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View article: CYP1A1/1A2 enzymes mediate glucose homeostasis and insulin secretion in mice in a sex-specific manner
CYP1A1/1A2 enzymes mediate glucose homeostasis and insulin secretion in mice in a sex-specific manner Open
Cytochrome P450 (CYP)1A1/1A2 enzymes have sex-specific roles in glucose homeostasis in mice. In females, global Cyp1a1/1a2 deletion partially protects from glucose intolerance in high-fat diet (HFD)-fed mice and lowers plasma insulin in ch…
View article: Cisplatin Exposure Dysregulates Insulin Secretion in Male and Female Mice
Cisplatin Exposure Dysregulates Insulin Secretion in Male and Female Mice Open
Cancer survivors have an increased risk of developing type 2 diabetes compared with the general population. Patients treated with cisplatin, a common chemotherapeutic agent, are more likely to develop metabolic syndrome and type 2 diabetes…
View article: Cisplatin exposure dysregulates insulin secretion in male and female mice
Cisplatin exposure dysregulates insulin secretion in male and female mice Open
Cancer survivors have an increased risk of developing Type 2 diabetes compared to the general population. Patients treated with cisplatin, a common chemotherapeutic agent, are more likely to develop metabolic syndrome and Type 2 diabetes t…
View article: Cisplatin exposure dysregulates insulin secretion in male and female mice
Cisplatin exposure dysregulates insulin secretion in male and female mice Open
Cancer survivors have an increased risk of developing Type 2 diabetes compared to the general population. Patients treated with cisplatin, a common chemotherapeutic agent, are more likely to develop metabolic syndrome and Type 2 diabetes t…
View article: Cisplatin exposure dysregulates pancreatic islet function in male mice
Cisplatin exposure dysregulates pancreatic islet function in male mice Open
Cancer survivors have an increased risk of developing new-onset Type 2 diabetes compared to the general population. Moreover, patients treated with cisplatin, a commonly used chemotherapeutic agent, are more likely to develop metabolic syn…
View article: The aryl hydrocarbon receptor in β-cells mediates the effects of TCDD on glucose homeostasis in mice
The aryl hydrocarbon receptor in β-cells mediates the effects of TCDD on glucose homeostasis in mice Open
Our study demonstrates that AhR signaling in β-cells is important for regulating baseline β-cell function in female mice and energy homeostasis in male mice. We also show that β-cell AhR signaling largely mediates the effects of TCDD on gl…
View article: The aryl hydrocarbon receptor in β-cells mediates the effects of TCDD on glucose homeostasis in mice
The aryl hydrocarbon receptor in β-cells mediates the effects of TCDD on glucose homeostasis in mice Open
Chronic exposure to persistent organic pollutants (POPs) is associated with increased incidence of type 2 diabetes, hyperglycemia, and poor insulin secretion in humans. Dioxins and dioxin-like compounds are a broad class of POPs that exert…