Lacey W. Heinsberg
YOU?
Author Swipe
View article: Gestational Diabetes - Risk Factors and Outcomes among American Samoan Women (GROW): A Longitudinal Cohort Study Protocol
Gestational Diabetes - Risk Factors and Outcomes among American Samoan Women (GROW): A Longitudinal Cohort Study Protocol Open
Background Gestational diabetes mellitus (GDM) is linked with adverse health outcomes for both mother and infant and increases the risk of type 2 diabetes mellitus (T2DM) and long-term metabolic dysfunction postpartum. American Samoa exper…
View article: Study protocol for the Health Outcomes in Pregnancy and Early Childhood (HOPE) Study: A mother-infant study in American Samoa
Study protocol for the Health Outcomes in Pregnancy and Early Childhood (HOPE) Study: A mother-infant study in American Samoa Open
Pacific Islanders, including those in American Samoa, face a disproportionately high burden of gestational diabetes mellitus (GDM) and related sequalae of metabolic conditions. The CREBRF rs373863828 genetic variant, which is uniquely comm…
View article: Allostatic Load Mediates Associations Between Race and Ethnicity and Hypertensive Disorders of Pregnancy
Allostatic Load Mediates Associations Between Race and Ethnicity and Hypertensive Disorders of Pregnancy Open
OBJECTIVE: To evaluate whether chronic stress exposure, measured by allostatic load (a biological measure of chronic stress embodiment, including stressors exacerbated by structural inequities [eg, structural racism]) and patient-reported …
View article: Differential DNA Methylation of the Brain-Derived Neurotrophic Factor Gene is Observed after Pediatric Traumatic Brain Injury Compared to Orthopedic Injury
Differential DNA Methylation of the Brain-Derived Neurotrophic Factor Gene is Observed after Pediatric Traumatic Brain Injury Compared to Orthopedic Injury Open
Importance Pediatric traumatic brain injury (TBI) triggers biological changes that may differ from those observed in non-brain injuries. BDNF DNA methylation (DNAm) may serve as a novel, dynamic biomarker of the brain’s response and help i…
View article: Study Protocol for the Health Outcomes in Pregnancy and Early Childhood (HOPE) Study: A Mother-Infant Study in American Samoa
Study Protocol for the Health Outcomes in Pregnancy and Early Childhood (HOPE) Study: A Mother-Infant Study in American Samoa Open
Introduction Pacific Islanders, including those in American Samoa, face a disproportionately high burden of gestational diabetes mellitus (GDM) and related sequalae of metabolic conditions. The CREBRF rs373863828 genetic variant, which is …
View article: Psychosocial correlates of HbA1c among adult Samoans without diabetes
Psychosocial correlates of HbA1c among adult Samoans without diabetes Open
Understanding psychosocial determinants of health is critical in understudied, high-risk populations, where such knowledge could have a major impact on health outcomes. In Samoa, where diabetes prevalence has rapidly increased over 30 year…
View article: Multivariate Bayesian Analyses in Nursing Research: An Introductory Guide
Multivariate Bayesian Analyses in Nursing Research: An Introductory Guide Open
In the era of precision health, nursing research has increasingly focused on the analysis of large, multidimensional data sets containing multiple correlated phenotypes (e.g., symptoms). This presents challenges for statistical analyses, e…
View article: Characterization of per- and polyfluoroalkyl substances (PFAS) concentrations in a community-based sample of infants from Samoa
Characterization of per- and polyfluoroalkyl substances (PFAS) concentrations in a community-based sample of infants from Samoa Open
Per- and polyfluoroalkyl substances (PFAS) are persistent contaminants with documented harmful health effects. Despite increasing research, little attention has been given to studying PFAS contamination in low- and middle-income countries,…
View article: Characterization of sleep apnea among a sample of adults from Samoa
Characterization of sleep apnea among a sample of adults from Samoa Open
Sleep apnea is a public health concern around the world, but little research has been dedicated to examining this issue in low- and middle-income countries, including Samoa. Using data collected through the Soifua Manuia (“Good Health”) st…
View article: Characterization of Per- and Polyfluoroalkyl Substance (PFAS) concentrations in a community-based sample of infants from Samoa
Characterization of Per- and Polyfluoroalkyl Substance (PFAS) concentrations in a community-based sample of infants from Samoa Open
Per- and polyfluoroalkyl substances (PFAS) are persistent contaminants with documented harmful health effects. Despite increasing research, little attention has been given to studying PFAS contamination in low- and middle-income countries,…
View article: A longitudinal epigenome-wide association study of preeclamptic and normotensive pregnancy
A longitudinal epigenome-wide association study of preeclamptic and normotensive pregnancy Open
