Lachlan T. Strike
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View article: Regional brain morphology and current antidepressant use: findings from 32 international cohorts from the ENIGMA major depressive disorder working group
Regional brain morphology and current antidepressant use: findings from 32 international cohorts from the ENIGMA major depressive disorder working group Open
The understanding of how antidepressant (AD) use is associated with brain structure in individuals with major depressive disorder (MDD) remains incomplete. We aimed to examine the association between AD medication use and brain morphology …
View article: Association between polygenic risk for Major Depression and brain structure in a mega-analysis of 50,975 participants across 11 studies
Association between polygenic risk for Major Depression and brain structure in a mega-analysis of 50,975 participants across 11 studies Open
Major Depression (MD) is a prevalent, disabling and life-limiting condition. The neurobiological associations of genetic risk for MD remain under-explored in large samples, with no comprehensive mega-analysis conducted to date. Our study a…
View article: Genetic and environmental contributions to ReHo and fALFF in early adolescence vary across brain regions
Genetic and environmental contributions to ReHo and fALFF in early adolescence vary across brain regions Open
Research on genetic and environmental influences on brain function generally focuses on connections between brain areas. A different yet unexplored approach is to examine activity within local brain regions. We investigated the influence o…
View article: Penetrance of Neurodevelopmental Copy Number Variants Is Associated With Variations in Cortical Morphology
Penetrance of Neurodevelopmental Copy Number Variants Is Associated With Variations in Cortical Morphology Open
Our findings link global and regional cortical morphometric features with CNV penetrance, providing new insights into neurobiological mechanisms of genetic risk for schizophrenia and other developmental disorders.
View article: Queensland Twin Adolescent Brain (QTAB) Non-Imaging Phenotypes
Queensland Twin Adolescent Brain (QTAB) Non-Imaging Phenotypes Open
Non-imaging phenotypes for the Queensland Twin Adolescent Brain (QTAB) project. The non-imaging phenotypes dataset contains restricted demographic data, as well as assessments of puberty, cognition, anxiety and/or depression, emotional and…
View article: Lifespan reference curves for harmonizing multi-site regional brain white matter metrics from diffusion MRI
Lifespan reference curves for harmonizing multi-site regional brain white matter metrics from diffusion MRI Open
View article: Dissecting heterogeneity in cortical thickness abnormalities in major depressive disorder: a large-scale ENIGMA MDD normative modelling study
Dissecting heterogeneity in cortical thickness abnormalities in major depressive disorder: a large-scale ENIGMA MDD normative modelling study Open
Importance Major depressive disorder (MDD) is highly heterogeneous, with marked individual differences in clinical presentation and neurobiology, which may obscure identification of structural brain abnormalities in MDD. To explore this, w…
View article: Genetic and Environmental Influences on Literacy and Numeracy Performance in School Children: A Longitudinal Twin Study
Genetic and Environmental Influences on Literacy and Numeracy Performance in School Children: A Longitudinal Twin Study Open
View article: Heritability of cerebellar subregion volumes in adolescent and young adult twins
Heritability of cerebellar subregion volumes in adolescent and young adult twins Open
Twin studies have found gross cerebellar volume to be highly heritable. However, whether fine‐grained regional volumes within the cerebellum are similarly heritable is still being determined. Anatomical MRI scans from two independent datas…
View article: Lifespan reference curves for harmonizing multi-site regional brain white matter metrics from diffusion MRI
Lifespan reference curves for harmonizing multi-site regional brain white matter metrics from diffusion MRI Open
Age-related white matter (WM) microstructure maturation and decline occur throughout the human lifespan with a unique trajectory in the brain, complementing the process of gray matter development and degeneration. Normative modeling can es…
View article: Autism-related dietary preferences mediate autism-gut microbiome associations
Autism-related dietary preferences mediate autism-gut microbiome associations Open
View article: Beyond the Global Brain Differences: Intraindividual Variability Differences in 1q21.1 Distal and 15q11.2 BP1-BP2 Deletion Carriers
Beyond the Global Brain Differences: Intraindividual Variability Differences in 1q21.1 Distal and 15q11.2 BP1-BP2 Deletion Carriers Open
We find evidence for regional effects beyond differences in global brain measures in 1q21.1 distal and 15q11.2 BP1-BP2 copy number variants. The results provide new insight into brain profiling of the 1q21.1 distal and 15q11.2 BP1-BP2 copy…
View article: Temporo-basal sulcal connections: a manual annotation protocol and an investigation of sexual dimorphism and heritability
Temporo-basal sulcal connections: a manual annotation protocol and an investigation of sexual dimorphism and heritability Open
The temporo-basal region of the human brain is composed of the collateral, the occipito-temporal, and the rhinal sulci. We manually rated (using a novel protocol) the connections between rhinal/collateral (RS-CS), collateral/occipito-tempo…
View article: The Queensland Twin Adolescent Brain Project, a longitudinal study of adolescent brain development
The Queensland Twin Adolescent Brain Project, a longitudinal study of adolescent brain development Open
View article: Interactions between the lipidome and genetic and environmental factors in autism
Interactions between the lipidome and genetic and environmental factors in autism Open
View article: Main Existing Datasets for Open Brain Research on Humans
