Lacey Williams
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View article: Reproducibility and repeatability of the Myoton to quantify sclerotic chronic graft-versus-host disease
Reproducibility and repeatability of the Myoton to quantify sclerotic chronic graft-versus-host disease Open
Validated tools to measure sclerotic cutaneous chronic Graft-versus-Host Disease (scGVHD) is an urgent need. We examined the inter-observer reproducibility within a session and intra-observer repeatability between sessions of the Myoton de…
View article: Glucose-6-phosphatase dehydrogenase [G6PD] serum level predicts acute monocytic leukemia differentiation.
Glucose-6-phosphatase dehydrogenase [G6PD] serum level predicts acute monocytic leukemia differentiation. Open
Introduction: Acute Myeloid Leukemia [AML] leukemogenesis follows differentiation fate that resembles normal hematopoiesis, albeit incompletely. Monocytic AML usually presents with hyperleukocytosis and occasional Leukostasis. Disease may,…
View article: Ancestry-associated social and genomic hallmarks linked with inferior outcome in elderly acute myeloid leukemia
Ancestry-associated social and genomic hallmarks linked with inferior outcome in elderly acute myeloid leukemia Open
Recent literature reports inferior outcomes for patients of African ancestry (AA) who develop acute myeloid leukemia (AML). We herein present a cohort of 396 patients with 116 patients of AA (29%) who show inferior survival outcomes for pa…
View article: Identifying Clinical and Deregulated Genomic Pathways for Phenotypic Leukostasis in Newly Diagnosed Acute Myelogenous Leukemia
Identifying Clinical and Deregulated Genomic Pathways for Phenotypic Leukostasis in Newly Diagnosed Acute Myelogenous Leukemia Open
Background: Leukostasis is highly fatal. The entity is associated with hyperviscosity and microvascular ischemia. Risk factors include white blood cell count (WBC) >50K/uL, blasts CD56 expression and specific genomic abnormalities such …
View article: Specific Nucleotide Modifications Induce Neopeptides with High Major Histocompatibility Complex Binding in Myeloid Malignancies
Specific Nucleotide Modifications Induce Neopeptides with High Major Histocompatibility Complex Binding in Myeloid Malignancies Open
Background: Single Base Substitutions (SBS) are linked to mutagenic endogenous and exogenous processes in human DNA. Substantial number of signatures [Wellcome Sanger Institute, COSMIC database] have already been uncovered. Smoking and agi…
View article: Parallel Immunotranscriptomic and Immunohistochemistry Enhance Cluster Discrimination in Acute Myelogenous Leukemia
Parallel Immunotranscriptomic and Immunohistochemistry Enhance Cluster Discrimination in Acute Myelogenous Leukemia Open
Background: Acute myeloid leukemia (AML) demonstrates cell differentiation stages emphasizing the role for hematopoietic maturation arrest during leukemogenesis. Indeed, less differentiated AML stages retain enhanced sensitivity to hypomet…
View article: Investigating Metabolic and Immunologic Consequences of Nucleotide Substitutions in Acute Myeloid Leukemia
Investigating Metabolic and Immunologic Consequences of Nucleotide Substitutions in Acute Myeloid Leukemia Open
Background Stressors, conventionally defined as cell extrinsic factors with the ability to promote clonal evolution, have been implicated as modulators of cancer development and progression. Smoking has previously been linked to unique sin…
View article: Improved survival for dose-intensive chemotherapy in primary mediastinal B-cell lymphoma: a systematic review and meta-analysis of 4,068 patients
Improved survival for dose-intensive chemotherapy in primary mediastinal B-cell lymphoma: a systematic review and meta-analysis of 4,068 patients Open
Primary mediastinal B-cell lymphoma (PMBCL) is a distinct clinicopathologic entity. Currently, there is a paucity of randomized prospective data to inform on optimal front-line chemoimmunotherapy (CIT) and use of consolidative mediastinal …
View article: A balanced chromosomal translocation involving chromosomes 3 and 16 in a patient with Mayer-Rokitansky-Kuster-Hauser syndrome reveals new candidate genes at 3p22.3 and 16p13.3
A balanced chromosomal translocation involving chromosomes 3 and 16 in a patient with Mayer-Rokitansky-Kuster-Hauser syndrome reveals new candidate genes at 3p22.3 and 16p13.3 Open
We have mapped the breakpoints of our t(3;16)(p22.3;p13.3) translocation patient using molecular methods to within 13.6 kb at 3p22.3 and within 1.9 kb for 16p13.3 and have suggested 10 nearby genes that become plausible candidate genes for…