Background While preeclampsia (PE) is a leading cause of pregnancy-related morbidity/mortality, its underlying mechanisms are not fully understood. DNA methylation (DNAm) is a dynamic regulator of gene expression that may offer insight int…
View article: Validity of anthropometric equation‐based estimators of fat mass in <scp>S</scp>amoan adults
Validity of anthropometric equation‐based estimators of fat mass in <span>S</span>amoan adults Open
Introduction In 1999, a set of highly accurate Polynesian‐specific equations to estimate adult body fat from non‐invasive field measures of age, sex, height, and weight (Equation 1), age, sex, height, weight, and bioelectrical impedance an…
View article: Multivariate analysis of a missense variant in <i>CREBRF</i> reveals associations with measures of adiposity in people of Polynesian ancestries
Multivariate analysis of a missense variant in <i>CREBRF</i> reveals associations with measures of adiposity in people of Polynesian ancestries Open
The minor allele of rs373863828, a missense variant in CREB3 Regulatory Factor, is associated with several cardiometabolic phenotypes in Polynesian peoples. To better understand the variant, we tested the association of rs373863828 with a …
View article: Brain-Derived Neurotrophic Factor (<i>BDNF</i>) Epigenomic Modifications and Brain-Related Phenotypes in Humans: A Systematic Review
Brain-Derived Neurotrophic Factor (<i>BDNF</i>) Epigenomic Modifications and Brain-Related Phenotypes in Humans: A Systematic Review Open
Epigenomic modifications of the brain-derived neurotrophic factor ( BDNF ) gene have been postulated to underlie the pathogenesis of neurodevelopmental, psychiatric, and neurological conditions. This systematic review summarizes current ev…
View article: Multivariate analysis of a missense variant in<i>CREBRF</i>reveals associations with measures of adiposity in people of Polynesian ancestries
Multivariate analysis of a missense variant in<i>CREBRF</i>reveals associations with measures of adiposity in people of Polynesian ancestries Open
Background The Pacific-specific minor allele of rs373863828, a missense variant in CREB3 Regulatory Factor ( CREBRF ), is associated with several cardiometabolic phenotypes in Polynesian peoples, but the variant’s function remains poorly u…
View article: Advancing Nursing Research Through Interactive Data Visualization With R Shiny
Advancing Nursing Research Through Interactive Data Visualization With R Shiny Open
Scientific data visualization is a critical aspect of fully understanding data patterns and trends. To date, the majority of data visualizations in nursing research – as with other biomedical fields – have been static. The availability of …
View article: Post hoc power is not informative
Post hoc power is not informative Open
Post hoc power estimates are often requested by reviewers and/or performed by researchers after a study has been conducted. The purpose of this commentary is to provide a heuristic explanation of why post hoc power should not be used. To i…
View article: Correlates of Daytime Sleepiness and Insomnia among Adults in Samoa
Correlates of Daytime Sleepiness and Insomnia among Adults in Samoa Open
Objective To describe daytime sleepiness and insomnia among adults in Samoa and identify modifiable factors associated with these measures. Design/setting Cross-sectional analysis of data from the Soifua Manuia (“Good Health”) study (n=519…
View article: An exploratory study of white blood cell proportions across preeclamptic and normotensive pregnancy by self-identified race in individuals with overweight or obesity
An exploratory study of white blood cell proportions across preeclamptic and normotensive pregnancy by self-identified race in individuals with overweight or obesity Open
Objective: Examine white blood cell (WBC) proportions across preeclamptic (n = 28 cases) and normotensive (n = 28 controls) pregnancy in individuals with overweight/obesity.Methods: WBC proportions were inferred from genome-wide DNA methyl…
View article: Acute <i>Brain-Derived</i><i> Neurotrophic Factor</i> DNA Methylation Trajectories in Cerebrospinal Fluid and Associations With Outcomes Following Severe Traumatic Brain Injury in Adults
Acute <i>Brain-Derived</i><i> Neurotrophic Factor</i> DNA Methylation Trajectories in Cerebrospinal Fluid and Associations With Outcomes Following Severe Traumatic Brain Injury in Adults Open
Background. Epigenetic biomarkers have the potential to explain outcome heterogeneity following traumatic brain injury (TBI) but are largely unexplored. Objective. This exploratory pilot study characterized brain-derived neurotrophic facto…
View article: Racial Differences in DNA Methylation-Based Age Acceleration in Preeclamptic and Normotensive Pregnancy
Racial Differences in DNA Methylation-Based Age Acceleration in Preeclamptic and Normotensive Pregnancy Open
Background Preeclampsia is a leading cause of maternal and neonatal morbidity and mortality. Chronological age and race are associated with increased risk of preeclampsia; however, the pathophysiology of preeclampsia and how these risk fac…