article: Research Progress of DNA Methylation Markers for Endometrial Carcinoma Diagnosis
Research Progress of DNA Methylation Markers for Endometrial Carcinoma Diagnosis Open
Endometrial carcinoma (EC) is the most common malignancies of the female reproductive system in developed countries and areas. Ultrasound-guided and hysteroscopic samplings are commonly used to diagnose EC. However, clinicians question the…
View article: Assessment of extreme climate stress across China’s maize harvest region in CMIP6 simulations
Assessment of extreme climate stress across China’s maize harvest region in CMIP6 simulations Open
Climate change is expected to increase the frequency and severity of climate extremes, which will negatively impact crop production. As one of the main food and feed crops, maize is also vulnerable to extreme climate events. In order to ac…
View article: A multidimensional analysis of the impact of obesity on immune checkpoint inhibitor therapy efficacy
A multidimensional analysis of the impact of obesity on immune checkpoint inhibitor therapy efficacy Open
This study corroborates the veracity of the "obesity paradox" under specific conditions and identifies NLR as an independent prognostic factor, with elevated NLR indicative of a poor prognosis.
View article: Inhibition of KDM4A restricts SQLE transcription and induces oxidative stress imbalance to suppress bladder cancer
Inhibition of KDM4A restricts SQLE transcription and induces oxidative stress imbalance to suppress bladder cancer Open
In clinical practice, the limited efficacy of standard comprehensive therapy for advanced bladder cancer and the lack of targeted treatment options are well recognized. Targeting abnormal epigenetic modifications in tumors has shown consid…
View article: Based on pN-stage to Identify Gastric Carcinoma Patients with Overall Survival Benefit from Postoperative Radiotherapy: A Propensity Score Matching Analysis and Subgroup Analysis
Based on pN-stage to Identify Gastric Carcinoma Patients with Overall Survival Benefit from Postoperative Radiotherapy: A Propensity Score Matching Analysis and Subgroup Analysis Open
Background: It is currently controversial whether regional lymph node status is related to the benefit of postoperative radiotherapy for gastric cancer. Methods: All surgically treated patients with more than 15 lymph nodes examined diagno…
View article: ARAP1-AS1: a novel long non-coding RNA with a vital regulatory role in human cancer development
ARAP1-AS1: a novel long non-coding RNA with a vital regulatory role in human cancer development Open
Long non-coding RNAs (lncRNAs) have garnered significant attention in biomedical research due to their pivotal roles in gene expression regulation and their association with various human diseases. Among these lncRNAs, ArfGAP With RhoGAP D…
View article: Fruquintinib in metastatic colorectal cancer: a multicenter real-world analysis on efficacy, safety, and predictive and prognostic factors
Fruquintinib in metastatic colorectal cancer: a multicenter real-world analysis on efficacy, safety, and predictive and prognostic factors Open
The real-world efficacy and safety of fruquintinib in advanced CRC patients are numerically superior to that in the previous phase III studies. SMI, brain metastasis and CEA could serve as potential markers for patient selection.