Lael D. Barlow
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View article: A large structural variant collection in Holstein cattle and associated database for variant discovery, characterization, and application
A large structural variant collection in Holstein cattle and associated database for variant discovery, characterization, and application Open
View article: Endosomal vesicle fusion machinery is involved with the contractile vacuole in <i>Dictyostelium discoideum</i>
Endosomal vesicle fusion machinery is involved with the contractile vacuole in <i>Dictyostelium discoideum</i> Open
Contractile vacuoles (CVs), enigmatic osmoregulatory organelles, share common characteristics, such as a requirement for RAB11 and high levels of V-ATPase. These commonalities suggest a conserved evolutionary origin for the CVs with implic…
View article: The <i>Mastigamoeba balamuthi</i> Genome and the Nature of the Free-Living Ancestor of <i>Entamoeba</i>
The <i>Mastigamoeba balamuthi</i> Genome and the Nature of the Free-Living Ancestor of <i>Entamoeba</i> Open
The transition of free-living organisms to parasitic organisms is a mysterious process that occurs in all major eukaryotic lineages. Parasites display seemingly unique features associated with their pathogenicity; however, it is important …
View article: Evolution and diversification of the nuclear envelope
Evolution and diversification of the nuclear envelope Open
Eukaryotic cells arose ~1.5 billion years ago, with the endomembrane system a central feature, facilitating evolution of intracellular compartments. Endomembranes include the nuclear envelope (NE) dividing the cytoplasm and nucleoplasm. Th…
View article: Evolution and diversification of the nuclear envelope
Evolution and diversification of the nuclear envelope Open
Eukaryotic cells arose ~1.5 billion years ago, with the endomembrane system a central feature, facilitating evolution of intracellular compartments. Endomembranes include the nuclear envelope (NE) dividing the cytoplasm and nucleoplasm. Th…
View article: Tracing animal genomic evolution with the chromosomal-level assembly of the freshwater sponge Ephydatia muelleri
Tracing animal genomic evolution with the chromosomal-level assembly of the freshwater sponge Ephydatia muelleri Open
View article: Evolution and Natural History of Membrane Trafficking in Eukaryotes
Evolution and Natural History of Membrane Trafficking in Eukaryotes Open
View article: Evolution of the eukaryotic membrane trafficking system as revealed by comparative genomic and phylogenetic analysis of adaptin, golgin, and SNARE proteins
Evolution of the eukaryotic membrane trafficking system as revealed by comparative genomic and phylogenetic analysis of adaptin, golgin, and SNARE proteins Open
All eukaryotic cells possess a complex system of endomembranes that functions in trafficking molecular cargo within the cell, which is not observed in prokaryotic cells. This membrane trafficking system is fundamental to the cellular physi…
View article: The Oxymonad Genome Displays Canonical Eukaryotic Complexity in the Absence of a Mitochondrion
The Oxymonad Genome Displays Canonical Eukaryotic Complexity in the Absence of a Mitochondrion Open
The discovery that the protist Monocercomonoides exilis completely lacks mitochondria demonstrates that these organelles are not absolutely essential to eukaryotic cells. However, the degree to which the metabolism and cellular systems of …
View article: Evolutionary cell biology traces the rise of the exomer complex in Fungi from an ancient eukaryotic component
Evolutionary cell biology traces the rise of the exomer complex in Fungi from an ancient eukaryotic component Open
View article: Correction to: A sophisticated, differentiated Golgi in the ancestor of eukaryotes
Correction to: A sophisticated, differentiated Golgi in the ancestor of eukaryotes Open
View article: A sophisticated, differentiated Golgi in the ancestor of eukaryotes
A sophisticated, differentiated Golgi in the ancestor of eukaryotes Open
None of the proteins examined show a phyletic distribution that correlates with the morphology of stacked cisternae, suggesting the possibility of stacking as an emergent property. Strikingly, however, the combination of golgins conserved …
View article: Additional file 10: of A sophisticated, differentiated Golgi in the ancestor of eukaryotes
Additional file 10: of A sophisticated, differentiated Golgi in the ancestor of eukaryotes Open
Table S4. Sources of genomic data used for this study. (CSV 23 kb)
View article: Additional file 9: of A sophisticated, differentiated Golgi in the ancestor of eukaryotes
Additional file 9: of A sophisticated, differentiated Golgi in the ancestor of eukaryotes Open
Amino acid sequence alignments used to construct Hidden Markov Models for homology searching. Alignment names correspond to HMM names in Additional file 6: Table S3. (AFA 5309 kb)
View article: Additional file 12: of A sophisticated, differentiated Golgi in the ancestor of eukaryotes
Additional file 12: of A sophisticated, differentiated Golgi in the ancestor of eukaryotes Open
Amino acid sequence alignments used for phylogenetics analyses of GRASP homologues (Additional file 7: Figure S4). The mask indicates the positions in the alignment that were included in the analysis. (AFA 22 kb)
View article: Additional file 11: of A sophisticated, differentiated Golgi in the ancestor of eukaryotes
Additional file 11: of A sophisticated, differentiated Golgi in the ancestor of eukaryotes Open
Amino acid sequence alignment used for phylogenetic analysis of beta subunits of COPI and adaptin complexes (Additional file 4: Figure S2). The mask indicates the positions in the alignment that were included in the analysis. (AFA 40 kb)
View article: Additional file 6: of A sophisticated, differentiated Golgi in the ancestor of eukaryotes
Additional file 6: of A sophisticated, differentiated Golgi in the ancestor of eukaryotes Open
Table S3. All potential Golgi stacking protein sequences identified. Some databases, including for Homo sapiens and Rattus norvegicus, include several predicted sequences for a single locus; therefore, each sequence does not necessarily co…
View article: Additional file 3: of A sophisticated, differentiated Golgi in the ancestor of eukaryotes
Additional file 3: of A sophisticated, differentiated Golgi in the ancestor of eukaryotes Open
Table S2. Annotated M. balamuthi genes encoding Golgi proteins. Predicted protein amino acid sequences of identified genes, after manual adjustment and annotation of gene models, are listed. BLAST search results are also listed for searche…
View article: Evolution of the endomembrane systems of trypanosomatids – conservation and specialisation
Evolution of the endomembrane systems of trypanosomatids – conservation and specialisation Open
Parasite surfaces support multiple functions required for survival within their hosts, and maintenance and functionality of the surface depends on membrane trafficking. To understand the evolutionary history of trypanosomatid trafficking, …
View article: A Eukaryote without a Mitochondrial Organelle
A Eukaryote without a Mitochondrial Organelle Open
View article: A Role for the Ancient SNARE Syntaxin 17 in Regulating Mitochondrial Division
A Role for the Ancient SNARE Syntaxin 17 in Regulating Mitochondrial Division Open