Main Existing Datasets for Open Brain Research on Humans Open
Recent advances in technology have made possible to quantify fine-grained individual differences at many levels, such as genetic, genomics, organ level, behavior, and clinical. The wealth of data becoming available raises great promises fo…
View article: Queensland Twin Adolescent Brain (QTAB) Non-Imaging Phenotypes
Queensland Twin Adolescent Brain (QTAB) Non-Imaging Phenotypes Open
Non-imaging phenotypes for the Queensland Twin Adolescent Brain (QTAB) project. The non-imaging phenotypes dataset contains restricted demographic data, as well as assessments of puberty, cognition, anxiety and/or depression, emotional and…
View article: Queensland Twin Adolescent Brain (QTAB) Non-Imaging Phenotypes
Queensland Twin Adolescent Brain (QTAB) Non-Imaging Phenotypes Open
<p>Non-imaging phenotypes for the Queensland Twin Adolescent Brain (QTAB) project. The non-imaging phenotypes dataset contains restricted demographic data, as well as assessments of puberty, cognition, anxiety and/or depression, emot…
View article: Genetic Specificity of Hippocampal Subfield Volumes, Relative to Hippocampal Formation, Identified in 2148 Young Adult Twins and Siblings
Genetic Specificity of Hippocampal Subfield Volumes, Relative to Hippocampal Formation, Identified in 2148 Young Adult Twins and Siblings Open
The hippocampus is a complex brain structure with key roles in cognitive and emotional processing and with subregion abnormalities associated with a range of disorders and psychopathologies. Here we combine data from two large independent …
View article: Persistence of Anxiety/Depression Symptoms in Early Adolescence: A Prospective Study of Daily Life Stress, Rumination, and Daytime Sleepiness in a Genetically Informative Cohort
Persistence of Anxiety/Depression Symptoms in Early Adolescence: A Prospective Study of Daily Life Stress, Rumination, and Daytime Sleepiness in a Genetically Informative Cohort Open
In this prospective study of mental health, we examine the influence of three interrelated traits — perceived stress, rumination, and daytime sleepiness — and their association with symptoms of anxiety and depression in early adolescence. …
View article: The Queensland Twin Adolescent Brain Project, a longitudinal study of adolescent brain development
The Queensland Twin Adolescent Brain Project, a longitudinal study of adolescent brain development Open
We describe the Queensland Twin Adolescent Brain (QTAB) dataset and provide a detailed methodology and technical validation to facilitate data usage. The QTAB dataset comprises multimodal neuroimaging, as well as cognitive and mental healt…
View article: Main existing datasets for open data research on humans
Main existing datasets for open data research on humans Open
Recent advances in technology have made possible to quantify fine-grained individual differences at many levels, such as genetic, genomics, organ level, behaviour, clinical. The wealth of data becoming available raises great promises for r…
View article: ErbB Signaling Pathway Genes Are Differentially Expressed in Monozygotic Twins Discordant for Sports-Related Concussion
ErbB Signaling Pathway Genes Are Differentially Expressed in Monozygotic Twins Discordant for Sports-Related Concussion Open
Transcriptional changes involved in neuronal recovery after sports-related concussion (SRC) may be obscured by inter-individual variation in mRNA expression and nonspecific changes related to physical exertion. Using a co-twin study, the o…
View article: Are Sex Differences in Human Brain Structure Associated With Sex Differences in Behavior?
Are Sex Differences in Human Brain Structure Associated With Sex Differences in Behavior? Open
On average, men and women differ in brain structure and behavior, raising the possibility of a link between sex differences in brain and behavior. But women and men are also subject to different societal and cultural norms. We navigated th…
View article: Are sex differences in human brain structure associated with sex differences in behaviour?
Are sex differences in human brain structure associated with sex differences in behaviour? Open
On average, men and women differ in brain structure and behaviour, raising the possibility of a link between sex differences in brain and behaviour. But women and men are also subject to different societal and cultural norms. We navigated …
View article: Brain Correlates of Suicide Attempt in 18,925 Participants Across 18 International Cohorts
Brain Correlates of Suicide Attempt in 18,925 Participants Across 18 International Cohorts Open
View article: Genetic and environmental influences on sleep-wake behaviors in adolescence
Genetic and environmental influences on sleep-wake behaviors in adolescence Open
Study Objectives To investigate the influence of genetic and environmental factors on sleep-wake behaviors across adolescence. Methods Four hundred and ninety-five participants (aged 9–17; 55% females), including 93 monozygotic and 117 diz…
View article: A unified framework for association and prediction from vertex‐wise grey‐matter structure
A unified framework for association and prediction from vertex‐wise grey‐matter structure Open
The recent availability of large‐scale neuroimaging cohorts facilitates deeper characterisation of the relationship between phenotypic and brain architecture variation in humans. Here, we investigate the association (previously coined morp…
View article: Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group
Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group Open
View article: Brain correlates of suicide attempt in 18,925 participants across 18 international cohorts
Brain correlates of suicide attempt in 18,925 participants across 18 international cohorts Open
SUMMARY Background Suicidal behavior is highly heterogeneous and complex. A better understanding of its biological substrates and mechanisms could inform the design of more effective suicide prevention and intervention strategies. Neuroima…