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View article: Prolonged Postnatal Hypoxia Impairs Lung Development and Causes Severe Pulmonary Hypertension in Mice
Prolonged Postnatal Hypoxia Impairs Lung Development and Causes Severe Pulmonary Hypertension in Mice Open
Background In children born at high altitude, lung development is affected by hypoxia, which can lead to pulmonary hypertension and right ventricular failure. Animal models of postnatal, transient, hypoxia failed to reproduce these conditi…
View article: Featured Cover
Featured Cover Open
Cover legend: The cover image is based on the article Exercise‐Induced Cardiac Lymphatic Remodeling Mitigates Inflammation in the Aging Heart by Kangsan Roh et al., https://doi.org/10.1111/acel.70043. [Image: see text]
View article: Exercise‐Induced Cardiac Lymphatic Remodeling Mitigates Inflammation in the Aging Heart
Exercise‐Induced Cardiac Lymphatic Remodeling Mitigates Inflammation in the Aging Heart Open
The lymphatic vasculature plays essential roles in fluid balance, immunity, and lipid transport. Chronic, low‐grade inflammation in peripheral tissues develops when lymphatic structure or function is impaired, as observed during aging. Whi…
View article: Effects of insulin therapy optimization with sensor augmented pumps on glycemic control and body composition in people with cystic fibrosis-related diabetes
Effects of insulin therapy optimization with sensor augmented pumps on glycemic control and body composition in people with cystic fibrosis-related diabetes Open
Objective Cystic fibrosis (CF)-related diabetes (CFRD) resulting from partial-to-complete insulin deficiency occurs in 40-50% of adults with CF. In people with CFRD, poor glycemic control leads to a catabolic state that may aggravate CF-in…
View article: Compositions and methods that promote hypoxia or the hypoxia response for treatment and prevention of mitochondrial dysfunction and oxidative stress disorders
Compositions and methods that promote hypoxia or the hypoxia response for treatment and prevention of mitochondrial dysfunction and oxidative stress disorders Open
Methods of promoting hypoxia or the hypoxia response for the treatment or prevention of mitochondrial dysfunction and oxidative stress disorders are described. Methods for screening for targets of mitochondrial dysfunction and oxidative st…
View article: Noninvasive respiratory support for COVID-19 patients: when, for whom, and how?
Noninvasive respiratory support for COVID-19 patients: when, for whom, and how? Open
The significant mortality rate and prolonged ventilator days associated with invasive mechanical ventilation (IMV) in patients with severe COVID-19 have incited a debate surrounding the use of noninvasive respiratory support (NIRS) (i.e., …
View article: Comparison of Published Guidelines for the Diagnosis and the Management of Vaccine-Induced Immune Thrombotic Thrombocytopenia
Comparison of Published Guidelines for the Diagnosis and the Management of Vaccine-Induced Immune Thrombotic Thrombocytopenia Open
OBJECTIVES: The development of thrombocytopenia and thrombosis after the administration of the AstraZeneca and Johnson & Johnson/Janssen vaccines has been recently described. This new condition has been called vaccine-induced immune thromb…
View article: Veno‐venous extracorporeal blood phototherapy increases the rate of carbon monoxide (CO) elimination in CO‐poisoned pigs
Veno‐venous extracorporeal blood phototherapy increases the rate of carbon monoxide (CO) elimination in CO‐poisoned pigs Open
Background and objectives Carbon monoxide (CO) inhalation is the leading cause of poison‐related deaths in the United States. CO binds to hemoglobin (Hb), displaces oxygen, and reduces oxygen delivery to tissues. The optimal treatment for …
View article: Multisystem effects of COVID-19: a concise review for practitioners
Multisystem effects of COVID-19: a concise review for practitioners Open
While COVID-19 has primarily been characterized by the respiratory impact of viral pneumonia, it affects every organ system and carries a high consequent risk of death in critically ill patients. Higher sequential organ failure assessment …
View article: Hypoxia as a therapy for mitochondrial disease
Hypoxia as a therapy for mitochondrial disease Open
Defects in the mitochondrial respiratory chain (RC) underlie a spectrum of human conditions, ranging from devastating inborn errors of metabolism to aging. We performed a genome-wide Cas9-mediated screen to identify factors that are protec…
View article: Hypoxia as a therapy for mitochondrial disease
Hypoxia as a therapy for mitochondrial disease Open
Thriving on a breath of low oxygen Mitochondrial diseases are debilitating and largely untreatable. Most are caused by genetic mutations that impair the mitochondrial respiratory chain, which generates cellular energy. Because these diseas…
View article: MOESM2 of Real-time urinary electrolyte monitoring after furosemide administration in surgical ICU patients with normal renal function
MOESM2 of Real-time urinary electrolyte monitoring after furosemide administration in surgical ICU patients with normal renal function Open
Additional file 2. Dataset of long-term group.
View article: MOESM1 of Real-time urinary electrolyte monitoring after furosemide administration in surgical ICU patients with normal renal function
MOESM1 of Real-time urinary electrolyte monitoring after furosemide administration in surgical ICU patients with normal renal function Open
Additional file 1. Dataset of single-dose group.
View article: MOESM3 of Real-time urinary electrolyte monitoring after furosemide administration in surgical ICU patients with normal renal function
MOESM3 of Real-time urinary electrolyte monitoring after furosemide administration in surgical ICU patients with normal renal function Open
Additional file 3. Dataset of multiple-dose group.
View article: Acid-base effects of different crystalloid solutions for ECMO priming: preliminary report
Acid-base effects of different crystalloid solutions for ECMO priming: preliminary report Open
The induction of ECMO may result in metabolic acidosis [1] due to circuit priming with chloride-rich fluids, and the sudden decrease in plasma strong ion difference (SID). This effect can be attenuated using balanced solutions with a SID e…